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Protein

Glycine N-acyltransferase-like protein 3

Gene

GLYATL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acyltransferase which transfers the acyl group to the N-terminus of glycine.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-177128. Conjugation of salicylate with glycine.
R-HSA-177135. Conjugation of benzoate with glycine.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-acyltransferase-like protein 3 (EC:2.3.1.-)
Gene namesi
Name:GLYATL3
Synonyms:C6orf140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21349. GLYATL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165617919.

Polymorphism and mutation databases

BioMutaiGLYATL3.
DMDMi269849680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Glycine N-acyltransferase-like protein 3PRO_0000336055Add
BLAST

Proteomic databases

EPDiQ5SZD4.
PaxDbiQ5SZD4.
PRIDEiQ5SZD4.

PTM databases

PhosphoSiteiQ5SZD4.

Expressioni

Gene expression databases

BgeeiQ5SZD4.
CleanExiHS_C6orf140.
ExpressionAtlasiQ5SZD4. baseline.

Organism-specific databases

HPAiHPA044044.

Interactioni

Protein-protein interaction databases

BioGridi133128. 1 interaction.
IntActiQ5SZD4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5SZD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycine N-acyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410IYSJ. Eukaryota.
ENOG4111RDK. LUCA.
GeneTreeiENSGT00390000004997.
HOGENOMiHOG000263599.
InParanoidiQ5SZD4.
OMAiAVHFSPV.
OrthoDBiEOG7MKW6X.
PhylomeDBiQ5SZD4.
TreeFamiTF353258.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERiPTHR15298. PTHR15298. 1 hit.
PfamiPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SZD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLNCSTKL LILEKMLKSC FPESLKVYGA VMNINRGNPF QKEVVLDSWP
60 70 80 90 100
DFKAVITRRQ REAETDNLDH YTNAYAVFYK DVRAYRQLLE ECDVFNWDQV
110 120 130 140 150
FQIQGLQSEL YDVSKAVANS KQLNIKLTSF KAVHFSPVSS LPDTSFLKGP
160 170 180 190 200
SPRLTYLSVA NADLLNRTWS RGGNEQCLRY IANLISCFPS VCVRDEKGNP
210 220 230 240 250
VSWSITDQFA TMCHGYTLPE HRRKGYSRLV ALTLARKLQS RGFPSQGNVL
260 270 280
DDNTASISLL KSLHAEFLPC RFHRLILTPA TFSGLPHL
Length:288
Mass (Da):32,704
Last modified:November 24, 2009 - v3
Checksum:iE83D9766EFB7F1B8
GO

Sequence cautioni

The sequence CAI13086.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041Q → K in AK126371 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126371 mRNA. No translation available.
AL590244 Genomic DNA. Translation: CAI13086.1. Sequence problems.
CCDSiCCDS47440.1.
RefSeqiNP_001010904.1. NM_001010904.1.
XP_011512901.1. XM_011514599.1.
UniGeneiHs.585172.

Genome annotation databases

EnsembliENST00000371197; ENSP00000360240; ENSG00000203972.
GeneIDi389396.
KEGGihsa:389396.
UCSCiuc003ozi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126371 mRNA. No translation available.
AL590244 Genomic DNA. Translation: CAI13086.1. Sequence problems.
CCDSiCCDS47440.1.
RefSeqiNP_001010904.1. NM_001010904.1.
XP_011512901.1. XM_011514599.1.
UniGeneiHs.585172.

3D structure databases

ProteinModelPortaliQ5SZD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133128. 1 interaction.
IntActiQ5SZD4. 1 interaction.

PTM databases

PhosphoSiteiQ5SZD4.

Polymorphism and mutation databases

BioMutaiGLYATL3.
DMDMi269849680.

Proteomic databases

EPDiQ5SZD4.
PaxDbiQ5SZD4.
PRIDEiQ5SZD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371197; ENSP00000360240; ENSG00000203972.
GeneIDi389396.
KEGGihsa:389396.
UCSCiuc003ozi.4. human.

Organism-specific databases

CTDi389396.
GeneCardsiGLYATL3.
HGNCiHGNC:21349. GLYATL3.
HPAiHPA044044.
MIMi614763. gene.
neXtProtiNX_Q5SZD4.
PharmGKBiPA165617919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYSJ. Eukaryota.
ENOG4111RDK. LUCA.
GeneTreeiENSGT00390000004997.
HOGENOMiHOG000263599.
InParanoidiQ5SZD4.
OMAiAVHFSPV.
OrthoDBiEOG7MKW6X.
PhylomeDBiQ5SZD4.
TreeFamiTF353258.

Enzyme and pathway databases

ReactomeiR-HSA-177128. Conjugation of salicylate with glycine.
R-HSA-177135. Conjugation of benzoate with glycine.

Miscellaneous databases

GenomeRNAii389396.
NextBioi102840.
PROiQ5SZD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SZD4.
CleanExiHS_C6orf140.
ExpressionAtlasiQ5SZD4. baseline.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERiPTHR15298. PTHR15298. 1 hit.
PfamiPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGLYL3_HUMAN
AccessioniPrimary (citable) accession number: Q5SZD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 24, 2009
Last modified: March 16, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.