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Protein

Uncharacterized serine/threonine-protein kinase SgK494

Gene

Sgk494

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291ATPPROSITE-ProRule annotation
Active sitei222 – 2221Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi106 – 1149ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized serine/threonine-protein kinase SgK494 (EC:2.7.11.1)
Alternative name(s):
Sugen kinase 494
Gene namesi
Name:Sgk494
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2652869. BC030499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Uncharacterized serine/threonine-protein kinase SgK494PRO_0000250647Add
BLAST

Proteomic databases

PaxDbiQ5SYL1.
PRIDEiQ5SYL1.

PTM databases

PhosphoSiteiQ5SYL1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037593.
CleanExiMM_BC030499.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038139.

Structurei

3D structure databases

ProteinModelPortaliQ5SYL1.
SMRiQ5SYL1. Positions 17-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 278179Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00800000124105.
HOGENOMiHOG000154304.
HOVERGENiHBG093948.
InParanoidiQ5SYL1.
OMAiLDCGQKA.
OrthoDBiEOG091G076X.
TreeFamiTF331546.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SYL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVSCRQGQ HTRVSAPQKG DNIQGHWVQG WKSLWCGMGT IRSGLEELWG
60 70 80 90 100
LQRHQCLHQE LLQPAPLLLE KPQSEWPVPQ FISLFLPEFP VRPVREQQEL
110 120 130 140 150
KILGLVAKGS FGTVLKVLDC AQKAVFAVKV VPKVKVLQRD TLRQCKEEVS
160 170 180 190 200
IQRQINHPFV HSLGDSWQGK QHLFIMCSYC SMDLYSLWST VGWFPEDSIR
210 220 230 240 250
LFAAELVLVL CYLHDLGIIH RDVKMENILL DERGHLKVTD FGLSRHLSQG
260 270
ARAYTICGTL QYMGEREAKV GREGDLRM
Length:278
Mass (Da):31,682
Last modified:December 21, 2004 - v1
Checksum:i00DF615E93861F68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591070 Genomic DNA. Translation: CAI24320.1.
UniGeneiMm.477146.

Genome annotation databases

EnsembliENSMUST00000046361; ENSMUSP00000038139; ENSMUSG00000037593.
UCSCiuc033fyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591070 Genomic DNA. Translation: CAI24320.1.
UniGeneiMm.477146.

3D structure databases

ProteinModelPortaliQ5SYL1.
SMRiQ5SYL1. Positions 17-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038139.

PTM databases

PhosphoSiteiQ5SYL1.

Proteomic databases

PaxDbiQ5SYL1.
PRIDEiQ5SYL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046361; ENSMUSP00000038139; ENSMUSG00000037593.
UCSCiuc033fyn.1. mouse.

Organism-specific databases

MGIiMGI:2652869. BC030499.

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00800000124105.
HOGENOMiHOG000154304.
HOVERGENiHBG093948.
InParanoidiQ5SYL1.
OMAiLDCGQKA.
OrthoDBiEOG091G076X.
TreeFamiTF331546.

Miscellaneous databases

PROiQ5SYL1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037593.
CleanExiMM_BC030499.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSG494_MOUSE
AccessioniPrimary (citable) accession number: Q5SYL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.