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Protein

Unconventional myosin-Id

Gene

Myo1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPSequence analysisBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Id
Gene namesi
Name:Myo1dImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107728 Myo1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001234482 – 1006Unconventional myosin-IdAdd BLAST1005

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei200PhosphoserineBy similarity1
Modified residuei536PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5SYD0
PeptideAtlasiQ5SYD0
PRIDEiQ5SYD0

PTM databases

iPTMnetiQ5SYD0
PhosphoSitePlusiQ5SYD0
SwissPalmiQ5SYD0

Expressioni

Gene expression databases

BgeeiENSMUSG00000035441
CleanExiMM_MYO1D
GenevisibleiQ5SYD0 MM

Interactioni

Subunit structurei

Binds calmodulin through its IQ motifs.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237219, 2 interactors
IntActiQ5SYD0, 3 interactors
MINTiQ5SYD0
STRINGi10090.ENSMUSP00000037819

Structurei

3D structure databases

ProteinModelPortaliQ5SYD0
SMRiQ5SYD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 695Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini699 – 719IQ 1PROSITE-ProRule annotationBy similarityAdd BLAST21
Domaini721 – 741IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini812 – 1005TH1PROSITE-ProRule annotationAdd BLAST194

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni572 – 594Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140778
HOGENOMiHOG000260264
HOVERGENiHBG062373
InParanoidiQ5SYD0
KOiK10356
OMAiFNRWRAS
OrthoDBiEOG091G0136
PhylomeDBiQ5SYD0
TreeFamiTF312960

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SYD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN
60 70 80 90 100
PYKVLNIYGR DTVEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIMI
110 120 130 140 150
SGESGAGKTE ASKYIMQYIA AITNPSQRAE IERVKNMLLK SNCVLEAFGN
160 170 180 190 200
AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS
210 220 230 240 250
FHSFYQLLQG GSEQMLHSLH LQKSLSSYNY IRVGAQLKSS INDAAEFKVV
260 270 280 290 300
ADAMKVIGFK PEEIQTVYKI LAVILHLGNL KFIVDGDTPL IENGKVVSVI
310 320 330 340 350
AELLSTKADM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER
360 370 380 390 400
LFCWIVTRIN DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI
410 420 430 440 450
NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK
460 470 480 490 500
GIIAILDDAC MNVGKVTDGM FLEALNSKLG KHGHFSSRKT CASDKILEFD
510 520 530 540 550
RDFRIRHYAG DVVYSAIGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG
560 570 580 590 600
KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI
610 620 630 640 650
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH
660 670 680 690 700
DLPSDKEAVK KLIERCGFQD DVAYGKSKIF IRTPRTLFTL EELRAQMLVR
710 720 730 740 750
VVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGV
760 770 780 790 800
KNMRDYGKHV KWPTPPKVLR RFEEALQSIF NRWRASQLIK TIPASDLPQV
810 820 830 840 850
RAKVAAMEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR
860 870 880 890 900
KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
910 920 930 940 950
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV
960 970 980 990 1000
NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI

LSVPGN
Length:1,006
Mass (Da):116,081
Last modified:December 21, 2004 - v1
Checksum:i547A7FDCA656E572
GO
Isoform 21 Publication (identifier: Q5SYD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     904-944: LTGLSVSNGK...QPTHESRIGE → ISHAHSSALT...QTGYKGGLQM
     945-1006: Missing.

Show »
Length:944
Mass (Da):109,278
Checksum:iCE250517FA680841
GO

Sequence cautioni

The sequence BAC33719 differs from that shown. Reason: Frameshift at position 784.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051938904 – 944LTGLS…SRIGE → ISHAHSSALTLHLLLGRTNF RTMEWLPPLVRQTGYKGGLQ M in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_051939945 – 1006Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049374 mRNA Translation: BAC33719.1 Frameshift.
AL591146, AL591410, AL663054 Genomic DNA Translation: CAI24746.1
AL591410, AL591146, AL663054 Genomic DNA Translation: CAI26106.1
AL591410, AL663054 Genomic DNA Translation: CAI26107.1
AL663054, AL591146, AL591410 Genomic DNA Translation: CAI25852.1
AL663054, AL591410 Genomic DNA Translation: CAI25853.1
CCDSiCCDS36242.1 [Q5SYD0-1]
RefSeqiNP_796364.2, NM_177390.3 [Q5SYD0-1]
XP_006533648.1, XM_006533585.1 [Q5SYD0-2]
UniGeneiMm.151948

Genome annotation databases

EnsembliENSMUST00000041065; ENSMUSP00000037819; ENSMUSG00000035441 [Q5SYD0-1]
ENSMUST00000070997; ENSMUSP00000066948; ENSMUSG00000035441 [Q5SYD0-2]
GeneIDi338367
KEGGimmu:338367
UCSCiuc007kmh.1 mouse [Q5SYD0-1]
uc011yau.1 mouse [Q5SYD0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMYO1D_MOUSE
AccessioniPrimary (citable) accession number: Q5SYD0
Secondary accession number(s): Q5SSK7, Q8BWY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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