Q5SYD0 (MYO1D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Unconventional myosin-Id

Gene names

Name:

Myo1d

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1006 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments By similarity. UniProtKB P97479
Subunit structure	Binds calmodulin through its IQ motifs By similarity. UniProtKB Q63357
Sequence similarities	Contains 2 IQ domains. Contains 1 myosin head-like domain.
Caution	Represents a unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).
Sequence caution	The sequence BAC33719.1 differs from that shown. Reason: Frameshift at position 784.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	ATP-binding Actin-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	axolemma Inferred from electronic annotation. Source: Compara myosin complex Inferred from electronic annotation. Source: UniProtKB-KW smooth endoplasmic reticulum Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW actin-dependent ATPase activity Inferred from electronic annotation. Source: Compara microfilament motor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.3 (identifier: Q5SYD0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 Ref.3 (identifier: Q5SYD0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     904-944: LTGLSVSNGK...QPTHESRIGE → ISHAHSSALT...QTGYKGGLQM
     945-1006: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 1006	1005	Unconventional myosin-Id		PRO_0000123448
Regions
	Domain	2 – 682	681	Myosin head-like
	Domain	699 – 719	21	IQ 1
	Domain	721 – 741	21	IQ 2
	Nucleotide binding	102 – 109	8	ATP Potential UniProtKB P08799
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	200	1	Phosphoserine By similarity
	Modified residue	536	1	Phosphotyrosine Ref.3
Natural variations
	Alternative sequence	904 – 944	41	LTGLS…SRIGE → ISHAHSSALTLHLLLGRTNF RTMEWLPPLVRQTGYKGGLQ M in isoform 2. Ref.1		VSP_051938
	Alternative sequence	945 – 1006	62	Missing in isoform 2. Ref.1		VSP_051939

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 547A7FDCA656E572	FASTA	1,006	116,081
	10 20 30 40 50 60 MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN PYKVLNIYGR 70 80 90 100 110 120 DTVEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIMI SGESGAGKTE ASKYIMQYIA 130 140 150 160 170 180 AITNPSQRAE IERVKNMLLK SNCVLEAFGN AKTNRNDNSS RFGKYMDINF DFKGDPIGGH 190 200 210 220 230 240 INNYLLEKSR VIVQQPGERS FHSFYQLLQG GSEQMLHSLH LQKSLSSYNY IRVGAQLKSS 250 260 270 280 290 300 INDAAEFKVV ADAMKVIGFK PEEIQTVYKI LAVILHLGNL KFIVDGDTPL IENGKVVSVI 310 320 330 340 350 360 AELLSTKADM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER LFCWIVTRIN 370 380 390 400 410 420 DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI NYCNEKLQQL FIQLVLKQEQ 430 440 450 460 470 480 EEYQREGIPW KHIDYFNNQI IVDLVEQQHK GIIAILDDAC MNVGKVTDGM FLEALNSKLG 490 500 510 520 530 540 KHGHFSSRKT CASDKILEFD RDFRIRHYAG DVVYSAIGFI DKNKDTLFQD FKRLMYNSSN 550 560 570 580 590 600 PVLKNMWPEG KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI 610 620 630 640 650 660 FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH DLPSDKEAVK 670 680 690 700 710 720 KLIERCGFQD DVAYGKSKIF IRTPRTLFTL EELRAQMLVR VVLFLQKVWR GTLARMRYKR 730 740 750 760 770 780 TKAALTIIRY YRRYKVKSYI HEVARRFHGV KNMRDYGKHV KWPTPPKVLR RFEEALQSIF 790 800 810 820 830 840 NRWRASQLIK TIPASDLPQV RAKVAAMEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT 850 860 870 880 890 900 FVPVANELKR KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP 910 920 930 940 950 960 LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV NHFKSEKRHL 970 980 990 1000 QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI LSVPGN
	Isoform 2 [UniParc]. Checksum: CE250517FA680841	FASTA	944	109,278
	10 20 30 40 50 60 MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN PYKVLNIYGR 70 80 90 100 110 120 DTVEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIMI SGESGAGKTE ASKYIMQYIA 130 140 150 160 170 180 AITNPSQRAE IERVKNMLLK SNCVLEAFGN AKTNRNDNSS RFGKYMDINF DFKGDPIGGH 190 200 210 220 230 240 INNYLLEKSR VIVQQPGERS FHSFYQLLQG GSEQMLHSLH LQKSLSSYNY IRVGAQLKSS 250 260 270 280 290 300 INDAAEFKVV ADAMKVIGFK PEEIQTVYKI LAVILHLGNL KFIVDGDTPL IENGKVVSVI 310 320 330 340 350 360 AELLSTKADM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER LFCWIVTRIN 370 380 390 400 410 420 DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI NYCNEKLQQL FIQLVLKQEQ 430 440 450 460 470 480 EEYQREGIPW KHIDYFNNQI IVDLVEQQHK GIIAILDDAC MNVGKVTDGM FLEALNSKLG 490 500 510 520 530 540 KHGHFSSRKT CASDKILEFD RDFRIRHYAG DVVYSAIGFI DKNKDTLFQD FKRLMYNSSN 550 560 570 580 590 600 PVLKNMWPEG KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI 610 620 630 640 650 660 FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH DLPSDKEAVK 670 680 690 700 710 720 KLIERCGFQD DVAYGKSKIF IRTPRTLFTL EELRAQMLVR VVLFLQKVWR GTLARMRYKR 730 740 750 760 770 780 TKAALTIIRY YRRYKVKSYI HEVARRFHGV KNMRDYGKHV KWPTPPKVLR RFEEALQSIF 790 800 810 820 830 840 NRWRASQLIK TIPASDLPQV RAKVAAMEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT 850 860 870 880 890 900 FVPVANELKR KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP 910 920 930 940 LYNISHAHSS ALTLHLLLGR TNFRTMEWLP PLVRQTGYKG GLQM

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Embryonic stem cell.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-536, MASS SPECTROMETRY. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK049374 mRNA. Translation: BAC33719.1. Frameshift. AL591146, AL591410, AL663054 Genomic DNA. Translation: CAI24746.1. AL591410, AL591146, AL663054 Genomic DNA. Translation: CAI26106.1. AL591410, AL663054 Genomic DNA. Translation: CAI26107.1. AL663054, AL591146, AL591410 Genomic DNA. Translation: CAI25852.1. AL663054, AL591410 Genomic DNA. Translation: CAI25853.1.
IPI	IPI00226551. IPI00408207.
RefSeq	NP_796364.2. NM_177390.3.
UniGene	Mm.151948.
3D structure databases
ProteinModelPortal	Q5SYD0.
SMR	Q5SYD0. Positions 10-736.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5SYD0. 2 interactions.
PTM databases
PhosphoSite	Q5SYD0.
Proteomic databases
PaxDb	Q5SYD0.
PRIDE	Q5SYD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000041065; ENSMUSP00000037819; ENSMUSG00000035441. ENSMUST00000070997; ENSMUSP00000066948; ENSMUSG00000035441.
GeneID	338367.
KEGG	mmu:338367.
UCSC	uc007kmh.1. mouse. uc011yau.1. mouse.
Organism-specific databases
CTD	4642.
MGI	MGI:107728. Myo1d.
Phylogenomic databases
eggNOG	COG5022.
GeneTree	ENSGT00690000101741.
HOGENOM	HOG000260264.
HOVERGEN	HBG062373.
InParanoid	Q5SYD0.
KO	K10356.
OMA	RFHGVKT.
OrthoDB	EOG4Z36CZ.
Gene expression databases
ArrayExpress	Q5SYD0.
Bgee	Q5SYD0.
CleanEx	MM_MYO1D.
Genevestigator	Q5SYD0.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR001609. Myosin_head_motor_dom. IPR010926. Myosin_tail_2. [Graphical view]
Pfam	PF00612. IQ. 1 hit. PF00063. Myosin_head. 1 hit. PF06017. Myosin_TH1. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	400167.
SOURCE	Search...

Entry information

Entry name

MYO1D_MOUSE

Accession

Primary (citable) accession number: Q5SYD0
Secondary accession number(s): Q5SSK7, Q8BWY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program