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Protein

Unconventional myosin-Id

Gene

Myo1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPSequence analysisBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Id
Gene namesi
Name:Myo1dImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107728. Myo1d.

Subcellular locationi

GO - Cellular componenti

  • apical dendrite Source: UniProtKB
  • axolemma Source: Ensembl
  • axon Source: UniProtKB
  • basolateral plasma membrane Source: UniProtKB
  • brush border Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • endosome Source: UniProtKB
  • extracellular exosome Source: MGI
  • myelin sheath Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: UniProtKB
  • plasma membrane raft Source: Ensembl
  • smooth endoplasmic reticulum Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 10061005Unconventional myosin-IdPRO_0000123448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei200 – 2001PhosphoserineBy similarity
Modified residuei536 – 5361PhosphotyrosineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5SYD0.
MaxQBiQ5SYD0.
PaxDbiQ5SYD0.
PRIDEiQ5SYD0.

PTM databases

iPTMnetiQ5SYD0.
PhosphoSiteiQ5SYD0.

Expressioni

Gene expression databases

BgeeiQ5SYD0.
CleanExiMM_MYO1D.
GenevisibleiQ5SYD0. MM.

Interactioni

Subunit structurei

Binds calmodulin through its IQ motifs.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237219. 1 interaction.
IntActiQ5SYD0. 3 interactions.
MINTiMINT-4113267.
STRINGi10090.ENSMUSP00000037819.

Structurei

3D structure databases

ProteinModelPortaliQ5SYD0.
SMRiQ5SYD0. Positions 10-718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 695687Myosin motorAdd
BLAST
Domaini699 – 71921IQ 1PROSITE-ProRule annotationBy similarityAdd
BLAST
Domaini721 – 74121IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini812 – 1005194TH1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiQ5SYD0.
KOiK10356.
OMAiNRWRASQ.
OrthoDBiEOG7V49XQ.
PhylomeDBiQ5SYD0.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SYD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN
60 70 80 90 100
PYKVLNIYGR DTVEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIMI
110 120 130 140 150
SGESGAGKTE ASKYIMQYIA AITNPSQRAE IERVKNMLLK SNCVLEAFGN
160 170 180 190 200
AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS
210 220 230 240 250
FHSFYQLLQG GSEQMLHSLH LQKSLSSYNY IRVGAQLKSS INDAAEFKVV
260 270 280 290 300
ADAMKVIGFK PEEIQTVYKI LAVILHLGNL KFIVDGDTPL IENGKVVSVI
310 320 330 340 350
AELLSTKADM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER
360 370 380 390 400
LFCWIVTRIN DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI
410 420 430 440 450
NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK
460 470 480 490 500
GIIAILDDAC MNVGKVTDGM FLEALNSKLG KHGHFSSRKT CASDKILEFD
510 520 530 540 550
RDFRIRHYAG DVVYSAIGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG
560 570 580 590 600
KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI
610 620 630 640 650
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH
660 670 680 690 700
DLPSDKEAVK KLIERCGFQD DVAYGKSKIF IRTPRTLFTL EELRAQMLVR
710 720 730 740 750
VVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGV
760 770 780 790 800
KNMRDYGKHV KWPTPPKVLR RFEEALQSIF NRWRASQLIK TIPASDLPQV
810 820 830 840 850
RAKVAAMEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR
860 870 880 890 900
KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
910 920 930 940 950
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV
960 970 980 990 1000
NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI

LSVPGN
Length:1,006
Mass (Da):116,081
Last modified:December 21, 2004 - v1
Checksum:i547A7FDCA656E572
GO
Isoform 21 Publication (identifier: Q5SYD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     904-944: LTGLSVSNGK...QPTHESRIGE → ISHAHSSALT...QTGYKGGLQM
     945-1006: Missing.

Show »
Length:944
Mass (Da):109,278
Checksum:iCE250517FA680841
GO

Sequence cautioni

The sequence BAC33719.1 differs from that shown. Reason: Frameshift at position 784. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei904 – 94441LTGLS…SRIGE → ISHAHSSALTLHLLLGRTNF RTMEWLPPLVRQTGYKGGLQ M in isoform 2. 1 PublicationVSP_051938Add
BLAST
Alternative sequencei945 – 100662Missing in isoform 2. 1 PublicationVSP_051939Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049374 mRNA. Translation: BAC33719.1. Frameshift.
AL591146, AL591410, AL663054 Genomic DNA. Translation: CAI24746.1.
AL591410, AL591146, AL663054 Genomic DNA. Translation: CAI26106.1.
AL591410, AL663054 Genomic DNA. Translation: CAI26107.1.
AL663054, AL591146, AL591410 Genomic DNA. Translation: CAI25852.1.
AL663054, AL591410 Genomic DNA. Translation: CAI25853.1.
CCDSiCCDS36242.1. [Q5SYD0-1]
RefSeqiNP_796364.2. NM_177390.3. [Q5SYD0-1]
XP_006533648.1. XM_006533585.1. [Q5SYD0-2]
UniGeneiMm.151948.

Genome annotation databases

EnsembliENSMUST00000041065; ENSMUSP00000037819; ENSMUSG00000035441. [Q5SYD0-1]
ENSMUST00000070997; ENSMUSP00000066948; ENSMUSG00000035441. [Q5SYD0-2]
GeneIDi338367.
KEGGimmu:338367.
UCSCiuc007kmh.1. mouse. [Q5SYD0-1]
uc011yau.1. mouse. [Q5SYD0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049374 mRNA. Translation: BAC33719.1. Frameshift.
AL591146, AL591410, AL663054 Genomic DNA. Translation: CAI24746.1.
AL591410, AL591146, AL663054 Genomic DNA. Translation: CAI26106.1.
AL591410, AL663054 Genomic DNA. Translation: CAI26107.1.
AL663054, AL591146, AL591410 Genomic DNA. Translation: CAI25852.1.
AL663054, AL591410 Genomic DNA. Translation: CAI25853.1.
CCDSiCCDS36242.1. [Q5SYD0-1]
RefSeqiNP_796364.2. NM_177390.3. [Q5SYD0-1]
XP_006533648.1. XM_006533585.1. [Q5SYD0-2]
UniGeneiMm.151948.

3D structure databases

ProteinModelPortaliQ5SYD0.
SMRiQ5SYD0. Positions 10-718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237219. 1 interaction.
IntActiQ5SYD0. 3 interactions.
MINTiMINT-4113267.
STRINGi10090.ENSMUSP00000037819.

PTM databases

iPTMnetiQ5SYD0.
PhosphoSiteiQ5SYD0.

Proteomic databases

EPDiQ5SYD0.
MaxQBiQ5SYD0.
PaxDbiQ5SYD0.
PRIDEiQ5SYD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041065; ENSMUSP00000037819; ENSMUSG00000035441. [Q5SYD0-1]
ENSMUST00000070997; ENSMUSP00000066948; ENSMUSG00000035441. [Q5SYD0-2]
GeneIDi338367.
KEGGimmu:338367.
UCSCiuc007kmh.1. mouse. [Q5SYD0-1]
uc011yau.1. mouse. [Q5SYD0-2]

Organism-specific databases

CTDi4642.
MGIiMGI:107728. Myo1d.

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiQ5SYD0.
KOiK10356.
OMAiNRWRASQ.
OrthoDBiEOG7V49XQ.
PhylomeDBiQ5SYD0.
TreeFamiTF312960.

Miscellaneous databases

ChiTaRSiMyo1d. mouse.
NextBioi400167.
PROiQ5SYD0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SYD0.
CleanExiMM_MYO1D.
GenevisibleiQ5SYD0. MM.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6JImported.
    Tissue: Embryonic stem cellImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiMYO1D_MOUSE
AccessioniPrimary (citable) accession number: Q5SYD0
Secondary accession number(s): Q5SSK7, Q8BWY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.