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Protein

Clavesin-2

Gene

CLVS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).By similarity1 Publication

GO - Molecular functioni

  • phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
  • transporter activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_19287. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Clavesin-2
Alternative name(s):
Retinaldehyde-binding protein 1-like 2
Gene namesi
Name:CLVS2
Synonyms:C6orf212, C6orf213, RLBP1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:23046. CLVS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165617885.

Polymorphism and mutation databases

DMDMi74744054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Clavesin-2PRO_0000297651Add
BLAST

Proteomic databases

PaxDbiQ5SYC1.
PRIDEiQ5SYC1.

PTM databases

PhosphoSiteiQ5SYC1.

Expressioni

Gene expression databases

BgeeiQ5SYC1.
CleanExiHS_RLBP1L2.
GenevestigatoriQ5SYC1.

Organism-specific databases

HPAiHPA043764.

Interactioni

Subunit structurei

Forms a complex with clathrin heavy chain and gamma-adaptin.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5SYC1.
SMRiQ5SYC1. Positions 11-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 257162CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST

Domaini

The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.1 Publication

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG295803.
GeneTreeiENSGT00550000074253.
HOGENOMiHOG000059544.
HOVERGENiHBG101105.
InParanoidiQ5SYC1.
OMAiKRIFMHG.
OrthoDBiEOG7H4DTZ.
PhylomeDBiQ5SYC1.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR028636. Clavesin-2.
IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PANTHERiPTHR10174:SF73. PTHR10174:SF73. 1 hit.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SYC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHLQAGLSP ETLEKARLEL NENPDTLHQD IQEVRDMVIT RPDIGFLRTD
60 70 80 90 100
DAFILRFLRA RKFHHFEAFR LLAQYFEYRQ QNLDMFKSFK ATDPGIKQAL
110 120 130 140 150
KDGFPGGLAN LDHYGRKILV LFAANWDQSR YTLVDILRAI LLSLEAMIED
160 170 180 190 200
PELQVNGFVL IIDWSNFTFK QASKLTPSML RLAIEGLQDS FPARFGGIHF
210 220 230 240 250
VNQPWYIHAL YTVIRPFLKE KTRKRIFLHG NNLNSLHQLI HPEILPSEFG
260 270 280 290 300
GMLPPYDMGT WARTLLDHEY DDDSEYNVDS YSMPVKEVEK ELSPKSMKRS
310 320
QSVVDPTVLK RMDKNEEENM QPLLSLD
Length:327
Mass (Da):38,000
Last modified:December 21, 2004 - v1
Checksum:iFF40A5A222A4DB1C
GO
Isoform 2 (identifier: Q5SYC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: No experimental confirmation available.

Show »
Length:181
Mass (Da):21,025
Checksum:i6C482FB6B59FB9C8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 146146Missing in isoform 2. 1 PublicationVSP_027325Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095527 mRNA. Translation: BAG53077.1.
AK295158 mRNA. Translation: BAG58172.1.
AL591428 Genomic DNA. Translation: CAI12306.1.
AL591428 Genomic DNA. Translation: CAI12307.1.
CH471051 Genomic DNA. Translation: EAW48161.1.
BC101376 mRNA. Translation: AAI01377.1.
BC101377 mRNA. Translation: AAI01378.1.
DC324799 mRNA. No translation available.
BK006900 mRNA. Translation: DAA06537.1.
CCDSiCCDS34525.1. [Q5SYC1-1]
RefSeqiNP_001010852.2. NM_001010852.3. [Q5SYC1-1]
UniGeneiHs.486361.
Hs.486362.

Genome annotation databases

EnsembliENST00000275162; ENSP00000275162; ENSG00000146352. [Q5SYC1-1]
ENST00000368438; ENSP00000357423; ENSG00000146352. [Q5SYC1-2]
GeneIDi134829.
KEGGihsa:134829.
UCSCiuc003pzi.1. human. [Q5SYC1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095527 mRNA. Translation: BAG53077.1.
AK295158 mRNA. Translation: BAG58172.1.
AL591428 Genomic DNA. Translation: CAI12306.1.
AL591428 Genomic DNA. Translation: CAI12307.1.
CH471051 Genomic DNA. Translation: EAW48161.1.
BC101376 mRNA. Translation: AAI01377.1.
BC101377 mRNA. Translation: AAI01378.1.
DC324799 mRNA. No translation available.
BK006900 mRNA. Translation: DAA06537.1.
CCDSiCCDS34525.1. [Q5SYC1-1]
RefSeqiNP_001010852.2. NM_001010852.3. [Q5SYC1-1]
UniGeneiHs.486361.
Hs.486362.

3D structure databases

ProteinModelPortaliQ5SYC1.
SMRiQ5SYC1. Positions 11-266.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ5SYC1.

Polymorphism and mutation databases

DMDMi74744054.

Proteomic databases

PaxDbiQ5SYC1.
PRIDEiQ5SYC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275162; ENSP00000275162; ENSG00000146352. [Q5SYC1-1]
ENST00000368438; ENSP00000357423; ENSG00000146352. [Q5SYC1-2]
GeneIDi134829.
KEGGihsa:134829.
UCSCiuc003pzi.1. human. [Q5SYC1-1]

Organism-specific databases

CTDi134829.
GeneCardsiGC06P123360.
HGNCiHGNC:23046. CLVS2.
HPAiHPA043764.
neXtProtiNX_Q5SYC1.
PharmGKBiPA165617885.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295803.
GeneTreeiENSGT00550000074253.
HOGENOMiHOG000059544.
HOVERGENiHBG101105.
InParanoidiQ5SYC1.
OMAiKRIFMHG.
OrthoDBiEOG7H4DTZ.
PhylomeDBiQ5SYC1.

Enzyme and pathway databases

ReactomeiREACT_19287. Lysosome Vesicle Biogenesis.

Miscellaneous databases

GenomeRNAii134829.
NextBioi83427.
PROiQ5SYC1.

Gene expression databases

BgeeiQ5SYC1.
CleanExiHS_RLBP1L2.
GenevestigatoriQ5SYC1.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR028636. Clavesin-2.
IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PANTHERiPTHR10174:SF73. PTHR10174:SF73. 1 hit.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology."
    Katoh Y., Ritter B., Gaffry T., Blondeau F., Honing S., McPherson P.S.
    J. Biol. Chem. 284:27646-27654(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH CLATHRIN HEAVY CHAIN AND GAMMA-ADAPTIN, SUBCELLULAR LOCATION, DOMAIN.

Entry informationi

Entry nameiCLVS2_HUMAN
AccessioniPrimary (citable) accession number: Q5SYC1
Secondary accession number(s): B3KTG5
, B4DHL0, C8UZT4, Q5SYC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 21, 2004
Last modified: May 27, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binding to PtdIns(3,5)P2 is not required for localization.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.