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Protein

Clavesin-2

Gene

CLVS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).By similarity1 Publication

Miscellaneous

Binding to PtdIns(3,5)P2 is not required for localization.By similarity

GO - Molecular functioni

  • phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
  • transporter activity Source: InterPro

GO - Biological processi

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-432720. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Clavesin-2
Alternative name(s):
Retinaldehyde-binding protein 1-like 2
clathrin vesicle-associated Sec14 protein 21 Publication
Gene namesi
Name:CLVS2
Synonyms:C6orf212, C6orf213, RLBP1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146352.12.
HGNCiHGNC:23046. CLVS2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi134829.
OpenTargetsiENSG00000146352.
PharmGKBiPA165617885.

Polymorphism and mutation databases

DMDMi74744054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976511 – 327Clavesin-2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei325PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5SYC1.
PaxDbiQ5SYC1.
PeptideAtlasiQ5SYC1.
PRIDEiQ5SYC1.

PTM databases

iPTMnetiQ5SYC1.
PhosphoSitePlusiQ5SYC1.

Expressioni

Gene expression databases

BgeeiENSG00000146352.
CleanExiHS_RLBP1L2.
GenevisibleiQ5SYC1. HS.

Organism-specific databases

HPAiHPA043764.

Interactioni

Subunit structurei

Forms a complex with clathrin heavy chain and gamma-adaptin.1 Publication

Protein-protein interaction databases

BioGridi126414. 3 interactors.
IntActiQ5SYC1. 1 interactor.
STRINGi9606.ENSP00000275162.

Structurei

3D structure databases

ProteinModelPortaliQ5SYC1.
SMRiQ5SYC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 257CRAL-TRIOPROSITE-ProRule annotationAdd BLAST162

Domaini

The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.1 Publication

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074253.
HOGENOMiHOG000059544.
HOVERGENiHBG101105.
InParanoidiQ5SYC1.
OMAiKRIFMHG.
OrthoDBiEOG091G0KN0.
PhylomeDBiQ5SYC1.

Family and domain databases

CDDicd00170. SEC14. 1 hit.
Gene3Di3.40.525.10. 1 hit.
InterProiView protein in InterPro
IPR028636. Clavesin-2.
IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
PANTHERiPTHR10174:SF176. PTHR10174:SF176. 1 hit.
PfamiView protein in Pfam
PF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
PRINTSiPR00180. CRETINALDHBP.
SMARTiView protein in SMART
SM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiView protein in PROSITE
PS50191. CRAL_TRIO. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SYC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHLQAGLSP ETLEKARLEL NENPDTLHQD IQEVRDMVIT RPDIGFLRTD
60 70 80 90 100
DAFILRFLRA RKFHHFEAFR LLAQYFEYRQ QNLDMFKSFK ATDPGIKQAL
110 120 130 140 150
KDGFPGGLAN LDHYGRKILV LFAANWDQSR YTLVDILRAI LLSLEAMIED
160 170 180 190 200
PELQVNGFVL IIDWSNFTFK QASKLTPSML RLAIEGLQDS FPARFGGIHF
210 220 230 240 250
VNQPWYIHAL YTVIRPFLKE KTRKRIFLHG NNLNSLHQLI HPEILPSEFG
260 270 280 290 300
GMLPPYDMGT WARTLLDHEY DDDSEYNVDS YSMPVKEVEK ELSPKSMKRS
310 320
QSVVDPTVLK RMDKNEEENM QPLLSLD
Length:327
Mass (Da):38,000
Last modified:December 21, 2004 - v1
Checksum:iFF40A5A222A4DB1C
GO
Isoform 2 (identifier: Q5SYC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):21,025
Checksum:i6C482FB6B59FB9C8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0273251 – 146Missing in isoform 2. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095527 mRNA. Translation: BAG53077.1.
AK295158 mRNA. Translation: BAG58172.1.
AL591428 Genomic DNA. Translation: CAI12306.1.
AL591428 Genomic DNA. Translation: CAI12307.1.
CH471051 Genomic DNA. Translation: EAW48161.1.
BC101376 mRNA. Translation: AAI01377.1.
BC101377 mRNA. Translation: AAI01378.1.
DC324799 mRNA. No translation available.
BK006900 mRNA. Translation: DAA06537.1.
CCDSiCCDS34525.1. [Q5SYC1-1]
RefSeqiNP_001010852.2. NM_001010852.3. [Q5SYC1-1]
XP_016865755.1. XM_017010266.1. [Q5SYC1-1]
UniGeneiHs.486361.
Hs.486362.

Genome annotation databases

EnsembliENST00000275162; ENSP00000275162; ENSG00000146352. [Q5SYC1-1]
ENST00000368438; ENSP00000357423; ENSG00000146352. [Q5SYC1-2]
GeneIDi134829.
KEGGihsa:134829.
UCSCiuc003pzi.3. human. [Q5SYC1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLVS2_HUMAN
AccessioniPrimary (citable) accession number: Q5SYC1
Secondary accession number(s): B3KTG5
, B4DHL0, C8UZT4, Q5SYC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 21, 2004
Last modified: September 27, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot