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Q5SYB0 (FRPD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FERM and PDZ domain-containing protein 1
Alternative name(s):
FERM domain-containing protein 2
Gene names
Name:FRMPD1
Synonyms:FRMD2, KIAA0967
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1578 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. Ref.6

Subunit structure

Interacts with GPSM1. Ref.6

Subcellular location

Cytoplasmcytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Found both in the cytoplasm and associated with the cell membrane. Ref.6

Sequence similarities

Contains 1 FERM domain.

Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Membrane
   Coding sequence diversityPolymorphism
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoskeleton

Inferred from electronic annotation. Source: InterPro

cytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15781578FERM and PDZ domain-containing protein 1
PRO_0000306805

Regions

Domain57 – 13579PDZ
Domain181 – 496316FERM

Natural variations

Natural variant61T → P.
Corresponds to variant rs3747539 [ dbSNP | Ensembl ].
VAR_035306
Natural variant441A → T.
Corresponds to variant rs2296556 [ dbSNP | Ensembl ].
VAR_035307
Natural variant501T → N.
Corresponds to variant rs7031966 [ dbSNP | Ensembl ].
VAR_035308
Natural variant2251A → V.
Corresponds to variant rs1359590 [ dbSNP | Ensembl ].
VAR_035309
Natural variant5721G → D in a breast cancer sample; somatic mutation. Ref.8
VAR_035445
Natural variant8461Y → D. Ref.5
Corresponds to variant rs34233395 [ dbSNP | Ensembl ].
VAR_035310
Natural variant10921G → E.
Corresponds to variant rs35075933 [ dbSNP | Ensembl ].
VAR_035311

Experimental info

Sequence conflict4041T → A in CAI46019. Ref.2
Sequence conflict4281I → T in CAI46019. Ref.2
Sequence conflict12781S → L in BAA76811. Ref.1
Sequence conflict14181T → A in CAI46019. Ref.2
Sequence conflict14461H → I in CAI46019. Ref.2

Secondary structure

................ 1578
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SYB0 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: DE1D285EEC3A743E

FASTA1,578173,437
        10         20         30         40         50         60 
MEELETSLFQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPARNPTQT LIPVRHTVKI 

        70         80         90        100        110        120 
DKDTLLQDYG FHISESLPLT VVAVTAGGSA HGKLFPGDQI LQMNNEPAED LSWERAVDIL 

       130        140        150        160        170        180 
REAEDSLSIT VVRCTSGVPK SSFLTEEKRA RLKTNPVKVH FAEEVLISGH SQGNSLLCMP 

       190        200        210        220        230        240 
NVLKLYLENG QTKAFKFEAN TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE 

       250        260        270        280        290        300 
EELIQQVVER EESHDYRCLF RVCFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM 

       310        320        330        340        350        360 
KCSSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK GKDIKKAISF 

       370        380        390        400        410        420 
HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGRI FNATLMLQDR ESYIALLVGA 

       430        440        450        460        470        480 
KYGISQVINS KLNIMSTLAE FANISRVELT EESEKVSVVK VYLQDVKVLT LLLESNSAKD 

       490        500        510        520        530        540 
LACLIAGYYR LLVDPVTSIF LWPGNKQQAH RVSAEEGYES RACSDSEESS EVDCVLEPLS 

       550        560        570        580        590        600 
DRRLVKLAPC RSLIKEEQPP GNSPTPEVAR RGPSTCGASS TTDSAESEAS DSANTESRGY 

       610        620        630        640        650        660 
RTSGSSESMD ALEEDDLDTC SSSRSTFFHF GSPGLAESID SDSQEERSGI ETSGFLCLLD 

       670        680        690        700        710        720 
LAQRANPQCQ KTEFSESAAL ETFGWAPELS TVRLDPRLYE GSHADYYSLC SSVSPASYLS 

       730        740        750        760        770        780 
DSSESTASRQ GGAPPAWGQQ GWTEAQPSSM LEPLALHPPL AFEDGSSDEE YYDAADKLTP 

       790        800        810        820        830        840 
PGPPSGPRDV STAEPSATSL QNKASTSSPE NSLPCGPDGR QPSRRGGVKK YAKTLRKRRS 

       850        860        870        880        890        900 
FLQTDYTSQV SFPLVPSASL ESVDDVCYYD REPYLALGAP SPTVSSLQDM QGEPGLLETK 

       910        920        930        940        950        960 
ALGLLAPLRE TKSTNPASRV MEMEPETMET KSVIDSRVSS ISAIRFRIDP NNKENSGVVP 

       970        980        990       1000       1010       1020 
AASSSASTPH CSNPGSSGPD TAQARPSQIL PLSQDLDGIA PKEPTIEHGD SSFSLSSGDP 

      1030       1040       1050       1060       1070       1080 
NPDRACLASN PGLNNVSQGD TLELQLEPHV QLEMGLESFC TNHIQETAPK YTEPLLSPRD 

      1090       1100       1110       1120       1130       1140 
EPRSDECGIN PGEKIASIPT KEEPQGQLSL ERDREVTNKN GTNVFQEESR KDSGDSPGDV 

      1150       1160       1170       1180       1190       1200 
SNNVSQTLDI SSPAGKIVTS LSLDAPVTGT EQIPPHPPRD PQGQSREPPG QGCQAQEQKL 

      1210       1220       1230       1240       1250       1260 
FVELDLDPDF FLGKQTVSPA VPPEGIKAEA PNHVTGQDIA PRDSPEWVCF NPEPSLPEPL 

      1270       1280       1290       1300       1310       1320 
PCPQEDPHLE TSNHCLLSEG KSDSSSICLS AEKSFLCFAP ESHPEVSASL RVATSLGFAG 

      1330       1340       1350       1360       1370       1380 
MNEMVAPRIG MDQCSCQFSY ATCFRGPQPE TEEEDRDLEA HPMAPLTSPP SAGSPVVLPW 

      1390       1400       1410       1420       1430       1440 
RPARAHSCTT APLSRKSHIW PEYCSRALRQ LKATPASTPE GFIQLMESLL ELQDILETSW 

      1450       1460       1470       1480       1490       1500 
GVGNKHPPEK CTWHFTESRS RLCMGSQKLL SSCRHVIRMD QSPEEMQGAV RDTFQHLVQL 

      1510       1520       1530       1540       1550       1560 
AGLCFQFTDC SRCSARHREA AGNLRDVVYT YHQFIEAAKS TCERGYHDLS VKLLARQCTA 

      1570 
LTAAVFCLTQ KFRASTAL 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-846.
[6]"The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins."
An N., Blumer J.B., Bernard M.L., Lanier S.M.
J. Biol. Chem. 283:24718-24728(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GPSM1, FUNCTION, SUBCELLULAR LOCATION.
[7]"Solution structure of the PDZ domain from human FERM and PDZ domain-containing 1."
RIKEN structural genomics initiative (RSGI)
Submitted (AUG-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 54-136.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-572.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023184 mRNA. Translation: BAA76811.1.
BX648967 mRNA. Translation: CAI46019.1.
AL591470, AL513165 Genomic DNA. Translation: CAI12951.1.
AL513165, AL591470 Genomic DNA. Translation: CAI16156.1.
CH471071 Genomic DNA. Translation: EAW58270.1.
CH471071 Genomic DNA. Translation: EAW58271.1.
BC114965 mRNA. Translation: AAI14966.1.
CCDSCCDS6612.1.
RefSeqNP_055722.2. NM_014907.2.
UniGeneHs.163990.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EDVNMR-A54-136[»]
4G2VX-ray2.40B901-938[»]
ProteinModelPortalQ5SYB0.
SMRQ5SYB0. Positions 54-141, 198-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000366995.

PTM databases

PhosphoSiteQ5SYB0.

Polymorphism databases

DMDM74754275.

Proteomic databases

PaxDbQ5SYB0.
PeptideAtlasQ5SYB0.
PRIDEQ5SYB0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377765; ENSP00000366995; ENSG00000070601.
ENST00000539465; ENSP00000444411; ENSG00000070601.
GeneID22844.
KEGGhsa:22844.
UCSCuc004aag.1. human.

Organism-specific databases

CTD22844.
GeneCardsGC09P037644.
H-InvDBHIX0008040.
HGNCHGNC:29159. FRMPD1.
HPAHPA042934.
neXtProtNX_Q5SYB0.
PharmGKBPA134910182.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237011.
HOGENOMHOG000112646.
HOVERGENHBG101205.
InParanoidQ5SYB0.
OMASHIWPEY.
OrthoDBEOG7W419W.
PhylomeDBQ5SYB0.
TreeFamTF316497.

Gene expression databases

ArrayExpressQ5SYB0.
BgeeQ5SYB0.
CleanExHS_FRMPD1.
GenevestigatorQ5SYB0.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFRMPD1. human.
EvolutionaryTraceQ5SYB0.
GenomeRNAi22844.
NextBio43297.
PROQ5SYB0.

Entry information

Entry nameFRPD1_HUMAN
AccessionPrimary (citable) accession number: Q5SYB0
Secondary accession number(s): D3DRQ3 expand/collapse secondary AC list , Q14C73, Q5HY96, Q9Y2H3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM