Q5SYB0 (FRPD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FERM and PDZ domain-containing protein 1

Alternative name(s):
FERM domain-containing protein 2

Gene names

Name:	FRMPD1
Synonyms:	FRMD2, KIAA0967

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1578 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. Ref.6
Subunit structure	Interacts with GPSM1. Ref.6
Subcellular location	Cytoplasm › cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Found both in the cytoplasm and associated with the cell membrane. Ref.6
Sequence similarities	Contains 1 FERM domain. Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA cytoskeleton Inferred from electronic annotation. Source: InterPro cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1578

1578

FERM and PDZ domain-containing protein 1

PRO_0000306805

Regions

Domain

57 – 135

79

PDZ

Domain

181 – 496

316

FERM

Amino acid modifications

Modified residue

1460

1

Phosphoserine By similarity

Modified residue

1466

1

Phosphoserine By similarity

Natural variations

Natural variant

6

1

T → P.
Corresponds to variant rs3747539 [ dbSNP | Ensembl ].

VAR_035306

Natural variant

44

1

A → T.
Corresponds to variant rs2296556 [ dbSNP | Ensembl ].

VAR_035307

Natural variant

50

1

T → N.
Corresponds to variant rs7031966 [ dbSNP | Ensembl ].

VAR_035308

Natural variant

225

1

A → V.
Corresponds to variant rs1359590 [ dbSNP | Ensembl ].

VAR_035309

Natural variant

572

1

G → D in a breast cancer sample; somatic mutation. Ref.8

VAR_035445

Natural variant

846

1

Y → D. Ref.5
Corresponds to variant rs34233395 [ dbSNP | Ensembl ].

VAR_035310

Natural variant

1092

1

G → E.
Corresponds to variant rs35075933 [ dbSNP | Ensembl ].

VAR_035311

Experimental info

Sequence conflict

404

1

T → A in CAI46019. Ref.2

Sequence conflict

428

1

I → T in CAI46019. Ref.2

Sequence conflict

1278

1

S → L in BAA76811. Ref.1

Sequence conflict

1418

1

T → A in CAI46019. Ref.2

Sequence conflict

1446

1

H → I in CAI46019. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1578

Helix Strand Turn

Details...

Beta strand

54 – 60

7

Beta strand

64 – 66

3

Beta strand

75 – 78

4

Beta strand

86 – 90

5

Turn

91 – 93

3

Beta strand

99 – 105

7

Helix

113 – 122

10

Beta strand

127 – 133

7

Sequences

	Sequence		Length	Mass (Da)
	Q5SYB0 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: DE1D285EEC3A743E	FASTA	1,578	173,437
	10 20 30 40 50 60 MEELETSLFQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPARNPTQT LIPVRHTVKI 70 80 90 100 110 120 DKDTLLQDYG FHISESLPLT VVAVTAGGSA HGKLFPGDQI LQMNNEPAED LSWERAVDIL 130 140 150 160 170 180 REAEDSLSIT VVRCTSGVPK SSFLTEEKRA RLKTNPVKVH FAEEVLISGH SQGNSLLCMP 190 200 210 220 230 240 NVLKLYLENG QTKAFKFEAN TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE 250 260 270 280 290 300 EELIQQVVER EESHDYRCLF RVCFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM 310 320 330 340 350 360 KCSSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK GKDIKKAISF 370 380 390 400 410 420 HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGRI FNATLMLQDR ESYIALLVGA 430 440 450 460 470 480 KYGISQVINS KLNIMSTLAE FANISRVELT EESEKVSVVK VYLQDVKVLT LLLESNSAKD 490 500 510 520 530 540 LACLIAGYYR LLVDPVTSIF LWPGNKQQAH RVSAEEGYES RACSDSEESS EVDCVLEPLS 550 560 570 580 590 600 DRRLVKLAPC RSLIKEEQPP GNSPTPEVAR RGPSTCGASS TTDSAESEAS DSANTESRGY 610 620 630 640 650 660 RTSGSSESMD ALEEDDLDTC SSSRSTFFHF GSPGLAESID SDSQEERSGI ETSGFLCLLD 670 680 690 700 710 720 LAQRANPQCQ KTEFSESAAL ETFGWAPELS TVRLDPRLYE GSHADYYSLC SSVSPASYLS 730 740 750 760 770 780 DSSESTASRQ GGAPPAWGQQ GWTEAQPSSM LEPLALHPPL AFEDGSSDEE YYDAADKLTP 790 800 810 820 830 840 PGPPSGPRDV STAEPSATSL QNKASTSSPE NSLPCGPDGR QPSRRGGVKK YAKTLRKRRS 850 860 870 880 890 900 FLQTDYTSQV SFPLVPSASL ESVDDVCYYD REPYLALGAP SPTVSSLQDM QGEPGLLETK 910 920 930 940 950 960 ALGLLAPLRE TKSTNPASRV MEMEPETMET KSVIDSRVSS ISAIRFRIDP NNKENSGVVP 970 980 990 1000 1010 1020 AASSSASTPH CSNPGSSGPD TAQARPSQIL PLSQDLDGIA PKEPTIEHGD SSFSLSSGDP 1030 1040 1050 1060 1070 1080 NPDRACLASN PGLNNVSQGD TLELQLEPHV QLEMGLESFC TNHIQETAPK YTEPLLSPRD 1090 1100 1110 1120 1130 1140 EPRSDECGIN PGEKIASIPT KEEPQGQLSL ERDREVTNKN GTNVFQEESR KDSGDSPGDV 1150 1160 1170 1180 1190 1200 SNNVSQTLDI SSPAGKIVTS LSLDAPVTGT EQIPPHPPRD PQGQSREPPG QGCQAQEQKL 1210 1220 1230 1240 1250 1260 FVELDLDPDF FLGKQTVSPA VPPEGIKAEA PNHVTGQDIA PRDSPEWVCF NPEPSLPEPL 1270 1280 1290 1300 1310 1320 PCPQEDPHLE TSNHCLLSEG KSDSSSICLS AEKSFLCFAP ESHPEVSASL RVATSLGFAG 1330 1340 1350 1360 1370 1380 MNEMVAPRIG MDQCSCQFSY ATCFRGPQPE TEEEDRDLEA HPMAPLTSPP SAGSPVVLPW 1390 1400 1410 1420 1430 1440 RPARAHSCTT APLSRKSHIW PEYCSRALRQ LKATPASTPE GFIQLMESLL ELQDILETSW 1450 1460 1470 1480 1490 1500 GVGNKHPPEK CTWHFTESRS RLCMGSQKLL SSCRHVIRMD QSPEEMQGAV RDTFQHLVQL 1510 1520 1530 1540 1550 1560 AGLCFQFTDC SRCSARHREA AGNLRDVVYT YHQFIEAAKS TCERGYHDLS VKLLARQCTA 1570 LTAAVFCLTQ KFRASTAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Retina.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-846.
[6]	"The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins." An N., Blumer J.B., Bernard M.L., Lanier S.M. J. Biol. Chem. 283:24718-24728(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GPSM1, FUNCTION, SUBCELLULAR LOCATION.
[7]	"Solution structure of the PDZ domain from human FERM and PDZ domain-containing 1." RIKEN structural genomics initiative (RSGI) Submitted (AUG-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 54-136.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-572.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB023184 mRNA. Translation: BAA76811.1.
BX648967 mRNA. Translation: CAI46019.1.
AL591470, AL513165 Genomic DNA. Translation: CAI12951.1.
AL513165, AL591470 Genomic DNA. Translation: CAI16156.1.
CH471071 Genomic DNA. Translation: EAW58270.1.
CH471071 Genomic DNA. Translation: EAW58271.1.
BC114965 mRNA. Translation: AAI14966.1.

IPI

IPI00646328.

RefSeq

NP_055722.2. NM_014907.2.

UniGene

Hs.163990.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EDV	NMR	-	A	54-136	[»]
4G2V	X-ray	2.40	B	901-938	[»]

ProteinModelPortal

Q5SYB0.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000366995.

PTM databases

PhosphoSite

Q5SYB0.

Polymorphism databases

DMDM

74754275.

Proteomic databases

PaxDb

Q5SYB0.

PeptideAtlas

Q5SYB0.

PRIDE

Q5SYB0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000377765; ENSP00000366995; ENSG00000070601.
ENST00000539465; ENSP00000444411; ENSG00000070601.

GeneID

22844.

KEGG

hsa:22844.

UCSC

uc004aag.1. human.

Organism-specific databases

CTD

22844.

GeneCards

GC09P037644.

H-InvDB

HIX0008040.

HGNC

HGNC:29159. FRMPD1.

HPA

HPA042934.

neXtProt

NX_Q5SYB0.

PharmGKB

PA134910182.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG237011.

HOGENOM

HOG000112646.

HOVERGEN

HBG101205.

InParanoid

Q5SYB0.

OMA

KYAKTLR.

OrthoDB

EOG48GW2D.

PhylomeDB

Q5SYB0.

Gene expression databases

ArrayExpress

Q5SYB0.

Bgee

Q5SYB0.

CleanEx

HS_FRMPD1.

Genevestigator

Q5SYB0.

Family and domain databases

InterPro

IPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR001478. PDZ.
[Graphical view]

Pfam

PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF47031. FERM_3-hlx. 1 hit.
SSF50156. PDZ. 1 hit.

PROSITE

PS00660. FERM_1. False negative.
PS00661. FERM_2. False negative.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

FRMPD1. human.

EvolutionaryTrace

Q5SYB0.

GenomeRNAi

22844.

NextBio

43297.

Entry information

Entry name

FRPD1_HUMAN

Accession

Primary (citable) accession number: Q5SYB0
Secondary accession number(s): D3DRQ3 , Q14C73, Q5HY96, Q9Y2H3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.