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Q5SYB0

- FRPD1_HUMAN

UniProt

Q5SYB0 - FRPD1_HUMAN

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Protein
FERM and PDZ domain-containing protein 1
Gene
FRMPD1, FRMD2, KIAA0967
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
FERM and PDZ domain-containing protein 1
Alternative name(s):
FERM domain-containing protein 2
Gene namesi
Name:FRMPD1
Synonyms:FRMD2, KIAA0967
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:29159. FRMPD1.

Subcellular locationi

Cytoplasmcytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Note: Found both in the cytoplasm and associated with the cell membrane.1 Publication

GO - Cellular componenti

  1. cytoskeleton Source: InterPro
  2. cytosol Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: UniProt
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15781578FERM and PDZ domain-containing protein 1
PRO_0000306805Add
BLAST

Proteomic databases

PaxDbiQ5SYB0.
PeptideAtlasiQ5SYB0.
PRIDEiQ5SYB0.

PTM databases

PhosphoSiteiQ5SYB0.

Expressioni

Gene expression databases

ArrayExpressiQ5SYB0.
BgeeiQ5SYB0.
CleanExiHS_FRMPD1.
GenevestigatoriQ5SYB0.

Organism-specific databases

HPAiHPA042934.

Interactioni

Subunit structurei

Interacts with GPSM1.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000366995.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi54 – 607
Beta strandi64 – 663
Beta strandi75 – 784
Beta strandi86 – 905
Turni91 – 933
Beta strandi99 – 1057
Helixi113 – 12210
Beta strandi127 – 1337

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EDVNMR-A54-136[»]
4G2VX-ray2.40B901-938[»]
ProteinModelPortaliQ5SYB0.
SMRiQ5SYB0. Positions 54-141, 198-503.

Miscellaneous databases

EvolutionaryTraceiQ5SYB0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 13579PDZ
Add
BLAST
Domaini181 – 496316FERM
Add
BLAST

Sequence similaritiesi

Contains 1 FERM domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiNOG237011.
HOGENOMiHOG000112646.
HOVERGENiHBG101205.
InParanoidiQ5SYB0.
OMAiSHIWPEY.
OrthoDBiEOG7W419W.
PhylomeDBiQ5SYB0.
TreeFamiTF316497.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SYB0-1 [UniParc]FASTAAdd to Basket

« Hide

MEELETSLFQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPARNPTQT     50
LIPVRHTVKI DKDTLLQDYG FHISESLPLT VVAVTAGGSA HGKLFPGDQI 100
LQMNNEPAED LSWERAVDIL REAEDSLSIT VVRCTSGVPK SSFLTEEKRA 150
RLKTNPVKVH FAEEVLISGH SQGNSLLCMP NVLKLYLENG QTKAFKFEAN 200
TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE EELIQQVVER 250
EESHDYRCLF RVCFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM 300
KCSSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK 350
GKDIKKAISF HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGRI 400
FNATLMLQDR ESYIALLVGA KYGISQVINS KLNIMSTLAE FANISRVELT 450
EESEKVSVVK VYLQDVKVLT LLLESNSAKD LACLIAGYYR LLVDPVTSIF 500
LWPGNKQQAH RVSAEEGYES RACSDSEESS EVDCVLEPLS DRRLVKLAPC 550
RSLIKEEQPP GNSPTPEVAR RGPSTCGASS TTDSAESEAS DSANTESRGY 600
RTSGSSESMD ALEEDDLDTC SSSRSTFFHF GSPGLAESID SDSQEERSGI 650
ETSGFLCLLD LAQRANPQCQ KTEFSESAAL ETFGWAPELS TVRLDPRLYE 700
GSHADYYSLC SSVSPASYLS DSSESTASRQ GGAPPAWGQQ GWTEAQPSSM 750
LEPLALHPPL AFEDGSSDEE YYDAADKLTP PGPPSGPRDV STAEPSATSL 800
QNKASTSSPE NSLPCGPDGR QPSRRGGVKK YAKTLRKRRS FLQTDYTSQV 850
SFPLVPSASL ESVDDVCYYD REPYLALGAP SPTVSSLQDM QGEPGLLETK 900
ALGLLAPLRE TKSTNPASRV MEMEPETMET KSVIDSRVSS ISAIRFRIDP 950
NNKENSGVVP AASSSASTPH CSNPGSSGPD TAQARPSQIL PLSQDLDGIA 1000
PKEPTIEHGD SSFSLSSGDP NPDRACLASN PGLNNVSQGD TLELQLEPHV 1050
QLEMGLESFC TNHIQETAPK YTEPLLSPRD EPRSDECGIN PGEKIASIPT 1100
KEEPQGQLSL ERDREVTNKN GTNVFQEESR KDSGDSPGDV SNNVSQTLDI 1150
SSPAGKIVTS LSLDAPVTGT EQIPPHPPRD PQGQSREPPG QGCQAQEQKL 1200
FVELDLDPDF FLGKQTVSPA VPPEGIKAEA PNHVTGQDIA PRDSPEWVCF 1250
NPEPSLPEPL PCPQEDPHLE TSNHCLLSEG KSDSSSICLS AEKSFLCFAP 1300
ESHPEVSASL RVATSLGFAG MNEMVAPRIG MDQCSCQFSY ATCFRGPQPE 1350
TEEEDRDLEA HPMAPLTSPP SAGSPVVLPW RPARAHSCTT APLSRKSHIW 1400
PEYCSRALRQ LKATPASTPE GFIQLMESLL ELQDILETSW GVGNKHPPEK 1450
CTWHFTESRS RLCMGSQKLL SSCRHVIRMD QSPEEMQGAV RDTFQHLVQL 1500
AGLCFQFTDC SRCSARHREA AGNLRDVVYT YHQFIEAAKS TCERGYHDLS 1550
VKLLARQCTA LTAAVFCLTQ KFRASTAL 1578
Length:1,578
Mass (Da):173,437
Last modified:July 5, 2005 - v1
Checksum:iDE1D285EEC3A743E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61T → P.
Corresponds to variant rs3747539 [ dbSNP | Ensembl ].
VAR_035306
Natural varianti44 – 441A → T.
Corresponds to variant rs2296556 [ dbSNP | Ensembl ].
VAR_035307
Natural varianti50 – 501T → N.
Corresponds to variant rs7031966 [ dbSNP | Ensembl ].
VAR_035308
Natural varianti225 – 2251A → V.
Corresponds to variant rs1359590 [ dbSNP | Ensembl ].
VAR_035309
Natural varianti572 – 5721G → D in a breast cancer sample; somatic mutation. 1 Publication
VAR_035445
Natural varianti846 – 8461Y → D.1 Publication
Corresponds to variant rs34233395 [ dbSNP | Ensembl ].
VAR_035310
Natural varianti1092 – 10921G → E.
Corresponds to variant rs35075933 [ dbSNP | Ensembl ].
VAR_035311

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti404 – 4041T → A in CAI46019. 1 Publication
Sequence conflicti428 – 4281I → T in CAI46019. 1 Publication
Sequence conflicti1278 – 12781S → L in BAA76811. 1 Publication
Sequence conflicti1418 – 14181T → A in CAI46019. 1 Publication
Sequence conflicti1446 – 14461H → I in CAI46019. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023184 mRNA. Translation: BAA76811.1.
BX648967 mRNA. Translation: CAI46019.1.
AL591470, AL513165 Genomic DNA. Translation: CAI12951.1.
AL513165, AL591470 Genomic DNA. Translation: CAI16156.1.
CH471071 Genomic DNA. Translation: EAW58270.1.
CH471071 Genomic DNA. Translation: EAW58271.1.
BC114965 mRNA. Translation: AAI14966.1.
CCDSiCCDS6612.1.
RefSeqiNP_055722.2. NM_014907.2.
UniGeneiHs.163990.

Genome annotation databases

EnsembliENST00000377765; ENSP00000366995; ENSG00000070601.
ENST00000539465; ENSP00000444411; ENSG00000070601.
GeneIDi22844.
KEGGihsa:22844.
UCSCiuc004aag.1. human.

Polymorphism databases

DMDMi74754275.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023184 mRNA. Translation: BAA76811.1 .
BX648967 mRNA. Translation: CAI46019.1 .
AL591470 , AL513165 Genomic DNA. Translation: CAI12951.1 .
AL513165 , AL591470 Genomic DNA. Translation: CAI16156.1 .
CH471071 Genomic DNA. Translation: EAW58270.1 .
CH471071 Genomic DNA. Translation: EAW58271.1 .
BC114965 mRNA. Translation: AAI14966.1 .
CCDSi CCDS6612.1.
RefSeqi NP_055722.2. NM_014907.2.
UniGenei Hs.163990.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EDV NMR - A 54-136 [» ]
4G2V X-ray 2.40 B 901-938 [» ]
ProteinModelPortali Q5SYB0.
SMRi Q5SYB0. Positions 54-141, 198-503.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000366995.

PTM databases

PhosphoSitei Q5SYB0.

Polymorphism databases

DMDMi 74754275.

Proteomic databases

PaxDbi Q5SYB0.
PeptideAtlasi Q5SYB0.
PRIDEi Q5SYB0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377765 ; ENSP00000366995 ; ENSG00000070601 .
ENST00000539465 ; ENSP00000444411 ; ENSG00000070601 .
GeneIDi 22844.
KEGGi hsa:22844.
UCSCi uc004aag.1. human.

Organism-specific databases

CTDi 22844.
GeneCardsi GC09P037644.
H-InvDB HIX0008040.
HGNCi HGNC:29159. FRMPD1.
HPAi HPA042934.
neXtProti NX_Q5SYB0.
PharmGKBi PA134910182.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237011.
HOGENOMi HOG000112646.
HOVERGENi HBG101205.
InParanoidi Q5SYB0.
OMAi SHIWPEY.
OrthoDBi EOG7W419W.
PhylomeDBi Q5SYB0.
TreeFami TF316497.

Miscellaneous databases

ChiTaRSi FRMPD1. human.
EvolutionaryTracei Q5SYB0.
GenomeRNAii 22844.
NextBioi 43297.
PROi Q5SYB0.

Gene expression databases

ArrayExpressi Q5SYB0.
Bgeei Q5SYB0.
CleanExi HS_FRMPD1.
Genevestigatori Q5SYB0.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-846.
  6. "The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins."
    An N., Blumer J.B., Bernard M.L., Lanier S.M.
    J. Biol. Chem. 283:24718-24728(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPSM1, FUNCTION, SUBCELLULAR LOCATION.
  7. "Solution structure of the PDZ domain from human FERM and PDZ domain-containing 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 54-136.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-572.

Entry informationi

Entry nameiFRPD1_HUMAN
AccessioniPrimary (citable) accession number: Q5SYB0
Secondary accession number(s): D3DRQ3
, Q14C73, Q5HY96, Q9Y2H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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