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Q5SYB0

- FRPD1_HUMAN

UniProt

Q5SYB0 - FRPD1_HUMAN

Protein

FERM and PDZ domain-containing protein 1

Gene

FRMPD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FERM and PDZ domain-containing protein 1
    Alternative name(s):
    FERM domain-containing protein 2
    Gene namesi
    Name:FRMPD1
    Synonyms:FRMD2, KIAA0967
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:29159. FRMPD1.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
    Note: Found both in the cytoplasm and associated with the cell membrane.

    GO - Cellular componenti

    1. cytoskeleton Source: InterPro
    2. cytosol Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134910182.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15781578FERM and PDZ domain-containing protein 1PRO_0000306805Add
    BLAST

    Proteomic databases

    PaxDbiQ5SYB0.
    PeptideAtlasiQ5SYB0.
    PRIDEiQ5SYB0.

    PTM databases

    PhosphoSiteiQ5SYB0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5SYB0.
    BgeeiQ5SYB0.
    CleanExiHS_FRMPD1.
    GenevestigatoriQ5SYB0.

    Organism-specific databases

    HPAiHPA042934.

    Interactioni

    Subunit structurei

    Interacts with GPSM1.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000366995.

    Structurei

    Secondary structure

    1
    1578
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi54 – 607
    Beta strandi64 – 663
    Beta strandi75 – 784
    Beta strandi86 – 905
    Turni91 – 933
    Beta strandi99 – 1057
    Helixi113 – 12210
    Beta strandi127 – 1337

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EDVNMR-A54-136[»]
    4G2VX-ray2.40B901-938[»]
    ProteinModelPortaliQ5SYB0.
    SMRiQ5SYB0. Positions 54-141, 198-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SYB0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 13579PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 496316FERMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG237011.
    HOGENOMiHOG000112646.
    HOVERGENiHBG101205.
    InParanoidiQ5SYB0.
    OMAiSHIWPEY.
    OrthoDBiEOG7W419W.
    PhylomeDBiQ5SYB0.
    TreeFamiTF316497.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5SYB0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEELETSLFQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPARNPTQT     50
    LIPVRHTVKI DKDTLLQDYG FHISESLPLT VVAVTAGGSA HGKLFPGDQI 100
    LQMNNEPAED LSWERAVDIL REAEDSLSIT VVRCTSGVPK SSFLTEEKRA 150
    RLKTNPVKVH FAEEVLISGH SQGNSLLCMP NVLKLYLENG QTKAFKFEAN 200
    TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE EELIQQVVER 250
    EESHDYRCLF RVCFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM 300
    KCSSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK 350
    GKDIKKAISF HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGRI 400
    FNATLMLQDR ESYIALLVGA KYGISQVINS KLNIMSTLAE FANISRVELT 450
    EESEKVSVVK VYLQDVKVLT LLLESNSAKD LACLIAGYYR LLVDPVTSIF 500
    LWPGNKQQAH RVSAEEGYES RACSDSEESS EVDCVLEPLS DRRLVKLAPC 550
    RSLIKEEQPP GNSPTPEVAR RGPSTCGASS TTDSAESEAS DSANTESRGY 600
    RTSGSSESMD ALEEDDLDTC SSSRSTFFHF GSPGLAESID SDSQEERSGI 650
    ETSGFLCLLD LAQRANPQCQ KTEFSESAAL ETFGWAPELS TVRLDPRLYE 700
    GSHADYYSLC SSVSPASYLS DSSESTASRQ GGAPPAWGQQ GWTEAQPSSM 750
    LEPLALHPPL AFEDGSSDEE YYDAADKLTP PGPPSGPRDV STAEPSATSL 800
    QNKASTSSPE NSLPCGPDGR QPSRRGGVKK YAKTLRKRRS FLQTDYTSQV 850
    SFPLVPSASL ESVDDVCYYD REPYLALGAP SPTVSSLQDM QGEPGLLETK 900
    ALGLLAPLRE TKSTNPASRV MEMEPETMET KSVIDSRVSS ISAIRFRIDP 950
    NNKENSGVVP AASSSASTPH CSNPGSSGPD TAQARPSQIL PLSQDLDGIA 1000
    PKEPTIEHGD SSFSLSSGDP NPDRACLASN PGLNNVSQGD TLELQLEPHV 1050
    QLEMGLESFC TNHIQETAPK YTEPLLSPRD EPRSDECGIN PGEKIASIPT 1100
    KEEPQGQLSL ERDREVTNKN GTNVFQEESR KDSGDSPGDV SNNVSQTLDI 1150
    SSPAGKIVTS LSLDAPVTGT EQIPPHPPRD PQGQSREPPG QGCQAQEQKL 1200
    FVELDLDPDF FLGKQTVSPA VPPEGIKAEA PNHVTGQDIA PRDSPEWVCF 1250
    NPEPSLPEPL PCPQEDPHLE TSNHCLLSEG KSDSSSICLS AEKSFLCFAP 1300
    ESHPEVSASL RVATSLGFAG MNEMVAPRIG MDQCSCQFSY ATCFRGPQPE 1350
    TEEEDRDLEA HPMAPLTSPP SAGSPVVLPW RPARAHSCTT APLSRKSHIW 1400
    PEYCSRALRQ LKATPASTPE GFIQLMESLL ELQDILETSW GVGNKHPPEK 1450
    CTWHFTESRS RLCMGSQKLL SSCRHVIRMD QSPEEMQGAV RDTFQHLVQL 1500
    AGLCFQFTDC SRCSARHREA AGNLRDVVYT YHQFIEAAKS TCERGYHDLS 1550
    VKLLARQCTA LTAAVFCLTQ KFRASTAL 1578
    Length:1,578
    Mass (Da):173,437
    Last modified:July 5, 2005 - v1
    Checksum:iDE1D285EEC3A743E
    GO
    Isoform 2 (identifier: Q5SYB0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-178: Missing.
         787-812: PRDVSTAEPSATSLQNKASTSSPENS → EPSLAGLQTRQAAPECLPGIKAWGQA
         813-1578: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:634
    Mass (Da):70,342
    Checksum:i033CB8E3B8A1B0FB
    GO
    Isoform 3 (identifier: Q5SYB0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-5: MEELE → MAEVG
         6-136: Missing.
         787-812: PRDVSTAEPSATSLQNKASTSSPENS → EPSLAGLQTRQAAPECLPGIKAWGQA
         813-1578: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:681
    Mass (Da):75,420
    Checksum:iDE916F42850847DC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti404 – 4041T → A in CAI46019. (PubMed:17974005)Curated
    Sequence conflicti428 – 4281I → T in CAI46019. (PubMed:17974005)Curated
    Sequence conflicti1278 – 12781S → L in BAA76811. (PubMed:10231032)Curated
    Sequence conflicti1418 – 14181T → A in CAI46019. (PubMed:17974005)Curated
    Sequence conflicti1446 – 14461H → I in CAI46019. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61T → P.
    Corresponds to variant rs3747539 [ dbSNP | Ensembl ].
    VAR_035306
    Natural varianti44 – 441A → T.
    Corresponds to variant rs2296556 [ dbSNP | Ensembl ].
    VAR_035307
    Natural varianti50 – 501T → N.
    Corresponds to variant rs7031966 [ dbSNP | Ensembl ].
    VAR_035308
    Natural varianti225 – 2251A → V.
    Corresponds to variant rs1359590 [ dbSNP | Ensembl ].
    VAR_035309
    Natural varianti572 – 5721G → D in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035445
    Natural varianti846 – 8461Y → D.1 Publication
    Corresponds to variant rs34233395 [ dbSNP | Ensembl ].
    VAR_035310
    Natural varianti1092 – 10921G → E.
    Corresponds to variant rs35075933 [ dbSNP | Ensembl ].
    VAR_035311

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 178178Missing in isoform 2. 1 PublicationVSP_056060Add
    BLAST
    Alternative sequencei1 – 55MEELE → MAEVG in isoform 3. 1 PublicationVSP_056061
    Alternative sequencei6 – 136131Missing in isoform 3. 1 PublicationVSP_056062Add
    BLAST
    Alternative sequencei787 – 81226PRDVS…SPENS → EPSLAGLQTRQAAPECLPGI KAWGQA in isoform 2 and isoform 3. 1 PublicationVSP_056063Add
    BLAST
    Alternative sequencei813 – 1578766Missing in isoform 2 and isoform 3. 1 PublicationVSP_056064Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023184 mRNA. Translation: BAA76811.1.
    AK302739 mRNA. Translation: BAH13793.1.
    AK302854 mRNA. Translation: BAG64040.1.
    BX648967 mRNA. Translation: CAI46019.1.
    AL591470, AL513165 Genomic DNA. Translation: CAI12951.1.
    AL513165, AL591470 Genomic DNA. Translation: CAI16156.1.
    CH471071 Genomic DNA. Translation: EAW58270.1.
    CH471071 Genomic DNA. Translation: EAW58271.1.
    BC114965 mRNA. Translation: AAI14966.1.
    CCDSiCCDS6612.1.
    RefSeqiNP_055722.2. NM_014907.2.
    UniGeneiHs.163990.

    Genome annotation databases

    EnsembliENST00000377765; ENSP00000366995; ENSG00000070601.
    ENST00000536622; ENSP00000437762; ENSG00000070601.
    ENST00000539465; ENSP00000444411; ENSG00000070601.
    ENST00000541302; ENSP00000444804; ENSG00000070601.
    GeneIDi22844.
    KEGGihsa:22844.
    UCSCiuc004aag.1. human.

    Polymorphism databases

    DMDMi74754275.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023184 mRNA. Translation: BAA76811.1 .
    AK302739 mRNA. Translation: BAH13793.1 .
    AK302854 mRNA. Translation: BAG64040.1 .
    BX648967 mRNA. Translation: CAI46019.1 .
    AL591470 , AL513165 Genomic DNA. Translation: CAI12951.1 .
    AL513165 , AL591470 Genomic DNA. Translation: CAI16156.1 .
    CH471071 Genomic DNA. Translation: EAW58270.1 .
    CH471071 Genomic DNA. Translation: EAW58271.1 .
    BC114965 mRNA. Translation: AAI14966.1 .
    CCDSi CCDS6612.1.
    RefSeqi NP_055722.2. NM_014907.2.
    UniGenei Hs.163990.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EDV NMR - A 54-136 [» ]
    4G2V X-ray 2.40 B 901-938 [» ]
    ProteinModelPortali Q5SYB0.
    SMRi Q5SYB0. Positions 54-141, 198-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000366995.

    PTM databases

    PhosphoSitei Q5SYB0.

    Polymorphism databases

    DMDMi 74754275.

    Proteomic databases

    PaxDbi Q5SYB0.
    PeptideAtlasi Q5SYB0.
    PRIDEi Q5SYB0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377765 ; ENSP00000366995 ; ENSG00000070601 .
    ENST00000536622 ; ENSP00000437762 ; ENSG00000070601 .
    ENST00000539465 ; ENSP00000444411 ; ENSG00000070601 .
    ENST00000541302 ; ENSP00000444804 ; ENSG00000070601 .
    GeneIDi 22844.
    KEGGi hsa:22844.
    UCSCi uc004aag.1. human.

    Organism-specific databases

    CTDi 22844.
    GeneCardsi GC09P037644.
    H-InvDB HIX0008040.
    HGNCi HGNC:29159. FRMPD1.
    HPAi HPA042934.
    neXtProti NX_Q5SYB0.
    PharmGKBi PA134910182.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237011.
    HOGENOMi HOG000112646.
    HOVERGENi HBG101205.
    InParanoidi Q5SYB0.
    OMAi SHIWPEY.
    OrthoDBi EOG7W419W.
    PhylomeDBi Q5SYB0.
    TreeFami TF316497.

    Miscellaneous databases

    ChiTaRSi FRMPD1. human.
    EvolutionaryTracei Q5SYB0.
    GenomeRNAii 22844.
    NextBioi 43297.
    PROi Q5SYB0.

    Gene expression databases

    ArrayExpressi Q5SYB0.
    Bgeei Q5SYB0.
    CleanExi HS_FRMPD1.
    Genevestigatori Q5SYB0.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Retina.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-846.
    7. "The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins."
      An N., Blumer J.B., Bernard M.L., Lanier S.M.
      J. Biol. Chem. 283:24718-24728(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GPSM1, FUNCTION, SUBCELLULAR LOCATION.
    8. "Solution structure of the PDZ domain from human FERM and PDZ domain-containing 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (AUG-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 54-136.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-572.

    Entry informationi

    Entry nameiFRPD1_HUMAN
    AccessioniPrimary (citable) accession number: Q5SYB0
    Secondary accession number(s): B4DZC8
    , B7Z807, D3DRQ3, Q14C73, Q5HY96, Q9Y2H3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3