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Q5SY80

- CA101_HUMAN

UniProt

Q5SY80 - CA101_HUMAN

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Protein
Uncharacterized protein C1orf101
Gene
C1orf101
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf101
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28491. C1orf101.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 903884Extracellular Reviewed prediction
Add
BLAST
Transmembranei904 – 92421Helical; Reviewed prediction
Add
BLAST
Topological domaini925 – 95127Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. CatSper complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 951932Uncharacterized protein C1orf101
PRO_0000251216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi472 – 4721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi535 – 5351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5SY80.
PRIDEiQ5SY80.

PTM databases

PhosphoSiteiQ5SY80.

Expressioni

Gene expression databases

ArrayExpressiQ5SY80.
BgeeiQ5SY80.
CleanExiHS_C1orf101.
GenevestigatoriQ5SY80.

Interactioni

Protein-protein interaction databases

BioGridi129192. 1 interaction.
IntActiQ5SY80. 1 interaction.
STRINGi9606.ENSP00000355492.

Structurei

3D structure databases

ProteinModelPortaliQ5SY80.

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG130667.
HOGENOMiHOG000082422.
HOVERGENiHBG080959.
InParanoidiQ5SY80.
OMAiVIYNEDT.
OrthoDBiEOG7TF78C.
PhylomeDBiQ5SY80.
TreeFamiTF336183.

Family and domain databases

InterProiIPR028751. CATSPERD.
[Graphical view]
PfamiPF15020. CATSPERD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5SY80-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE    50
WSVPETCFVL NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT 100
CFLWYYRVRH FFNNFTQLIT VWAYDPESAD PDELLGNAEE PSINSIVLST 150
QMATLGQKPV IHTVLKRKVY SSNEKMRRGT WRIVVPMTKD DALKEIRGNQ 200
VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM ASWDACVVAS 250
AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL 300
INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST 350
FAVWTENEIY LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP 400
LEIAVFLNYC TVCNVTKKIF LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF 450
TFSALPGLLL WNKHSIYYCY HNFTFTGILQ TPAGHGNLSM LSNDSIIHEV 500
FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA FIFLSTSGQT 550
YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD 600
KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL 650
TLTFYQNVDY ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA 700
VGCDDKKFIA IKGFSKKGCH HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY 750
GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA NFIVWEIHGR DDYSFNNTMA 800
QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI GKPGDLNQPY 850
EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP 900
SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK 950
N 951
Length:951
Mass (Da):109,662
Last modified:December 21, 2004 - v1
Checksum:iD00AA5E03F6DBF47
GO
Isoform 2 (identifier: Q5SY80-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     831-832: NY → FL
     833-951: Missing.

Note: No experimental confirmation available.

Show »
Length:832
Mass (Da):95,559
Checksum:i54BDC52DCC4F0C03
GO
Isoform 3 (identifier: Q5SY80-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:800
Mass (Da):92,316
Checksum:i83993958154F297F
GO

Sequence cautioni

The sequence BC028392 differs from that shown. Reason: Frameshift at position 418.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561T → S.
Corresponds to variant rs58602830 [ dbSNP | Ensembl ].
VAR_061566
Natural varianti66 – 661T → K.
Corresponds to variant rs11586356 [ dbSNP | Ensembl ].
VAR_027661
Natural varianti653 – 6531T → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_035494

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 151151Missing in isoform 3.
VSP_044251Add
BLAST
Alternative sequencei831 – 8322NY → FL in isoform 2.
VSP_020748
Alternative sequencei833 – 951119Missing in isoform 2.
VSP_020749Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK302609 mRNA. Translation: BAH13761.1.
AK303059 mRNA. Translation: BAG64176.1.
AL591594, AC099757 Genomic DNA. Translation: CAI14039.1.
AL591594, AC099757 Genomic DNA. Translation: CAI14040.1.
CH471148 Genomic DNA. Translation: EAW77109.1.
BC032859 mRNA. Translation: AAH32859.1.
BC028392 mRNA. No translation available.
CCDSiCCDS1625.1. [Q5SY80-2]
CCDS44340.1. [Q5SY80-1]
CCDS55693.1. [Q5SY80-3]
RefSeqiNP_001124429.1. NM_001130957.1. [Q5SY80-1]
NP_001229269.1. NM_001242340.1. [Q5SY80-3]
NP_776168.1. NM_173807.4. [Q5SY80-2]
UniGeneiHs.459534.

Genome annotation databases

EnsembliENST00000366531; ENSP00000355489; ENSG00000179397. [Q5SY80-3]
ENST00000366533; ENSP00000355491; ENSG00000179397. [Q5SY80-2]
ENST00000366534; ENSP00000355492; ENSG00000179397. [Q5SY80-1]
GeneIDi257044.
KEGGihsa:257044.
UCSCiuc001ial.3. human. [Q5SY80-2]
uc001iam.3. human. [Q5SY80-1]

Polymorphism databases

DMDMi74744048.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK302609 mRNA. Translation: BAH13761.1 .
AK303059 mRNA. Translation: BAG64176.1 .
AL591594 , AC099757 Genomic DNA. Translation: CAI14039.1 .
AL591594 , AC099757 Genomic DNA. Translation: CAI14040.1 .
CH471148 Genomic DNA. Translation: EAW77109.1 .
BC032859 mRNA. Translation: AAH32859.1 .
BC028392 mRNA. No translation available.
CCDSi CCDS1625.1. [Q5SY80-2 ]
CCDS44340.1. [Q5SY80-1 ]
CCDS55693.1. [Q5SY80-3 ]
RefSeqi NP_001124429.1. NM_001130957.1. [Q5SY80-1 ]
NP_001229269.1. NM_001242340.1. [Q5SY80-3 ]
NP_776168.1. NM_173807.4. [Q5SY80-2 ]
UniGenei Hs.459534.

3D structure databases

ProteinModelPortali Q5SY80.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129192. 1 interaction.
IntActi Q5SY80. 1 interaction.
STRINGi 9606.ENSP00000355492.

PTM databases

PhosphoSitei Q5SY80.

Polymorphism databases

DMDMi 74744048.

Proteomic databases

PaxDbi Q5SY80.
PRIDEi Q5SY80.

Protocols and materials databases

DNASUi 257044.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366531 ; ENSP00000355489 ; ENSG00000179397 . [Q5SY80-3 ]
ENST00000366533 ; ENSP00000355491 ; ENSG00000179397 . [Q5SY80-2 ]
ENST00000366534 ; ENSP00000355492 ; ENSG00000179397 . [Q5SY80-1 ]
GeneIDi 257044.
KEGGi hsa:257044.
UCSCi uc001ial.3. human. [Q5SY80-2 ]
uc001iam.3. human. [Q5SY80-1 ]

Organism-specific databases

CTDi 257044.
GeneCardsi GC01P244618.
H-InvDB HIX0001749.
HGNCi HGNC:28491. C1orf101.
neXtProti NX_Q5SY80.
PharmGKBi PA142672485.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG130667.
HOGENOMi HOG000082422.
HOVERGENi HBG080959.
InParanoidi Q5SY80.
OMAi VIYNEDT.
OrthoDBi EOG7TF78C.
PhylomeDBi Q5SY80.
TreeFami TF336183.

Miscellaneous databases

GenomeRNAii 257044.
NextBioi 92912.

Gene expression databases

ArrayExpressi Q5SY80.
Bgeei Q5SY80.
CleanExi HS_C1orf101.
Genevestigatori Q5SY80.

Family and domain databases

InterProi IPR028751. CATSPERD.
[Graphical view ]
Pfami PF15020. CATSPERD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-653.

Entry informationi

Entry nameiCA101_HUMAN
AccessioniPrimary (citable) accession number: Q5SY80
Secondary accession number(s): B4DZR4
, B7Z7X5, E9PEA3, Q8IYZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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