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Protein

Uncharacterized protein C1orf101

Gene

C1orf101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf101
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28491. C1orf101.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 903884ExtracellularSequence AnalysisAdd
BLAST
Transmembranei904 – 92421HelicalSequence AnalysisAdd
BLAST
Topological domaini925 – 95127CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672485.

Polymorphism and mutation databases

BioMutaiC1orf101.
DMDMi74744048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 951932Uncharacterized protein C1orf101PRO_0000251216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5SY80.
PRIDEiQ5SY80.

PTM databases

PhosphoSiteiQ5SY80.

Expressioni

Gene expression databases

BgeeiQ5SY80.
CleanExiHS_C1orf101.
ExpressionAtlasiQ5SY80. baseline and differential.
GenevisibleiQ5SY80. HS.

Organism-specific databases

HPAiHPA058285.

Interactioni

Protein-protein interaction databases

IntActiQ5SY80. 1 interaction.
STRINGi9606.ENSP00000355492.

Structurei

3D structure databases

ProteinModelPortaliQ5SY80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG130667.
GeneTreeiENSGT00560000077286.
HOGENOMiHOG000082422.
HOVERGENiHBG080959.
InParanoidiQ5SY80.
OMAiVIYNEDT.
OrthoDBiEOG7TF78C.
PhylomeDBiQ5SY80.
TreeFamiTF336183.

Family and domain databases

InterProiIPR028751. CATSPERD.
[Graphical view]
PfamiPF15020. CATSPERD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SY80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE
60 70 80 90 100
WSVPETCFVL NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT
110 120 130 140 150
CFLWYYRVRH FFNNFTQLIT VWAYDPESAD PDELLGNAEE PSINSIVLST
160 170 180 190 200
QMATLGQKPV IHTVLKRKVY SSNEKMRRGT WRIVVPMTKD DALKEIRGNQ
210 220 230 240 250
VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM ASWDACVVAS
260 270 280 290 300
AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL
310 320 330 340 350
INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST
360 370 380 390 400
FAVWTENEIY LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP
410 420 430 440 450
LEIAVFLNYC TVCNVTKKIF LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF
460 470 480 490 500
TFSALPGLLL WNKHSIYYCY HNFTFTGILQ TPAGHGNLSM LSNDSIIHEV
510 520 530 540 550
FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA FIFLSTSGQT
560 570 580 590 600
YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD
610 620 630 640 650
KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL
660 670 680 690 700
TLTFYQNVDY ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA
710 720 730 740 750
VGCDDKKFIA IKGFSKKGCH HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY
760 770 780 790 800
GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA NFIVWEIHGR DDYSFNNTMA
810 820 830 840 850
QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI GKPGDLNQPY
860 870 880 890 900
EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP
910 920 930 940 950
SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK

N
Length:951
Mass (Da):109,662
Last modified:December 21, 2004 - v1
Checksum:iD00AA5E03F6DBF47
GO
Isoform 2 (identifier: Q5SY80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     831-832: NY → FL
     833-951: Missing.

Note: No experimental confirmation available.
Show »
Length:832
Mass (Da):95,559
Checksum:i54BDC52DCC4F0C03
GO
Isoform 3 (identifier: Q5SY80-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:800
Mass (Da):92,316
Checksum:i83993958154F297F
GO

Sequence cautioni

The sequence BC028392 differs from that shown. Reason: Frameshift at position 418. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561T → S.
Corresponds to variant rs58602830 [ dbSNP | Ensembl ].
VAR_061566
Natural varianti66 – 661T → K.
Corresponds to variant rs11586356 [ dbSNP | Ensembl ].
VAR_027661
Natural varianti653 – 6531T → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_035494

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 151151Missing in isoform 3. 1 PublicationVSP_044251Add
BLAST
Alternative sequencei831 – 8322NY → FL in isoform 2. 1 PublicationVSP_020748
Alternative sequencei833 – 951119Missing in isoform 2. 1 PublicationVSP_020749Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302609 mRNA. Translation: BAH13761.1.
AK303059 mRNA. Translation: BAG64176.1.
AL591594, AC099757 Genomic DNA. Translation: CAI14039.1.
AL591594, AC099757 Genomic DNA. Translation: CAI14040.1.
CH471148 Genomic DNA. Translation: EAW77109.1.
BC032859 mRNA. Translation: AAH32859.1.
BC028392 mRNA. No translation available.
CCDSiCCDS1625.1. [Q5SY80-2]
CCDS44340.1. [Q5SY80-1]
CCDS55693.1. [Q5SY80-3]
RefSeqiNP_001124429.1. NM_001130957.1. [Q5SY80-1]
NP_001229269.1. NM_001242340.1. [Q5SY80-3]
NP_776168.1. NM_173807.4. [Q5SY80-2]
UniGeneiHs.459534.

Genome annotation databases

EnsembliENST00000366531; ENSP00000355489; ENSG00000179397. [Q5SY80-3]
ENST00000366533; ENSP00000355491; ENSG00000179397. [Q5SY80-2]
ENST00000366534; ENSP00000355492; ENSG00000179397. [Q5SY80-1]
GeneIDi257044.
KEGGihsa:257044.
UCSCiuc001ial.3. human. [Q5SY80-2]
uc001iam.3. human. [Q5SY80-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302609 mRNA. Translation: BAH13761.1.
AK303059 mRNA. Translation: BAG64176.1.
AL591594, AC099757 Genomic DNA. Translation: CAI14039.1.
AL591594, AC099757 Genomic DNA. Translation: CAI14040.1.
CH471148 Genomic DNA. Translation: EAW77109.1.
BC032859 mRNA. Translation: AAH32859.1.
BC028392 mRNA. No translation available.
CCDSiCCDS1625.1. [Q5SY80-2]
CCDS44340.1. [Q5SY80-1]
CCDS55693.1. [Q5SY80-3]
RefSeqiNP_001124429.1. NM_001130957.1. [Q5SY80-1]
NP_001229269.1. NM_001242340.1. [Q5SY80-3]
NP_776168.1. NM_173807.4. [Q5SY80-2]
UniGeneiHs.459534.

3D structure databases

ProteinModelPortaliQ5SY80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SY80. 1 interaction.
STRINGi9606.ENSP00000355492.

PTM databases

PhosphoSiteiQ5SY80.

Polymorphism and mutation databases

BioMutaiC1orf101.
DMDMi74744048.

Proteomic databases

PaxDbiQ5SY80.
PRIDEiQ5SY80.

Protocols and materials databases

DNASUi257044.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366531; ENSP00000355489; ENSG00000179397. [Q5SY80-3]
ENST00000366533; ENSP00000355491; ENSG00000179397. [Q5SY80-2]
ENST00000366534; ENSP00000355492; ENSG00000179397. [Q5SY80-1]
GeneIDi257044.
KEGGihsa:257044.
UCSCiuc001ial.3. human. [Q5SY80-2]
uc001iam.3. human. [Q5SY80-1]

Organism-specific databases

CTDi257044.
GeneCardsiGC01P244618.
H-InvDBHIX0001749.
HGNCiHGNC:28491. C1orf101.
HPAiHPA058285.
neXtProtiNX_Q5SY80.
PharmGKBiPA142672485.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG130667.
GeneTreeiENSGT00560000077286.
HOGENOMiHOG000082422.
HOVERGENiHBG080959.
InParanoidiQ5SY80.
OMAiVIYNEDT.
OrthoDBiEOG7TF78C.
PhylomeDBiQ5SY80.
TreeFamiTF336183.

Miscellaneous databases

ChiTaRSiC1orf101. human.
GenomeRNAii257044.
NextBioi92912.
PROiQ5SY80.

Gene expression databases

BgeeiQ5SY80.
CleanExiHS_C1orf101.
ExpressionAtlasiQ5SY80. baseline and differential.
GenevisibleiQ5SY80. HS.

Family and domain databases

InterProiIPR028751. CATSPERD.
[Graphical view]
PfamiPF15020. CATSPERD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-653.

Entry informationi

Entry nameiCA101_HUMAN
AccessioniPrimary (citable) accession number: Q5SY80
Secondary accession number(s): B4DZR4
, B7Z7X5, E9PEA3, Q8IYZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.