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Q5SY80 (CA101_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C1orf101
Gene names
Name:C1orf101
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length951 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence caution

The sequence BC028392 differs from that shown. Reason: Frameshift at position 418.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5SY80-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5SY80-2)

The sequence of this isoform differs from the canonical sequence as follows:
     831-832: NY → FL
     833-951: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q5SY80-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 951932Uncharacterized protein C1orf101
PRO_0000251216

Regions

Topological domain20 – 903884Extracellular Potential
Transmembrane904 – 92421Helical; Potential
Topological domain925 – 95127Cytoplasmic Potential

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation4721N-linked (GlcNAc...) Potential
Glycosylation5351N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 151151Missing in isoform 3.
VSP_044251
Alternative sequence831 – 8322NY → FL in isoform 2.
VSP_020748
Alternative sequence833 – 951119Missing in isoform 2.
VSP_020749
Natural variant561T → S.
Corresponds to variant rs58602830 [ dbSNP | Ensembl ].
VAR_061566
Natural variant661T → K.
Corresponds to variant rs11586356 [ dbSNP | Ensembl ].
VAR_027661
Natural variant6531T → I in a breast cancer sample; somatic mutation. Ref.5
VAR_035494

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: D00AA5E03F6DBF47

FASTA951109,662
        10         20         30         40         50         60 
MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE WSVPETCFVL 

        70         80         90        100        110        120 
NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT CFLWYYRVRH FFNNFTQLIT 

       130        140        150        160        170        180 
VWAYDPESAD PDELLGNAEE PSINSIVLST QMATLGQKPV IHTVLKRKVY SSNEKMRRGT 

       190        200        210        220        230        240 
WRIVVPMTKD DALKEIRGNQ VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM 

       250        260        270        280        290        300 
ASWDACVVAS AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL 

       310        320        330        340        350        360 
INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST FAVWTENEIY 

       370        380        390        400        410        420 
LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP LEIAVFLNYC TVCNVTKKIF 

       430        440        450        460        470        480 
LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF TFSALPGLLL WNKHSIYYCY HNFTFTGILQ 

       490        500        510        520        530        540 
TPAGHGNLSM LSNDSIIHEV FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA 

       550        560        570        580        590        600 
FIFLSTSGQT YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD 

       610        620        630        640        650        660 
KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL TLTFYQNVDY 

       670        680        690        700        710        720 
ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA VGCDDKKFIA IKGFSKKGCH 

       730        740        750        760        770        780 
HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA 

       790        800        810        820        830        840 
NFIVWEIHGR DDYSFNNTMA QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI 

       850        860        870        880        890        900 
GKPGDLNQPY EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP 

       910        920        930        940        950 
SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK N 

« Hide

Isoform 2 [UniParc].

Checksum: 54BDC52DCC4F0C03
Show »

FASTA83295,559
Isoform 3 [UniParc].

Checksum: 83993958154F297F
Show »

FASTA80092,316

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Testis.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Testis.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-653.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK302609 mRNA. Translation: BAH13761.1.
AK303059 mRNA. Translation: BAG64176.1.
AL591594, AC099757 Genomic DNA. Translation: CAI14039.1.
AL591594, AC099757 Genomic DNA. Translation: CAI14040.1.
CH471148 Genomic DNA. Translation: EAW77109.1.
BC032859 mRNA. Translation: AAH32859.1.
BC028392 mRNA. No translation available.
RefSeqNP_001124429.1. NM_001130957.1.
NP_001229269.1. NM_001242340.1.
NP_776168.1. NM_173807.4.
UniGeneHs.459534.

3D structure databases

ProteinModelPortalQ5SY80.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129192. 1 interaction.
IntActQ5SY80. 1 interaction.
STRING9606.ENSP00000355492.

PTM databases

PhosphoSiteQ5SY80.

Polymorphism databases

DMDM74744048.

Proteomic databases

PaxDbQ5SY80.
PRIDEQ5SY80.

Protocols and materials databases

DNASU257044.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366531; ENSP00000355489; ENSG00000179397. [Q5SY80-3]
ENST00000366533; ENSP00000355491; ENSG00000179397. [Q5SY80-2]
ENST00000366534; ENSP00000355492; ENSG00000179397. [Q5SY80-1]
GeneID257044.
KEGGhsa:257044.
UCSCuc001ial.3. human. [Q5SY80-2]
uc001iam.3. human. [Q5SY80-1]

Organism-specific databases

CTD257044.
GeneCardsGC01P244618.
H-InvDBHIX0001749.
HGNCHGNC:28491. C1orf101.
neXtProtNX_Q5SY80.
PharmGKBPA142672485.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG130667.
HOGENOMHOG000082422.
HOVERGENHBG080959.
InParanoidQ5SY80.
OMAVIYNEDT.
OrthoDBEOG7TF78C.
TreeFamTF336183.

Gene expression databases

ArrayExpressQ5SY80.
BgeeQ5SY80.
CleanExHS_C1orf101.
GenevestigatorQ5SY80.

Family and domain databases

InterProIPR028751. CATSPERD.
[Graphical view]
PfamPF15020. CATSPERD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi257044.
NextBio92912.

Entry information

Entry nameCA101_HUMAN
AccessionPrimary (citable) accession number: Q5SY80
Secondary accession number(s): B4DZR4 expand/collapse secondary AC list , B7Z7X5, E9PEA3, Q8IYZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: March 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM