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Q5SY80

- CA101_HUMAN

UniProt

Q5SY80 - CA101_HUMAN

Protein

Uncharacterized protein C1orf101

Gene

C1orf101

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C1orf101
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28491. C1orf101.

    Subcellular locationi

    GO - Cellular componenti

    1. CatSper complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672485.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 951932Uncharacterized protein C1orf101PRO_0000251216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5SY80.
    PRIDEiQ5SY80.

    PTM databases

    PhosphoSiteiQ5SY80.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5SY80.
    BgeeiQ5SY80.
    CleanExiHS_C1orf101.
    GenevestigatoriQ5SY80.

    Interactioni

    Protein-protein interaction databases

    BioGridi129192. 1 interaction.
    IntActiQ5SY80. 1 interaction.
    STRINGi9606.ENSP00000355492.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SY80.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 903884ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini925 – 95127CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei904 – 92421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG130667.
    HOGENOMiHOG000082422.
    HOVERGENiHBG080959.
    InParanoidiQ5SY80.
    OMAiVIYNEDT.
    OrthoDBiEOG7TF78C.
    PhylomeDBiQ5SY80.
    TreeFamiTF336183.

    Family and domain databases

    InterProiIPR028751. CATSPERD.
    [Graphical view]
    PfamiPF15020. CATSPERD. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5SY80-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE    50
    WSVPETCFVL NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT 100
    CFLWYYRVRH FFNNFTQLIT VWAYDPESAD PDELLGNAEE PSINSIVLST 150
    QMATLGQKPV IHTVLKRKVY SSNEKMRRGT WRIVVPMTKD DALKEIRGNQ 200
    VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM ASWDACVVAS 250
    AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL 300
    INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST 350
    FAVWTENEIY LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP 400
    LEIAVFLNYC TVCNVTKKIF LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF 450
    TFSALPGLLL WNKHSIYYCY HNFTFTGILQ TPAGHGNLSM LSNDSIIHEV 500
    FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA FIFLSTSGQT 550
    YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD 600
    KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL 650
    TLTFYQNVDY ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA 700
    VGCDDKKFIA IKGFSKKGCH HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY 750
    GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA NFIVWEIHGR DDYSFNNTMA 800
    QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI GKPGDLNQPY 850
    EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP 900
    SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK 950
    N 951
    Length:951
    Mass (Da):109,662
    Last modified:December 21, 2004 - v1
    Checksum:iD00AA5E03F6DBF47
    GO
    Isoform 2 (identifier: Q5SY80-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         831-832: NY → FL
         833-951: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:832
    Mass (Da):95,559
    Checksum:i54BDC52DCC4F0C03
    GO
    Isoform 3 (identifier: Q5SY80-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-151: Missing.

    Show »
    Length:800
    Mass (Da):92,316
    Checksum:i83993958154F297F
    GO

    Sequence cautioni

    The sequence BC028392 differs from that shown. Reason: Frameshift at position 418.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561T → S.
    Corresponds to variant rs58602830 [ dbSNP | Ensembl ].
    VAR_061566
    Natural varianti66 – 661T → K.
    Corresponds to variant rs11586356 [ dbSNP | Ensembl ].
    VAR_027661
    Natural varianti653 – 6531T → I in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035494

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 151151Missing in isoform 3. 1 PublicationVSP_044251Add
    BLAST
    Alternative sequencei831 – 8322NY → FL in isoform 2. 1 PublicationVSP_020748
    Alternative sequencei833 – 951119Missing in isoform 2. 1 PublicationVSP_020749Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK302609 mRNA. Translation: BAH13761.1.
    AK303059 mRNA. Translation: BAG64176.1.
    AL591594, AC099757 Genomic DNA. Translation: CAI14039.1.
    AL591594, AC099757 Genomic DNA. Translation: CAI14040.1.
    CH471148 Genomic DNA. Translation: EAW77109.1.
    BC032859 mRNA. Translation: AAH32859.1.
    BC028392 mRNA. No translation available.
    CCDSiCCDS1625.1. [Q5SY80-2]
    CCDS44340.1. [Q5SY80-1]
    CCDS55693.1. [Q5SY80-3]
    RefSeqiNP_001124429.1. NM_001130957.1. [Q5SY80-1]
    NP_001229269.1. NM_001242340.1. [Q5SY80-3]
    NP_776168.1. NM_173807.4. [Q5SY80-2]
    UniGeneiHs.459534.

    Genome annotation databases

    EnsembliENST00000366531; ENSP00000355489; ENSG00000179397. [Q5SY80-3]
    ENST00000366533; ENSP00000355491; ENSG00000179397. [Q5SY80-2]
    ENST00000366534; ENSP00000355492; ENSG00000179397. [Q5SY80-1]
    GeneIDi257044.
    KEGGihsa:257044.
    UCSCiuc001ial.3. human. [Q5SY80-2]
    uc001iam.3. human. [Q5SY80-1]

    Polymorphism databases

    DMDMi74744048.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK302609 mRNA. Translation: BAH13761.1 .
    AK303059 mRNA. Translation: BAG64176.1 .
    AL591594 , AC099757 Genomic DNA. Translation: CAI14039.1 .
    AL591594 , AC099757 Genomic DNA. Translation: CAI14040.1 .
    CH471148 Genomic DNA. Translation: EAW77109.1 .
    BC032859 mRNA. Translation: AAH32859.1 .
    BC028392 mRNA. No translation available.
    CCDSi CCDS1625.1. [Q5SY80-2 ]
    CCDS44340.1. [Q5SY80-1 ]
    CCDS55693.1. [Q5SY80-3 ]
    RefSeqi NP_001124429.1. NM_001130957.1. [Q5SY80-1 ]
    NP_001229269.1. NM_001242340.1. [Q5SY80-3 ]
    NP_776168.1. NM_173807.4. [Q5SY80-2 ]
    UniGenei Hs.459534.

    3D structure databases

    ProteinModelPortali Q5SY80.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129192. 1 interaction.
    IntActi Q5SY80. 1 interaction.
    STRINGi 9606.ENSP00000355492.

    PTM databases

    PhosphoSitei Q5SY80.

    Polymorphism databases

    DMDMi 74744048.

    Proteomic databases

    PaxDbi Q5SY80.
    PRIDEi Q5SY80.

    Protocols and materials databases

    DNASUi 257044.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366531 ; ENSP00000355489 ; ENSG00000179397 . [Q5SY80-3 ]
    ENST00000366533 ; ENSP00000355491 ; ENSG00000179397 . [Q5SY80-2 ]
    ENST00000366534 ; ENSP00000355492 ; ENSG00000179397 . [Q5SY80-1 ]
    GeneIDi 257044.
    KEGGi hsa:257044.
    UCSCi uc001ial.3. human. [Q5SY80-2 ]
    uc001iam.3. human. [Q5SY80-1 ]

    Organism-specific databases

    CTDi 257044.
    GeneCardsi GC01P244618.
    H-InvDB HIX0001749.
    HGNCi HGNC:28491. C1orf101.
    neXtProti NX_Q5SY80.
    PharmGKBi PA142672485.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG130667.
    HOGENOMi HOG000082422.
    HOVERGENi HBG080959.
    InParanoidi Q5SY80.
    OMAi VIYNEDT.
    OrthoDBi EOG7TF78C.
    PhylomeDBi Q5SY80.
    TreeFami TF336183.

    Miscellaneous databases

    GenomeRNAii 257044.
    NextBioi 92912.

    Gene expression databases

    ArrayExpressi Q5SY80.
    Bgeei Q5SY80.
    CleanExi HS_C1orf101.
    Genevestigatori Q5SY80.

    Family and domain databases

    InterProi IPR028751. CATSPERD.
    [Graphical view ]
    Pfami PF15020. CATSPERD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-653.

    Entry informationi

    Entry nameiCA101_HUMAN
    AccessioniPrimary (citable) accession number: Q5SY80
    Secondary accession number(s): B4DZR4
    , B7Z7X5, E9PEA3, Q8IYZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3