Q5SY80 (CA101_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C1orf101

Gene names

Name:

C1orf101

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	951 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence caution	The sequence BC028392 differs from that shown. Reason: Frameshift at position 418.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SY80-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SY80-2)

The sequence of this isoform differs from the canonical sequence as follows:
     831-832: NY → FL
     833-951: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5SY80-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 951	932	Uncharacterized protein C1orf101		PRO_0000251216
Regions
	Topological domain	20 – 903	884	Extracellular Potential
	Transmembrane	904 – 924	21	Helical; Potential
	Topological domain	925 – 951	27	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Glycosylation	472	1	N-linked (GlcNAc...) Potential
	Glycosylation	535	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 151	151	Missing in isoform 3.		VSP_044251
	Alternative sequence	831 – 832	2	NY → FL in isoform 2.		VSP_020748
	Alternative sequence	833 – 951	119	Missing in isoform 2.		VSP_020749
	Natural variant	56	1	T → S. Corresponds to variant rs58602830 [ dbSNP | Ensembl ].		VAR_061566
	Natural variant	66	1	T → K. Corresponds to variant rs11586356 [ dbSNP | Ensembl ].		VAR_027661
	Natural variant	653	1	T → I in a breast cancer sample; somatic mutation. Ref.5		VAR_035494

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: D00AA5E03F6DBF47	FASTA	951	109,662
	10 20 30 40 50 60 MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE WSVPETCFVL 70 80 90 100 110 120 NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT CFLWYYRVRH FFNNFTQLIT 130 140 150 160 170 180 VWAYDPESAD PDELLGNAEE PSINSIVLST QMATLGQKPV IHTVLKRKVY SSNEKMRRGT 190 200 210 220 230 240 WRIVVPMTKD DALKEIRGNQ VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM 250 260 270 280 290 300 ASWDACVVAS AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL 310 320 330 340 350 360 INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST FAVWTENEIY 370 380 390 400 410 420 LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP LEIAVFLNYC TVCNVTKKIF 430 440 450 460 470 480 LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF TFSALPGLLL WNKHSIYYCY HNFTFTGILQ 490 500 510 520 530 540 TPAGHGNLSM LSNDSIIHEV FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA 550 560 570 580 590 600 FIFLSTSGQT YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD 610 620 630 640 650 660 KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL TLTFYQNVDY 670 680 690 700 710 720 ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA VGCDDKKFIA IKGFSKKGCH 730 740 750 760 770 780 HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA 790 800 810 820 830 840 NFIVWEIHGR DDYSFNNTMA QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI 850 860 870 880 890 900 GKPGDLNQPY EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP 910 920 930 940 950 SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK N
	Isoform 2 [UniParc]. Checksum: 54BDC52DCC4F0C03	FASTA	832	95,559
	10 20 30 40 50 60 MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE WSVPETCFVL 70 80 90 100 110 120 NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT CFLWYYRVRH FFNNFTQLIT 130 140 150 160 170 180 VWAYDPESAD PDELLGNAEE PSINSIVLST QMATLGQKPV IHTVLKRKVY SSNEKMRRGT 190 200 210 220 230 240 WRIVVPMTKD DALKEIRGNQ VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM 250 260 270 280 290 300 ASWDACVVAS AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL 310 320 330 340 350 360 INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST FAVWTENEIY 370 380 390 400 410 420 LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP LEIAVFLNYC TVCNVTKKIF 430 440 450 460 470 480 LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF TFSALPGLLL WNKHSIYYCY HNFTFTGILQ 490 500 510 520 530 540 TPAGHGNLSM LSNDSIIHEV FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA 550 560 570 580 590 600 FIFLSTSGQT YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD 610 620 630 640 650 660 KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL TLTFYQNVDY 670 680 690 700 710 720 ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA VGCDDKKFIA IKGFSKKGCH 730 740 750 760 770 780 HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA 790 800 810 820 830 NFIVWEIHGR DDYSFNNTMA QSGCLHEAQT WKSMIELNKH LPLEEVWGPE FL
	Isoform 3 [UniParc]. Checksum: 83993958154F297F	FASTA	800	92,316
	10 20 30 40 50 60 MATLGQKPVI HTVLKRKVYS SNEKMRRGTW RIVVPMTKDD ALKEIRGNQV TFQDCFIADF 70 80 90 100 110 120 LILLTFPLLT IPEIPGYLPI SSPRGSQLMA SWDACVVASA VLVTDMETFH TTDSFKSWTR 130 140 150 160 170 180 IRVPPDILSD DERRSVAHVI LSRDGIVFLI NGVLYIKSFR GFIRLGGIVN LPDGGITGIS 190 200 210 220 230 240 SRKWCWVNYL LKAKGRRSTF AVWTENEIYL GSILLKFARL VTTTELKNIL SLSVTATLTI 250 260 270 280 290 300 DRVEYTGHPL EIAVFLNYCT VCNVTKKIFL VIYNEDTKQW VSQDFTLDAP IDSVTMPHFT 310 320 330 340 350 360 FSALPGLLLW NKHSIYYCYH NFTFTGILQT PAGHGNLSML SNDSIIHEVF IDYYGDILVK 370 380 390 400 410 420 MENNVIFYSK INTRDAVKLH LWTNYTTRAF IFLSTSGQTY FLYALDDGTI QIQDYPLHLE 430 440 450 460 470 480 AQSIAFTTKD KCPYMAFHNN VAHVFYFLDK GEALTVWTQI VYPENTGLYV IVESYGPKIL 490 500 510 520 530 540 QESHEISFEA AFGYCTKTLT LTFYQNVDYE RISDYFETQD KHTGLVLVQF RPSEYSKACP 550 560 570 580 590 600 IAQKVFQIAV GCDDKKFIAI KGFSKKGCHH HDFSYVIEKS YLRHQPSKNL RVRYIWGEYG 610 620 630 640 650 660 CPLRLDFTEK FQPVVQLFDD NGYVKDVEAN FIVWEIHGRD DYSFNNTMAQ SGCLHEAQTW 670 680 690 700 710 720 KSMIELNKHL PLEEVWGPEN YKHCFSYAIG KPGDLNQPYE IINSSNGNHI FWPMGHSGMY 730 740 750 760 770 780 VFRVKILDPN YSFCNLTAMF AIETFGLIPS PSVYLVASFL FVLMLLFFTI LVLSYFRYMR 790 800 IYRRYIYEPL HKPQRKRKKN

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-653.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK302609 mRNA. Translation: BAH13761.1. AK303059 mRNA. Translation: BAG64176.1. AL591594, AC099757 Genomic DNA. Translation: CAI14039.1. AL591594, AC099757 Genomic DNA. Translation: CAI14040.1. CH471148 Genomic DNA. Translation: EAW77109.1. BC032859 mRNA. Translation: AAH32859.1. BC028392 mRNA. No translation available.
IPI	IPI00217937. IPI00645983.
RefSeq	NP_001124429.1. NM_001130957.1. NP_001229269.1. NM_001242340.1. NP_776168.1. NM_173807.4.
UniGene	Hs.459534.
3D structure databases
ProteinModelPortal	Q5SY80.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5SY80. 1 interaction.
STRING	9606.ENSP00000355492.
PTM databases
PhosphoSite	Q5SY80.
Polymorphism databases
DMDM	74744048.
Proteomic databases
PaxDb	Q5SY80.
PRIDE	Q5SY80.
Protocols and materials databases
DNASU	257044.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366531; ENSP00000355489; ENSG00000179397. ENST00000366533; ENSP00000355491; ENSG00000179397. ENST00000366534; ENSP00000355492; ENSG00000179397.
GeneID	257044.
KEGG	hsa:257044.
UCSC	uc001ial.3. human. uc001iam.3. human.
Organism-specific databases
CTD	257044.
GeneCards	GC01P244618.
H-InvDB	HIX0001749.
HGNC	HGNC:28491. C1orf101.
neXtProt	NX_Q5SY80.
PharmGKB	PA142672485.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG130667.
HOGENOM	HOG000082422.
HOVERGEN	HBG080959.
InParanoid	Q5SY80.
OMA	VIYNEDT.
Gene expression databases
ArrayExpress	Q5SY80.
Bgee	Q5SY80.
CleanEx	HS_C1orf101.
Genevestigator	Q5SY80.
GermOnline	ENSG00000179397. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	257044.
NextBio	92912.

Entry information

Entry name

CA101_HUMAN

Accession

Primary (citable) accession number: Q5SY80
Secondary accession number(s): B4DZR4 , B7Z7X5, E9PEA3, Q8IYZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.