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Protein

Protein S100-A7-like 2

Gene

S100A7L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87ZincBy similarity1
Metal bindingi91ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A7-like 2
Alternative name(s):
S100 calcium-binding protein A7-like 2
Gene namesi
Name:S100A7L2
Synonyms:S100A7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197364.6.
HGNCiHGNC:21655. S100A7L2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74744045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002708311 – 101Protein S100-A7-like 2Add BLAST101

Proteomic databases

EPDiQ5SY68.
PaxDbiQ5SY68.
PeptideAtlasiQ5SY68.
PRIDEiQ5SY68.

Expressioni

Gene expression databases

BgeeiENSG00000197364.
CleanExiHS_S100A7L2.

Organism-specific databases

HPAiHPA057828.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
S100A7P311514EBI-12006206,EBI-357520

Protein-protein interaction databases

IntActiQ5SY68. 3 interactors.
STRINGi9606.ENSP00000405610.

Structurei

3D structure databases

ProteinModelPortaliQ5SY68.
SMRiQ5SY68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiQ5SY68.
OrthoDBiEOG091G0Y5T.
PhylomeDBiQ5SY68.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR034325. S-100_dom.
IPR013787. S100_Ca-bd_sub.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SY68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIPLGEKVM LDIVAMFRQY SGDDGRMDMP GLVNLMKENF PNFLSGCEKS
60 70 80 90 100
DMDYLSNALE KKDDNKDKKV NYSEFLSLLG DITIDHHKIM HGVAPCSGGS

Q
Length:101
Mass (Da):11,302
Last modified:December 21, 2004 - v1
Checksum:iD49E9BEB7CFBC97C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591704 Genomic DNA. No translation available.
BR000043 Genomic DNA. Translation: FAA00016.1.
UniGeneiHs.647713.

Genome annotation databases

EnsembliENST00000368724; ENSP00000357713; ENSG00000197364.
ENST00000368725; ENSP00000357714; ENSG00000197364.
UCSCiuc010pdx.3. human.

Similar proteinsi

Entry informationi

Entry nameiS1A7B_HUMAN
AccessioniPrimary (citable) accession number: Q5SY68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: September 27, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families