Q5SY68 (S1A7B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-A7-like 2

Alternative name(s):
S100 calcium-binding protein A7-like 2

Gene names

Name:	S100A7L2
Synonyms:	S100A7B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Protein S100-A7-like 2		PRO_0000270831
Regions
	Domain	13 – 48	36	EF-hand 1
	Domain	50 – 85	36	EF-hand 2
	Calcium binding	63 – 74	12	2; high affinity Potential
Sites
	Metal binding	87	1	Zinc By similarity
	Metal binding	91	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5SY68 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: D49E9BEB7CFBC97C	FASTA	101	11,302
	10 20 30 40 50 60 MNIPLGEKVM LDIVAMFRQY SGDDGRMDMP GLVNLMKENF PNFLSGCEKS DMDYLSNALE 70 80 90 100 KKDDNKDKKV NYSEFLSLLG DITIDHHKIM HGVAPCSGGS Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21." Kulski J.K., Lim C.P., Dunn D.S., Bellgard M. J. Mol. Evol. 56:397-406(2003) [PubMed: 12664160] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591704 Genomic DNA. Translation: CAI19501.1. BR000043 Genomic DNA. Translation: FAA00016.1.
IPI	IPI00477977.
UniGene	Hs.647713.
3D structure databases
HSSP	HSSP built from PDB template 1PSR based on UniProtKB P31151.
ProteinModelPortal	Q5SY68.
SMR	Q5SY68. Positions 2-101.
ModBase	Search...
Polymorphism databases
DMDM	74744045.
Proteomic databases
PRIDE	Q5SY68.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368724; ENSP00000357713; ENSG00000197364. ENST00000368725; ENSP00000357714; ENSG00000197364. ENST00000453814; ENSP00000405610; ENSG00000197364.
UCSC	uc001fbu.1. human.
Organism-specific databases
GeneCards	GC01M153409.
HGNC	HGNC:21655. S100A7L2.
neXtProt	NX_Q5SY68.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21256.
GeneTree	ENSGT00390000017320.
HOGENOM	HBG506094.
HOVERGEN	HBG095357.
InParanoid	Q5SY68.
OrthoDB	EOG46T333.
PhylomeDB	Q5SY68.
Gene expression databases
CleanEx	HS_S100A7L2.
Genevestigator	Q5SY68.
Family and domain databases
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	118117.

Entry information

Entry name

S1A7B_HUMAN

Accession

Primary (citable) accession number: Q5SY68

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.