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Protein

snRNA-activating protein complex subunit 4

Gene

SNAPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi317 – 341H-T-H motifPROSITE-ProRule annotationAdd BLAST25
DNA bindingi424 – 447H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi476 – 499H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • snRNA transcription Source: ProtInc
  • snRNA transcription from RNA polymerase III promoter Source: UniProtKB
  • snRNA transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription from RNA polymerase III promoter Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 4
Short name:
SNAPc subunit 4
Alternative name(s):
Proximal sequence element-binding transcription factor subunit alpha
Short name:
PSE-binding factor subunit alpha
Short name:
PTF subunit alpha
snRNA-activating protein complex 190 kDa subunit
Short name:
SNAPc 190 kDa subunit
Gene namesi
Name:SNAPC4Imported
Synonyms:SNAP190Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11137. SNAPC4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • snRNA-activating protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi94Q → A: Abolishes SNAPC5 binding in the absence of SNAPC1. Minimal effect on SNAPC5 binding in the presence of SNAPC1. 1 Publication1
Mutagenesisi94Q → L: Abolishes SNAPC5 binding in the absence of SNAPC1. Minimal effect on SNAPC5 binding in the presence of SNAPC1. 1 Publication1
Mutagenesisi115Q → L: Abolishes SNAPC5 binding in the absence of SNAPC1. Minimal effect on SNAPC5 binding in the presence of SNAPC1. 1 Publication1
Mutagenesisi1314L → A: Abolishes SNAPC2-binding. 1 Publication1
Mutagenesisi1355L → A: Abolishes SNAPC2-binding. 1 Publication1
Mutagenesisi1362L → A: Abolishes SNAPC2-binding. 1 Publication1
Mutagenesisi1364L → A: Abolishes SNAPC2-binding. 1 Publication1
Mutagenesisi1369L → A: Decreased binding to SNAPC2. 1 Publication1

Organism-specific databases

DisGeNETi6621.
OpenTargetsiENSG00000165684.
PharmGKBiPA35985.

Polymorphism and mutation databases

BioMutaiSNAPC4.
DMDMi74762223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971201 – 1469snRNA-activating protein complex subunit 4Add BLAST1469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Modified residuei1157PhosphothreonineCombined sources1
Modified residuei1224PhosphoserineCombined sources1
Modified residuei1398PhosphoserineCombined sources1
Modified residuei1400PhosphoserineCombined sources1
Modified residuei1440PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5SXM2.
MaxQBiQ5SXM2.
PaxDbiQ5SXM2.
PeptideAtlasiQ5SXM2.
PRIDEiQ5SXM2.

PTM databases

iPTMnetiQ5SXM2.
PhosphoSitePlusiQ5SXM2.

Expressioni

Gene expression databases

BgeeiENSG00000165684.
CleanExiHS_SNAPC4.
ExpressionAtlasiQ5SXM2. baseline and differential.
GenevisibleiQ5SXM2. HS.

Organism-specific databases

HPAiHPA046627.
HPA073243.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC4 interacts with SNAPC1, SNAPC2, SNAPC5, BRF2 and TBP.3 Publications

Protein-protein interaction databases

BioGridi112505. 12 interactors.
IntActiQ5SXM2. 18 interactors.
MINTiMINT-149201.
STRINGi9606.ENSP00000298532.

Structurei

3D structure databases

ProteinModelPortaliQ5SXM2.
SMRiQ5SXM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 288Myb-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini289 – 343HTH myb-type 1PROSITE-ProRule annotationAdd BLAST55
Domaini344 – 395Myb-like 2PROSITE-ProRule annotationAdd BLAST52
Domaini396 – 451HTH myb-type 2PROSITE-ProRule annotationAdd BLAST56
Domaini452 – 503HTH myb-type 3PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 133SNAPC5-binding1 PublicationAdd BLAST50
Regioni1281 – 1393SNAPC2-binding1 PublicationAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi931 – 1264Pro-richSequence analysisAdd BLAST334

Sequence similaritiesi

Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation
Contains 2 Myb-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231537.
HOVERGENiHBG080315.
InParanoidiQ5SXM2.
KOiK09453.
OMAiPVTWVLT.
OrthoDBiEOG091G02PC.
PhylomeDBiQ5SXM2.
TreeFamiTF313064.

Family and domain databases

Gene3Di1.10.10.60. 5 hits.
InterProiIPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 5 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 3 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SXM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVDAEREKI TQEIKELERI LDPGSSGSHV EISESSLESD SEADSLPSED
60 70 80 90 100
LDPADPPISE EERWGEASND EDDPKDKTLP EDPETCLQLN MVYQEVIQEK
110 120 130 140 150
LAEANLLLAQ NREQQEELMR DLAGSKGTKV KDGKSLPPST YMGHFMKPYF
160 170 180 190 200
KDKVTGVGPP ANEDTREKAA QGIKAFEELL VTKWKNWEKA LLRKSVVSDR
210 220 230 240 250
LQRLLQPKLL KLEYLHQKQS KVSSELERQA LEKQGREAEK EIQDINQLPE
260 270 280 290 300
EALLGNRLDS HDWEKISNIN FEGSRSAEEI RKFWQNSEHP SINKQEWSRE
310 320 330 340 350
EEERLQAIAA AHGHLEWQKI AEELGTSRSA FQCLQKFQQH NKALKRKEWT
360 370 380 390 400
EEEDRMLTQL VQEMRVGSHI PYRRIVYYME GRDSMQLIYR WTKSLDPGLK
410 420 430 440 450
KGYWAPEEDA KLLQAVAKYG EQDWFKIREE VPGRSDAQCR DRYLRRLHFS
460 470 480 490 500
LKKGRWNLKE EEQLIELIEK YGVGHWAKIA SELPHRSGSQ CLSKWKIMMG
510 520 530 540 550
KKQGLRRRRR RARHSVRWSS TSSSGSSSGS SGGSSSSSSS SSEEDEPEQA
560 570 580 590 600
QAGEGDRALL SPQYMVPDMD LWVPARQSTS QPWRGGAGAW LGGPAASLSP
610 620 630 640 650
PKGSSASQGG SKEASTTAAA PGEETSPVQV PARAHGPVPR SAQASHSADT
660 670 680 690 700
RPAGAEKQAL EGGRRLLTVP VETVLRVLRA NTAARSCTQK EQLRQPPLPT
710 720 730 740 750
SSPGVSSGDS VARSHVQWLR HRATQSGQRR WRHALHRRLL NRRLLLAVTP
760 770 780 790 800
WVGDVVVPCT QASQRPAVVQ TQADGLREQL QQARLASTPV FTLFTQLFHI
810 820 830 840 850
DTAGCLEVVR ERKALPPRLP QAGARDPPVH LLQASSSAQS TPGHLFPNVP
860 870 880 890 900
AQEASKSASH KGSRRLASSR VERTLPQASL LASTGPRPKP KTVSELLQEK
910 920 930 940 950
RLQEARAREA TRGPVVLPSQ LLVSSSVILQ PPLPHTPHGR PAPGPTVLNV
960 970 980 990 1000
PLSGPGAPAA AKPGTSGSWQ EAGTSAKDKR LSTMQALPLA PVFSEAEGTA
1010 1020 1030 1040 1050
PAASQAPALG PGQISVSCPE SGLGQSQAPA ASRKQGLPEA PPFLPAAPSP
1060 1070 1080 1090 1100
TPLPVQPLSL THIGGPHVAT SVPLPVTWVL TAQGLLPVPV PAVVSLPRPA
1110 1120 1130 1140 1150
GTPGPAGLLA TLLPPLTETR AAQGPRAPAL SSSWQPPANM NREPEPSCRT
1160 1170 1180 1190 1200
DTPAPPTHAL SQSPAEADGS VAFVPGEAQV AREIPEPRTS SHADPPEAEP
1210 1220 1230 1240 1250
PWSGRLPAFG GVIPATEPRG TPGSPSGTQE PRGPLGLEKL PLRQPGPEKG
1260 1270 1280 1290 1300
ALDLEKPPLP QPGPEKGALD LGLLSQEGEA ATQQWLGGQR GVRVPLLGSR
1310 1320 1330 1340 1350
LPYQPPALCS LRALSGLLLH KKALEHKATS LVVGGEAERP AGALQASLGL
1360 1370 1380 1390 1400
VRGQLQDNPA YLLLRARFLA AFTLPALLAT LAPQGVRTTL SVPSRVGSES
1410 1420 1430 1440 1450
EDEDLLSELE LADRDGQPGC TTATCPIQGA PDSGKCSASS CLDTSNDPDD
1460
LDVLRTRHAR HTRKRRRLV
Length:1,469
Mass (Da):159,433
Last modified:December 21, 2004 - v1
Checksum:i78CBCFB1887E106C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1046A → G in AAC02972 (PubMed:9418884).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05945544D → N.Corresponds to variant rs7031489dbSNPEnsembl.1
Natural variantiVAR_050193799H → Q.Corresponds to variant rs3812571dbSNPEnsembl.1
Natural variantiVAR_0501941448P → S.Corresponds to variant rs3812561dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032387 mRNA. Translation: AAC02972.1.
AL592301 Genomic DNA. Translation: CAI13935.1.
CCDSiCCDS6998.1.
PIRiT09219.
RefSeqiNP_003077.2. NM_003086.3.
XP_005266153.1. XM_005266096.2.
XP_006717304.1. XM_006717241.2.
XP_006717305.1. XM_006717242.3.
UniGeneiHs.113265.

Genome annotation databases

EnsembliENST00000298532; ENSP00000298532; ENSG00000165684.
GeneIDi6621.
KEGGihsa:6621.
UCSCiuc004chh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032387 mRNA. Translation: AAC02972.1.
AL592301 Genomic DNA. Translation: CAI13935.1.
CCDSiCCDS6998.1.
PIRiT09219.
RefSeqiNP_003077.2. NM_003086.3.
XP_005266153.1. XM_005266096.2.
XP_006717304.1. XM_006717241.2.
XP_006717305.1. XM_006717242.3.
UniGeneiHs.113265.

3D structure databases

ProteinModelPortaliQ5SXM2.
SMRiQ5SXM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112505. 12 interactors.
IntActiQ5SXM2. 18 interactors.
MINTiMINT-149201.
STRINGi9606.ENSP00000298532.

PTM databases

iPTMnetiQ5SXM2.
PhosphoSitePlusiQ5SXM2.

Polymorphism and mutation databases

BioMutaiSNAPC4.
DMDMi74762223.

Proteomic databases

EPDiQ5SXM2.
MaxQBiQ5SXM2.
PaxDbiQ5SXM2.
PeptideAtlasiQ5SXM2.
PRIDEiQ5SXM2.

Protocols and materials databases

DNASUi6621.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298532; ENSP00000298532; ENSG00000165684.
GeneIDi6621.
KEGGihsa:6621.
UCSCiuc004chh.4. human.

Organism-specific databases

CTDi6621.
DisGeNETi6621.
GeneCardsiSNAPC4.
H-InvDBHIX0008543.
HIX0201404.
HGNCiHGNC:11137. SNAPC4.
HPAiHPA046627.
HPA073243.
MIMi602777. gene.
neXtProtiNX_Q5SXM2.
OpenTargetsiENSG00000165684.
PharmGKBiPA35985.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231537.
HOVERGENiHBG080315.
InParanoidiQ5SXM2.
KOiK09453.
OMAiPVTWVLT.
OrthoDBiEOG091G02PC.
PhylomeDBiQ5SXM2.
TreeFamiTF313064.

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSiSNAPC4. human.
GeneWikiiSNAPC4.
GenomeRNAii6621.
PROiQ5SXM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165684.
CleanExiHS_SNAPC4.
ExpressionAtlasiQ5SXM2. baseline and differential.
GenevisibleiQ5SXM2. HS.

Family and domain databases

Gene3Di1.10.10.60. 5 hits.
InterProiIPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 5 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 3 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNPC4_HUMAN
AccessioniPrimary (citable) accession number: Q5SXM2
Secondary accession number(s): Q9Y6P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.