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Protein

Zinc finger protein 678

Gene

ZNF678

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri97 – 11923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri153 – 17523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 15; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 678
Gene namesi
Name:ZNF678
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28652. ZNF678.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74756138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Zinc finger protein 678PRO_0000233998Add
BLAST

Proteomic databases

EPDiQ5SXM1.
PaxDbiQ5SXM1.
PeptideAtlasiQ5SXM1.
PRIDEiQ5SXM1.

PTM databases

iPTMnetiQ5SXM1.
PhosphoSiteiQ5SXM1.

Expressioni

Gene expression databases

BgeeiQ5SXM1.
CleanExiHS_ZNF678.
ExpressionAtlasiQ5SXM1. baseline and differential.
GenevisibleiQ5SXM1. HS.

Organism-specific databases

HPAiHPA028507.

Interactioni

Protein-protein interaction databases

IntActiQ5SXM1. 1 interaction.
STRINGi9606.ENSP00000440403.

Structurei

3D structure databases

ProteinModelPortaliQ5SXM1.
SMRiQ5SXM1. Positions 95-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri97 – 11923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri153 – 17523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 15; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5SXM1.
OMAiQFSNLTQ.
PhylomeDBiQ5SXM1.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SXM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTISLCIGV CAFEGANTST SFYKLVYTAI LSYSIQDLLP EQDMKDLCQK
60 70 80 90 100
VTLTRHRSWG LDNLHLVKDW RTVNEGKGQK EYCNRLTQCS STKSKIFQCI
110 120 130 140 150
ECGRNFSWRS ILTEHKRIHT GEKPYKCEEC GKVFNRCSNL TKHKRIHTGE
160 170 180 190 200
KPYKCDECGK VFNWWSQLTN HKKIHTGEKP YKCDECDKVF NWWSQLTSHK
210 220 230 240 250
KIHSGEKPYP CEECGKAFTQ FSNLTQHKRI HTGEKPYKCK ECCKAFNKFS
260 270 280 290 300
NLTQHKRIHT GEKPYKCEEC GNVFNECSHL TRHRRIHTGE KPYKCEECGK
310 320 330 340 350
AFTQFASLTR HKRIHTGEKP YQCEECGKTF NRCSHLSSHK RIHTGEKPYK
360 370 380 390 400
CEECGRTFTQ FSNLTQHKRI HTGEKPYKCK ECGKAFNKFS SLTQHRRIHT
410 420 430 440 450
GVKPYKCEEC GKVFKQCSHL TSHKRIHTGE KPYKCKECGK AFYQSSILSK
460 470 480 490 500
HKRIHTEEKP YKCEECGKAF NQFSSLTRHK RIHTGEKRYK CKECGKGFYQ
510 520
SSIHSKYKRI YTGEEPDKCK KCGSL
Length:525
Mass (Da):61,411
Last modified:December 21, 2004 - v1
Checksum:i23FD2180FF0F0152
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441K → E.1 Publication
Corresponds to variant rs17854209 [ dbSNP | Ensembl ].
VAR_026154
Natural varianti152 – 1521P → T.
Corresponds to variant rs61283390 [ dbSNP | Ensembl ].
VAR_061962
Natural varianti197 – 1971T → I.
Corresponds to variant rs12118505 [ dbSNP | Ensembl ].
VAR_057441

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592310 Genomic DNA. Translation: CAI21826.1.
BC042500 mRNA. Translation: AAH42500.1.
UniGeneiHs.30323.

Genome annotation databases

EnsembliENST00000343776; ENSP00000344828; ENSG00000181450.
ENST00000397097; ENSP00000440403; ENSG00000181450.
UCSCiuc001hqw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592310 Genomic DNA. Translation: CAI21826.1.
BC042500 mRNA. Translation: AAH42500.1.
UniGeneiHs.30323.

3D structure databases

ProteinModelPortaliQ5SXM1.
SMRiQ5SXM1. Positions 95-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SXM1. 1 interaction.
STRINGi9606.ENSP00000440403.

PTM databases

iPTMnetiQ5SXM1.
PhosphoSiteiQ5SXM1.

Polymorphism and mutation databases

DMDMi74756138.

Proteomic databases

EPDiQ5SXM1.
PaxDbiQ5SXM1.
PeptideAtlasiQ5SXM1.
PRIDEiQ5SXM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343776; ENSP00000344828; ENSG00000181450.
ENST00000397097; ENSP00000440403; ENSG00000181450.
UCSCiuc001hqw.3. human.

Organism-specific databases

GeneCardsiZNF678.
HGNCiHGNC:28652. ZNF678.
HPAiHPA028507.
neXtProtiNX_Q5SXM1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5SXM1.
OMAiQFSNLTQ.
PhylomeDBiQ5SXM1.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF678. human.
PROiQ5SXM1.

Gene expression databases

BgeeiQ5SXM1.
CleanExiHS_ZNF678.
ExpressionAtlasiQ5SXM1. baseline and differential.
GenevisibleiQ5SXM1. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-144.
    Tissue: Testis.

Entry informationi

Entry nameiZN678_HUMAN
AccessioniPrimary (citable) accession number: Q5SXM1
Secondary accession number(s): Q8IVQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.