ID   NBPFF_HUMAN             Reviewed;         670 AA.
AC   Q8N660; A8MPT6; Q3BBV9; Q5SXJ2; Q8IX77;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   24-JAN-2024, entry version 144.
DE   RecName: Full=Neuroblastoma breakpoint family member 15 {ECO:0000312|HGNC:HGNC:28791};
DE   AltName: Full=Neuroblastoma breakpoint family member 16 {ECO:0000312|HGNC:HGNC:28791};
GN   Name=NBPF15 {ECO:0000312|HGNC:HGNC:28791};
GN   Synonyms=NBPF16 {ECO:0000312|HGNC:HGNC:28791};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Mammary gland;
RX   PubMed=16079250; DOI=10.1093/molbev/msi222;
RA   Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.;
RT   "A novel gene family NBPF: intricate structure generated by gene
RT   duplications during primate evolution.";
RL   Mol. Biol. Evol. 22:2265-2274(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLN-615.
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed with a higher expression
CC       observed in breast and liver. Also expressed in neuroblastoma cell
CC       line. {ECO:0000269|PubMed:16079250}.
CC   -!- MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes
CC       clustered in the p36, p12 and q21 region of the chromosome 1.
CC       {ECO:0000303|PubMed:16079250}.
CC   -!- SIMILARITY: Belongs to the NBPF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF379630; AAO15398.1; -; mRNA.
DR   EMBL; AY894566; AAX85105.1; -; mRNA.
DR   EMBL; AC246785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL592492; CAI16654.1; -; Genomic_DNA.
DR   EMBL; AL954711; CAM22821.1; -; Genomic_DNA.
DR   EMBL; BC023087; AAH23087.1; -; mRNA.
DR   CCDS; CCDS72852.1; -.
DR   RefSeq; NP_001164226.1; NM_001170755.2.
DR   RefSeq; NP_775909.2; NM_173638.4.
DR   RefSeq; XP_016856566.1; XM_017001077.1.
DR   AlphaFoldDB; Q8N660; -.
DR   SMR; Q8N660; -.
DR   BioGRID; 129901; 9.
DR   IntAct; Q8N660; 6.
DR   MINT; Q8N660; -.
DR   STRING; 9606.ENSP00000462600; -.
DR   iPTMnet; Q8N660; -.
DR   PhosphoSitePlus; Q8N660; -.
DR   BioMuta; NBPF15; -.
DR   DMDM; 74743973; -.
DR   EPD; Q8N660; -.
DR   jPOST; Q8N660; -.
DR   MassIVE; Q8N660; -.
DR   MaxQB; Q8N660; -.
DR   PaxDb; 9606-ENSP00000462600; -.
DR   PeptideAtlas; Q8N660; -.
DR   ProteomicsDB; 63994; -.
DR   ProteomicsDB; 72133; -.
DR   Antibodypedia; 74526; 14 antibodies from 8 providers.
DR   DNASU; 284565; -.
DR   Ensembl; ENST00000488031.6; ENSP00000481835.1; ENSG00000266338.7.
DR   Ensembl; ENST00000577412.6; ENSP00000462600.1; ENSG00000266338.7.
DR   Ensembl; ENST00000581897.7; ENSP00000463178.1; ENSG00000266338.7.
DR   GeneID; 284565; -.
DR   KEGG; hsa:284565; -.
DR   MANE-Select; ENST00000581897.7; ENSP00000463178.1; NM_001385408.1; NP_001372337.1.
DR   UCSC; uc010pay.3; human.
DR   AGR; HGNC:28791; -.
DR   CTD; 284565; -.
DR   DisGeNET; 284565; -.
DR   GeneCards; NBPF15; -.
DR   HGNC; HGNC:28791; NBPF15.
DR   HPA; ENSG00000266338; Low tissue specificity.
DR   MIM; 610414; gene.
DR   neXtProt; NX_Q8N660; -.
DR   OpenTargets; ENSG00000266338; -.
DR   PharmGKB; PA142671274; -.
DR   VEuPathDB; HostDB:ENSG00000266338; -.
DR   eggNOG; ENOG502RU1I; Eukaryota.
DR   GeneTree; ENSGT00420000029746; -.
DR   HOGENOM; CLU_030855_0_0_1; -.
DR   InParanoid; Q8N660; -.
DR   OMA; SSHIEWE; -.
DR   PhylomeDB; Q8N660; -.
DR   TreeFam; TF341151; -.
DR   PathwayCommons; Q8N660; -.
DR   SignaLink; Q8N660; -.
DR   BioGRID-ORCS; 284565; 146 hits in 679 CRISPR screens.
DR   ChiTaRS; NBPF15; human.
DR   GenomeRNAi; 284565; -.
DR   Pharos; Q8N660; Tdark.
DR   PRO; PR:Q8N660; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8N660; Protein.
DR   Bgee; ENSG00000266338; Expressed in ventricular zone and 101 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010630; Olduvai_dom.
DR   PANTHER; PTHR14199:SF35; NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 1-RELATED; 1.
DR   PANTHER; PTHR14199; UNCHARACTERIZED; 1.
DR   Pfam; PF06758; Olduvai; 6.
DR   SMART; SM01148; DUF1220; 6.
DR   PROSITE; PS51316; ODV; 6.
DR   Genevisible; Q8N660; HS.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome; Repeat.
FT   CHAIN           1..670
FT                   /note="Neuroblastoma breakpoint family member 15"
FT                   /id="PRO_0000288049"
FT   DOMAIN          165..257
FT                   /note="Olduvai 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          258..329
FT                   /note="Olduvai 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          330..421
FT                   /note="Olduvai 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          424..479
FT                   /note="Olduvai 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          480..572
FT                   /note="Olduvai 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          573..670
FT                   /note="Olduvai 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   REGION          180..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          558..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          70..130
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        268..282
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        561..576
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         615
FT                   /note="P -> Q (in dbSNP:rs6695216)"
FT                   /id="VAR_032383"
FT   CONFLICT        477
FT                   /note="D -> A (in Ref. 3; AAH23087)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        518
FT                   /note="C -> Y (in Ref. 2; CAI16654)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        592
FT                   /note="Y -> N (in Ref. 2; CAI16654)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        621
FT                   /note="Q -> L (in Ref. 2; CAI16654)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   670 AA;  77563 MW;  80944E05C2FC4511 CRC64;
     MVVSAGPLSS EKAEMNILEI NEKLRPQLAE KKQQFRNLKE KCFLTQLAGF LANRQKKYKY
     EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH AQERELTQLR EKLREGRDAS
     RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLTQHLVQ KLSPENDNDD DEDVQVEVAE
     KVQKSSAPRE MQKAEEKEVP EDSLEECAIT CSNSHGPYDS NQPHKKTKIT FEEDKVDSTL
     IGSSSHVEWE DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
     PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR ELLDEKEPEV
     LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA IDMDEIEKYQ EVEEDQDPSC
     PRLSRELLDE KEPEVLQDSL DRCYSTPSDY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR
     IKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY
     ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKKRRRGRKE GEDDNPPCPR LYGVLMEVEE
     PEVLQDSLDR CYSTPSMYFE QPDSFQHYRS VFYSFEEEHI SFALYVDNRF FTLTVTSLHL
     VFQMGVIFPQ
//