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Q5SXJ2 (NBPFG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuroblastoma breakpoint family member 16
Gene names
Name:NBPF16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Cytoplasm Probable.

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Sequence similarities

Belongs to the NBPF family.

Contains 6 NBPF domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainCoiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Neuroblastoma breakpoint family member 16
PRO_0000288050

Regions

Domain165 – 25793NBPF 1
Domain258 – 32972NBPF 2
Domain330 – 42192NBPF 3
Domain424 – 47956NBPF 4
Domain480 – 57293NBPF 5
Domain573 – 67098NBPF 6
Coiled coil70 – 13061 Potential
Compositional bias264 – 2685Poly-Glu
Compositional bias279 – 2846Poly-Glu
Compositional bias486 – 4894Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q5SXJ2 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 12368C7951CC4C28

FASTA67077,590
        10         20         30         40         50         60 
MVVSAGPLSS EKAEMNILEI NEKLRPQLAE KKQQFRNLKE KCFLTQLAGF LANRQKKYKY 

        70         80         90        100        110        120 
EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH AQERELTQLR EKLREGRDAS 

       130        140        150        160        170        180 
RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLTQHLVQ KLSPENDNDD DEDVQVEVAE 

       190        200        210        220        230        240 
KVQKSSAPRE MQKAEEKEVP EDSLEECAIT CSNSHGPYDS NQPHKKTKIT FEEDKVDSTL 

       250        260        270        280        290        300 
IGSSSHVEWE DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP 

       310        320        330        340        350        360 
PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR ELLDEKEPEV 

       370        380        390        400        410        420 
LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA IDMDEIEKYQ EVEEDQDPSC 

       430        440        450        460        470        480 
PRLSRELLDE KEPEVLQDSL DRCYSTPSDY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR 

       490        500        510        520        530        540 
IKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRYYS TPSSCLEQPD SCQPYGSSFY 

       550        560        570        580        590        600 
ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKKRRRGRKE GEDDNPPCPR LNGVLMEVEE 

       610        620        630        640        650        660 
PEVLQDSLDR CYSTQSMYFE LPDSFQHYRS VFYSFEEEHI SFALYVDNRF FTLTVTSLHL 

       670 
VFQMGVIFPQ 

« Hide

References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL592492 Genomic DNA. Translation: CAI16654.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ5SXJ2. 1 interaction.
STRING9606.ENSP00000254372.

Polymorphism databases

DMDM74743973.

Proteomic databases

PaxDbQ5SXJ2.
PRIDEQ5SXJ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc009wkt.1. human.

Organism-specific databases

GeneCardsGC01P148741.
HGNCHGNC:31996. NBPF16.
MIM614005. gene.
neXtProtNX_Q5SXJ2.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG116165.
HOGENOMHOG000049041.
HOVERGENHBG058300.
InParanoidQ5SXJ2.
OMASTFEEDK.
OrthoDBEOG7GBFWV.
PhylomeDBQ5SXJ2.
TreeFamTF341151.

Gene expression databases

BgeeQ5SXJ2.
GenevestigatorQ5SXJ2.

Family and domain databases

InterProIPR010630. NBPF_dom.
[Graphical view]
PfamPF06758. DUF1220. 6 hits.
[Graphical view]
PROSITEPS51316. NBPF. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ5SXJ2.
SOURCESearch...

Entry information

Entry nameNBPFG_HUMAN
AccessionPrimary (citable) accession number: Q5SXJ2
Secondary accession number(s): A8MPT6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM