Q5SXJ2 (NBPFG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroblastoma breakpoint family member 16

Gene names

Name:

NBPF16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	670 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Probable.
Miscellaneous	Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
Sequence similarities	Belongs to the NBPF family. Contains 6 NBPF domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 670	670	Neuroblastoma breakpoint family member 16		PRO_0000288050
Regions
	Domain	165 – 257	93	NBPF 1
	Domain	258 – 329	72	NBPF 2
	Domain	330 – 421	92	NBPF 3
	Domain	424 – 479	56	NBPF 4
	Domain	480 – 572	93	NBPF 5
	Domain	573 – 670	98	NBPF 6
	Coiled coil	70 – 130	61	Potential
	Compositional bias	264 – 268	5	Poly-Glu
	Compositional bias	279 – 284	6	Poly-Glu
	Compositional bias	486 – 489	4	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q5SXJ2 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 12368C7951CC4C28	FASTA	670	77,590
	10 20 30 40 50 60 MVVSAGPLSS EKAEMNILEI NEKLRPQLAE KKQQFRNLKE KCFLTQLAGF LANRQKKYKY 70 80 90 100 110 120 EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH AQERELTQLR EKLREGRDAS 130 140 150 160 170 180 RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLTQHLVQ KLSPENDNDD DEDVQVEVAE 190 200 210 220 230 240 KVQKSSAPRE MQKAEEKEVP EDSLEECAIT CSNSHGPYDS NQPHKKTKIT FEEDKVDSTL 250 260 270 280 290 300 IGSSSHVEWE DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP 310 320 330 340 350 360 PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR ELLDEKEPEV 370 380 390 400 410 420 LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA IDMDEIEKYQ EVEEDQDPSC 430 440 450 460 470 480 PRLSRELLDE KEPEVLQDSL DRCYSTPSDY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR 490 500 510 520 530 540 IKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRYYS TPSSCLEQPD SCQPYGSSFY 550 560 570 580 590 600 ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKKRRRGRKE GEDDNPPCPR LNGVLMEVEE 610 620 630 640 650 660 PEVLQDSLDR CYSTQSMYFE LPDSFQHYRS VFYSFEEEHI SFALYVDNRF FTLTVTSLHL 670 VFQMGVIFPQ

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL592492 Genomic DNA. Translation: CAI16654.1.
IPI	IPI00166936.
UniGene	Hs.445080. Hs.523572. Hs.534675. Hs.714127.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5SXJ2. 1 interaction.
STRING	9606.ENSP00000254372.
Polymorphism databases
DMDM	74743973.
Proteomic databases
PaxDb	Q5SXJ2.
PRIDE	Q5SXJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000417839; ENSP00000395369; ENSG00000203827.
UCSC	uc009wkt.1. human.
Organism-specific databases
GeneCards	GC01P148741.
HGNC	HGNC:31996. NBPF16.
MIM	614005. gene.
neXtProt	NX_Q5SXJ2.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG116165.
HOGENOM	HOG000049041.
HOVERGEN	HBG058300.
InParanoid	Q5SXJ2.
OMA	CPRISRE.
OrthoDB	EOG4DNF45.
Gene expression databases
ArrayExpress	Q5SXJ2.
Bgee	Q5SXJ2.
Genevestigator	Q5SXJ2.
Family and domain databases
InterPro	IPR010630. NBPF_dom. [Graphical view]
Pfam	PF06758. DUF1220. 6 hits. [Graphical view]
PROSITE	PS51316. NBPF. 6 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

NBPFG_HUMAN

Accession

Primary (citable) accession number: Q5SXJ2
Secondary accession number(s): A8MPT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.