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Q5SXJ2

- NBPFG_HUMAN

UniProt

Q5SXJ2 - NBPFG_HUMAN

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Protein

Neuroblastoma breakpoint family member 16

Gene

NBPF16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 16
Gene namesi
Name:NBPF16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:31996. NBPF16.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Neuroblastoma breakpoint family member 16PRO_0000288050Add
BLAST

Proteomic databases

PaxDbiQ5SXJ2.
PRIDEiQ5SXJ2.

Expressioni

Gene expression databases

BgeeiQ5SXJ2.
GenevestigatoriQ5SXJ2.

Interactioni

Protein-protein interaction databases

IntActiQ5SXJ2. 1 interaction.
STRINGi9606.ENSP00000254372.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 25793NBPF 1PROSITE-ProRule annotationAdd
BLAST
Domaini258 – 32972NBPF 2PROSITE-ProRule annotationAdd
BLAST
Domaini330 – 42192NBPF 3PROSITE-ProRule annotationAdd
BLAST
Domaini424 – 47956NBPF 4PROSITE-ProRule annotationAdd
BLAST
Domaini480 – 57293NBPF 5PROSITE-ProRule annotationAdd
BLAST
Domaini573 – 67098NBPF 6PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili70 – 13061Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi264 – 2685Poly-Glu
Compositional biasi279 – 2846Poly-Glu
Compositional biasi486 – 4894Poly-Glu

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 6 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG116165.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ5SXJ2.
OMAiSTFEEDK.
OrthoDBiEOG7GBFWV.
PhylomeDBiQ5SXJ2.
TreeFamiTF341151.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 6 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SXJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVSAGPLSS EKAEMNILEI NEKLRPQLAE KKQQFRNLKE KCFLTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH
110 120 130 140 150
AQERELTQLR EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLTQHLVQ KLSPENDNDD DEDVQVEVAE KVQKSSAPRE MQKAEEKEVP
210 220 230 240 250
EDSLEECAIT CSNSHGPYDS NQPHKKTKIT FEEDKVDSTL IGSSSHVEWE
260 270 280 290 300
DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
310 320 330 340 350
PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR
360 370 380 390 400
ELLDEKEPEV LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA
410 420 430 440 450
IDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSTPSDY
460 470 480 490 500
LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR
510 520 530 540 550
ELLEVVEPEV LQDSLDRYYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS
560 570 580 590 600
LDVGEIEKKG KGKKRRGRRS KKKRRRGRKE GEDDNPPCPR LNGVLMEVEE
610 620 630 640 650
PEVLQDSLDR CYSTQSMYFE LPDSFQHYRS VFYSFEEEHI SFALYVDNRF
660 670
FTLTVTSLHL VFQMGVIFPQ
Length:670
Mass (Da):77,590
Last modified:December 21, 2004 - v1
Checksum:i12368C7951CC4C28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL592492 Genomic DNA. Translation: CAI16654.1.

Genome annotation databases

UCSCiuc009wkt.1. human.

Polymorphism databases

DMDMi74743973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL592492 Genomic DNA. Translation: CAI16654.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5SXJ2. 1 interaction.
STRINGi 9606.ENSP00000254372.

Polymorphism databases

DMDMi 74743973.

Proteomic databases

PaxDbi Q5SXJ2.
PRIDEi Q5SXJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc009wkt.1. human.

Organism-specific databases

GeneCardsi GC01P148743.
HGNCi HGNC:31996. NBPF16.
MIMi 614005. gene.
neXtProti NX_Q5SXJ2.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG116165.
HOGENOMi HOG000049041.
HOVERGENi HBG058300.
InParanoidi Q5SXJ2.
OMAi STFEEDK.
OrthoDBi EOG7GBFWV.
PhylomeDBi Q5SXJ2.
TreeFami TF341151.

Miscellaneous databases

PROi Q5SXJ2.
SOURCEi Search...

Gene expression databases

Bgeei Q5SXJ2.
Genevestigatori Q5SXJ2.

Family and domain databases

InterProi IPR010630. NBPF_dom.
[Graphical view ]
Pfami PF06758. DUF1220. 6 hits.
[Graphical view ]
PROSITEi PS51316. NBPF. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNBPFG_HUMAN
AccessioniPrimary (citable) accession number: Q5SXJ2
Secondary accession number(s): A8MPT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3