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Protein
Submitted name:

Acetylcholine receptor subunit epsilon

Gene

Chrne

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Acetylcholine receptor subunit epsilonImported
Gene namesi
Name:ChrneImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:87894 Chrne

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei241 – 263HelicalSequence analysisAdd BLAST23
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Transmembranei307 – 330HelicalSequence analysisAdd BLAST24
Transmembranei458 – 480HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500426190221 – 494Sequence analysisAdd BLAST474

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ5SXG9

Expressioni

Gene expression databases

BgeeiENSMUSG00000014609
ExpressionAtlasiQ5SXG9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5SXG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 240Neur_chan_LBDInterPro annotationAdd BLAST215
Domaini247 – 475Neur_chan_membInterPro annotationAdd BLAST229

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006757
HOVERGENiHBG003756
OMAiESTRDQE
OrthoDBiEOG091G0R20
PhylomeDBiQ5SXG9

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SXG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGALLGALL LLTLFGRSQG KNEELSLYHH LFDNYDPECR PVRRPEDTVT
60 70 80 90 100
ITLKVTLTNL ISLNEKEETL TTSVWIGIDW HDYRLNYSKD DFAGVGILRV
110 120 130 140 150
PSEHVWLPEI VLENNIDGQF GVAYDSNVLV YEGGYVSWLP PAIYRSTCAV
160 170 180 190 200
EVTYFPFDWQ NCSLIFRSQT YNAEEVEFIF AVDDDGNTIN KIDIDTAAFT
210 220 230 240 250
ENGEWAIDYC PGMIRRYEGG STEGPGETDV IYTLIIRRKP LFYVINIIVP
260 270 280 290 300
CVLISGLVLL AYFLPAQAGG QKCTVSINVL LAQTVFLFLI AQKIPETSLS
310 320 330 340 350
VPLLGRYLIF VMVVATLIVM NCVIVLNVSL RTPTTHATSP RLRQILLELL
360 370 380 390 400
PRLLGSSPPP EDPRTASPAR RASSVGILLR AEELILKKPR SELVFEGQRH
410 420 430 440 450
RHGTWTAAAL CQNLGAAAPE IRCCVDAVNF VAESTRDQEA TGEELSDWVR
460 470 480 490
MGKALDNVCF WAALVLFSVG STLIFLGGYF NQVPDLPYPP CIQP
Length:494
Mass (Da):54,985
Last modified:December 21, 2004 - v1
Checksum:i8C495880AACA9F61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592547 Genomic DNA No translation available.
RefSeqiXP_006532069.1, XM_006532006.3
UniGeneiMm.4980

Genome annotation databases

EnsembliENSMUST00000014753; ENSMUSP00000014753; ENSMUSG00000014609
GeneIDi11448

Similar proteinsi

Entry informationi

Entry nameiQ5SXG9_MOUSE
AccessioniPrimary (citable) accession number: Q5SXG9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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