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Q5SXA9

- KIBRA_MOUSE

UniProt

Q5SXA9 - KIBRA_MOUSE

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Protein

Protein KIBRA

Gene

Wwc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance By similarity. Regulates collagen-stimulated activation of the ERK/MAPK cascade.By similarity1 Publication

GO - Molecular functioni

  1. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. negative regulation of hippo signaling Source: Ensembl
  3. negative regulation of organ growth Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of MAPK cascade Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_196537. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KIBRA
Alternative name(s):
Kidney and brain protein
Short name:
KIBRA
WW domain-containing protein 1
Gene namesi
Name:Wwc1
Synonyms:Kiaa0869
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2388637. Wwc1.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmperinuclear region By similarity. Nucleus By similarity. Cell projectionruffle membrane By similarity
Note: Colocalizes with PRKCZ in the perinuclear region.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Ensembl
  3. nucleus Source: UniProtKB
  4. perinuclear region of cytoplasm Source: Ensembl
  5. protein complex Source: Ensembl
  6. ruffle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11041104Protein KIBRAPRO_0000242154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei542 – 5421Phosphoserine; by CDK1By similarity
Modified residuei887 – 8871Phosphoserine1 Publication
Modified residuei891 – 8911Phosphoserine1 Publication
Modified residuei921 – 9211PhosphothreonineBy similarity
Modified residuei923 – 9231Phosphoserine; by CDK1By similarity
Modified residuei939 – 9391PhosphoserineBy similarity
Modified residuei967 – 9671Phosphoserine; by PKC/PRKCZBy similarity
Modified residuei970 – 9701Phosphoserine; by PKC/PRKCZBy similarity

Post-translational modificationi

Phosphorylation at Ser-542 and Ser-923 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5SXA9.
PaxDbiQ5SXA9.
PRIDEiQ5SXA9.

PTM databases

PhosphoSiteiQ5SXA9.

Expressioni

Tissue specificityi

Mammary epithelium.1 Publication

Developmental stagei

Expressed in mammary tissue throughout development (at protein level). Strongly up-regulated during pregnancy, falls during lactation and is again up-regulated during involution of the gland at weaning.1 Publication

Gene expression databases

BgeeiQ5SXA9.
CleanExiMM_WWC1.
ExpressionAtlasiQ5SXA9. baseline and differential.
GenevestigatoriQ5SXA9.

Interactioni

Subunit structurei

Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4 By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5SXA9.
SMRiQ5SXA9. Positions 7-86, 659-786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 3934WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8634WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini656 – 784129C2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni836 – 1104269Interaction with histone H3By similarityAdd
BLAST
Regioni945 – 98844Interaction with PRKCZBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili107 – 19387Sequence AnalysisAdd
BLAST
Coiled coili994 – 102431Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1102 – 11043ADDV motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi255 – 29440Ser-richAdd
BLAST
Compositional biasi421 – 46141Ser-richAdd
BLAST
Compositional biasi816 – 87358Glu-richAdd
BLAST

Domaini

The C2-domain mediates homodimerization.By similarity

Sequence similaritiesi

Belongs to the WWC family. KIBRA subfamily.Curated
Contains 1 C2 domain.Curated
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5021.
GeneTreeiENSGT00410000025556.
HOGENOMiHOG000013211.
HOVERGENiHBG058082.
InParanoidiQ5SXA9.
KOiK16685.
OMAiDPQVGDY.
OrthoDBiEOG7DJSNR.
PhylomeDBiQ5SXA9.
TreeFamiTF324040.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SXA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRPELPLPE GWEEARDFDG KVYYIDHRNR TTSWIDPRDR YTKPLTFADC
60 70 80 90 100
ISDELPLGWE EAYDPQVGDY FIDHNTKTTQ IEDPRVQWRR EQEHMLKDYL
110 120 130 140 150
VVAQEALSAQ KEIYQVKQQR LELAQQEYQQ LHAVWEHKLG SQVSLVSGSS
160 170 180 190 200
SSSKYDPEIL KAEIATAKSR VNKLKREMVH LQHELQFKER GFQTLKKIDE
210 220 230 240 250
RMSDAQGGYK LDEAQAVLRE TKAIKKAITC GEKEKQDLIK SLAMLKDGFR
260 270 280 290 300
TDRGSHSDLW SSSSSLESSS FPMPKQFLDV SSQTDISGSF STSSNNQLAE
310 320 330 340 350
KVRLRLRYEE AKRRIANLKI QLAKLDSEAW PGVLDSERDR LILINEKEEL
360 370 380 390 400
LKEMRFISPR KWTQGEVEQL EMARRRLEKD LQAARDTQSK ALTERLKLNS
410 420 430 440 450
KRNQLVRELE EATRQVATLH SQLKSLSSSM QSLSSGSSPG SLTSSRGSLA
460 470 480 490 500
ASSLDSSTSA SFTDLYYDPF EQLDSELQSK VELLFLEGAT GFRPSGCITT
510 520 530 540 550
IHEDEVAKTQ KAEGGSRLQA LRSLSGTPRS MTSLSPRSSL SSPSPPCSPL
560 570 580 590 600
ITDPLLTGDA FLAPLEFEDT ELSTTLCELN LGGSGTQERY RLEEPGPEGK
610 620 630 640 650
PLGQAASVAP GCGLKVACVS AAVSDESVAG DSGVYEASAQ RPGTSEAAAF
660 670 680 690 700
DSDESEAVGA TRVQIALKYD EKNKQFAILI IQLSHLSALS LQQDQKVNIR
710 720 730 740 750
VAILPCSESS TCLFRTRPLD SANTLVFNEA FWVSISYPAL HQKTLRVDVC
760 770 780 790 800
TTDRSHTEEC LGGAQISLAE VCRSGERSTR WYNLLSYKYL KKQCREPQPT
810 820 830 840 850
EAPGPDHVDA VSALLEQTAV ELEKRQEGRS SSQTLEGSWT YEEEASENEA
860 870 880 890 900
VAEEEEEGEE DVFTEKVSPE AEECPALKVD RETNTDSVAP SPTVVRPKDR
910 920 930 940 950
RVGAPSTGPF LRGNTIIRSK TFSPGPQSQY VCRLNRSDSD SSTLSKKPPF
960 970 980 990 1000
VRNSLERRSV RMKRPSSVKS LRTERLIRTS LDLELDLQAT RTWHSQLTQE
1010 1020 1030 1040 1050
ISVLKELKEH LEQAKNHGEK ELPQWLREDE RFRLLLRMLE KKVDRGEHKS
1060 1070 1080 1090 1100
ELQADKMMRA AAKDVHRLRG QSCKEPPEVQ SFREKMAFFT RPRMNIPALS

ADDV
Length:1,104
Mass (Da):124,110
Last modified:December 21, 2004 - v1
Checksum:iD827EFD9AAB19FBA
GO

Sequence cautioni

The sequence AAH06733.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH37006.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1455SQVSL → AGLPV in BAD90184. 1 PublicationCurated
Sequence conflicti348 – 3481E → K in AAH06733. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ256090 mRNA. Translation: ABB51169.1.
AL596084, AL645912 Genomic DNA. Translation: CAI24387.1.
AL645912, AL596084 Genomic DNA. Translation: CAI35081.1.
AK220259 mRNA. Translation: BAD90184.1.
BC006733 mRNA. Translation: AAH06733.1. Different initiation.
BC017638 mRNA. Translation: AAH17638.1.
BC037006 mRNA. Translation: AAH37006.1. Different initiation.
CCDSiCCDS24545.1.
RefSeqiNP_740749.1. NM_170779.1.
UniGeneiMm.31267.

Genome annotation databases

EnsembliENSMUST00000018993; ENSMUSP00000018993; ENSMUSG00000018849.
GeneIDi211652.
KEGGimmu:211652.
UCSCiuc007ili.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ256090 mRNA. Translation: ABB51169.1 .
AL596084 , AL645912 Genomic DNA. Translation: CAI24387.1 .
AL645912 , AL596084 Genomic DNA. Translation: CAI35081.1 .
AK220259 mRNA. Translation: BAD90184.1 .
BC006733 mRNA. Translation: AAH06733.1 . Different initiation.
BC017638 mRNA. Translation: AAH17638.1 .
BC037006 mRNA. Translation: AAH37006.1 . Different initiation.
CCDSi CCDS24545.1.
RefSeqi NP_740749.1. NM_170779.1.
UniGenei Mm.31267.

3D structure databases

ProteinModelPortali Q5SXA9.
SMRi Q5SXA9. Positions 7-86, 659-786.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5SXA9.

Proteomic databases

MaxQBi Q5SXA9.
PaxDbi Q5SXA9.
PRIDEi Q5SXA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018993 ; ENSMUSP00000018993 ; ENSMUSG00000018849 .
GeneIDi 211652.
KEGGi mmu:211652.
UCSCi uc007ili.1. mouse.

Organism-specific databases

CTDi 23286.
MGIi MGI:2388637. Wwc1.
Rougei Search...

Phylogenomic databases

eggNOGi COG5021.
GeneTreei ENSGT00410000025556.
HOGENOMi HOG000013211.
HOVERGENi HBG058082.
InParanoidi Q5SXA9.
KOi K16685.
OMAi DPQVGDY.
OrthoDBi EOG7DJSNR.
PhylomeDBi Q5SXA9.
TreeFami TF324040.

Enzyme and pathway databases

Reactomei REACT_196537. Signaling by Hippo.

Miscellaneous databases

NextBioi 373320.
PROi Q5SXA9.
SOURCEi Search...

Gene expression databases

Bgeei Q5SXA9.
CleanExi MM_WWC1.
ExpressionAtlasi Q5SXA9. baseline and differential.
Genevestigatori Q5SXA9.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00397. WW. 2 hits.
[Graphical view ]
SMARTi SM00456. WW. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEi PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein-coding sequence of KIBRA from Mus musculus."
    Kremerskothen J.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvEv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Seino S., Nishimura M., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-1104.
    Tissue: Pancreatic islet.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 146-1104.
    Strain: FVB/N.
    Tissue: Mammary gland, Mammary tumor and Salivary gland.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887 AND SER-891, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling."
    Hilton H.N., Stanford P.M., Harris J., Oakes S.R., Kaplan W., Daly R.J., Ormandy C.J.
    Biochim. Biophys. Acta 1783:383-393(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiKIBRA_MOUSE
AccessioniPrimary (citable) accession number: Q5SXA9
Secondary accession number(s): Q571D0
, Q8K1Y3, Q8VD17, Q922W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3