SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5SXA9

- KIBRA_MOUSE

UniProt

Q5SXA9 - KIBRA_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein KIBRA
Gene
Wwc1, Kiaa0869
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance By similarity. Regulates collagen-stimulated activation of the ERK/MAPK cascade.1 Publication

GO - Molecular functioni

  1. transcription coactivator activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. positive regulation of MAPK cascade Source: UniProtKB
  3. regulation of hippo signaling Source: Ensembl
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_196537. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KIBRA
Alternative name(s):
Kidney and brain protein
Short name:
KIBRA
WW domain-containing protein 1
Gene namesi
Name:Wwc1
Synonyms:Kiaa0869
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2388637. Wwc1.

Subcellular locationi

Cytoplasm. Cytoplasmperinuclear region By similarity. Nucleus By similarity. Cell projectionruffle membrane By similarity
Note: Colocalizes with PRKCZ in the perinuclear region By similarity.1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  5. protein complex Source: Ensembl
  6. ruffle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11041104Protein KIBRA
PRO_0000242154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei542 – 5421Phosphoserine; by CDK1 By similarity
Modified residuei887 – 8871Phosphoserine1 Publication
Modified residuei891 – 8911Phosphoserine1 Publication
Modified residuei921 – 9211Phosphothreonine By similarity
Modified residuei923 – 9231Phosphoserine; by CDK1 By similarity
Modified residuei939 – 9391Phosphoserine By similarity
Modified residuei967 – 9671Phosphoserine; by PKC/PRKCZ By similarity
Modified residuei970 – 9701Phosphoserine; by PKC/PRKCZ By similarity

Post-translational modificationi

Phosphorylation at Ser-542 and Ser-923 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5SXA9.
PaxDbiQ5SXA9.
PRIDEiQ5SXA9.

PTM databases

PhosphoSiteiQ5SXA9.

Expressioni

Tissue specificityi

Mammary epithelium.1 Publication

Developmental stagei

Expressed in mammary tissue throughout development (at protein level). Strongly up-regulated during pregnancy, falls during lactation and is again up-regulated during involution of the gland at weaning.1 Publication

Gene expression databases

ArrayExpressiQ5SXA9.
BgeeiQ5SXA9.
CleanExiMM_WWC1.
GenevestigatoriQ5SXA9.

Interactioni

Subunit structurei

Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5SXA9.
SMRiQ5SXA9. Positions 7-86, 659-786.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 3934WW 1
Add
BLAST
Domaini53 – 8634WW 2
Add
BLAST
Domaini656 – 784129C2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni836 – 1104269Interaction with histone H3 By similarity
Add
BLAST
Regioni945 – 98844Interaction with PRKCZ By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili107 – 19387 Reviewed prediction
Add
BLAST
Coiled coili994 – 102431 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1102 – 11043ADDV motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi255 – 29440Ser-rich
Add
BLAST
Compositional biasi421 – 46141Ser-rich
Add
BLAST
Compositional biasi816 – 87358Glu-rich
Add
BLAST

Domaini

The C2-domain mediates homodimerization By similarity.

Sequence similaritiesi

Belongs to the WWC family. KIBRA subfamily.
Contains 1 C2 domain.
Contains 2 WW domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5021.
GeneTreeiENSGT00410000025556.
HOGENOMiHOG000013211.
HOVERGENiHBG058082.
InParanoidiQ5SXA9.
KOiK16685.
OMAiDPQVGDY.
OrthoDBiEOG7DJSNR.
PhylomeDBiQ5SXA9.
TreeFamiTF324040.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SXA9-1 [UniParc]FASTAAdd to Basket

« Hide

MPRPELPLPE GWEEARDFDG KVYYIDHRNR TTSWIDPRDR YTKPLTFADC     50
ISDELPLGWE EAYDPQVGDY FIDHNTKTTQ IEDPRVQWRR EQEHMLKDYL 100
VVAQEALSAQ KEIYQVKQQR LELAQQEYQQ LHAVWEHKLG SQVSLVSGSS 150
SSSKYDPEIL KAEIATAKSR VNKLKREMVH LQHELQFKER GFQTLKKIDE 200
RMSDAQGGYK LDEAQAVLRE TKAIKKAITC GEKEKQDLIK SLAMLKDGFR 250
TDRGSHSDLW SSSSSLESSS FPMPKQFLDV SSQTDISGSF STSSNNQLAE 300
KVRLRLRYEE AKRRIANLKI QLAKLDSEAW PGVLDSERDR LILINEKEEL 350
LKEMRFISPR KWTQGEVEQL EMARRRLEKD LQAARDTQSK ALTERLKLNS 400
KRNQLVRELE EATRQVATLH SQLKSLSSSM QSLSSGSSPG SLTSSRGSLA 450
ASSLDSSTSA SFTDLYYDPF EQLDSELQSK VELLFLEGAT GFRPSGCITT 500
IHEDEVAKTQ KAEGGSRLQA LRSLSGTPRS MTSLSPRSSL SSPSPPCSPL 550
ITDPLLTGDA FLAPLEFEDT ELSTTLCELN LGGSGTQERY RLEEPGPEGK 600
PLGQAASVAP GCGLKVACVS AAVSDESVAG DSGVYEASAQ RPGTSEAAAF 650
DSDESEAVGA TRVQIALKYD EKNKQFAILI IQLSHLSALS LQQDQKVNIR 700
VAILPCSESS TCLFRTRPLD SANTLVFNEA FWVSISYPAL HQKTLRVDVC 750
TTDRSHTEEC LGGAQISLAE VCRSGERSTR WYNLLSYKYL KKQCREPQPT 800
EAPGPDHVDA VSALLEQTAV ELEKRQEGRS SSQTLEGSWT YEEEASENEA 850
VAEEEEEGEE DVFTEKVSPE AEECPALKVD RETNTDSVAP SPTVVRPKDR 900
RVGAPSTGPF LRGNTIIRSK TFSPGPQSQY VCRLNRSDSD SSTLSKKPPF 950
VRNSLERRSV RMKRPSSVKS LRTERLIRTS LDLELDLQAT RTWHSQLTQE 1000
ISVLKELKEH LEQAKNHGEK ELPQWLREDE RFRLLLRMLE KKVDRGEHKS 1050
ELQADKMMRA AAKDVHRLRG QSCKEPPEVQ SFREKMAFFT RPRMNIPALS 1100
ADDV 1104
Length:1,104
Mass (Da):124,110
Last modified:December 21, 2004 - v1
Checksum:iD827EFD9AAB19FBA
GO

Sequence cautioni

The sequence AAH06733.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH37006.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1455SQVSL → AGLPV in BAD90184. 1 Publication
Sequence conflicti348 – 3481E → K in AAH06733. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ256090 mRNA. Translation: ABB51169.1.
AL596084, AL645912 Genomic DNA. Translation: CAI24387.1.
AL645912, AL596084 Genomic DNA. Translation: CAI35081.1.
AK220259 mRNA. Translation: BAD90184.1.
BC006733 mRNA. Translation: AAH06733.1. Different initiation.
BC017638 mRNA. Translation: AAH17638.1.
BC037006 mRNA. Translation: AAH37006.1. Different initiation.
CCDSiCCDS24545.1.
RefSeqiNP_740749.1. NM_170779.1.
UniGeneiMm.31267.

Genome annotation databases

EnsembliENSMUST00000018993; ENSMUSP00000018993; ENSMUSG00000018849.
GeneIDi211652.
KEGGimmu:211652.
UCSCiuc007ili.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ256090 mRNA. Translation: ABB51169.1 .
AL596084 , AL645912 Genomic DNA. Translation: CAI24387.1 .
AL645912 , AL596084 Genomic DNA. Translation: CAI35081.1 .
AK220259 mRNA. Translation: BAD90184.1 .
BC006733 mRNA. Translation: AAH06733.1 . Different initiation.
BC017638 mRNA. Translation: AAH17638.1 .
BC037006 mRNA. Translation: AAH37006.1 . Different initiation.
CCDSi CCDS24545.1.
RefSeqi NP_740749.1. NM_170779.1.
UniGenei Mm.31267.

3D structure databases

ProteinModelPortali Q5SXA9.
SMRi Q5SXA9. Positions 7-86, 659-786.
ModBasei Search...

PTM databases

PhosphoSitei Q5SXA9.

Proteomic databases

MaxQBi Q5SXA9.
PaxDbi Q5SXA9.
PRIDEi Q5SXA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018993 ; ENSMUSP00000018993 ; ENSMUSG00000018849 .
GeneIDi 211652.
KEGGi mmu:211652.
UCSCi uc007ili.1. mouse.

Organism-specific databases

CTDi 23286.
MGIi MGI:2388637. Wwc1.
Rougei Search...

Phylogenomic databases

eggNOGi COG5021.
GeneTreei ENSGT00410000025556.
HOGENOMi HOG000013211.
HOVERGENi HBG058082.
InParanoidi Q5SXA9.
KOi K16685.
OMAi DPQVGDY.
OrthoDBi EOG7DJSNR.
PhylomeDBi Q5SXA9.
TreeFami TF324040.

Enzyme and pathway databases

Reactomei REACT_196537. Signaling by Hippo.

Miscellaneous databases

NextBioi 373320.
PROi Q5SXA9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5SXA9.
Bgeei Q5SXA9.
CleanExi MM_WWC1.
Genevestigatori Q5SXA9.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00397. WW. 2 hits.
[Graphical view ]
SMARTi SM00456. WW. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEi PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein-coding sequence of KIBRA from Mus musculus."
    Kremerskothen J.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvEv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Seino S., Nishimura M., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-1104.
    Tissue: Pancreatic islet.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 146-1104.
    Strain: FVB/N.
    Tissue: Mammary gland, Mammary tumor and Salivary gland.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887 AND SER-891, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling."
    Hilton H.N., Stanford P.M., Harris J., Oakes S.R., Kaplan W., Daly R.J., Ormandy C.J.
    Biochim. Biophys. Acta 1783:383-393(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiKIBRA_MOUSE
AccessioniPrimary (citable) accession number: Q5SXA9
Secondary accession number(s): Q571D0
, Q8K1Y3, Q8VD17, Q922W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi