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Q5SXA9

- KIBRA_MOUSE

UniProt

Q5SXA9 - KIBRA_MOUSE

Protein

Protein KIBRA

Gene

Wwc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance By similarity. Regulates collagen-stimulated activation of the ERK/MAPK cascade.By similarity1 Publication

    GO - Molecular functioni

    1. transcription coactivator activity Source: Ensembl

    GO - Biological processi

    1. cell migration Source: UniProtKB
    2. positive regulation of MAPK cascade Source: UniProtKB
    3. regulation of hippo signaling Source: Ensembl
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_196537. Signaling by Hippo.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein KIBRA
    Alternative name(s):
    Kidney and brain protein
    Short name:
    KIBRA
    WW domain-containing protein 1
    Gene namesi
    Name:Wwc1
    Synonyms:Kiaa0869
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2388637. Wwc1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmperinuclear region By similarity. Nucleus By similarity. Cell projectionruffle membrane By similarity
    Note: Colocalizes with PRKCZ in the perinuclear region.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. Golgi apparatus Source: Ensembl
    3. nucleus Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    5. protein complex Source: Ensembl
    6. ruffle membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11041104Protein KIBRAPRO_0000242154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei542 – 5421Phosphoserine; by CDK1By similarity
    Modified residuei887 – 8871Phosphoserine1 Publication
    Modified residuei891 – 8911Phosphoserine1 Publication
    Modified residuei921 – 9211PhosphothreonineBy similarity
    Modified residuei923 – 9231Phosphoserine; by CDK1By similarity
    Modified residuei939 – 9391PhosphoserineBy similarity
    Modified residuei967 – 9671Phosphoserine; by PKC/PRKCZBy similarity
    Modified residuei970 – 9701Phosphoserine; by PKC/PRKCZBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-542 and Ser-923 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5SXA9.
    PaxDbiQ5SXA9.
    PRIDEiQ5SXA9.

    PTM databases

    PhosphoSiteiQ5SXA9.

    Expressioni

    Tissue specificityi

    Mammary epithelium.1 Publication

    Developmental stagei

    Expressed in mammary tissue throughout development (at protein level). Strongly up-regulated during pregnancy, falls during lactation and is again up-regulated during involution of the gland at weaning.1 Publication

    Gene expression databases

    ArrayExpressiQ5SXA9.
    BgeeiQ5SXA9.
    CleanExiMM_WWC1.
    GenevestigatoriQ5SXA9.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SXA9.
    SMRiQ5SXA9. Positions 7-86, 659-786.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 3934WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini53 – 8634WW 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini656 – 784129C2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni836 – 1104269Interaction with histone H3By similarityAdd
    BLAST
    Regioni945 – 98844Interaction with PRKCZBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili107 – 19387Sequence AnalysisAdd
    BLAST
    Coiled coili994 – 102431Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1102 – 11043ADDV motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi255 – 29440Ser-richAdd
    BLAST
    Compositional biasi421 – 46141Ser-richAdd
    BLAST
    Compositional biasi816 – 87358Glu-richAdd
    BLAST

    Domaini

    The C2-domain mediates homodimerization.By similarity

    Sequence similaritiesi

    Belongs to the WWC family. KIBRA subfamily.Curated
    Contains 1 C2 domain.Curated
    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5021.
    GeneTreeiENSGT00410000025556.
    HOGENOMiHOG000013211.
    HOVERGENiHBG058082.
    InParanoidiQ5SXA9.
    KOiK16685.
    OMAiDPQVGDY.
    OrthoDBiEOG7DJSNR.
    PhylomeDBiQ5SXA9.
    TreeFamiTF324040.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00397. WW. 2 hits.
    [Graphical view]
    SMARTiSM00456. WW. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51045. SSF51045. 2 hits.
    PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SXA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRPELPLPE GWEEARDFDG KVYYIDHRNR TTSWIDPRDR YTKPLTFADC     50
    ISDELPLGWE EAYDPQVGDY FIDHNTKTTQ IEDPRVQWRR EQEHMLKDYL 100
    VVAQEALSAQ KEIYQVKQQR LELAQQEYQQ LHAVWEHKLG SQVSLVSGSS 150
    SSSKYDPEIL KAEIATAKSR VNKLKREMVH LQHELQFKER GFQTLKKIDE 200
    RMSDAQGGYK LDEAQAVLRE TKAIKKAITC GEKEKQDLIK SLAMLKDGFR 250
    TDRGSHSDLW SSSSSLESSS FPMPKQFLDV SSQTDISGSF STSSNNQLAE 300
    KVRLRLRYEE AKRRIANLKI QLAKLDSEAW PGVLDSERDR LILINEKEEL 350
    LKEMRFISPR KWTQGEVEQL EMARRRLEKD LQAARDTQSK ALTERLKLNS 400
    KRNQLVRELE EATRQVATLH SQLKSLSSSM QSLSSGSSPG SLTSSRGSLA 450
    ASSLDSSTSA SFTDLYYDPF EQLDSELQSK VELLFLEGAT GFRPSGCITT 500
    IHEDEVAKTQ KAEGGSRLQA LRSLSGTPRS MTSLSPRSSL SSPSPPCSPL 550
    ITDPLLTGDA FLAPLEFEDT ELSTTLCELN LGGSGTQERY RLEEPGPEGK 600
    PLGQAASVAP GCGLKVACVS AAVSDESVAG DSGVYEASAQ RPGTSEAAAF 650
    DSDESEAVGA TRVQIALKYD EKNKQFAILI IQLSHLSALS LQQDQKVNIR 700
    VAILPCSESS TCLFRTRPLD SANTLVFNEA FWVSISYPAL HQKTLRVDVC 750
    TTDRSHTEEC LGGAQISLAE VCRSGERSTR WYNLLSYKYL KKQCREPQPT 800
    EAPGPDHVDA VSALLEQTAV ELEKRQEGRS SSQTLEGSWT YEEEASENEA 850
    VAEEEEEGEE DVFTEKVSPE AEECPALKVD RETNTDSVAP SPTVVRPKDR 900
    RVGAPSTGPF LRGNTIIRSK TFSPGPQSQY VCRLNRSDSD SSTLSKKPPF 950
    VRNSLERRSV RMKRPSSVKS LRTERLIRTS LDLELDLQAT RTWHSQLTQE 1000
    ISVLKELKEH LEQAKNHGEK ELPQWLREDE RFRLLLRMLE KKVDRGEHKS 1050
    ELQADKMMRA AAKDVHRLRG QSCKEPPEVQ SFREKMAFFT RPRMNIPALS 1100
    ADDV 1104
    Length:1,104
    Mass (Da):124,110
    Last modified:December 21, 2004 - v1
    Checksum:iD827EFD9AAB19FBA
    GO

    Sequence cautioni

    The sequence AAH06733.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH37006.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti141 – 1455SQVSL → AGLPV in BAD90184. 1 PublicationCurated
    Sequence conflicti348 – 3481E → K in AAH06733. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ256090 mRNA. Translation: ABB51169.1.
    AL596084, AL645912 Genomic DNA. Translation: CAI24387.1.
    AL645912, AL596084 Genomic DNA. Translation: CAI35081.1.
    AK220259 mRNA. Translation: BAD90184.1.
    BC006733 mRNA. Translation: AAH06733.1. Different initiation.
    BC017638 mRNA. Translation: AAH17638.1.
    BC037006 mRNA. Translation: AAH37006.1. Different initiation.
    CCDSiCCDS24545.1.
    RefSeqiNP_740749.1. NM_170779.1.
    UniGeneiMm.31267.

    Genome annotation databases

    EnsembliENSMUST00000018993; ENSMUSP00000018993; ENSMUSG00000018849.
    GeneIDi211652.
    KEGGimmu:211652.
    UCSCiuc007ili.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ256090 mRNA. Translation: ABB51169.1 .
    AL596084 , AL645912 Genomic DNA. Translation: CAI24387.1 .
    AL645912 , AL596084 Genomic DNA. Translation: CAI35081.1 .
    AK220259 mRNA. Translation: BAD90184.1 .
    BC006733 mRNA. Translation: AAH06733.1 . Different initiation.
    BC017638 mRNA. Translation: AAH17638.1 .
    BC037006 mRNA. Translation: AAH37006.1 . Different initiation.
    CCDSi CCDS24545.1.
    RefSeqi NP_740749.1. NM_170779.1.
    UniGenei Mm.31267.

    3D structure databases

    ProteinModelPortali Q5SXA9.
    SMRi Q5SXA9. Positions 7-86, 659-786.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5SXA9.

    Proteomic databases

    MaxQBi Q5SXA9.
    PaxDbi Q5SXA9.
    PRIDEi Q5SXA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018993 ; ENSMUSP00000018993 ; ENSMUSG00000018849 .
    GeneIDi 211652.
    KEGGi mmu:211652.
    UCSCi uc007ili.1. mouse.

    Organism-specific databases

    CTDi 23286.
    MGIi MGI:2388637. Wwc1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5021.
    GeneTreei ENSGT00410000025556.
    HOGENOMi HOG000013211.
    HOVERGENi HBG058082.
    InParanoidi Q5SXA9.
    KOi K16685.
    OMAi DPQVGDY.
    OrthoDBi EOG7DJSNR.
    PhylomeDBi Q5SXA9.
    TreeFami TF324040.

    Enzyme and pathway databases

    Reactomei REACT_196537. Signaling by Hippo.

    Miscellaneous databases

    NextBioi 373320.
    PROi Q5SXA9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5SXA9.
    Bgeei Q5SXA9.
    CleanExi MM_WWC1.
    Genevestigatori Q5SXA9.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00397. WW. 2 hits.
    [Graphical view ]
    SMARTi SM00456. WW. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51045. SSF51045. 2 hits.
    PROSITEi PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein-coding sequence of KIBRA from Mus musculus."
      Kremerskothen J.
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvEv.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Seino S., Nishimura M., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-1104.
      Tissue: Pancreatic islet.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 146-1104.
      Strain: FVB/N.
      Tissue: Mammary gland, Mammary tumor and Salivary gland.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887 AND SER-891, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling."
      Hilton H.N., Stanford P.M., Harris J., Oakes S.R., Kaplan W., Daly R.J., Ormandy C.J.
      Biochim. Biophys. Acta 1783:383-393(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiKIBRA_MOUSE
    AccessioniPrimary (citable) accession number: Q5SXA9
    Secondary accession number(s): Q571D0
    , Q8K1Y3, Q8VD17, Q922W3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3