GDI2

Functionⁱ

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functionⁱ

GTPase activator activity Source: UniProtKB-KW
oxidoreductase activity Source: InterPro
Rab GDP-dissociation inhibitor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

protein transport Source: InterPro
small GTPase mediated signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	GTPase activationUniRule annotation

Molecular function

GTPase activationUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Rab GDP dissociation inhibitorUniRule annotation
Gene namesⁱ	Name:GDI2Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

HGNCⁱ

HGNC:4227. GDI2.

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU363124

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000057608.

OpenTargetsⁱ

ENSG00000057608.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5SX91.
PeptideAtlas More...PeptideAtlasⁱ	Q5SX91.
PRIDEⁱ	Q5SX91.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000057608.
ExpressionAtlasⁱ	Q5SX91. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5SX91.
SMRⁱ	Q5SX91.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063044.
HOGENOMⁱ	HOG000171762.
HOVERGENⁱ	HBG000839.

Family and domain databases

Gene3Dⁱ	3.50.50.60. 1 hit.
InterProⁱ	View protein in InterPro IPR023753. FAD/NAD-binding_dom. IPR018203. GDP_dissociation_inhibitor. IPR000806. RabGDI.
PANTHERⁱ	PTHR11787. PTHR11787. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00996. GDI. 1 hit.
PRINTSⁱ	PR00892. RABGDI. PR00891. RABGDIREP.
SUPFAMⁱ	SSF51905. SSF51905. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q5SX91-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
KKFDLGQDVI DFTGHALALY RTDDYLDQPC YETINRIKLY SESLARYGKS 
        60         70         80         90        100
PYLYPLYGLG ELPQGFARLS AIYGGTYMLN KPIEEIIVQN GKVIGVKSEG 
       110        120        130        140        150
EIARCKQLIC DPSYVKDRVE KVGQVIRVIC ILSHPIKNTN DANSCQIIIP 
       160        170        180        190        200
QNQVNRKSDL LASVTSWYQK TWEQKARSLF PAHMMPPLIL RQRVMTLKTS 

IRG

Length:203

Mass (Da):23,115

Last modified:December 21, 2004 - v1

Checksum:ⁱC454C5614E2FCCF3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL596094 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL596094 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000447751; ENSP00000387565; ENSG00000057608.
UCSC genome browser More...UCSCⁱ	uc057rkm.1. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL596094 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL596094 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	Q5SX91.
SMRⁱ	Q5SX91.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5SX91.
PeptideAtlas More...PeptideAtlasⁱ	Q5SX91.
PRIDEⁱ	Q5SX91.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000447751; ENSP00000387565; ENSG00000057608.
UCSC genome browser More...UCSCⁱ	uc057rkm.1. human.

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4227. GDI2.
Open Targets More...OpenTargetsⁱ	ENSG00000057608.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063044.
HOGENOMⁱ	HOG000171762.
HOVERGENⁱ	HBG000839.

Miscellaneous databases

ChiTaRSⁱ	GDI2. human.

ChiTaRSⁱ

GDI2. human.

Gene expression databases

Bgeeⁱ	ENSG00000057608.
ExpressionAtlasⁱ	Q5SX91. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.50.50.60. 1 hit.
InterProⁱ	View protein in InterPro IPR023753. FAD/NAD-binding_dom. IPR018203. GDP_dissociation_inhibitor. IPR000806. RabGDI.
PANTHERⁱ	PTHR11787. PTHR11787. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00996. GDI. 1 hit.
PRINTSⁱ	PR00892. RABGDI. PR00891. RABGDIREP.
SUPFAMⁱ	SSF51905. SSF51905. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5SX91_HUMAN
Accessionⁱ	Q5SX91Primary (citable) accession number: Q5SX91
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	March 15, 2017
	This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5SX91 (Q5SX91_HUMAN)

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Rab GDP dissociation inhibitor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ