UniProtKB - Q5SX91 (Q5SX91_HUMAN)
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Protein
Rab GDP dissociation inhibitor
Gene
GDI2
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- Rab GDP-dissociation inhibitor activity Source: InterPro
GO - Biological processi
- protein transport Source: InterPro
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activationUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Rab GDP dissociation inhibitorUniRule annotation |
Gene namesi | Name:GDI2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000057608.16. |
HGNCi | HGNC:4227. GDI2. |
Expressioni
Gene expression databases
Bgeei | ENSG00000057608. |
ExpressionAtlasi | Q5SX91. baseline and differential. |
Structurei
3D structure databases
ProteinModelPortali | Q5SX91. |
SMRi | Q5SX91. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the Rab GDI family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00530000063044. |
HOGENOMi | HOG000171762. |
HOVERGENi | HBG000839. |
Family and domain databases
InterProi | View protein in InterPro IPR036188. FAD/NAD-bd_sf. IPR018203. GDP_dissociation_inhibitor. IPR000806. RabGDI. |
PANTHERi | PTHR11787. PTHR11787. 1 hit. |
Pfami | View protein in Pfam PF00996. GDI. 1 hit. |
PRINTSi | PR00892. RABGDI. PR00891. RABGDIREP. |
SUPFAMi | SSF51905. SSF51905. 1 hit. |
i Sequence
Sequence statusi: Fragment.
Q5SX91-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KKFDLGQDVI DFTGHALALY RTDDYLDQPC YETINRIKLY SESLARYGKS
60 70 80 90 100
PYLYPLYGLG ELPQGFARLS AIYGGTYMLN KPIEEIIVQN GKVIGVKSEG
110 120 130 140 150
EIARCKQLIC DPSYVKDRVE KVGQVIRVIC ILSHPIKNTN DANSCQIIIP
160 170 180 190 200
QNQVNRKSDL LASVTSWYQK TWEQKARSLF PAHMMPPLIL RQRVMTLKTS
IRG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596094 Genomic DNA. No translation available. |
Genome annotation databases
Ensembli | ENST00000447751; ENSP00000387565; ENSG00000057608. |
UCSCi | uc057rkm.1. human. |
Similar proteinsi
Entry informationi
Entry namei | Q5SX91_HUMAN | |
Accessioni | Q5SX91Primary (citable) accession number: Q5SX91 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | March 28, 2018 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |