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Protein

Rab GDP dissociation inhibitor

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitorUniRule annotation
Gene namesi
Name:GDI2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:4227. GDI2.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000057608.

PTM / Processingi

Proteomic databases

MaxQBiQ5SX90.
PaxDbiQ5SX90.
PeptideAtlasiQ5SX90.
PRIDEiQ5SX90.

Expressioni

Gene expression databases

BgeeiENSG00000057608.
ExpressionAtlasiQ5SX90. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369538.

Structurei

3D structure databases

ProteinModelPortaliQ5SX90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000134240.
HOVERGENiHBG055026.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
PANTHERiPTHR11787. PTHR11787. 1 hit.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5SX90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGKRKPSN FYLANFLGKE CILSGIMSVN GKKVLHMDRN PYYGGESASI
60 70 80 90 100
TPLEDLYKRF KIPGSPPESM GRGRDWNVDL IPKFLMANGQ LVKMLLYTEV
110 120 130 140
TRYLDFKVTE GSFVYKGGKI YKVPSTEAEA LASSLMGLFE KRRFRKFL
Length:148
Mass (Da):16,820
Last modified:December 21, 2004 - v1
Checksum:i0C0B20134A0BA47B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei148Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596094 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000380127; ENSP00000369470; ENSG00000057608.
UCSCiuc057rkq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596094 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5SX90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369538.

Proteomic databases

MaxQBiQ5SX90.
PaxDbiQ5SX90.
PeptideAtlasiQ5SX90.
PRIDEiQ5SX90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380127; ENSP00000369470; ENSG00000057608.
UCSCiuc057rkq.1. human.

Organism-specific databases

HGNCiHGNC:4227. GDI2.
OpenTargetsiENSG00000057608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000134240.
HOVERGENiHBG055026.

Miscellaneous databases

ChiTaRSiGDI2. human.

Gene expression databases

BgeeiENSG00000057608.
ExpressionAtlasiQ5SX90. baseline and differential.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
PANTHERiPTHR11787. PTHR11787. 1 hit.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SX90_HUMAN
AccessioniPrimary (citable) accession number: Q5SX90
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 15, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.