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Protein

Rab GDP dissociation inhibitor

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitorUniRule annotation
Gene namesi
Name:GDI2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000057608.16
HGNCiHGNC:4227 GDI2

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000057608

PTM / Processingi

Proteomic databases

EPDiQ5SX90
MaxQBiQ5SX90
PeptideAtlasiQ5SX90
PRIDEiQ5SX90

Expressioni

Gene expression databases

BgeeiENSG00000057608
ExpressionAtlasiQ5SX90 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5SX90
SMRiQ5SX90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOGENOMiHOG000134240
HOVERGENiHBG055026

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 1 hit

Sequencei

Sequence statusi: Fragment.

Q5SX90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGKRKPSN FYLANFLGKE CILSGIMSVN GKKVLHMDRN PYYGGESASI
60 70 80 90 100
TPLEDLYKRF KIPGSPPESM GRGRDWNVDL IPKFLMANGQ LVKMLLYTEV
110 120 130 140
TRYLDFKVTE GSFVYKGGKI YKVPSTEAEA LASSLMGLFE KRRFRKFL
Length:148
Mass (Da):16,820
Last modified:December 21, 2004 - v1
Checksum:i0C0B20134A0BA47B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei148Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596094 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000380127; ENSP00000369470; ENSG00000057608
UCSCiuc057rkq.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5SX90_HUMAN
AccessioniPrimary (citable) accession number: Q5SX90
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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