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Protein

Rab GDP dissociation inhibitor

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitorUniRule annotation
Gene namesi
Name:GDI2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:4227. GDI2.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000057608.

PTM / Processingi

Proteomic databases

MaxQBiQ5SX87.
PaxDbiQ5SX87.
PeptideAtlasiQ5SX87.
PRIDEiQ5SX87.

Expressioni

Gene expression databases

BgeeiENSG00000057608.
ExpressionAtlasiQ5SX87. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369538.

Structurei

3D structure databases

ProteinModelPortaliQ5SX87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5SX87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKIPG SPPESMGRGR DWNVDLIPKF LMANEVTRYL DFKVTEGSFV
110 120 130 140 150
YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF DEKDPRTFEG
160 170 180 190 200
IDPKKTTMRD VYKKFDLGQD VIDFTGHALA LYRTDDYLDQ PCYETINRIK
210 220 230 240 250
LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM LNKPIEEIIV
260
QNGKVIGVKS EGE
Length:263
Mass (Da):29,856
Last modified:December 21, 2004 - v1
Checksum:i18E0227BFCC39421
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei263Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596094 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000456041; ENSP00000401733; ENSG00000057608.
UCSCiuc057rkn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596094 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5SX87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369538.

Proteomic databases

MaxQBiQ5SX87.
PaxDbiQ5SX87.
PeptideAtlasiQ5SX87.
PRIDEiQ5SX87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456041; ENSP00000401733; ENSG00000057608.
UCSCiuc057rkn.1. human.

Organism-specific databases

HGNCiHGNC:4227. GDI2.
OpenTargetsiENSG00000057608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.

Miscellaneous databases

ChiTaRSiGDI2. human.

Gene expression databases

BgeeiENSG00000057608.
ExpressionAtlasiQ5SX87. baseline and differential.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SX87_HUMAN
AccessioniPrimary (citable) accession number: Q5SX87
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: February 15, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.