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Protein

Rab GDP dissociation inhibitor

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitorUniRule annotation
Gene namesi
Name:GDI2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000057608.16.
HGNCiHGNC:4227. GDI2.

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000057608.

PTM / Processingi

Proteomic databases

EPDiQ5SX86.
MaxQBiQ5SX86.
PeptideAtlasiQ5SX86.
PRIDEiQ5SX86.

Expressioni

Gene expression databases

BgeeiENSG00000057608.
ExpressionAtlasiQ5SX86. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5SX86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063044.
HOGENOMiHOG000134240.
HOVERGENiHBG055026.

Family and domain databases

InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
PANTHERiPTHR11787. PTHR11787. 1 hit.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PRINTSiPR00892. RABGDI.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5SX86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEYDVIVL GTGLTLYKRF KIPGSPPESM GRGRDWNVDL IPKFLMANGQ
60 70 80 90 100
LVKMLLYTEV TRYLDFKVTE GSFVYKGGKI YKVPSTEAEA LASSLMGLFE
110 120 130 140 150
KRRFRKFLVY VANFDEKDPR TFEGIDPKKT TMRDVYKKFD LGQDVIDFTG

HALAL
Length:155
Mass (Da):17,783
Last modified:December 21, 2004 - v1
Checksum:iD6BF5339C1590C30
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei155Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596094 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000418688; ENSP00000394177; ENSG00000057608.
UCSCiuc057rko.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ5SX86_HUMAN
AccessioniPrimary (citable) accession number: Q5SX86
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 27, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported