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Q5SX78

- Q5SX78_MOUSE

UniProt

Q5SX78 - Q5SX78_MOUSE

Protein
Submitted name:

Colony stimulating factor 2 (Granulocyte-macrophage)

Gene

Csf2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. cellular response to lipopolysaccharide Source: Ensembl
    2. embryonic placenta development Source: MGI
    3. epithelial fluid transport Source: Ensembl
    4. immune response Source: InterPro
    5. macrophage activation Source: Ensembl
    6. myeloid dendritic cell differentiation Source: MGI
    7. negative regulation of cytolysis Source: Ensembl
    8. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    9. positive regulation of cell proliferation Source: MGI
    10. positive regulation of DNA replication Source: Ensembl
    11. positive regulation of gene expression Source: Ensembl
    12. positive regulation of interleukin-23 production Source: Ensembl
    13. positive regulation of macrophage derived foam cell differentiation Source: Ensembl
    14. positive regulation of podosome assembly Source: Ensembl
    15. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    16. regulation of cell proliferation Source: MGI
    17. regulation of gene expression Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Colony stimulating factor 2 (Granulocyte-macrophage)Imported
    Submitted name:
    Granulocyte-macrophage colony stimulating factor 2Imported
    Gene namesi
    Name:Csf2Imported
    ORF Names:mCG_13784Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1339752. Csf2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ5SX78.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000019060.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000013425.
    HOVERGENiHBG000532.
    InParanoidiQ5SX78.
    KOiK05427.
    OMAiTCLQTRL.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000773. GM_colony-stim-fac.
    [Graphical view]
    PANTHERiPTHR10059. PTHR10059. 1 hit.
    PfamiPF01109. GM_CSF. 1 hit.
    [Graphical view]
    PRINTSiPR00693. GMCSFACTOR.
    ProDomiPD007349. GM_colony-stim-fac. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00040. CSF2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00702. GM_CSF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SX78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL    50
    NEEVEVVSNE FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT 100
    YCPPTPETDC ETQVTTYADF IDSLKTFLTD IPFECKKPGQ K 141
    Length:141
    Mass (Da):16,091
    Last modified:May 10, 2005 - v1
    Checksum:i209C7CBB4FF77349
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU366957 mRNA. Translation: ABY66391.1.
    AK053196 mRNA. Translation: BAE20692.1.
    CH466575 Genomic DNA. Translation: EDL33540.1.
    RefSeqiNP_034099.2. NM_009969.4.
    UniGeneiMm.4922.

    Genome annotation databases

    GeneIDi12981.
    KEGGimmu:12981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU366957 mRNA. Translation: ABY66391.1 .
    AK053196 mRNA. Translation: BAE20692.1 .
    CH466575 Genomic DNA. Translation: EDL33540.1 .
    RefSeqi NP_034099.2. NM_009969.4.
    UniGenei Mm.4922.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000019060.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12981.
    KEGGi mmu:12981.

    Organism-specific databases

    CTDi 1437.
    MGIi MGI:1339752. Csf2.

    Phylogenomic databases

    GeneTreei ENSGT00390000013425.
    HOVERGENi HBG000532.
    InParanoidi Q5SX78.
    KOi K05427.
    OMAi TCLQTRL.

    Miscellaneous databases

    ChiTaRSi CSF2. mouse.
    NextBioi 282756.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q5SX78.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000773. GM_colony-stim-fac.
    [Graphical view ]
    PANTHERi PTHR10059. PTHR10059. 1 hit.
    Pfami PF01109. GM_CSF. 1 hit.
    [Graphical view ]
    PRINTSi PR00693. GMCSFACTOR.
    ProDomi PD007349. GM_colony-stim-fac. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00040. CSF2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00702. GM_CSF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    11. "Cloning of mouse cDNA encoding GM-CSF from the spleen."
      Xu L.-H., Shi H.-J., Lu H.-S., Han J., He X.-H.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.

    Entry informationi

    Entry nameiQ5SX78_MOUSE
    AccessioniPrimary (citable) accession number: Q5SX78
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)