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Q5SX78

- Q5SX78_MOUSE

UniProt

Q5SX78 - Q5SX78_MOUSE

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Protein
Submitted name:

Colony stimulating factor 2 (Granulocyte-macrophage)

Gene

Csf2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: Ensembl
  2. embryonic placenta development Source: MGI
  3. epithelial fluid transport Source: Ensembl
  4. immune response Source: InterPro
  5. macrophage activation Source: Ensembl
  6. myeloid dendritic cell differentiation Source: MGI
  7. negative regulation of cytolysis Source: Ensembl
  8. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  9. positive regulation of cell proliferation Source: MGI
  10. positive regulation of DNA replication Source: Ensembl
  11. positive regulation of gene expression Source: Ensembl
  12. positive regulation of interleukin-23 production Source: Ensembl
  13. positive regulation of macrophage derived foam cell differentiation Source: Ensembl
  14. positive regulation of podosome assembly Source: Ensembl
  15. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  16. regulation of cell proliferation Source: MGI
  17. regulation of gene expression Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Colony stimulating factor 2 (Granulocyte-macrophage)Imported
Submitted name:
Granulocyte-macrophage colony stimulating factor 2Imported
Gene namesi
Name:Csf2Imported
ORF Names:mCG_13784Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1339752. Csf2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ5SX78.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019060.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000013425.
HOVERGENiHBG000532.
KOiK05427.
OMAiTCLQTRL.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000773. GM_colony-stim-fac.
[Graphical view]
PANTHERiPTHR10059. PTHR10059. 1 hit.
PfamiPF01109. GM_CSF. 1 hit.
[Graphical view]
PRINTSiPR00693. GMCSFACTOR.
ProDomiPD007349. GM_colony-stim-fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00040. CSF2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00702. GM_CSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SX78-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL
60 70 80 90 100
NEEVEVVSNE FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT
110 120 130 140
YCPPTPETDC ETQVTTYADF IDSLKTFLTD IPFECKKPGQ K
Length:141
Mass (Da):16,091
Last modified:May 10, 2005 - v1
Checksum:i209C7CBB4FF77349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU366957 mRNA. Translation: ABY66391.1.
AK053196 mRNA. Translation: BAE20692.1.
CH466575 Genomic DNA. Translation: EDL33540.1.
RefSeqiNP_034099.2. NM_009969.4.
UniGeneiMm.4922.

Genome annotation databases

GeneIDi12981.
KEGGimmu:12981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU366957 mRNA. Translation: ABY66391.1 .
AK053196 mRNA. Translation: BAE20692.1 .
CH466575 Genomic DNA. Translation: EDL33540.1 .
RefSeqi NP_034099.2. NM_009969.4.
UniGenei Mm.4922.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000019060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12981.
KEGGi mmu:12981.

Organism-specific databases

CTDi 1437.
MGIi MGI:1339752. Csf2.

Phylogenomic databases

GeneTreei ENSGT00390000013425.
HOVERGENi HBG000532.
KOi K05427.
OMAi TCLQTRL.

Miscellaneous databases

ChiTaRSi Csf2. mouse.
NextBioi 282756.
SOURCEi Search...

Gene expression databases

Genevestigatori Q5SX78.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000773. GM_colony-stim-fac.
[Graphical view ]
PANTHERi PTHR10059. PTHR10059. 1 hit.
Pfami PF01109. GM_CSF. 1 hit.
[Graphical view ]
PRINTSi PR00693. GMCSFACTOR.
ProDomi PD007349. GM_colony-stim-fac. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00040. CSF2. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00702. GM_CSF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  11. "Cloning of mouse cDNA encoding GM-CSF from the spleen."
    Xu L.-H., Shi H.-J., Lu H.-S., Han J., He X.-H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.

Entry informationi

Entry nameiQ5SX78_MOUSE
AccessioniPrimary (citable) accession number: Q5SX78
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)