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Protein

Interleukin-3

Gene

Il3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.UniRule annotation
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3UniRule annotation
Short name:
IL-3UniRule annotation
Alternative name(s):
Hematopoietic growth factorUniRule annotation
Mast cell growth factorUniRule annotation
Multipotential colony-stimulating factorUniRule annotation
P-cell-stimulating factorUniRule annotation
Gene namesi
Name:Il3Imported
ORF Names:mCG_13767Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96552 Il3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501431001627 – 166Interleukin-3Sequence analysisAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 106UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000018914
ExpressionAtlasiQ5SX77 baseline and differential

Interactioni

Subunit structurei

Monomer.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ5SX77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-3 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG006148
KOiK04736
OMAiSGRDTHR
OrthoDBiEOG091G15R6

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002183 IL-3
PfamiView protein in Pfam
PF02059 IL3, 1 hit
PIRSFiPIRSF001939 IL-3, 1 hit
PRINTSiPR00430 INTERLEUKIN3
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SX77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLASSTTSI HTMLLLLLML FHLGLQASIS GRDTHRLTRT LNCSSIVKEI
60 70 80 90 100
IGKLPEPELK TDDEGPSLRN KSFRRVNLSK FVESQGEVDP EDRYVIKSNL
110 120 130 140 150
QKLNCCLPTS ANDSALPGVF IRDLDDFRKK LRFYMVHLND LETVLTSRPP
160
QPASGSVSPN RGTVEC
Length:166
Mass (Da):18,540
Last modified:May 10, 2005 - v1
Checksum:iF38EE7A9E361CAA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125552 mRNA Translation: AAI25553.1
BC125554 mRNA Translation: AAI25555.1
AK153634 mRNA Translation: BAE32129.1
CH466575 Genomic DNA Translation: EDL33539.1
RefSeqiNP_034686.2, NM_010556.4
UniGeneiMm.983

Genome annotation databases

GeneIDi16187
KEGGimmu:16187

Similar proteinsi

Entry informationi

Entry nameiQ5SX77_MOUSE
AccessioniPrimary (citable) accession number: Q5SX77
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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