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Q5SX40

- MYH1_MOUSE

UniProt

Q5SX40 - MYH1_MOUSE

Protein

Myosin-1

Gene

Myh1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Muscle contraction.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi179 – 1868ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro

    GO - Biological processi

    1. muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-1
    Alternative name(s):
    Myosin heavy chain 1
    Myosin heavy chain 2x
    Short name:
    MyHC-2x
    Myosin heavy chain, skeletal muscle, adult 1
    Gene namesi
    Name:Myh1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1339711. Myh1.

    Subcellular locationi

    Cytoplasmmyofibril
    Note: Thick filaments of the myofibrils.

    GO - Cellular componenti

    1. A band Source: MGI
    2. focal adhesion Source: Ensembl
    3. intercalated disc Source: MGI
    4. muscle myosin complex Source: MGI
    5. myosin filament Source: UniProtKB-KW
    6. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Thick filament

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19421942Myosin-1PRO_0000123392Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301N6,N6,N6-trimethyllysineSequence Analysis

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiQ5SX40.
    PaxDbiQ5SX40.
    PRIDEiQ5SX40.

    PTM databases

    PhosphoSiteiQ5SX40.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5SX40.
    BgeeiQ5SX40.
    GenevestigatoriQ5SX40.

    Interactioni

    Subunit structurei

    Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

    Protein-protein interaction databases

    BioGridi201643. 1 interaction.
    IntActiQ5SX40. 2 interactions.
    MINTiMINT-4102740.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SX40.
    SMRiQ5SX40. Positions 4-970.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 785700Myosin motorAdd
    BLAST
    Domaini788 – 81730IQPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni662 – 68423Actin-bindingBy similarityAdd
    BLAST
    Regioni764 – 77815Actin-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili846 – 19421097Sequence AnalysisAdd
    BLAST

    Domaini

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5022.
    GeneTreeiENSGT00720000108596.
    HOGENOMiHOG000173959.
    HOVERGENiHBG004704.
    InParanoidiQ32P18.
    KOiK10352.
    OMAiIMDVEND.
    OrthoDBiEOG7RBZ7G.
    PhylomeDBiQ5SX40.
    TreeFamiTF314375.

    Family and domain databases

    Gene3Di4.10.270.10. 1 hit.
    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SX40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDAEMAVF GEAAPYLRKS EKERIEAQNK PFDAKSSVFV VDAKESFVKA     50
    TVQSREGGKV TAKTEGGTTV TVKDDQVYPM NPPKYDKIED MAMMTHLHEP 100
    AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV AAYRGKKRQE 150
    APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA 200
    VTGEKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF 250
    IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL 300
    IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFTSDERV 350
    SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK 400
    ALCYPRVKVG NEYVTKGQTV QQVYNSVGAL AKAVYEKMFL WMVTRINQQL 450
    DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE 500
    QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS 550
    FKNKLYEQHL GKSNNFQKPK PAKGKVEAHF SLVHYAGTVD YNIAGWLDKN 600
    KDPLNETVVG LYQKSSMKTL AYLFSGAAAA AEAESGGGGG KKGAKKKGSS 650
    FQTVSALFRE NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL 700
    RCNGVLEGIR ICRKGFPSRI LYADFKQRYK VLNASAIPEG QFIDSKKASE 750
    KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL EEMRDDKLAQ LITRTQAMCR 800
    GYLARVEYQK MVERRESIFC IQYNVRAFMN VKHWPWMKLY FKIKPLLKSA 850
    ETEKEMANMK EEFEKAKENL AKAEAKRKEL EEKMVALMQE KNDLQLQVQS 900
    EADSLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL 950
    EDECSELKKD IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT 1000
    KEKKALQEAH QQTLDDLQAE EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK 1050
    IRMDLERAKR KLEGDLKLAQ ESTMDVENDK QQLDEKLKKK EFEMSNLQSK 1100
    IEDEQALGMQ LQKKIKELQA RIEELEEEIE AERASRAKAE KQRSDLSREL 1150
    EEISERLEEA GGATSAQIEM NKKREAEFQK MRRDLEEATL QHEATAATLR 1200
    KKHADSVAEL GEQIDNLQRV KQKLEKEKSE MKMEIDDLAS NMEVISKSKG 1250
    NLEKMCRTLE DQVSELKTKE EEQQRLINEL TAQRGRLQTE SGEYSRQLDE 1300
    KDSLVSQLSR GKQAFTQQIE ELKRQLEEEI KAKSALAHAL QSSRHDCDLL 1350
    REQYEEEQEA KAELQRAMSK ANSEVAQWRT KYETDAIQRT EELEEAKKKL 1400
    AQRLQDAEEH VEAVNAKCAS LEKTKQRLQN EVEDLMIDVE RTNAACAALD 1450
    KKQRNFDKIL AEWKQKYEET HAELEASQKE SRSLSTELFK IKNAYEESLD 1500
    HLETLKRENK NLQQEISDLT EQIAEGGKRI HELEKIKKQI EQEKSELQAA 1550
    LEEAEASLEH EEGKILRIQL ELNQVKSEID RKIAEKDEEI DQLKRNHIRV 1600
    VESMQSTLDA EIRSRNDAIR LKKKMEGDLN EMEIQLNHSN RMAAEALRNY 1650
    RNTQGILKDT QLHLDDALRG QEDLKEQLAM VERRANLLQA EIEELRATLE 1700
    QTERSRKIAE QELLDASERV QLLHTQNTSL INTKKKLETD ISQIQGEMED 1750
    IVQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNLEQTVKDL 1800
    QHRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVENEQKRN VEAIKGLRKH 1850
    ERRVKELTYQ TEEDRKNVLR LQDLVDKLQS KVKAYKRQAE EAEEQSNVNL 1900
    AKFRKIQHEL EEAEERADIA ESQVNKLRVK SREVHTKIIS EE 1942
    Length:1,942
    Mass (Da):223,342
    Last modified:December 21, 2004 - v1
    Checksum:i946BBA18567A2FB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596129 Genomic DNA. Translation: CAI24987.1.
    BC108329 mRNA. Translation: AAI08330.1.
    CCDSiCCDS24855.1.
    RefSeqiNP_109604.1. NM_030679.1.
    UniGeneiMm.477065.

    Genome annotation databases

    EnsembliENSMUST00000018637; ENSMUSP00000018637; ENSMUSG00000056328.
    ENSMUST00000075734; ENSMUSP00000075147; ENSMUSG00000056328.
    ENSMUST00000124516; ENSMUSP00000117569; ENSMUSG00000056328.
    GeneIDi17879.
    KEGGimmu:17879.
    UCSCiuc007jmg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596129 Genomic DNA. Translation: CAI24987.1 .
    BC108329 mRNA. Translation: AAI08330.1 .
    CCDSi CCDS24855.1.
    RefSeqi NP_109604.1. NM_030679.1.
    UniGenei Mm.477065.

    3D structure databases

    ProteinModelPortali Q5SX40.
    SMRi Q5SX40. Positions 4-970.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201643. 1 interaction.
    IntActi Q5SX40. 2 interactions.
    MINTi MINT-4102740.

    PTM databases

    PhosphoSitei Q5SX40.

    Proteomic databases

    MaxQBi Q5SX40.
    PaxDbi Q5SX40.
    PRIDEi Q5SX40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018637 ; ENSMUSP00000018637 ; ENSMUSG00000056328 .
    ENSMUST00000075734 ; ENSMUSP00000075147 ; ENSMUSG00000056328 .
    ENSMUST00000124516 ; ENSMUSP00000117569 ; ENSMUSG00000056328 .
    GeneIDi 17879.
    KEGGi mmu:17879.
    UCSCi uc007jmg.1. mouse.

    Organism-specific databases

    CTDi 4619.
    MGIi MGI:1339711. Myh1.

    Phylogenomic databases

    eggNOGi COG5022.
    GeneTreei ENSGT00720000108596.
    HOGENOMi HOG000173959.
    HOVERGENi HBG004704.
    InParanoidi Q32P18.
    KOi K10352.
    OMAi IMDVEND.
    OrthoDBi EOG7RBZ7G.
    PhylomeDBi Q5SX40.
    TreeFami TF314375.

    Miscellaneous databases

    NextBioi 292673.
    PROi Q5SX40.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5SX40.
    Bgeei Q5SX40.
    Genevestigatori Q5SX40.

    Family and domain databases

    Gene3Di 4.10.270.10. 1 hit.
    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thyroid.

    Entry informationi

    Entry nameiMYH1_MOUSE
    AccessioniPrimary (citable) accession number: Q5SX40
    Secondary accession number(s): Q32P18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3