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Q5SX40

- MYH1_MOUSE

UniProt

Q5SX40 - MYH1_MOUSE

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Protein

Myosin-1

Gene

Myh1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 1868ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro

GO - Biological processi

  1. muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Myosin heavy chain 1
Myosin heavy chain 2x
Short name:
MyHC-2x
Myosin heavy chain, skeletal muscle, adult 1
Gene namesi
Name:Myh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1339711. Myh1.

Subcellular locationi

Cytoplasmmyofibril
Note: Thick filaments of the myofibrils.

GO - Cellular componenti

  1. A band Source: MGI
  2. intercalated disc Source: MGI
  3. muscle myosin complex Source: MGI
  4. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19421942Myosin-1PRO_0000123392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301N6,N6,N6-trimethyllysineSequence Analysis

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ5SX40.
PaxDbiQ5SX40.
PRIDEiQ5SX40.

PTM databases

PhosphoSiteiQ5SX40.

Expressioni

Gene expression databases

BgeeiQ5SX40.
ExpressionAtlasiQ5SX40. baseline and differential.
GenevestigatoriQ5SX40.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Protein-protein interaction databases

BioGridi201643. 1 interaction.
IntActiQ5SX40. 2 interactions.
MINTiMINT-4102740.

Structurei

3D structure databases

ProteinModelPortaliQ5SX40.
SMRiQ5SX40. Positions 4-970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 785700Myosin motorAdd
BLAST
Domaini788 – 81730IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni662 – 68423Actin-bindingBy similarityAdd
BLAST
Regioni764 – 77815Actin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili846 – 19421097Sequence AnalysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiQ5SX40.
KOiK10352.
OMAiIMDVEND.
OrthoDBiEOG7RBZ7G.
PhylomeDBiQ5SX40.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SX40 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSDAEMAVF GEAAPYLRKS EKERIEAQNK PFDAKSSVFV VDAKESFVKA
60 70 80 90 100
TVQSREGGKV TAKTEGGTTV TVKDDQVYPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV AAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGEKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL
310 320 330 340 350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFTSDERV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV QQVYNSVGAL AKAVYEKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYEQHL GKSNNFQKPK PAKGKVEAHF SLVHYAGTVD YNIAGWLDKN
610 620 630 640 650
KDPLNETVVG LYQKSSMKTL AYLFSGAAAA AEAESGGGGG KKGAKKKGSS
660 670 680 690 700
FQTVSALFRE NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL
710 720 730 740 750
RCNGVLEGIR ICRKGFPSRI LYADFKQRYK VLNASAIPEG QFIDSKKASE
760 770 780 790 800
KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL EEMRDDKLAQ LITRTQAMCR
810 820 830 840 850
GYLARVEYQK MVERRESIFC IQYNVRAFMN VKHWPWMKLY FKIKPLLKSA
860 870 880 890 900
ETEKEMANMK EEFEKAKENL AKAEAKRKEL EEKMVALMQE KNDLQLQVQS
910 920 930 940 950
EADSLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL
960 970 980 990 1000
EDECSELKKD IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT
1010 1020 1030 1040 1050
KEKKALQEAH QQTLDDLQAE EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK
1060 1070 1080 1090 1100
IRMDLERAKR KLEGDLKLAQ ESTMDVENDK QQLDEKLKKK EFEMSNLQSK
1110 1120 1130 1140 1150
IEDEQALGMQ LQKKIKELQA RIEELEEEIE AERASRAKAE KQRSDLSREL
1160 1170 1180 1190 1200
EEISERLEEA GGATSAQIEM NKKREAEFQK MRRDLEEATL QHEATAATLR
1210 1220 1230 1240 1250
KKHADSVAEL GEQIDNLQRV KQKLEKEKSE MKMEIDDLAS NMEVISKSKG
1260 1270 1280 1290 1300
NLEKMCRTLE DQVSELKTKE EEQQRLINEL TAQRGRLQTE SGEYSRQLDE
1310 1320 1330 1340 1350
KDSLVSQLSR GKQAFTQQIE ELKRQLEEEI KAKSALAHAL QSSRHDCDLL
1360 1370 1380 1390 1400
REQYEEEQEA KAELQRAMSK ANSEVAQWRT KYETDAIQRT EELEEAKKKL
1410 1420 1430 1440 1450
AQRLQDAEEH VEAVNAKCAS LEKTKQRLQN EVEDLMIDVE RTNAACAALD
1460 1470 1480 1490 1500
KKQRNFDKIL AEWKQKYEET HAELEASQKE SRSLSTELFK IKNAYEESLD
1510 1520 1530 1540 1550
HLETLKRENK NLQQEISDLT EQIAEGGKRI HELEKIKKQI EQEKSELQAA
1560 1570 1580 1590 1600
LEEAEASLEH EEGKILRIQL ELNQVKSEID RKIAEKDEEI DQLKRNHIRV
1610 1620 1630 1640 1650
VESMQSTLDA EIRSRNDAIR LKKKMEGDLN EMEIQLNHSN RMAAEALRNY
1660 1670 1680 1690 1700
RNTQGILKDT QLHLDDALRG QEDLKEQLAM VERRANLLQA EIEELRATLE
1710 1720 1730 1740 1750
QTERSRKIAE QELLDASERV QLLHTQNTSL INTKKKLETD ISQIQGEMED
1760 1770 1780 1790 1800
IVQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNLEQTVKDL
1810 1820 1830 1840 1850
QHRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVENEQKRN VEAIKGLRKH
1860 1870 1880 1890 1900
ERRVKELTYQ TEEDRKNVLR LQDLVDKLQS KVKAYKRQAE EAEEQSNVNL
1910 1920 1930 1940
AKFRKIQHEL EEAEERADIA ESQVNKLRVK SREVHTKIIS EE
Length:1,942
Mass (Da):223,342
Last modified:December 21, 2004 - v1
Checksum:i946BBA18567A2FB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596129 Genomic DNA. Translation: CAI24987.1.
BC108329 mRNA. Translation: AAI08330.1.
CCDSiCCDS24855.1.
RefSeqiNP_109604.1. NM_030679.1.
UniGeneiMm.477065.

Genome annotation databases

EnsembliENSMUST00000018637; ENSMUSP00000018637; ENSMUSG00000056328.
ENSMUST00000075734; ENSMUSP00000075147; ENSMUSG00000056328.
ENSMUST00000124516; ENSMUSP00000117569; ENSMUSG00000056328.
GeneIDi17879.
KEGGimmu:17879.
UCSCiuc007jmg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596129 Genomic DNA. Translation: CAI24987.1 .
BC108329 mRNA. Translation: AAI08330.1 .
CCDSi CCDS24855.1.
RefSeqi NP_109604.1. NM_030679.1.
UniGenei Mm.477065.

3D structure databases

ProteinModelPortali Q5SX40.
SMRi Q5SX40. Positions 4-970.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201643. 1 interaction.
IntActi Q5SX40. 2 interactions.
MINTi MINT-4102740.

PTM databases

PhosphoSitei Q5SX40.

Proteomic databases

MaxQBi Q5SX40.
PaxDbi Q5SX40.
PRIDEi Q5SX40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018637 ; ENSMUSP00000018637 ; ENSMUSG00000056328 .
ENSMUST00000075734 ; ENSMUSP00000075147 ; ENSMUSG00000056328 .
ENSMUST00000124516 ; ENSMUSP00000117569 ; ENSMUSG00000056328 .
GeneIDi 17879.
KEGGi mmu:17879.
UCSCi uc007jmg.1. mouse.

Organism-specific databases

CTDi 4619.
MGIi MGI:1339711. Myh1.

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00760000118919.
HOGENOMi HOG000173959.
HOVERGENi HBG004704.
InParanoidi Q5SX40.
KOi K10352.
OMAi IMDVEND.
OrthoDBi EOG7RBZ7G.
PhylomeDBi Q5SX40.
TreeFami TF314375.

Miscellaneous databases

NextBioi 292673.
PROi Q5SX40.
SOURCEi Search...

Gene expression databases

Bgeei Q5SX40.
ExpressionAtlasi Q5SX40. baseline and differential.
Genevestigatori Q5SX40.

Family and domain databases

Gene3Di 4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiMYH1_MOUSE
AccessioniPrimary (citable) accession number: Q5SX40
Secondary accession number(s): Q32P18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3