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Q5SX40 (MYH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin-1
Alternative name(s):
Myosin heavy chain 1
Myosin heavy chain 2x
Short name=MyHC-2x
Myosin heavy chain, skeletal muscle, adult 1
Gene names
Name:Myh1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1942 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Muscle contraction.

Subunit structure

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Subcellular location

Cytoplasmmyofibril. Note: Thick filaments of the myofibrils.

Domain

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similarities

Contains 1 IQ domain.

Contains 1 myosin head-like domain.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19421942Myosin-1
PRO_0000123392

Regions

Domain1 – 787787Myosin head-like
Domain788 – 81730IQ
Nucleotide binding179 – 1868ATP Potential
Region662 – 68423Actin-binding By similarity
Region764 – 77815Actin-binding By similarity
Coiled coil846 – 19421097 Potential

Amino acid modifications

Modified residue1301N6,N6,N6-trimethyllysine Potential

Sequences

Sequence LengthMass (Da)Tools
Q5SX40 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 946BBA18567A2FB0

FASTA1,942223,342
        10         20         30         40         50         60 
MSSDAEMAVF GEAAPYLRKS EKERIEAQNK PFDAKSSVFV VDAKESFVKA TVQSREGGKV 

        70         80         90        100        110        120 
TAKTEGGTTV TVKDDQVYPM NPPKYDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG 

       130        140        150        160        170        180 
LFCVTVNPYK WLPVYNAEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSILITGE 

       190        200        210        220        230        240 
SGAGKTVNTK RVIQYFATIA VTGEKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR 

       250        260        270        280        290        300 
NDNSSRFGKF IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL 

       310        320        330        340        350        360 
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFTSDERV SIYKLTGAVM 

       370        380        390        400        410        420 
HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK ALCYPRVKVG NEYVTKGQTV 

       430        440        450        460        470        480 
QQVYNSVGAL AKAVYEKMFL WMVTRINQQL DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC 

       490        500        510        520        530        540 
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE 

       550        560        570        580        590        600 
CMFPKATDTS FKNKLYEQHL GKSNNFQKPK PAKGKVEAHF SLVHYAGTVD YNIAGWLDKN 

       610        620        630        640        650        660 
KDPLNETVVG LYQKSSMKTL AYLFSGAAAA AEAESGGGGG KKGAKKKGSS FQTVSALFRE 

       670        680        690        700        710        720 
NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL RCNGVLEGIR ICRKGFPSRI 

       730        740        750        760        770        780 
LYADFKQRYK VLNASAIPEG QFIDSKKASE KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL 

       790        800        810        820        830        840 
EEMRDDKLAQ LITRTQAMCR GYLARVEYQK MVERRESIFC IQYNVRAFMN VKHWPWMKLY 

       850        860        870        880        890        900 
FKIKPLLKSA ETEKEMANMK EEFEKAKENL AKAEAKRKEL EEKMVALMQE KNDLQLQVQS 

       910        920        930        940        950        960 
EADSLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL EDECSELKKD 

       970        980        990       1000       1010       1020 
IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT KEKKALQEAH QQTLDDLQAE 

      1030       1040       1050       1060       1070       1080 
EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK IRMDLERAKR KLEGDLKLAQ ESTMDVENDK 

      1090       1100       1110       1120       1130       1140 
QQLDEKLKKK EFEMSNLQSK IEDEQALGMQ LQKKIKELQA RIEELEEEIE AERASRAKAE 

      1150       1160       1170       1180       1190       1200 
KQRSDLSREL EEISERLEEA GGATSAQIEM NKKREAEFQK MRRDLEEATL QHEATAATLR 

      1210       1220       1230       1240       1250       1260 
KKHADSVAEL GEQIDNLQRV KQKLEKEKSE MKMEIDDLAS NMEVISKSKG NLEKMCRTLE 

      1270       1280       1290       1300       1310       1320 
DQVSELKTKE EEQQRLINEL TAQRGRLQTE SGEYSRQLDE KDSLVSQLSR GKQAFTQQIE 

      1330       1340       1350       1360       1370       1380 
ELKRQLEEEI KAKSALAHAL QSSRHDCDLL REQYEEEQEA KAELQRAMSK ANSEVAQWRT 

      1390       1400       1410       1420       1430       1440 
KYETDAIQRT EELEEAKKKL AQRLQDAEEH VEAVNAKCAS LEKTKQRLQN EVEDLMIDVE 

      1450       1460       1470       1480       1490       1500 
RTNAACAALD KKQRNFDKIL AEWKQKYEET HAELEASQKE SRSLSTELFK IKNAYEESLD 

      1510       1520       1530       1540       1550       1560 
HLETLKRENK NLQQEISDLT EQIAEGGKRI HELEKIKKQI EQEKSELQAA LEEAEASLEH 

      1570       1580       1590       1600       1610       1620 
EEGKILRIQL ELNQVKSEID RKIAEKDEEI DQLKRNHIRV VESMQSTLDA EIRSRNDAIR 

      1630       1640       1650       1660       1670       1680 
LKKKMEGDLN EMEIQLNHSN RMAAEALRNY RNTQGILKDT QLHLDDALRG QEDLKEQLAM 

      1690       1700       1710       1720       1730       1740 
VERRANLLQA EIEELRATLE QTERSRKIAE QELLDASERV QLLHTQNTSL INTKKKLETD 

      1750       1760       1770       1780       1790       1800 
ISQIQGEMED IVQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNLEQTVKDL 

      1810       1820       1830       1840       1850       1860 
QHRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVENEQKRN VEAIKGLRKH ERRVKELTYQ 

      1870       1880       1890       1900       1910       1920 
TEEDRKNVLR LQDLVDKLQS KVKAYKRQAE EAEEQSNVNL AKFRKIQHEL EEAEERADIA 

      1930       1940 
ESQVNKLRVK SREVHTKIIS EE 

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References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thyroid.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596129 Genomic DNA. Translation: CAI24987.1.
BC108329 mRNA. Translation: AAI08330.1.
RefSeqNP_109604.1. NM_030679.1.
UniGeneMm.477065.

3D structure databases

ProteinModelPortalQ5SX40.
SMRQ5SX40. Positions 4-970.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201643. 1 interaction.
IntActQ5SX40. 2 interactions.
MINTMINT-4102740.

PTM databases

PhosphoSiteQ5SX40.

Proteomic databases

PaxDbQ5SX40.
PRIDEQ5SX40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000018637; ENSMUSP00000018637; ENSMUSG00000056328.
ENSMUST00000075734; ENSMUSP00000075147; ENSMUSG00000056328.
ENSMUST00000124516; ENSMUSP00000117569; ENSMUSG00000056328.
GeneID17879.
KEGGmmu:17879.
UCSCuc007jmg.1. mouse.

Organism-specific databases

CTD4619.
MGIMGI:1339711. Myh1.

Phylogenomic databases

eggNOGCOG5022.
GeneTreeENSGT00720000108596.
HOGENOMHOG000173959.
HOVERGENHBG004704.
InParanoidQ32P18.
KOK10352.
OMAQPTEEIS.
OrthoDBEOG7RBZ7G.
PhylomeDBQ5SX40.
TreeFamTF314375.

Gene expression databases

ArrayExpressQ5SX40.
BgeeQ5SX40.
GenevestigatorQ5SX40.

Family and domain databases

Gene3D4.10.270.10. 1 hit.
InterProIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR015650. Myosin_1/23/4/6/7/8/13/15.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR13140:SF22. PTHR13140:SF22. 1 hit.
PfamPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292673.
PROQ5SX40.
SOURCESearch...

Entry information

Entry nameMYH1_MOUSE
AccessionPrimary (citable) accession number: Q5SX40
Secondary accession number(s): Q32P18
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot