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Q5SX40

- MYH1_MOUSE

UniProt

Q5SX40 - MYH1_MOUSE

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Protein
Myosin-1
Gene
Myh1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 1868ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro

GO - Biological processi

  1. muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Myosin heavy chain 1
Myosin heavy chain 2x
Short name:
MyHC-2x
Myosin heavy chain, skeletal muscle, adult 1
Gene namesi
Name:Myh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1339711. Myh1.

Subcellular locationi

Cytoplasmmyofibril
Note: Thick filaments of the myofibrils.

GO - Cellular componenti

  1. A band Source: MGI
  2. focal adhesion Source: Ensembl
  3. intercalated disc Source: MGI
  4. muscle myosin complex Source: MGI
  5. myosin filament Source: UniProtKB-KW
  6. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19421942Myosin-1
PRO_0000123392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301N6,N6,N6-trimethyllysine Reviewed prediction

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ5SX40.
PaxDbiQ5SX40.
PRIDEiQ5SX40.

PTM databases

PhosphoSiteiQ5SX40.

Expressioni

Gene expression databases

ArrayExpressiQ5SX40.
BgeeiQ5SX40.
GenevestigatoriQ5SX40.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Protein-protein interaction databases

BioGridi201643. 1 interaction.
IntActiQ5SX40. 2 interactions.
MINTiMINT-4102740.

Structurei

3D structure databases

ProteinModelPortaliQ5SX40.
SMRiQ5SX40. Positions 4-970.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 785700Myosin motor
Add
BLAST
Domaini788 – 81730IQ
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni662 – 68423Actin-binding By similarity
Add
BLAST
Regioni764 – 77815Actin-binding By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili846 – 19421097 Reviewed prediction
Add
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00720000108596.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiQ32P18.
KOiK10352.
OMAiIMDVEND.
OrthoDBiEOG7RBZ7G.
PhylomeDBiQ5SX40.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SX40-1 [UniParc]FASTAAdd to Basket

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MSSDAEMAVF GEAAPYLRKS EKERIEAQNK PFDAKSSVFV VDAKESFVKA     50
TVQSREGGKV TAKTEGGTTV TVKDDQVYPM NPPKYDKIED MAMMTHLHEP 100
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV AAYRGKKRQE 150
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA 200
VTGEKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF 250
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL 300
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFTSDERV 350
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK 400
ALCYPRVKVG NEYVTKGQTV QQVYNSVGAL AKAVYEKMFL WMVTRINQQL 450
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE 500
QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS 550
FKNKLYEQHL GKSNNFQKPK PAKGKVEAHF SLVHYAGTVD YNIAGWLDKN 600
KDPLNETVVG LYQKSSMKTL AYLFSGAAAA AEAESGGGGG KKGAKKKGSS 650
FQTVSALFRE NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL 700
RCNGVLEGIR ICRKGFPSRI LYADFKQRYK VLNASAIPEG QFIDSKKASE 750
KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL EEMRDDKLAQ LITRTQAMCR 800
GYLARVEYQK MVERRESIFC IQYNVRAFMN VKHWPWMKLY FKIKPLLKSA 850
ETEKEMANMK EEFEKAKENL AKAEAKRKEL EEKMVALMQE KNDLQLQVQS 900
EADSLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL 950
EDECSELKKD IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT 1000
KEKKALQEAH QQTLDDLQAE EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK 1050
IRMDLERAKR KLEGDLKLAQ ESTMDVENDK QQLDEKLKKK EFEMSNLQSK 1100
IEDEQALGMQ LQKKIKELQA RIEELEEEIE AERASRAKAE KQRSDLSREL 1150
EEISERLEEA GGATSAQIEM NKKREAEFQK MRRDLEEATL QHEATAATLR 1200
KKHADSVAEL GEQIDNLQRV KQKLEKEKSE MKMEIDDLAS NMEVISKSKG 1250
NLEKMCRTLE DQVSELKTKE EEQQRLINEL TAQRGRLQTE SGEYSRQLDE 1300
KDSLVSQLSR GKQAFTQQIE ELKRQLEEEI KAKSALAHAL QSSRHDCDLL 1350
REQYEEEQEA KAELQRAMSK ANSEVAQWRT KYETDAIQRT EELEEAKKKL 1400
AQRLQDAEEH VEAVNAKCAS LEKTKQRLQN EVEDLMIDVE RTNAACAALD 1450
KKQRNFDKIL AEWKQKYEET HAELEASQKE SRSLSTELFK IKNAYEESLD 1500
HLETLKRENK NLQQEISDLT EQIAEGGKRI HELEKIKKQI EQEKSELQAA 1550
LEEAEASLEH EEGKILRIQL ELNQVKSEID RKIAEKDEEI DQLKRNHIRV 1600
VESMQSTLDA EIRSRNDAIR LKKKMEGDLN EMEIQLNHSN RMAAEALRNY 1650
RNTQGILKDT QLHLDDALRG QEDLKEQLAM VERRANLLQA EIEELRATLE 1700
QTERSRKIAE QELLDASERV QLLHTQNTSL INTKKKLETD ISQIQGEMED 1750
IVQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNLEQTVKDL 1800
QHRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVENEQKRN VEAIKGLRKH 1850
ERRVKELTYQ TEEDRKNVLR LQDLVDKLQS KVKAYKRQAE EAEEQSNVNL 1900
AKFRKIQHEL EEAEERADIA ESQVNKLRVK SREVHTKIIS EE 1942
Length:1,942
Mass (Da):223,342
Last modified:December 21, 2004 - v1
Checksum:i946BBA18567A2FB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596129 Genomic DNA. Translation: CAI24987.1.
BC108329 mRNA. Translation: AAI08330.1.
CCDSiCCDS24855.1.
RefSeqiNP_109604.1. NM_030679.1.
UniGeneiMm.477065.

Genome annotation databases

EnsembliENSMUST00000018637; ENSMUSP00000018637; ENSMUSG00000056328.
ENSMUST00000075734; ENSMUSP00000075147; ENSMUSG00000056328.
ENSMUST00000124516; ENSMUSP00000117569; ENSMUSG00000056328.
GeneIDi17879.
KEGGimmu:17879.
UCSCiuc007jmg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596129 Genomic DNA. Translation: CAI24987.1 .
BC108329 mRNA. Translation: AAI08330.1 .
CCDSi CCDS24855.1.
RefSeqi NP_109604.1. NM_030679.1.
UniGenei Mm.477065.

3D structure databases

ProteinModelPortali Q5SX40.
SMRi Q5SX40. Positions 4-970.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201643. 1 interaction.
IntActi Q5SX40. 2 interactions.
MINTi MINT-4102740.

PTM databases

PhosphoSitei Q5SX40.

Proteomic databases

MaxQBi Q5SX40.
PaxDbi Q5SX40.
PRIDEi Q5SX40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018637 ; ENSMUSP00000018637 ; ENSMUSG00000056328 .
ENSMUST00000075734 ; ENSMUSP00000075147 ; ENSMUSG00000056328 .
ENSMUST00000124516 ; ENSMUSP00000117569 ; ENSMUSG00000056328 .
GeneIDi 17879.
KEGGi mmu:17879.
UCSCi uc007jmg.1. mouse.

Organism-specific databases

CTDi 4619.
MGIi MGI:1339711. Myh1.

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00720000108596.
HOGENOMi HOG000173959.
HOVERGENi HBG004704.
InParanoidi Q32P18.
KOi K10352.
OMAi IMDVEND.
OrthoDBi EOG7RBZ7G.
PhylomeDBi Q5SX40.
TreeFami TF314375.

Miscellaneous databases

NextBioi 292673.
PROi Q5SX40.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5SX40.
Bgeei Q5SX40.
Genevestigatori Q5SX40.

Family and domain databases

Gene3Di 4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiMYH1_MOUSE
AccessioniPrimary (citable) accession number: Q5SX40
Secondary accession number(s): Q32P18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi