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Protein

N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

Pigl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity).By similarity

Catalytic activityi

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class L protein
Short name:
PIG-L
Gene namesi
Name:Pigl
Synonyms:Gm737
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2681271 Pigl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 252CytoplasmicSequence analysisAdd BLAST230

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078241 – 252N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseAdd BLAST252

Proteomic databases

MaxQBiQ5SX19
PaxDbiQ5SX19
PRIDEiQ5SX19

PTM databases

PhosphoSitePlusiQ5SX19

Expressioni

Gene expression databases

BgeeiENSMUSG00000014245
GenevisibleiQ5SX19 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014389

Structurei

3D structure databases

ProteinModelPortaliQ5SX19
SMRiQ5SX19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3332 Eukaryota
COG2120 LUCA
GeneTreeiENSGT00390000018434
HOGENOMiHOG000176611
HOVERGENiHBG019149
InParanoidiQ5SX19
KOiK03434
OMAiLVWFRWL
OrthoDBiEOG091G0HS4
PhylomeDBiQ5SX19
TreeFamiTF315150

Family and domain databases

Gene3Di3.40.50.10320, 1 hit
InterProiView protein in InterPro
IPR003737 GlcNAc_PI_deacetylase-related
IPR024078 LmbE-like_dom_sf
PANTHERiPTHR12993 PTHR12993, 1 hit
PfamiView protein in Pfam
PF02585 PIG-L, 1 hit
SUPFAMiSSF102588 SSF102588, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SX19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVGFLCVA VAVLTWGFLR VWNSAERMRS PEQAGLPGAG SRALVVIAHP
60 70 80 90 100
DDEAMFFAPT MLGLARLEQQ VSLLCFSSGN YYNQGEIRKK ELLQSCAVLG
110 120 130 140 150
IPPSRVMIID KRDFPDDPEV QWDTELVAST LLQHIHANGT DLVVTFDAEG
160 170 180 190 200
VSGHSNHIAL YKAVRALHSG GKLPKGCSVL TLQSVNALRK YAFLLDLPWT
210 220 230 240 250
LLSPQDVLFV LTSKEVAQAK KAMSCHRSQL LWFRYLYVLF SRYMRINSLR

FL
Length:252
Mass (Da):28,183
Last modified:December 21, 2004 - v1
Checksum:i5C243350751F3A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158149 mRNA Translation: BAE34385.1
BX248411, AL596181, BX470084 Genomic DNA Translation: CAI24059.1
AL596181, BX248411, BX470084 Genomic DNA Translation: CAI24669.1
BX470084, AL596181, BX248411 Genomic DNA Translation: CAI24686.1
CCDSiCCDS24824.1
RefSeqiNP_001034625.1, NM_001039536.2
UniGeneiMm.390358

Genome annotation databases

EnsembliENSMUST00000014389; ENSMUSP00000014389; ENSMUSG00000014245
GeneIDi327942
KEGGimmu:327942
UCSCiuc007jje.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPIGL_MOUSE
AccessioniPrimary (citable) accession number: Q5SX19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health