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Q5SX19

- PIGL_MOUSE

UniProt

Q5SX19 - PIGL_MOUSE

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Protein

N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

Pigl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity).By similarity

Catalytic activityi

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

Pathwayi

GO - Molecular functioni

  1. N-acetylglucosaminylphosphatidylinositol deacetylase activity Source: UniProtKB-EC

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class L protein
Short name:
PIG-L
Gene namesi
Name:Pigl
Synonyms:Gm737
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2681271. Pigl.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252N-acetylglucosaminyl-phosphatidylinositol de-N-acetylasePRO_0000307824Add
BLAST

Proteomic databases

PRIDEiQ5SX19.

Expressioni

Gene expression databases

BgeeiQ5SX19.
GenevestigatoriQ5SX19.

Structurei

3D structure databases

ProteinModelPortaliQ5SX19.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 252230CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2120.
GeneTreeiENSGT00390000018434.
HOGENOMiHOG000176611.
HOVERGENiHBG019149.
InParanoidiQ5SX19.
KOiK03434.
OMAiHTQDVLF.
OrthoDBiEOG7KWSJF.
PhylomeDBiQ5SX19.
TreeFamiTF315150.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SX19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELVGFLCVA VAVLTWGFLR VWNSAERMRS PEQAGLPGAG SRALVVIAHP
60 70 80 90 100
DDEAMFFAPT MLGLARLEQQ VSLLCFSSGN YYNQGEIRKK ELLQSCAVLG
110 120 130 140 150
IPPSRVMIID KRDFPDDPEV QWDTELVAST LLQHIHANGT DLVVTFDAEG
160 170 180 190 200
VSGHSNHIAL YKAVRALHSG GKLPKGCSVL TLQSVNALRK YAFLLDLPWT
210 220 230 240 250
LLSPQDVLFV LTSKEVAQAK KAMSCHRSQL LWFRYLYVLF SRYMRINSLR

FL
Length:252
Mass (Da):28,183
Last modified:December 21, 2004 - v1
Checksum:i5C243350751F3A6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK158149 mRNA. Translation: BAE34385.1.
BX248411, AL596181, BX470084 Genomic DNA. Translation: CAI24059.1.
AL596181, BX248411, BX470084 Genomic DNA. Translation: CAI24669.1.
BX470084, AL596181, BX248411 Genomic DNA. Translation: CAI24686.1.
CCDSiCCDS24824.1.
RefSeqiNP_001034625.1. NM_001039536.2.
UniGeneiMm.390358.

Genome annotation databases

EnsembliENSMUST00000014389; ENSMUSP00000014389; ENSMUSG00000014245.
GeneIDi327942.
KEGGimmu:327942.
UCSCiuc007jje.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK158149 mRNA. Translation: BAE34385.1 .
BX248411 , AL596181 , BX470084 Genomic DNA. Translation: CAI24059.1 .
AL596181 , BX248411 , BX470084 Genomic DNA. Translation: CAI24669.1 .
BX470084 , AL596181 , BX248411 Genomic DNA. Translation: CAI24686.1 .
CCDSi CCDS24824.1.
RefSeqi NP_001034625.1. NM_001039536.2.
UniGenei Mm.390358.

3D structure databases

ProteinModelPortali Q5SX19.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5SX19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014389 ; ENSMUSP00000014389 ; ENSMUSG00000014245 .
GeneIDi 327942.
KEGGi mmu:327942.
UCSCi uc007jje.1. mouse.

Organism-specific databases

CTDi 9487.
MGIi MGI:2681271. Pigl.

Phylogenomic databases

eggNOGi COG2120.
GeneTreei ENSGT00390000018434.
HOGENOMi HOG000176611.
HOVERGENi HBG019149.
InParanoidi Q5SX19.
KOi K03434.
OMAi HTQDVLF.
OrthoDBi EOG7KWSJF.
PhylomeDBi Q5SX19.
TreeFami TF315150.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Miscellaneous databases

NextBioi 398008.
PROi Q5SX19.
SOURCEi Search...

Gene expression databases

Bgeei Q5SX19.
Genevestigatori Q5SX19.

Family and domain databases

Gene3Di 3.40.50.10320. 1 hit.
InterProi IPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
[Graphical view ]
PANTHERi PTHR12993. PTHR12993. 1 hit.
Pfami PF02585. PIG-L. 1 hit.
[Graphical view ]
SUPFAMi SSF102588. SSF102588. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Inner ear.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPIGL_MOUSE
AccessioniPrimary (citable) accession number: Q5SX19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3