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Q5SX19

- PIGL_MOUSE

UniProt

Q5SX19 - PIGL_MOUSE

Protein

N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

Pigl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol By similarity.By similarity

    Catalytic activityi

    6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

    Pathwayi

    GO - Molecular functioni

    1. N-acetylglucosaminylphosphatidylinositol deacetylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00196.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
    Alternative name(s):
    Phosphatidylinositol-glycan biosynthesis class L protein
    Short name:
    PIG-L
    Gene namesi
    Name:Pigl
    Synonyms:Gm737
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2681271. Pigl.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252N-acetylglucosaminyl-phosphatidylinositol de-N-acetylasePRO_0000307824Add
    BLAST

    Proteomic databases

    PRIDEiQ5SX19.

    Expressioni

    Gene expression databases

    BgeeiQ5SX19.
    GenevestigatoriQ5SX19.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SX19.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 252230CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIGL family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2120.
    GeneTreeiENSGT00390000018434.
    HOGENOMiHOG000176611.
    HOVERGENiHBG019149.
    InParanoidiQ5SX19.
    KOiK03434.
    OMAiHTQDVLF.
    OrthoDBiEOG7KWSJF.
    PhylomeDBiQ5SX19.
    TreeFamiTF315150.

    Family and domain databases

    Gene3Di3.40.50.10320. 1 hit.
    InterProiIPR003737. GlcNAc_PI_deacetylase-related.
    IPR024078. LmbE-like_dom.
    [Graphical view]
    PANTHERiPTHR12993. PTHR12993. 1 hit.
    PfamiPF02585. PIG-L. 1 hit.
    [Graphical view]
    SUPFAMiSSF102588. SSF102588. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5SX19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELVGFLCVA VAVLTWGFLR VWNSAERMRS PEQAGLPGAG SRALVVIAHP    50
    DDEAMFFAPT MLGLARLEQQ VSLLCFSSGN YYNQGEIRKK ELLQSCAVLG 100
    IPPSRVMIID KRDFPDDPEV QWDTELVAST LLQHIHANGT DLVVTFDAEG 150
    VSGHSNHIAL YKAVRALHSG GKLPKGCSVL TLQSVNALRK YAFLLDLPWT 200
    LLSPQDVLFV LTSKEVAQAK KAMSCHRSQL LWFRYLYVLF SRYMRINSLR 250
    FL 252
    Length:252
    Mass (Da):28,183
    Last modified:December 21, 2004 - v1
    Checksum:i5C243350751F3A6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK158149 mRNA. Translation: BAE34385.1.
    BX248411, AL596181, BX470084 Genomic DNA. Translation: CAI24059.1.
    AL596181, BX248411, BX470084 Genomic DNA. Translation: CAI24669.1.
    BX470084, AL596181, BX248411 Genomic DNA. Translation: CAI24686.1.
    CCDSiCCDS24824.1.
    RefSeqiNP_001034625.1. NM_001039536.2.
    UniGeneiMm.390358.

    Genome annotation databases

    EnsembliENSMUST00000014389; ENSMUSP00000014389; ENSMUSG00000014245.
    GeneIDi327942.
    KEGGimmu:327942.
    UCSCiuc007jje.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK158149 mRNA. Translation: BAE34385.1 .
    BX248411 , AL596181 , BX470084 Genomic DNA. Translation: CAI24059.1 .
    AL596181 , BX248411 , BX470084 Genomic DNA. Translation: CAI24669.1 .
    BX470084 , AL596181 , BX248411 Genomic DNA. Translation: CAI24686.1 .
    CCDSi CCDS24824.1.
    RefSeqi NP_001034625.1. NM_001039536.2.
    UniGenei Mm.390358.

    3D structure databases

    ProteinModelPortali Q5SX19.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5SX19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014389 ; ENSMUSP00000014389 ; ENSMUSG00000014245 .
    GeneIDi 327942.
    KEGGi mmu:327942.
    UCSCi uc007jje.1. mouse.

    Organism-specific databases

    CTDi 9487.
    MGIi MGI:2681271. Pigl.

    Phylogenomic databases

    eggNOGi COG2120.
    GeneTreei ENSGT00390000018434.
    HOGENOMi HOG000176611.
    HOVERGENi HBG019149.
    InParanoidi Q5SX19.
    KOi K03434.
    OMAi HTQDVLF.
    OrthoDBi EOG7KWSJF.
    PhylomeDBi Q5SX19.
    TreeFami TF315150.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .

    Miscellaneous databases

    NextBioi 398008.
    PROi Q5SX19.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5SX19.
    Genevestigatori Q5SX19.

    Family and domain databases

    Gene3Di 3.40.50.10320. 1 hit.
    InterProi IPR003737. GlcNAc_PI_deacetylase-related.
    IPR024078. LmbE-like_dom.
    [Graphical view ]
    PANTHERi PTHR12993. PTHR12993. 1 hit.
    Pfami PF02585. PIG-L. 1 hit.
    [Graphical view ]
    SUPFAMi SSF102588. SSF102588. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Inner ear.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiPIGL_MOUSE
    AccessioniPrimary (citable) accession number: Q5SX19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3