Reviewed,
UniProtKB/Swiss-Prot Q5SWZ9 (PLD6_MOUSE)
Last modified
November 3, 2009.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phospholipase D6 Short name=PLD 6 EC=3.1.4.4 Alternative name(s): Choline phosphatase 6 Phosphatidylcholine-hydrolyzing phospholipase D6 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 221 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | A phosphatidylcholine + H2O = choline + a phosphatidate. |
| Subcellular location | Membrane; Single-pass membrane protein Potential. |
| Sequence similarities | Belongs to the Phospholipase D family. Contains 1 PLD phosphodiesterase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Transmembrane |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q5SWZ9-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q5SWZ9-2) The sequence of this isoform differs from the canonical sequence as follows: 139-147: AGIQVRHDQ → GYRYGTTRT 148-221: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 221 | 221 | Phospholipase D6 | PRO_0000325911 | |||||
Regions | |||||||||
| Transmembrane | 5 – 27 | 23 | Potential | ||||||
| Domain | 148 – 175 | 28 | PLD phosphodiesterase | ||||||
Sites | |||||||||
| Active site | 153 | 1 | Potential | ||||||
| Active site | 155 | 1 | Potential | ||||||
| Active site | 160 | 1 | Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 139 – 147 | 9 | AGIQVRHDQ → GYRYGTTRT in isoform 2. | VSP_032474 | |||||
| Alternative sequence | 148 – 221 | 74 | Missing in isoform 2. | VSP_032475 | |||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AK077214 mRNA. Translation: BAC36687.1. AK139586 mRNA. Translation: BAE24077.1. AL596204 Genomic DNA. Translation: CAI24298.1. BC119245 mRNA. Translation: AAI19246.1. | |
| IPI | IPI00225919. IPI00889236. |
| RefSeq | NP_898962.2. |
| UniGene | Mm.344651 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5SWZ9. |
Proteomic databases | |
| PRIDE | Q5SWZ9. |
Genome annotation databases | |
| Ensembl | ENSMUST00000051493; ENSMUSP00000058189; ENSMUSG00000043648; Mus musculus. [Genome view] |
| GeneID | 194908. |
| KEGG | mmu:194908. |
| UCSC | uc007jev.1. mouse. |
Organism-specific databases | |
| CTD | 194908. |
| MGI | MGI:2687283. Pld6. |
Phylogenomic databases | |
| HOGENOM | Q5SWZ9. |
| HOVERGEN | Q5SWZ9. |
| OMA | FPSQVTC. |
Enzyme and pathway databases | |
| BRENDA | 3.1.4.4. 244. |
Gene expression databases | |
| ArrayExpress | Q5SWZ9. |
| Bgee | Q5SWZ9. |
| Genevestigator | Q5SWZ9. |
Family and domain databases | |
| InterPro | IPR001736. PLipase_D/transphosphatidylase. [Graphical view] |
| SMART | SM00155. PLDc. 1 hit. [Graphical view] |
| PROSITE | PS50035. PLD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 371672. |
| SOURCE | Search... |
Entry information
| Entry name | PLD6_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q5SWZ9 Secondary accession number(s): Q3UTA3, Q8BVM0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


