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Protein

Sodium/glucose cotransporter 5

Gene

Slc5a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 5
Short name:
Na(+)/glucose cotransporter 5
Alternative name(s):
Solute carrier family 5 member 10
Gene namesi
Name:Slc5a10
Synonyms:Sglt5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926089 Slc5a10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15ExtracellularSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 72CytoplasmicSequence analysisAdd BLAST36
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 99ExtracellularSequence analysis6
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 149CytoplasmicSequence analysisAdd BLAST29
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 173ExtracellularSequence analysis3
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 200CytoplasmicSequence analysis6
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 264ExtracellularSequence analysisAdd BLAST43
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 300CytoplasmicSequence analysisAdd BLAST15
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 355ExtracellularSequence analysisAdd BLAST34
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 409CytoplasmicSequence analysisAdd BLAST33
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 443ExtracellularSequence analysisAdd BLAST13
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 471CytoplasmicSequence analysis7
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 513ExtracellularSequence analysisAdd BLAST21
Transmembranei514 – 534HelicalSequence analysisAdd BLAST21
Topological domaini535 – 575CytoplasmicSequence analysisAdd BLAST41
Transmembranei576 – 596HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112121 – 596Sodium/glucose cotransporter 5Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei48PhosphoserineCombined sources1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei141PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei148PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ5SWY8
PaxDbiQ5SWY8
PRIDEiQ5SWY8

PTM databases

iPTMnetiQ5SWY8
PhosphoSitePlusiQ5SWY8

Expressioni

Gene expression databases

BgeeiENSMUSG00000042371
ExpressionAtlasiQ5SWY8 baseline and differential
GenevisibleiQ5SWY8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054407

Structurei

3D structure databases

ProteinModelPortaliQ5SWY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000025422
HOVERGENiHBG052859
InParanoidiQ5SWY8
KOiK14390
OMAiCGAEIGC
OrthoDBiEOG091G077U
PhylomeDBiQ5SWY8
TreeFamiTF352855

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SWY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNSTGDAH VPGSQLSVTD IIVISVYFAL NVAVGIWSAC RANKNTVSGY
60 70 80 90 100
FLAGRDMAWW PIGASLFASS EGSGLFVGLA GSGAAGGLAV AGFEWNATYV
110 120 130 140 150
LLALAWVFVP IYISSEIVTL PEYIQKRFGG QRIRTYLSVL SLMLSVFTKI
160 170 180 190 200
SIDLYAGALF VHICLGWNFY LSTILTLAIT ALYTIAGGLA TVIYTDALQT
210 220 230 240 250
IIMVVGAVIL AVKAFNQIGG YEQLEAAYAQ AIPSRTIPNT TCHLPRADAM
260 270 280 290 300
HMFRDPSTGD LPWTGMTFGL TIMATWYWCT DQVIVQRSLS ARNLNHAKAG
310 320 330 340 350
SILASYLKML PMGLMIMPGM ISRVLFPDDV GCVVPSECLR ACGAEIGCSN
360 370 380 390 400
IAYPKLVMEL MPIGLRGLMI AVMMAALLSS LTSIFNSSST LFTMDIWRQL
410 420 430 440 450
RPSAGERELL LVGRLVIVVL IGVSVAWIPV LQGSNSGQLF IYMQSVTSSL
460 470 480 490 500
APPVTAIFIL GIFWRRANEQ GAFWGLMAGL VVGALRLVLE FLYPEPPCGQ
510 520 530 540 550
IDTRPAPLRS LHYLHFAIAL FLLTCAVMAA GSLLSPPPQQ RQIENLTWWT
560 570 580 590
LAPNWSLGTK TGDGQTPQKR AFWARVCNVN AIFLMCVNIF FYAYFA
Length:596
Mass (Da):64,706
Last modified:December 21, 2004 - v1
Checksum:i08203C11701BD48B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144033 mRNA Translation: BAE25665.1
AK165337 mRNA Translation: BAE38140.1
AL596209 Genomic DNA No translation available.
BC141325 mRNA Translation: AAI41326.1
CCDSiCCDS24818.1
RefSeqiNP_001028399.1, NM_001033227.2
XP_006532043.1, XM_006531980.3
UniGeneiMm.441070

Genome annotation databases

EnsembliENSMUST00000051552; ENSMUSP00000054407; ENSMUSG00000042371
ENSMUST00000148584; ENSMUSP00000114523; ENSMUSG00000042371
GeneIDi109342
KEGGimmu:109342
UCSCiuc007jia.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSC5AA_MOUSE
AccessioniPrimary (citable) accession number: Q5SWY8
Secondary accession number(s): B9EJ50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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