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Protein

Sodium/glucose cotransporter 5

Gene

Slc5a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 5
Short name:
Na(+)/glucose cotransporter 5
Alternative name(s):
Solute carrier family 5 member 10
Gene namesi
Name:Slc5a10
Synonyms:Sglt5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926089. Slc5a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularSequence analysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Topological domaini37 – 7236CytoplasmicSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Topological domaini94 – 996ExtracellularSequence analysis
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Topological domaini121 – 14929CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 1733ExtracellularSequence analysis
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Topological domaini195 – 2006CytoplasmicSequence analysis
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Topological domaini222 – 26443ExtracellularSequence analysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Topological domaini286 – 30015CytoplasmicSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST
Topological domaini322 – 35534ExtracellularSequence analysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Topological domaini377 – 40933CytoplasmicSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Topological domaini431 – 44313ExtracellularSequence analysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence analysisAdd
BLAST
Topological domaini465 – 4717CytoplasmicSequence analysis
Transmembranei472 – 49221HelicalSequence analysisAdd
BLAST
Topological domaini493 – 51321ExtracellularSequence analysisAdd
BLAST
Transmembranei514 – 53421HelicalSequence analysisAdd
BLAST
Topological domaini535 – 57541CytoplasmicSequence analysisAdd
BLAST
Transmembranei576 – 59621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Sodium/glucose cotransporter 5PRO_0000311212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Modified residuei48 – 481PhosphoserineCombined sources
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Modified residuei141 – 1411PhosphoserineBy similarity
Modified residuei145 – 1451PhosphoserineBy similarity
Modified residuei148 – 1481PhosphothreonineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ5SWY8.
PaxDbiQ5SWY8.
PRIDEiQ5SWY8.

PTM databases

iPTMnetiQ5SWY8.
PhosphoSiteiQ5SWY8.

Expressioni

Gene expression databases

BgeeiQ5SWY8.
ExpressionAtlasiQ5SWY8. baseline and differential.
GenevisibleiQ5SWY8. MM.

Structurei

3D structure databases

ProteinModelPortaliQ5SWY8.
SMRiQ5SWY8. Positions 17-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ5SWY8.
KOiK14390.
OMAiRRINARG.
PhylomeDBiQ5SWY8.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SWY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNSTGDAH VPGSQLSVTD IIVISVYFAL NVAVGIWSAC RANKNTVSGY
60 70 80 90 100
FLAGRDMAWW PIGASLFASS EGSGLFVGLA GSGAAGGLAV AGFEWNATYV
110 120 130 140 150
LLALAWVFVP IYISSEIVTL PEYIQKRFGG QRIRTYLSVL SLMLSVFTKI
160 170 180 190 200
SIDLYAGALF VHICLGWNFY LSTILTLAIT ALYTIAGGLA TVIYTDALQT
210 220 230 240 250
IIMVVGAVIL AVKAFNQIGG YEQLEAAYAQ AIPSRTIPNT TCHLPRADAM
260 270 280 290 300
HMFRDPSTGD LPWTGMTFGL TIMATWYWCT DQVIVQRSLS ARNLNHAKAG
310 320 330 340 350
SILASYLKML PMGLMIMPGM ISRVLFPDDV GCVVPSECLR ACGAEIGCSN
360 370 380 390 400
IAYPKLVMEL MPIGLRGLMI AVMMAALLSS LTSIFNSSST LFTMDIWRQL
410 420 430 440 450
RPSAGERELL LVGRLVIVVL IGVSVAWIPV LQGSNSGQLF IYMQSVTSSL
460 470 480 490 500
APPVTAIFIL GIFWRRANEQ GAFWGLMAGL VVGALRLVLE FLYPEPPCGQ
510 520 530 540 550
IDTRPAPLRS LHYLHFAIAL FLLTCAVMAA GSLLSPPPQQ RQIENLTWWT
560 570 580 590
LAPNWSLGTK TGDGQTPQKR AFWARVCNVN AIFLMCVNIF FYAYFA
Length:596
Mass (Da):64,706
Last modified:December 21, 2004 - v1
Checksum:i08203C11701BD48B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144033 mRNA. Translation: BAE25665.1.
AK165337 mRNA. Translation: BAE38140.1.
AL596209 Genomic DNA. Translation: CAI24869.1.
BC141325 mRNA. Translation: AAI41326.1.
CCDSiCCDS24818.1.
RefSeqiNP_001028399.1. NM_001033227.2.
XP_006532043.1. XM_006531980.2.
UniGeneiMm.441070.

Genome annotation databases

EnsembliENSMUST00000051552; ENSMUSP00000054407; ENSMUSG00000042371.
ENSMUST00000148584; ENSMUSP00000114523; ENSMUSG00000042371.
GeneIDi109342.
KEGGimmu:109342.
UCSCiuc007jia.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144033 mRNA. Translation: BAE25665.1.
AK165337 mRNA. Translation: BAE38140.1.
AL596209 Genomic DNA. Translation: CAI24869.1.
BC141325 mRNA. Translation: AAI41326.1.
CCDSiCCDS24818.1.
RefSeqiNP_001028399.1. NM_001033227.2.
XP_006532043.1. XM_006531980.2.
UniGeneiMm.441070.

3D structure databases

ProteinModelPortaliQ5SWY8.
SMRiQ5SWY8. Positions 17-480.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5SWY8.
PhosphoSiteiQ5SWY8.

Proteomic databases

MaxQBiQ5SWY8.
PaxDbiQ5SWY8.
PRIDEiQ5SWY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051552; ENSMUSP00000054407; ENSMUSG00000042371.
ENSMUST00000148584; ENSMUSP00000114523; ENSMUSG00000042371.
GeneIDi109342.
KEGGimmu:109342.
UCSCiuc007jia.1. mouse.

Organism-specific databases

CTDi125206.
MGIiMGI:1926089. Slc5a10.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ5SWY8.
KOiK14390.
OMAiRRINARG.
PhylomeDBiQ5SWY8.
TreeFamiTF352855.

Miscellaneous databases

PROiQ5SWY8.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SWY8.
ExpressionAtlasiQ5SWY8. baseline and differential.
GenevisibleiQ5SWY8. MM.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiSC5AA_MOUSE
AccessioniPrimary (citable) accession number: Q5SWY8
Secondary accession number(s): B9EJ50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.