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Protein

Protein odr-4 homolog

Gene

ODR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the trafficking of a subset of G-protein coupled receptors.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odr-4 homolog
Short name:
hODR-4
Alternative name(s):
LAG1-interacting protein
Transactivated by transforming growth factor beta protein 1
Gene namesi
Name:ODR4Imported
Synonyms:C1orf27, TTG1, TTG1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000157181.15
HGNCiHGNC:24299 ODR4
MIMi609335 gene
neXtProtiNX_Q5SWX8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157181
PharmGKBiPA134934744

Polymorphism and mutation databases

BioMutaiODR4
DMDMi74743951

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003046831 – 454Protein odr-4 homologAdd BLAST454

Proteomic databases

EPDiQ5SWX8
MaxQBiQ5SWX8
PaxDbiQ5SWX8
PeptideAtlasiQ5SWX8
PRIDEiQ5SWX8

PTM databases

iPTMnetiQ5SWX8
PhosphoSitePlusiQ5SWX8

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000157181
CleanExiHS_C1orf27
GenevisibleiQ5SWX8 HS

Organism-specific databases

HPAiHPA015988
HPA031352

Interactioni

Protein-protein interaction databases

BioGridi120291, 8 interactors
IntActiQ5SWX8, 5 interactors
STRINGi9606.ENSP00000287859

Structurei

3D structure databases

ProteinModelPortaliQ5SWX8
SMRiQ5SWX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODR-4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4703 Eukaryota
ENOG410XSI8 LUCA
GeneTreeiENSGT00390000012568
HOGENOMiHOG000115259
HOVERGENiHBG057033
InParanoidiQ5SWX8
OMAiMGRTYIV
OrthoDBiEOG091G0I7M
PhylomeDBiQ5SWX8
TreeFamiTF323772

Family and domain databases

InterProiView protein in InterPro
IPR029454 ODR-4-like
PANTHERiPTHR33966 PTHR33966, 1 hit
PfamiView protein in Pfam
PF14778 ODR4-like, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SWX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRTYIVEET VGQYLSNINL QGKAFVSGLL IGQCSSQKDY VILATRTPPK
60 70 80 90 100
EEQSENLKHP KAKLDNLDEE WATEHACQVS RMLPGGLLVL GVFIITTLEL
110 120 130 140 150
ANDFQNALRR LMFAVEKSIN RKRLWNFTEE EVSERVTLHI CASTKKIFCR
160 170 180 190 200
TYDIHDPKSS ARPADWKYQS GLSSSWLSLE CTVHINIHIP LSATSVSYTL
210 220 230 240 250
EKNTKNGLTR WAKEIENGVY LINGQVKDED CDLLEGQKKS SRGNTQATSH
260 270 280 290 300
SFDVRVLTQL LLNSDHRSTA TVQICSGSVN LKGAVKCRAY IHSSKPKVKD
310 320 330 340 350
AVQAVKRDIL NTVADRCEML FEDLLLNEIP EKKDSEKEFH VLPYRVFVPL
360 370 380 390 400
PGSTVMLCDY KFDDESAEEI RDHFMEMLDH TIQIEDLEIA EETNTACMSS
410 420 430 440 450
SMNSQASLDN TDDEQPKQPI KTTMLLKIQQ NIGVIAAFTV AVLAAGISFH

YFSD
Length:454
Mass (Da):51,103
Last modified:December 21, 2004 - v1
Checksum:i8D59C9136A4ED975
GO
Isoform 2 (identifier: Q5SWX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-260: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):48,560
Checksum:i672FE9694DF8BB95
GO
Isoform 3 (identifier: Q5SWX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-335: DS → RF
     336-454: Missing.

Show »
Length:335
Mass (Da):37,773
Checksum:i9F8D0004E98074FD
GO
Isoform 4 (identifier: Q5SWX8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-110: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):47,593
Checksum:i87B8FCD01570C697
GO

Sequence cautioni

The sequence BAB15356 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51E → G in ABF71985 (Ref. 2) Curated1
Sequence conflicti104F → S in ABF71985 (Ref. 2) Curated1
Sequence conflicti158K → E in ABF71985 (Ref. 2) Curated1
Sequence conflicti216E → G in ABF71985 (Ref. 2) Curated1
Sequence conflicti358C → R in ABF71985 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035059251S → C1 PublicationCorresponds to variant dbSNP:rs12084264Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04447879 – 110Missing in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_028098238 – 260Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_028099334 – 335DS → RF in isoform 3. 1 Publication2
Alternative sequenceiVSP_028100336 – 454Missing in isoform 3. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY854248 mRNA Translation: AAW30011.1
DQ323046 mRNA Translation: ABC50092.1
DQ529299 mRNA Translation: ABF71985.1
AK000512 mRNA Translation: BAA91218.1
AK026086 mRNA Translation: BAB15356.1 Different initiation.
AK298107 mRNA Translation: BAG60392.1
AL596220 Genomic DNA No translation available.
BC003397 mRNA Translation: AAH03397.2
AF214011 mRNA Translation: AAL56643.1
CCDSiCCDS53448.1 [Q5SWX8-1]
CCDS53449.1 [Q5SWX8-2]
CCDS53450.1 [Q5SWX8-4]
RefSeqiNP_001157717.1, NM_001164245.1 [Q5SWX8-2]
NP_001157718.1, NM_001164246.1 [Q5SWX8-4]
NP_060317.3, NM_017847.5 [Q5SWX8-1]
XP_011507962.1, XM_011509660.1 [Q5SWX8-1]
UniGeneiHs.371210

Genome annotation databases

EnsembliENST00000287859; ENSP00000287859; ENSG00000157181 [Q5SWX8-1]
ENST00000367470; ENSP00000356440; ENSG00000157181 [Q5SWX8-2]
ENST00000419367; ENSP00000395084; ENSG00000157181 [Q5SWX8-4]
GeneIDi54953
KEGGihsa:54953
UCSCiuc057nzb.1 human [Q5SWX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiODR4_HUMAN
AccessioniPrimary (citable) accession number: Q5SWX8
Secondary accession number(s): B4DNY0
, E9PFR7, Q19CC6, Q8WYB6, Q9BTS2, Q9H6A6, Q9NX06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health