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Protein

Protein odr-4 homolog

Gene

ODR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the trafficking of a subset of G-protein coupled receptors.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odr-4 homolog
Short name:
hODR-4
Alternative name(s):
LAG1-interacting protein
Transactivated by transforming growth factor beta protein 1
Gene namesi
Name:ODR4
Synonyms:C1orf27, TTG1, TTG1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24299. C1orf27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934744.

Polymorphism and mutation databases

BioMutaiODR4.
DMDMi74743951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Protein odr-4 homologPRO_0000304683Add
BLAST

Proteomic databases

EPDiQ5SWX8.
MaxQBiQ5SWX8.
PaxDbiQ5SWX8.
PRIDEiQ5SWX8.

PTM databases

iPTMnetiQ5SWX8.
PhosphoSiteiQ5SWX8.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ5SWX8.
CleanExiHS_C1orf27.
GenevisibleiQ5SWX8. HS.

Organism-specific databases

HPAiHPA015988.
HPA031352.

Interactioni

Protein-protein interaction databases

BioGridi120291. 3 interactions.
IntActiQ5SWX8. 4 interactions.
STRINGi9606.ENSP00000287859.

Structurei

3D structure databases

ProteinModelPortaliQ5SWX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODR-4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4703. Eukaryota.
ENOG410XSI8. LUCA.
GeneTreeiENSGT00390000012568.
HOGENOMiHOG000115259.
HOVERGENiHBG057033.
InParanoidiQ5SWX8.
OMAiRRLMFAV.
OrthoDBiEOG74BJRW.
PhylomeDBiQ5SWX8.
TreeFamiTF323772.

Family and domain databases

InterProiIPR029454. ODR-4-like.
[Graphical view]
PfamiPF14778. ODR4-like. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SWX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRTYIVEET VGQYLSNINL QGKAFVSGLL IGQCSSQKDY VILATRTPPK
60 70 80 90 100
EEQSENLKHP KAKLDNLDEE WATEHACQVS RMLPGGLLVL GVFIITTLEL
110 120 130 140 150
ANDFQNALRR LMFAVEKSIN RKRLWNFTEE EVSERVTLHI CASTKKIFCR
160 170 180 190 200
TYDIHDPKSS ARPADWKYQS GLSSSWLSLE CTVHINIHIP LSATSVSYTL
210 220 230 240 250
EKNTKNGLTR WAKEIENGVY LINGQVKDED CDLLEGQKKS SRGNTQATSH
260 270 280 290 300
SFDVRVLTQL LLNSDHRSTA TVQICSGSVN LKGAVKCRAY IHSSKPKVKD
310 320 330 340 350
AVQAVKRDIL NTVADRCEML FEDLLLNEIP EKKDSEKEFH VLPYRVFVPL
360 370 380 390 400
PGSTVMLCDY KFDDESAEEI RDHFMEMLDH TIQIEDLEIA EETNTACMSS
410 420 430 440 450
SMNSQASLDN TDDEQPKQPI KTTMLLKIQQ NIGVIAAFTV AVLAAGISFH

YFSD
Length:454
Mass (Da):51,103
Last modified:December 21, 2004 - v1
Checksum:i8D59C9136A4ED975
GO
Isoform 2 (identifier: Q5SWX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-260: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):48,560
Checksum:i672FE9694DF8BB95
GO
Isoform 3 (identifier: Q5SWX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-335: DS → RF
     336-454: Missing.

Show »
Length:335
Mass (Da):37,773
Checksum:i9F8D0004E98074FD
GO
Isoform 4 (identifier: Q5SWX8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-110: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):47,593
Checksum:i87B8FCD01570C697
GO

Sequence cautioni

The sequence BAB15356.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511E → G in ABF71985 (Ref. 2) Curated
Sequence conflicti104 – 1041F → S in ABF71985 (Ref. 2) Curated
Sequence conflicti158 – 1581K → E in ABF71985 (Ref. 2) Curated
Sequence conflicti216 – 2161E → G in ABF71985 (Ref. 2) Curated
Sequence conflicti358 – 3581C → R in ABF71985 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511S → C.1 Publication
Corresponds to variant rs12084264 [ dbSNP | Ensembl ].
VAR_035059

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 11032Missing in isoform 4. 1 PublicationVSP_044478Add
BLAST
Alternative sequencei238 – 26023Missing in isoform 2. 1 PublicationVSP_028098Add
BLAST
Alternative sequencei334 – 3352DS → RF in isoform 3. 1 PublicationVSP_028099
Alternative sequencei336 – 454119Missing in isoform 3. 1 PublicationVSP_028100Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY854248 mRNA. Translation: AAW30011.1.
DQ323046 mRNA. Translation: ABC50092.1.
DQ529299 mRNA. Translation: ABF71985.1.
AK000512 mRNA. Translation: BAA91218.1.
AK026086 mRNA. Translation: BAB15356.1. Different initiation.
AK298107 mRNA. Translation: BAG60392.1.
AL596220 Genomic DNA. Translation: CAI13121.1.
BC003397 mRNA. Translation: AAH03397.2.
AF214011 mRNA. Translation: AAL56643.1.
CCDSiCCDS53448.1. [Q5SWX8-1]
CCDS53449.1. [Q5SWX8-2]
CCDS53450.1. [Q5SWX8-4]
RefSeqiNP_001157717.1. NM_001164245.1. [Q5SWX8-2]
NP_001157718.1. NM_001164246.1. [Q5SWX8-4]
NP_060317.3. NM_017847.5. [Q5SWX8-1]
XP_011507962.1. XM_011509660.1. [Q5SWX8-1]
XP_011507964.1. XM_011509662.1. [Q5SWX8-3]
UniGeneiHs.371210.

Genome annotation databases

EnsembliENST00000287859; ENSP00000287859; ENSG00000157181. [Q5SWX8-1]
ENST00000367470; ENSP00000356440; ENSG00000157181. [Q5SWX8-2]
ENST00000419367; ENSP00000395084; ENSG00000157181. [Q5SWX8-4]
GeneIDi54953.
KEGGihsa:54953.
UCSCiuc057nzb.1. human. [Q5SWX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY854248 mRNA. Translation: AAW30011.1.
DQ323046 mRNA. Translation: ABC50092.1.
DQ529299 mRNA. Translation: ABF71985.1.
AK000512 mRNA. Translation: BAA91218.1.
AK026086 mRNA. Translation: BAB15356.1. Different initiation.
AK298107 mRNA. Translation: BAG60392.1.
AL596220 Genomic DNA. Translation: CAI13121.1.
BC003397 mRNA. Translation: AAH03397.2.
AF214011 mRNA. Translation: AAL56643.1.
CCDSiCCDS53448.1. [Q5SWX8-1]
CCDS53449.1. [Q5SWX8-2]
CCDS53450.1. [Q5SWX8-4]
RefSeqiNP_001157717.1. NM_001164245.1. [Q5SWX8-2]
NP_001157718.1. NM_001164246.1. [Q5SWX8-4]
NP_060317.3. NM_017847.5. [Q5SWX8-1]
XP_011507962.1. XM_011509660.1. [Q5SWX8-1]
XP_011507964.1. XM_011509662.1. [Q5SWX8-3]
UniGeneiHs.371210.

3D structure databases

ProteinModelPortaliQ5SWX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120291. 3 interactions.
IntActiQ5SWX8. 4 interactions.
STRINGi9606.ENSP00000287859.

PTM databases

iPTMnetiQ5SWX8.
PhosphoSiteiQ5SWX8.

Polymorphism and mutation databases

BioMutaiODR4.
DMDMi74743951.

Proteomic databases

EPDiQ5SWX8.
MaxQBiQ5SWX8.
PaxDbiQ5SWX8.
PRIDEiQ5SWX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287859; ENSP00000287859; ENSG00000157181. [Q5SWX8-1]
ENST00000367470; ENSP00000356440; ENSG00000157181. [Q5SWX8-2]
ENST00000419367; ENSP00000395084; ENSG00000157181. [Q5SWX8-4]
GeneIDi54953.
KEGGihsa:54953.
UCSCiuc057nzb.1. human. [Q5SWX8-1]

Organism-specific databases

CTDi54953.
GeneCardsiC1orf27.
HGNCiHGNC:24299. C1orf27.
HPAiHPA015988.
HPA031352.
MIMi609335. gene.
neXtProtiNX_Q5SWX8.
PharmGKBiPA134934744.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4703. Eukaryota.
ENOG410XSI8. LUCA.
GeneTreeiENSGT00390000012568.
HOGENOMiHOG000115259.
HOVERGENiHBG057033.
InParanoidiQ5SWX8.
OMAiRRLMFAV.
OrthoDBiEOG74BJRW.
PhylomeDBiQ5SWX8.
TreeFamiTF323772.

Miscellaneous databases

GenomeRNAii54953.
PROiQ5SWX8.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SWX8.
CleanExiHS_C1orf27.
GenevisibleiQ5SWX8. HS.

Family and domain databases

InterProiIPR029454. ODR-4-like.
[Graphical view]
PfamiPF14778. ODR4-like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ubiquitously expressed GPCR membrane-trafficking orthologs."
    Lehman C.W., Lee J.D.R., Komives C.F.
    Genomics 85:386-391(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Cloning of a gene transactivated by recombinant transforming growth factor beta."
    Xiao L., Cheng J., Hong Y.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-454 (ISOFORM 1), VARIANT CYS-251.
    Tissue: Lung and Signet-ring cell carcinoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "Interactors of a human homolog of yeast LAG1 gene."
    Pan H., Huo K.K., Li Y.Y.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-454 (ISOFORMS 1/2).
    Tissue: Brain.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiODR4_HUMAN
AccessioniPrimary (citable) accession number: Q5SWX8
Secondary accession number(s): B4DNY0
, E9PFR7, Q19CC6, Q8WYB6, Q9BTS2, Q9H6A6, Q9NX06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.