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Protein

Solute carrier family 25 member 35

Gene

Slc25a35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 35
Gene namesi
Name:Slc25a35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919248. Slc25a35.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei91 – 11929Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei169 – 19022Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei277 – 30024Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Solute carrier family 25 member 35PRO_0000291795Add
BLAST

Proteomic databases

EPDiQ5SWT3.
MaxQBiQ5SWT3.
PaxDbiQ5SWT3.
PRIDEiQ5SWT3.

Expressioni

Gene expression databases

BgeeiQ5SWT3.
CleanExiMM_SLC25A35.
ExpressionAtlasiQ5SWT3. baseline and differential.
GenevisibleiQ5SWT3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ5SWT3. 2 interactions.
MINTiMINT-4127750.
STRINGi10090.ENSMUSP00000099666.

Structurei

3D structure databases

ProteinModelPortaliQ5SWT3.
SMRiQ5SWT3. Positions 3-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 9090Solcar 1Add
BLAST
Repeati100 – 19394Solcar 2Add
BLAST
Repeati203 – 29492Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0755. Eukaryota.
ENOG410XS37. LUCA.
GeneTreeiENSGT00550000074760.
HOGENOMiHOG000165141.
HOVERGENiHBG108440.
InParanoidiQ5SWT3.
KOiK15117.
OMAiMYRGILD.
OrthoDBiEOG793B7Z.
PhylomeDBiQ5SWT3.
TreeFamiTF324506.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SWT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLMSGVAA CGACVFTNPL EVVKTRMQLQ GELQAPGTYQ RHYRNVFHAF
60 70 80 90 100
FTIGKVDGLA ALQKGLGPAL LYQFLMNGIR LGTYGLAESR GYLHTNEGTH
110 120 130 140 150
SPVRSAAAGA LAGVMGAYLG SPIYMVKTHL QAQAASEIAV GHQYKHQGMF
160 170 180 190 200
QALTEIGQKH GLVGLWRGAV GGLPRVVIGS STQLCTFSSI KDLLSQWEIF
210 220 230 240 250
PPQSWKVALA AAMVSGVAIV VAMTPFDVAS TRLYNQPTDT RGKGLMYRGI
260 270 280 290 300
LDALLQTART EGFFGMYKGI GASYFRLGPH TILSLFFWDQ LRSFYNTYAK
Length:300
Mass (Da):32,631
Last modified:June 26, 2007 - v2
Checksum:iD7D6C151D7ED4AA3
GO

Sequence cautioni

The sequence AAH04569.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI25535.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007453 mRNA. Translation: BAB25048.1.
AK171131 mRNA. Translation: BAE42267.1.
AL603662 Genomic DNA. Translation: CAI25535.1. Sequence problems.
AL603662 Genomic DNA. Translation: CAI25536.1.
BC004569 mRNA. Translation: AAH04569.1. Different initiation.
BC019996 mRNA. Translation: AAH19996.1.
CCDSiCCDS24874.1.
RefSeqiNP_082324.1. NM_028048.2.
XP_006534336.1. XM_006534273.1.
UniGeneiMm.298622.
Mm.371612.

Genome annotation databases

EnsembliENSMUST00000102606; ENSMUSP00000099666; ENSMUSG00000018740.
GeneIDi71998.
KEGGimmu:71998.
UCSCiuc007jop.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007453 mRNA. Translation: BAB25048.1.
AK171131 mRNA. Translation: BAE42267.1.
AL603662 Genomic DNA. Translation: CAI25535.1. Sequence problems.
AL603662 Genomic DNA. Translation: CAI25536.1.
BC004569 mRNA. Translation: AAH04569.1. Different initiation.
BC019996 mRNA. Translation: AAH19996.1.
CCDSiCCDS24874.1.
RefSeqiNP_082324.1. NM_028048.2.
XP_006534336.1. XM_006534273.1.
UniGeneiMm.298622.
Mm.371612.

3D structure databases

ProteinModelPortaliQ5SWT3.
SMRiQ5SWT3. Positions 3-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SWT3. 2 interactions.
MINTiMINT-4127750.
STRINGi10090.ENSMUSP00000099666.

Proteomic databases

EPDiQ5SWT3.
MaxQBiQ5SWT3.
PaxDbiQ5SWT3.
PRIDEiQ5SWT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102606; ENSMUSP00000099666; ENSMUSG00000018740.
GeneIDi71998.
KEGGimmu:71998.
UCSCiuc007jop.1. mouse.

Organism-specific databases

CTDi399512.
MGIiMGI:1919248. Slc25a35.

Phylogenomic databases

eggNOGiKOG0755. Eukaryota.
ENOG410XS37. LUCA.
GeneTreeiENSGT00550000074760.
HOGENOMiHOG000165141.
HOVERGENiHBG108440.
InParanoidiQ5SWT3.
KOiK15117.
OMAiMYRGILD.
OrthoDBiEOG793B7Z.
PhylomeDBiQ5SWT3.
TreeFamiTF324506.

Miscellaneous databases

ChiTaRSiSlc25a35. mouse.
PROiQ5SWT3.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SWT3.
CleanExiMM_SLC25A35.
ExpressionAtlasiQ5SWT3. baseline and differential.
GenevisibleiQ5SWT3. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Lung, Pancreas and Testis.

Entry informationi

Entry nameiS2535_MOUSE
AccessioniPrimary (citable) accession number: Q5SWT3
Secondary accession number(s): Q3TBP2, Q99KM5, Q9D913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: June 8, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.