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Protein

Centrosomal protein of 170 kDa

Gene

CEP170

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in microtubule organization.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 170 kDa
Short name:
Cep170
Alternative name(s):
KARP-1-binding protein
Short name:
KARP1-binding protein
Gene namesi
Name:CEP170
Synonyms:FAM68A, KAB, KIAA0470
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28920. CEP170.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • microtubule Source: UniProtKB-KW
  • nuclear membrane Source: HPA
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi9859.
OpenTargetsiENSG00000143702.
ENSG00000276725.
PharmGKBiPA128395757.

Polymorphism and mutation databases

BioMutaiCEP170.
DMDMi74743919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828871 – 1584Centrosomal protein of 170 kDaAdd BLAST1584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei364PhosphotyrosineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei497PhosphoserineCombined sources1
Modified residuei501PhosphothreonineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei644PhosphothreonineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei760PhosphothreonineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei881PhosphoserineCombined sources1
Modified residuei914PhosphothreonineCombined sources1
Modified residuei920PhosphothreonineCombined sources1
Modified residuei930PhosphoserineCombined sources1
Modified residuei933PhosphoserineCombined sources1
Modified residuei958PhosphoserineCombined sources1
Modified residuei1019PhosphoserineBy similarity1
Modified residuei1023PhosphothreonineBy similarity1
Modified residuei1058PhosphothreonineCombined sources1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1112PhosphoserineCombined sources1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1132PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1198PhosphoserineCombined sources1
Modified residuei1205PhosphoserineCombined sources1
Modified residuei1210PhosphoserineCombined sources1
Modified residuei1239PhosphoserineBy similarity1
Modified residuei1241PhosphoserineCombined sources1
Modified residuei1251PhosphoserineCombined sources1
Modified residuei1270PhosphoserineCombined sources1
Modified residuei1280PhosphoserineCombined sources1
Modified residuei1362PhosphoserineCombined sources1
Modified residuei1521PhosphoserineBy similarity1
Modified residuei1522PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated; probably by PLK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5SW79.
MaxQBiQ5SW79.
PaxDbiQ5SW79.
PeptideAtlasiQ5SW79.
PRIDEiQ5SW79.

PTM databases

iPTMnetiQ5SW79.
PhosphoSitePlusiQ5SW79.

Miscellaneous databases

PMAP-CutDBQ5SW79.

Expressioni

Gene expression databases

BgeeiENSG00000143702.
CleanExiHS_CEP170.
ExpressionAtlasiQ5SW79. baseline and differential.
GenevisibleiQ5SW79. HS.

Organism-specific databases

HPAiHPA042151.
HPA045787.

Interactioni

Subunit structurei

Interacts with PLK1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
vprP125204EBI-1104799,EBI-6164519From a different organism.

Protein-protein interaction databases

BioGridi115193. 186 interactors.
DIPiDIP-37594N.
IntActiQ5SW79. 156 interactors.
MINTiMINT-1790395.
STRINGi9606.ENSP00000355500.

Structurei

Secondary structure

11584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 10Combined sources9
Beta strandi15 – 17Combined sources3
Beta strandi23 – 29Combined sources7
Beta strandi31 – 33Combined sources3
Beta strandi44 – 49Combined sources6
Turni50 – 53Combined sources4
Beta strandi54 – 59Combined sources6
Beta strandi66 – 68Combined sources3
Beta strandi86 – 89Combined sources4
Beta strandi96 – 104Combined sources9
Helixi107 – 111Combined sources5
Helixi113 – 120Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JONX-ray2.15A/B/C/D/E1-126[»]
ProteinModelPortaliQ5SW79.
SMRiQ5SW79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 73FHAPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni853 – 1584Targeting to microtubulesAdd BLAST732
Regioni1113 – 1584Targeting to centrosomesAdd BLAST472

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1467 – 1495Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the CEP170 family.Curated
Contains 1 FHA domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6S. Eukaryota.
ENOG4110JY6. LUCA.
GeneTreeiENSGT00640000091476.
HOVERGENiHBG058059.
InParanoidiQ5SW79.
KOiK16463.
OMAiTEVQHKP.
OrthoDBiEOG091G00LH.
PhylomeDBiQ5SW79.
TreeFamiTF328469.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR026644. CEP170.
IPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR15715:SF17. PTHR15715:SF17. 3 hits.
PfamiPF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SW79-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA
60 70 80 90 100
STDEHLVKDL GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVQ
110 120 130 140 150
GEMRVPEEAL KHEKFTIQLQ LSQKSSESEL SKSASAKSID SKVADAATEV
160 170 180 190 200
QHKTTEALKS EEKAMDISAM PRGTPLYGQP SWWGDDEVDE KRAFKTNGKP
210 220 230 240 250
EEKNHEAGTS GCGIDAKQVE EQSAAANEEV LFPFCREPSY FEIPTKEFQQ
260 270 280 290 300
PSQITESTIH EIPTKDTPSS HITGAGHASF TIEFDDSTPG KVTIRDHVTK
310 320 330 340 350
FTSDQRHKSK KSSPGTQDLL GIQTGMMAPE NKVADWLAQN NPPQMLWERT
360 370 380 390 400
EEDSKSIKSD VPVYLKRLKG NKHDDGTQSD SENAGAHRRC SKRATLEEHL
410 420 430 440 450
RRHHSEHKKL QKVQATEKHQ DQAVTSSAHH RGGHGVPHGK LLKQKSEEPS
460 470 480 490 500
VSIPFLQTAL LRSSGSLGHR PSQEMDKMLK NQATSATSEK DNDDDQSDKG
510 520 530 540 550
TYTIELENPN SEEVEARKMI DKVFGVDDNQ DYNRPVINEK HKDLIKDWAL
560 570 580 590 600
SSAAAVMEER KPLTTSGFHH SEEGTSSSGS KRWVSQWASL AANHTRHDQE
610 620 630 640 650
ERIMEFSAPL PLENETEISE SGMTVRSTGS ATSLASQGER RRRTLPQLPN
660 670 680 690 700
EEKSLESHRA KVVTQRSEIG EKQDTELQEK ETPTQVYQKD KQDADRPLSK
710 720 730 740 750
MNRAVNGETL KTGGDNKTLL HLGSSAPGKE KSETDKETSL VKQTLAKLQQ
760 770 780 790 800
QEQREEAQWT PTKLSSKNVS GQTDKCREET FKQESQPPEK NSGHSTSKGD
810 820 830 840 850
RVAQSESKRR KAEEILKSQT PKGGDKKESS KSLVRQGSFT IEKPSPNIPI
860 870 880 890 900
ELIPHINKQT SSTPSSLALT SASRIRERSE SLDPDSSMDT TLILKDTEAV
910 920 930 940 950
MAFLEAKLRE DNKTDEGPDT PSYNRDNSIS PESDVDTAST ISLVTGETER
960 970 980 990 1000
KSTQKRKSFT SLYKDRCSTG SPSKDVTKSS SSGAREKMEK KTKSRSTDVG
1010 1020 1030 1040 1050
SRADGRKFVQ SSGRIRQPSV DLTDDDQTSS VPHSAISDIM SSDQETYSCK
1060 1070 1080 1090 1100
PHGRTPLTSA DEHVHSKLEG SKVTKSKTSP VVSGSSSKST TLPRPRPTRT
1110 1120 1130 1140 1150
SLLRRARLGE ASDSELADAD KASVASEVST TSSTSKPPTG RRNISRIDLL
1160 1170 1180 1190 1200
AQPRRTRLGS LSARSDSEAT ISRSSASSRT AEAIIRSGAR LVPSDKFSPR
1210 1220 1230 1240 1250
IRANSISRLS DSKVKSMTSA HGSASVNSRW RRFPTDYAST SEDEFGSNRN
1260 1270 1280 1290 1300
SPKHTRLRTS PALKTTRLQS AGSAMPTSSS FKHRIKEQED YIRDWTAHRE
1310 1320 1330 1340 1350
EIARISQDLA LIAREINDVA GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT
1360 1370 1380 1390 1400
REELVDRVFD ESLNFRKIPP LVHSKTPEGN NGRSGDPRPQ AAEPPDHLTI
1410 1420 1430 1440 1450
TRRRTWSRDE VMGDNLLLSS VFQFSKKIRQ SIDKTAGKIR ILFKDKDRNW
1460 1470 1480 1490 1500
DDIESKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQAI NAMIDPDGTL
1510 1520 1530 1540 1550
EALNNMGFPS AMLPSPPKQK SSPVNNHHSP GQTPTLGQPE ARALHPAAVS
1560 1570 1580
AAAEFENAES EADFSIHFNR FNPDGEEEDV TVQE
Length:1,584
Mass (Da):175,293
Last modified:December 21, 2004 - v1
Checksum:i50E981650D21B2E6
GO
Isoform 2 (identifier: Q5SW79-2) [UniParc]FASTAAdd to basket
Also known as: Gamma, 3

The sequence of this isoform differs from the canonical sequence as follows:
     425-522: Missing.
     1226-1261: Missing.
     1353-1353: E → EVGDLHGEMHK

Show »
Length:1,460
Mass (Da):161,408
Checksum:i4EEECA047C7B0EFA
GO
Isoform 3 (identifier: Q5SW79-3) [UniParc]FASTAAdd to basket
Also known as: Beta, KAB2

The sequence of this isoform differs from the canonical sequence as follows:
     425-522: Missing.

Show »
Length:1,486
Mass (Da):164,539
Checksum:i376DEE4949EC24D1
GO

Sequence cautioni

The sequence BAA32315 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031437213G → S.3 PublicationsCorresponds to variant rs2631092dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024240425 – 522Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST98
Alternative sequenceiVSP_0242411226 – 1261Missing in isoform 2. 3 PublicationsAdd BLAST36
Alternative sequenceiVSP_0242421353E → EVGDLHGEMHK in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022657 mRNA. Translation: BAA83378.1.
AB022658 mRNA. Translation: BAA83379.1.
AB022659 mRNA. Translation: BAA83380.1.
AB007939 mRNA. Translation: BAA32315.2. Different initiation.
AL606534, AC092782 Genomic DNA. Translation: CAI12943.1.
AL606534, AC092782 Genomic DNA. Translation: CAI12944.1.
AL606534, AC092782 Genomic DNA. Translation: CAI12945.1.
BC050722 mRNA. Translation: AAH50722.1. Different termination.
CCDSiCCDS44337.1. [Q5SW79-3]
CCDS44338.1. [Q5SW79-2]
CCDS44339.1. [Q5SW79-1]
PIRiT00095.
RefSeqiNP_001035863.1. NM_001042404.1. [Q5SW79-3]
NP_001035864.1. NM_001042405.1. [Q5SW79-2]
NP_055627.2. NM_014812.2. [Q5SW79-1]
XP_016858425.1. XM_017002936.1. [Q5SW79-1]
UniGeneiHs.533635.

Genome annotation databases

EnsembliENST00000366542; ENSP00000355500; ENSG00000143702. [Q5SW79-1]
ENST00000366543; ENSP00000355501; ENSG00000143702. [Q5SW79-2]
ENST00000366544; ENSP00000355502; ENSG00000143702. [Q5SW79-3]
ENST00000450306; ENSP00000482707; ENSG00000276725. [Q5SW79-3]
ENST00000612450; ENSP00000483344; ENSG00000276725. [Q5SW79-1]
ENST00000621831; ENSP00000484359; ENSG00000276725. [Q5SW79-2]
GeneIDi9859.
KEGGihsa:9859.
UCSCiuc057qug.1. human. [Q5SW79-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022657 mRNA. Translation: BAA83378.1.
AB022658 mRNA. Translation: BAA83379.1.
AB022659 mRNA. Translation: BAA83380.1.
AB007939 mRNA. Translation: BAA32315.2. Different initiation.
AL606534, AC092782 Genomic DNA. Translation: CAI12943.1.
AL606534, AC092782 Genomic DNA. Translation: CAI12944.1.
AL606534, AC092782 Genomic DNA. Translation: CAI12945.1.
BC050722 mRNA. Translation: AAH50722.1. Different termination.
CCDSiCCDS44337.1. [Q5SW79-3]
CCDS44338.1. [Q5SW79-2]
CCDS44339.1. [Q5SW79-1]
PIRiT00095.
RefSeqiNP_001035863.1. NM_001042404.1. [Q5SW79-3]
NP_001035864.1. NM_001042405.1. [Q5SW79-2]
NP_055627.2. NM_014812.2. [Q5SW79-1]
XP_016858425.1. XM_017002936.1. [Q5SW79-1]
UniGeneiHs.533635.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JONX-ray2.15A/B/C/D/E1-126[»]
ProteinModelPortaliQ5SW79.
SMRiQ5SW79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115193. 186 interactors.
DIPiDIP-37594N.
IntActiQ5SW79. 156 interactors.
MINTiMINT-1790395.
STRINGi9606.ENSP00000355500.

PTM databases

iPTMnetiQ5SW79.
PhosphoSitePlusiQ5SW79.

Polymorphism and mutation databases

BioMutaiCEP170.
DMDMi74743919.

Proteomic databases

EPDiQ5SW79.
MaxQBiQ5SW79.
PaxDbiQ5SW79.
PeptideAtlasiQ5SW79.
PRIDEiQ5SW79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366542; ENSP00000355500; ENSG00000143702. [Q5SW79-1]
ENST00000366543; ENSP00000355501; ENSG00000143702. [Q5SW79-2]
ENST00000366544; ENSP00000355502; ENSG00000143702. [Q5SW79-3]
ENST00000450306; ENSP00000482707; ENSG00000276725. [Q5SW79-3]
ENST00000612450; ENSP00000483344; ENSG00000276725. [Q5SW79-1]
ENST00000621831; ENSP00000484359; ENSG00000276725. [Q5SW79-2]
GeneIDi9859.
KEGGihsa:9859.
UCSCiuc057qug.1. human. [Q5SW79-1]

Organism-specific databases

CTDi9859.
DisGeNETi9859.
GeneCardsiCEP170.
H-InvDBHIX0004456.
HGNCiHGNC:28920. CEP170.
HPAiHPA042151.
HPA045787.
MIMi613023. gene.
neXtProtiNX_Q5SW79.
OpenTargetsiENSG00000143702.
ENSG00000276725.
PharmGKBiPA128395757.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II6S. Eukaryota.
ENOG4110JY6. LUCA.
GeneTreeiENSGT00640000091476.
HOVERGENiHBG058059.
InParanoidiQ5SW79.
KOiK16463.
OMAiTEVQHKP.
OrthoDBiEOG091G00LH.
PhylomeDBiQ5SW79.
TreeFamiTF328469.

Miscellaneous databases

GeneWikiiCEP170.
GenomeRNAii9859.
PMAP-CutDBQ5SW79.
PROiQ5SW79.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143702.
CleanExiHS_CEP170.
ExpressionAtlasiQ5SW79. baseline and differential.
GenevisibleiQ5SW79. HS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR026644. CEP170.
IPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR15715:SF17. PTHR15715:SF17. 3 hits.
PfamiPF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCE170_HUMAN
AccessioniPrimary (citable) accession number: Q5SW79
Secondary accession number(s): O75058
, Q5SW77, Q5SW78, Q7LGA9, Q86W31, Q9UQ08, Q9UQ09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.