Q5SW75 (SSH2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase Slingshot homolog 2
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
SSH-like protein 2
Short name=SSH-2L
Short name=mSSH-2L

Gene names

Name:	Ssh2
Synonyms:	Kiaa1725, Ssh2l

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1423 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Ref.1
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subunit structure	Interacts with filamentous actin. Ref.1
Subcellular location	Cytoplasm › cytoskeleton. Cell junction › focal adhesion. Note: Colocalizes with filamentous actin in the cytoplasm and the cell periphery. Also localizes to focal adhesions. Ref.1
Tissue specificity	Expressed in brain, heart, liver, skeletal muscle, testis and thymus. Also expressed at lower levels in kidney, small intestine and spleen. Ref.1
Developmental stage	Expressed in the nervous system at E14.5. Ref.1
Miscellaneous	Tyrosine phosphatase activity has not been demonstrated for this protein to date.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.
Sequence caution	The sequence BAE41593.1 differs from that shown. Reason: Intron retention. The sequence CAI24907.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI35940.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI51882.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing
Ligand	Actin-binding
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: Compara peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC regulation of actin polymerization or depolymerization Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of axonogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of lamellipodium assembly Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro actin binding Inferred from Biological aspect of Ancestor. Source: RefGenome protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SW75-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SW75-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MALVTVQRSP...EEECRSQPRS → MTLSTLAGER...VISQNAINQL

Isoform 3 (identifier: Q5SW75-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MALVTVQRSP...EEECRSQPRS → MTLSTLAGER...VISQNAINQL
     133-133: S → R
     134-1423: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5SW75-4)

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: S → SSSYLEDSESAALLCCEYGESEIFSDFN

Note: Gene prediction based on EST data. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1423	1423	Protein phosphatase Slingshot homolog 2		PRO_0000094844
Regions
	Domain	307 – 447	141	Tyrosine-protein phosphatase
Sites
	Active site	392	1	Phosphocysteine intermediate Probable
Amino acid modifications
	Modified residue	36	1	Phosphoserine By similarity
	Modified residue	487	1	Phosphoserine By similarity
	Modified residue	1422	1	Phosphothreonine Ref.6
Natural variations
	Alternative sequence	1 – 36	36	MALVT…SQPRS → MTLSTLAGERKALPASTCSL GGPDMIPYFSANAVISQNAI NQL in isoform 2 and isoform 3.		VSP_016326
	Alternative sequence	21	1	S → SSSYLEDSESAALLCCEYGE SEIFSDFN in isoform 4.		VSP_016327
	Alternative sequence	133	1	S → R in isoform 3.		VSP_016328
	Alternative sequence	134 – 1423	1290	Missing in isoform 3.		VSP_016329
Experimental info
	Mutagenesis	392	1	C → S: Abrogates phosphatase activity. Ref.1
	Sequence conflict	133	1	Missing in BAE33137. Ref.2
	Sequence conflict	325	1	N → D in BAE41593. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 15, 2005. Version 2. Checksum: 7F2608E87A72BAFD	FASTA	1,423	158,230
	10 20 30 40 50 60 MALVTVQRSP TPSTTSSPCA SEADSGEEEC RSQPRSISES FLTVKGAALF LPRGNGSSTP 70 80 90 100 110 120 RVSHRRNKHA GDLQQHLQAM FILLRPEDNI RLAVRLESTY QNRTRYMVVV STNGRQDTEE 130 140 150 160 170 180 SIVLGMDFSS NDSSTCTMGL VLPLWSDTLI HLDGDGGFSV STDNRVHIFK PVSVQAMWSA 190 200 210 220 230 240 LQSLHKACEV ARMHNYYPGS LFLTWVSYYE SHINSDQSSV NEWNAMQDVQ SHRPDSPALF 250 260 270 280 290 300 TDIPTERERT ERLIKTKLRE IMMQKDLENI TSKEIRTELE MQMVCNLREF KEFIDNEMIV 310 320 330 340 350 360 ILGQMDSPTQ IFEHVFLGSE WNASNLEDLQ NRGVRYILNV TREIDNFFPG VFEYHNIRVY 370 380 390 400 410 420 DEEATDLLAY WNDTYKFISK AKKHGSKCLV HCKMGVSRSA STVIAYAMKE YGWNLDRAYD 430 440 450 460 470 480 YVKERRTVTK PNPSFMRQLE EYQGILLASK QRHNKLWRSH SDSDLSDHHE PICKPGLELN 490 500 510 520 530 540 KKEMTTSADQ IAEVKTVENL AAMPTVFMEH VVPQDANQKG LHTKERVICL EFSSQEFRAG 550 560 570 580 590 600 QIEDELNLND INGCSSGCCL SESKLPLDNC HASKALLQPG QAPDIANKFP DLAVEDLETD 610 620 630 640 650 660 ALKADMNVHL LPMEELTSRL KDLPMSPDLE SPSPQASCQA AISDFSTDRI DFFSALEKFV 670 680 690 700 710 720 ELSQETRSRS FSHSRIEELG GGRSEGCRLS VIEVAASEMA ADDQRSSSLS NTPHASEESS 730 740 750 760 770 780 VDEDQSKAIT ELVSPDIIMQ SHSENAISVK EIVTEIESIS QGVGQVQLKG DILSNPCHTP 790 800 810 820 830 840 KKSTIHELPL ERVPAPESKP GHWEQDESFC SVQPELARDS GKCAPEEGCL TTHSSTADLE 850 860 870 880 890 900 EEEPVEGEHD WGPGMHSGAK WCPGSVRRAT LEFEERLRQE QENHGTASAG PTLSNRKNSK 910 920 930 940 950 960 NDSSVADLMP KWKSDETTPE HSFFLKEAEP SKGKGKCSGS EAGSLSHCER NPTMPDCELL 970 980 990 1000 1010 1020 EHHSLPAPQD CLGSDSRSKK QEGDLKKQRA VVPNQECDTQ AILLPLPKKI EIIEYTPTVT 1030 1040 1050 1060 1070 1080 SLGHTEPGGE ATPSKEGEKQ GLRKVKMEQS ITMFCALDEN LNRTLEPSQV SLHPQVLPLP 1090 1100 1110 1120 1130 1140 HSSSECDRPA DPNPMLSSPQ DKGDCPSTPF KTAAPFVSCS TQGASFSLDY LLPHSVVHLE 1150 1160 1170 1180 1190 1200 GCTEQSSATD NELSPEQASW EDSRGHFLSS GSGMAHTSSP LTNEDLSLIN KLGDSVGVLQ 1210 1220 1230 1240 1250 1260 KKLDPSPEAC RIPHSSSSEN IRDLSHSRGV VKEHAKEIES RVIFQAGFSK TSQMKRSASL 1270 1280 1290 1300 1310 1320 AKLGYLDLCK DYLPDRELVS SESPHLKLLQ PFLRTDSGMH ALMAHEPSES AGAQQNPQPT 1330 1340 1350 1360 1370 1380 KYSVEQLKTS ECIVQSKPVE RPSVQYAKEF GYSQQCLLPK ARPELTSSEG GLPLLQTQGL 1390 1400 1410 1420 QYTGPSPGLA VAPRQQHGRT HPLRRLKRAN DKKRTTNPFY NTM
	Isoform 2 [UniParc]. Checksum: DC554069F95CD99D	FASTA	1,430	158,900
	10 20 30 40 50 60 MTLSTLAGER KALPASTCSL GGPDMIPYFS ANAVISQNAI NQLISESFLT VKGAALFLPR 70 80 90 100 110 120 GNGSSTPRVS HRRNKHAGDL QQHLQAMFIL LRPEDNIRLA VRLESTYQNR TRYMVVVSTN 130 140 150 160 170 180 GRQDTEESIV LGMDFSSNDS STCTMGLVLP LWSDTLIHLD GDGGFSVSTD NRVHIFKPVS 190 200 210 220 230 240 VQAMWSALQS LHKACEVARM HNYYPGSLFL TWVSYYESHI NSDQSSVNEW NAMQDVQSHR 250 260 270 280 290 300 PDSPALFTDI PTERERTERL IKTKLREIMM QKDLENITSK EIRTELEMQM VCNLREFKEF 310 320 330 340 350 360 IDNEMIVILG QMDSPTQIFE HVFLGSEWNA SNLEDLQNRG VRYILNVTRE IDNFFPGVFE 370 380 390 400 410 420 YHNIRVYDEE ATDLLAYWND TYKFISKAKK HGSKCLVHCK MGVSRSASTV IAYAMKEYGW 430 440 450 460 470 480 NLDRAYDYVK ERRTVTKPNP SFMRQLEEYQ GILLASKQRH NKLWRSHSDS DLSDHHEPIC 490 500 510 520 530 540 KPGLELNKKE MTTSADQIAE VKTVENLAAM PTVFMEHVVP QDANQKGLHT KERVICLEFS 550 560 570 580 590 600 SQEFRAGQIE DELNLNDING CSSGCCLSES KLPLDNCHAS KALLQPGQAP DIANKFPDLA 610 620 630 640 650 660 VEDLETDALK ADMNVHLLPM EELTSRLKDL PMSPDLESPS PQASCQAAIS DFSTDRIDFF 670 680 690 700 710 720 SALEKFVELS QETRSRSFSH SRIEELGGGR SEGCRLSVIE VAASEMAADD QRSSSLSNTP 730 740 750 760 770 780 HASEESSVDE DQSKAITELV SPDIIMQSHS ENAISVKEIV TEIESISQGV GQVQLKGDIL 790 800 810 820 830 840 SNPCHTPKKS TIHELPLERV PAPESKPGHW EQDESFCSVQ PELARDSGKC APEEGCLTTH 850 860 870 880 890 900 SSTADLEEEE PVEGEHDWGP GMHSGAKWCP GSVRRATLEF EERLRQEQEN HGTASAGPTL 910 920 930 940 950 960 SNRKNSKNDS SVADLMPKWK SDETTPEHSF FLKEAEPSKG KGKCSGSEAG SLSHCERNPT 970 980 990 1000 1010 1020 MPDCELLEHH SLPAPQDCLG SDSRSKKQEG DLKKQRAVVP NQECDTQAIL LPLPKKIEII 1030 1040 1050 1060 1070 1080 EYTPTVTSLG HTEPGGEATP SKEGEKQGLR KVKMEQSITM FCALDENLNR TLEPSQVSLH 1090 1100 1110 1120 1130 1140 PQVLPLPHSS SECDRPADPN PMLSSPQDKG DCPSTPFKTA APFVSCSTQG ASFSLDYLLP 1150 1160 1170 1180 1190 1200 HSVVHLEGCT EQSSATDNEL SPEQASWEDS RGHFLSSGSG MAHTSSPLTN EDLSLINKLG 1210 1220 1230 1240 1250 1260 DSVGVLQKKL DPSPEACRIP HSSSSENIRD LSHSRGVVKE HAKEIESRVI FQAGFSKTSQ 1270 1280 1290 1300 1310 1320 MKRSASLAKL GYLDLCKDYL PDRELVSSES PHLKLLQPFL RTDSGMHALM AHEPSESAGA 1330 1340 1350 1360 1370 1380 QQNPQPTKYS VEQLKTSECI VQSKPVERPS VQYAKEFGYS QQCLLPKARP ELTSSEGGLP 1390 1400 1410 1420 1430 LLQTQGLQYT GPSPGLAVAP RQQHGRTHPL RRLKRANDKK RTTNPFYNTM
	Isoform 3 [UniParc]. Checksum: 05F40C9021BA2B9D	FASTA	140	15,439
	10 20 30 40 50 60 MTLSTLAGER KALPASTCSL GGPDMIPYFS ANAVISQNAI NQLISESFLT VKGAALFLPR 70 80 90 100 110 120 GNGSSTPRVS HRRNKHAGDL QQHLQAMFIL LRPEDNIRLA VRLESTYQNR TRYMVVVSTN 130 140 GRQDTEESIV LGMDFSSNDR
	Isoform 4 [UniParc]. Checksum: A76802D4C70636BF	FASTA	1,450	161,221
	10 20 30 40 50 60 MALVTVQRSP TPSTTSSPCA SSSYLEDSES AALLCCEYGE SEIFSDFNEA DSGEEECRSQ 70 80 90 100 110 120 PRSISESFLT VKGAALFLPR GNGSSTPRVS HRRNKHAGDL QQHLQAMFIL LRPEDNIRLA 130 140 150 160 170 180 VRLESTYQNR TRYMVVVSTN GRQDTEESIV LGMDFSSNDS STCTMGLVLP LWSDTLIHLD 190 200 210 220 230 240 GDGGFSVSTD NRVHIFKPVS VQAMWSALQS LHKACEVARM HNYYPGSLFL TWVSYYESHI 250 260 270 280 290 300 NSDQSSVNEW NAMQDVQSHR PDSPALFTDI PTERERTERL IKTKLREIMM QKDLENITSK 310 320 330 340 350 360 EIRTELEMQM VCNLREFKEF IDNEMIVILG QMDSPTQIFE HVFLGSEWNA SNLEDLQNRG 370 380 390 400 410 420 VRYILNVTRE IDNFFPGVFE YHNIRVYDEE ATDLLAYWND TYKFISKAKK HGSKCLVHCK 430 440 450 460 470 480 MGVSRSASTV IAYAMKEYGW NLDRAYDYVK ERRTVTKPNP SFMRQLEEYQ GILLASKQRH 490 500 510 520 530 540 NKLWRSHSDS DLSDHHEPIC KPGLELNKKE MTTSADQIAE VKTVENLAAM PTVFMEHVVP 550 560 570 580 590 600 QDANQKGLHT KERVICLEFS SQEFRAGQIE DELNLNDING CSSGCCLSES KLPLDNCHAS 610 620 630 640 650 660 KALLQPGQAP DIANKFPDLA VEDLETDALK ADMNVHLLPM EELTSRLKDL PMSPDLESPS 670 680 690 700 710 720 PQASCQAAIS DFSTDRIDFF SALEKFVELS QETRSRSFSH SRIEELGGGR SEGCRLSVIE 730 740 750 760 770 780 VAASEMAADD QRSSSLSNTP HASEESSVDE DQSKAITELV SPDIIMQSHS ENAISVKEIV 790 800 810 820 830 840 TEIESISQGV GQVQLKGDIL SNPCHTPKKS TIHELPLERV PAPESKPGHW EQDESFCSVQ 850 860 870 880 890 900 PELARDSGKC APEEGCLTTH SSTADLEEEE PVEGEHDWGP GMHSGAKWCP GSVRRATLEF 910 920 930 940 950 960 EERLRQEQEN HGTASAGPTL SNRKNSKNDS SVADLMPKWK SDETTPEHSF FLKEAEPSKG 970 980 990 1000 1010 1020 KGKCSGSEAG SLSHCERNPT MPDCELLEHH SLPAPQDCLG SDSRSKKQEG DLKKQRAVVP 1030 1040 1050 1060 1070 1080 NQECDTQAIL LPLPKKIEII EYTPTVTSLG HTEPGGEATP SKEGEKQGLR KVKMEQSITM 1090 1100 1110 1120 1130 1140 FCALDENLNR TLEPSQVSLH PQVLPLPHSS SECDRPADPN PMLSSPQDKG DCPSTPFKTA 1150 1160 1170 1180 1190 1200 APFVSCSTQG ASFSLDYLLP HSVVHLEGCT EQSSATDNEL SPEQASWEDS RGHFLSSGSG 1210 1220 1230 1240 1250 1260 MAHTSSPLTN EDLSLINKLG DSVGVLQKKL DPSPEACRIP HSSSSENIRD LSHSRGVVKE 1270 1280 1290 1300 1310 1320 HAKEIESRVI FQAGFSKTSQ MKRSASLAKL GYLDLCKDYL PDRELVSSES PHLKLLQPFL 1330 1340 1350 1360 1370 1380 RTDSGMHALM AHEPSESAGA QQNPQPTKYS VEQLKTSECI VQSKPVERPS VQYAKEFGYS 1390 1400 1410 1420 1430 1440 QQCLLPKARP ELTSSEGGLP LLQTQGLQYT GPSPGLAVAP RQQHGRTHPL RRLKRANDKK 1450 RTTNPFYNTM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin." Ohta Y., Kousaka K., Nagata-Ohashi K., Ohashi K., Muramoto A., Shima Y., Niwa R., Uemura T., Mizuno K. Genes Cells 8:811-824(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ACTIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF CYS-392. Tissue: Kidney.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: NOD.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 371-1423 (ISOFORMS 1/2). Tissue: Brain.
[6]	"Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1422, MASS SPECTROMETRY. Tissue: Embryonic brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB099288 mRNA. Translation: BAC97811.1. AK155232 mRNA. Translation: BAE33137.1. AK158449 mRNA. Translation: BAE34514.1. AK170142 mRNA. Translation: BAE41593.1. Sequence problems. AL606724, AL607072, AL663066 Genomic DNA. Translation: CAI24906.2. AL606724, AL663066 Genomic DNA. Translation: CAI24907.1. Sequence problems. AL663066, AL606724, AL607072 Genomic DNA. Translation: CAI35939.2. AL663066, AL606724 Genomic DNA. Translation: CAI35940.1. Sequence problems. AL606724 Genomic DNA. Translation: CAI51882.1. Sequence problems. AL607072, AL606724, AL663066 Genomic DNA. Translation: CAI52040.1. BC141392 mRNA. Translation: AAI41393.1. BC141393 mRNA. Translation: AAI41394.1. AK173243 mRNA. Translation: BAD32521.1.
IPI	IPI00223805. IPI00553668. IPI00649165. IPI00656233.
RefSeq	NP_808378.2. NM_177710.4.
UniGene	Mm.440381.
3D structure databases
ProteinModelPortal	Q5SW75.
SMR	Q5SW75. Positions 307-448.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000104034.
PTM databases
PhosphoSite	Q5SW75.
Proteomic databases
PaxDb	Q5SW75.
PRIDE	Q5SW75.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000037912; ENSMUSP00000042625; ENSMUSG00000037926. ENSMUST00000156488; ENSMUSP00000119681; ENSMUSG00000037926. ENSMUST00000181283; ENSMUSP00000137933; ENSMUSG00000037926.
GeneID	237860.
KEGG	mmu:237860.
UCSC	uc007kgl.1. mouse. uc007kgo.1. mouse.
Organism-specific databases
CTD	85464.
MGI	MGI:2679255. Ssh2.
Rouge	Search...
Phylogenomic databases
eggNOG	COG2453.
GeneTree	ENSGT00700000104026.
HOVERGEN	HBG094002.
KO	K05766.
OMA	KHGSKCL.
OrthoDB	EOG4ZGPBG.
Gene expression databases
Bgee	Q5SW75.
CleanEx	MM_SSH2.
Genevestigator	Q5SW75.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR014876. DEK_C. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR009057. Homeodomain-like. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF08766. DEK_C. 1 hit. PF00782. DSPc. 1 hit. [Graphical view]
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	383532.
SOURCE	Search...

Entry information

Entry name

SSH2_MOUSE

Accession

Primary (citable) accession number: Q5SW75
Secondary accession number(s): B9EJ94 , Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	March 15, 2005
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program