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Q5SW75

- SSH2_MOUSE

UniProt

Q5SW75 - SSH2_MOUSE

Protein

Protein phosphatase Slingshot homolog 2

Gene

Ssh2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei392 – 3921Phosphocysteine intermediateCurated

    GO - Molecular functioni

    1. actin binding Source: RefGenome
    2. DNA binding Source: InterPro
    3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. protein dephosphorylation Source: RefGenome
    3. regulation of actin polymerization or depolymerization Source: RefGenome
    4. regulation of axonogenesis Source: RefGenome
    5. regulation of lamellipodium assembly Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase Slingshot homolog 2 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    SSH-like protein 2
    Short name:
    SSH-2L
    Short name:
    mSSH-2L
    Gene namesi
    Name:Ssh2
    Synonyms:Kiaa1725, Ssh2l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2679255. Ssh2.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cell junctionfocal adhesion 1 Publication
    Note: Colocalizes with filamentous actin in the cytoplasm and the cell periphery. Also localizes to focal adhesions.

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytoskeleton Source: UniProtKB-SubCell
    3. focal adhesion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi392 – 3921C → S: Abrogates phosphatase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14231423Protein phosphatase Slingshot homolog 2PRO_0000094844Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei36 – 361PhosphoserineBy similarity
    Modified residuei487 – 4871PhosphoserineBy similarity
    Modified residuei1422 – 14221PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5SW75.
    PRIDEiQ5SW75.

    PTM databases

    PhosphoSiteiQ5SW75.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, liver, skeletal muscle, testis and thymus. Also expressed at lower levels in kidney, small intestine and spleen.1 Publication

    Developmental stagei

    Expressed in the nervous system at E14.5.1 Publication

    Gene expression databases

    BgeeiQ5SW75.
    CleanExiMM_SSH2.
    GenevestigatoriQ5SW75.

    Interactioni

    Subunit structurei

    Interacts with filamentous actin.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000104034.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SW75.
    SMRiQ5SW75. Positions 307-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini307 – 447141Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117282.
    HOVERGENiHBG094002.
    KOiK05766.
    OrthoDBiEOG7B8S33.
    PhylomeDBiQ5SW75.
    TreeFamiTF319444.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR014876. DEK_C.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR009057. Homeodomain-like.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF08766. DEK_C. 1 hit.
    PF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5SW75-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALVTVQRSP TPSTTSSPCA SEADSGEEEC RSQPRSISES FLTVKGAALF     50
    LPRGNGSSTP RVSHRRNKHA GDLQQHLQAM FILLRPEDNI RLAVRLESTY 100
    QNRTRYMVVV STNGRQDTEE SIVLGMDFSS NDSSTCTMGL VLPLWSDTLI 150
    HLDGDGGFSV STDNRVHIFK PVSVQAMWSA LQSLHKACEV ARMHNYYPGS 200
    LFLTWVSYYE SHINSDQSSV NEWNAMQDVQ SHRPDSPALF TDIPTERERT 250
    ERLIKTKLRE IMMQKDLENI TSKEIRTELE MQMVCNLREF KEFIDNEMIV 300
    ILGQMDSPTQ IFEHVFLGSE WNASNLEDLQ NRGVRYILNV TREIDNFFPG 350
    VFEYHNIRVY DEEATDLLAY WNDTYKFISK AKKHGSKCLV HCKMGVSRSA 400
    STVIAYAMKE YGWNLDRAYD YVKERRTVTK PNPSFMRQLE EYQGILLASK 450
    QRHNKLWRSH SDSDLSDHHE PICKPGLELN KKEMTTSADQ IAEVKTVENL 500
    AAMPTVFMEH VVPQDANQKG LHTKERVICL EFSSQEFRAG QIEDELNLND 550
    INGCSSGCCL SESKLPLDNC HASKALLQPG QAPDIANKFP DLAVEDLETD 600
    ALKADMNVHL LPMEELTSRL KDLPMSPDLE SPSPQASCQA AISDFSTDRI 650
    DFFSALEKFV ELSQETRSRS FSHSRIEELG GGRSEGCRLS VIEVAASEMA 700
    ADDQRSSSLS NTPHASEESS VDEDQSKAIT ELVSPDIIMQ SHSENAISVK 750
    EIVTEIESIS QGVGQVQLKG DILSNPCHTP KKSTIHELPL ERVPAPESKP 800
    GHWEQDESFC SVQPELARDS GKCAPEEGCL TTHSSTADLE EEEPVEGEHD 850
    WGPGMHSGAK WCPGSVRRAT LEFEERLRQE QENHGTASAG PTLSNRKNSK 900
    NDSSVADLMP KWKSDETTPE HSFFLKEAEP SKGKGKCSGS EAGSLSHCER 950
    NPTMPDCELL EHHSLPAPQD CLGSDSRSKK QEGDLKKQRA VVPNQECDTQ 1000
    AILLPLPKKI EIIEYTPTVT SLGHTEPGGE ATPSKEGEKQ GLRKVKMEQS 1050
    ITMFCALDEN LNRTLEPSQV SLHPQVLPLP HSSSECDRPA DPNPMLSSPQ 1100
    DKGDCPSTPF KTAAPFVSCS TQGASFSLDY LLPHSVVHLE GCTEQSSATD 1150
    NELSPEQASW EDSRGHFLSS GSGMAHTSSP LTNEDLSLIN KLGDSVGVLQ 1200
    KKLDPSPEAC RIPHSSSSEN IRDLSHSRGV VKEHAKEIES RVIFQAGFSK 1250
    TSQMKRSASL AKLGYLDLCK DYLPDRELVS SESPHLKLLQ PFLRTDSGMH 1300
    ALMAHEPSES AGAQQNPQPT KYSVEQLKTS ECIVQSKPVE RPSVQYAKEF 1350
    GYSQQCLLPK ARPELTSSEG GLPLLQTQGL QYTGPSPGLA VAPRQQHGRT 1400
    HPLRRLKRAN DKKRTTNPFY NTM 1423
    Length:1,423
    Mass (Da):158,230
    Last modified:March 15, 2005 - v2
    Checksum:i7F2608E87A72BAFD
    GO
    Isoform 2 (identifier: Q5SW75-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: MALVTVQRSP...EEECRSQPRS → MTLSTLAGER...VISQNAINQL

    Show »
    Length:1,430
    Mass (Da):158,900
    Checksum:iDC554069F95CD99D
    GO
    Isoform 3 (identifier: Q5SW75-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: MALVTVQRSP...EEECRSQPRS → MTLSTLAGER...VISQNAINQL
         133-133: S → R
         134-1423: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:140
    Mass (Da):15,439
    Checksum:i05F40C9021BA2B9D
    GO
    Isoform 4 (identifier: Q5SW75-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         21-21: S → SSSYLEDSESAALLCCEYGESEIFSDFN

    Note: Gene prediction based on EST data. No experimental confirmation available.

    Show »
    Length:1,450
    Mass (Da):161,221
    Checksum:iA76802D4C70636BF
    GO

    Sequence cautioni

    The sequence BAE41593.1 differs from that shown. Reason: Intron retention.
    The sequence CAI24907.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI35940.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI51882.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331Missing in BAE33137. (PubMed:16141072)Curated
    Sequence conflicti325 – 3251N → D in BAE41593. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636MALVT…SQPRS → MTLSTLAGERKALPASTCSL GGPDMIPYFSANAVISQNAI NQL in isoform 2 and isoform 3. 1 PublicationVSP_016326Add
    BLAST
    Alternative sequencei21 – 211S → SSSYLEDSESAALLCCEYGE SEIFSDFN in isoform 4. CuratedVSP_016327
    Alternative sequencei133 – 1331S → R in isoform 3. 1 PublicationVSP_016328
    Alternative sequencei134 – 14231290Missing in isoform 3. 1 PublicationVSP_016329Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB099288 mRNA. Translation: BAC97811.1.
    AK155232 mRNA. Translation: BAE33137.1.
    AK158449 mRNA. Translation: BAE34514.1.
    AK170142 mRNA. Translation: BAE41593.1. Sequence problems.
    AL606724, AL607072, AL663066 Genomic DNA. Translation: CAI24906.2.
    AL606724, AL663066 Genomic DNA. Translation: CAI24907.1. Sequence problems.
    AL663066, AL606724, AL607072 Genomic DNA. Translation: CAI35939.2.
    AL663066, AL606724 Genomic DNA. Translation: CAI35940.1. Sequence problems.
    AL606724 Genomic DNA. Translation: CAI51882.1. Sequence problems.
    AL607072, AL606724, AL663066 Genomic DNA. Translation: CAI52040.1.
    BC141392 mRNA. Translation: AAI41393.1.
    BC141393 mRNA. Translation: AAI41394.1.
    AK173243 mRNA. Translation: BAD32521.1.
    CCDSiCCDS25076.1. [Q5SW75-1]
    RefSeqiNP_001278119.1. NM_001291190.1.
    NP_808378.2. NM_177710.4. [Q5SW75-1]
    XP_006533290.1. XM_006533227.1. [Q5SW75-4]
    XP_006533292.1. XM_006533229.1. [Q5SW75-2]
    UniGeneiMm.440381.

    Genome annotation databases

    EnsembliENSMUST00000037912; ENSMUSP00000042625; ENSMUSG00000037926. [Q5SW75-1]
    ENSMUST00000181283; ENSMUSP00000137933; ENSMUSG00000037926.
    GeneIDi237860.
    KEGGimmu:237860.
    UCSCiuc007kgl.2. mouse. [Q5SW75-1]
    uc007kgo.2. mouse. [Q5SW75-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB099288 mRNA. Translation: BAC97811.1 .
    AK155232 mRNA. Translation: BAE33137.1 .
    AK158449 mRNA. Translation: BAE34514.1 .
    AK170142 mRNA. Translation: BAE41593.1 . Sequence problems.
    AL606724 , AL607072 , AL663066 Genomic DNA. Translation: CAI24906.2 .
    AL606724 , AL663066 Genomic DNA. Translation: CAI24907.1 . Sequence problems.
    AL663066 , AL606724 , AL607072 Genomic DNA. Translation: CAI35939.2 .
    AL663066 , AL606724 Genomic DNA. Translation: CAI35940.1 . Sequence problems.
    AL606724 Genomic DNA. Translation: CAI51882.1 . Sequence problems.
    AL607072 , AL606724 , AL663066 Genomic DNA. Translation: CAI52040.1 .
    BC141392 mRNA. Translation: AAI41393.1 .
    BC141393 mRNA. Translation: AAI41394.1 .
    AK173243 mRNA. Translation: BAD32521.1 .
    CCDSi CCDS25076.1. [Q5SW75-1 ]
    RefSeqi NP_001278119.1. NM_001291190.1.
    NP_808378.2. NM_177710.4. [Q5SW75-1 ]
    XP_006533290.1. XM_006533227.1. [Q5SW75-4 ]
    XP_006533292.1. XM_006533229.1. [Q5SW75-2 ]
    UniGenei Mm.440381.

    3D structure databases

    ProteinModelPortali Q5SW75.
    SMRi Q5SW75. Positions 307-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000104034.

    PTM databases

    PhosphoSitei Q5SW75.

    Proteomic databases

    PaxDbi Q5SW75.
    PRIDEi Q5SW75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037912 ; ENSMUSP00000042625 ; ENSMUSG00000037926 . [Q5SW75-1 ]
    ENSMUST00000181283 ; ENSMUSP00000137933 ; ENSMUSG00000037926 .
    GeneIDi 237860.
    KEGGi mmu:237860.
    UCSCi uc007kgl.2. mouse. [Q5SW75-1 ]
    uc007kgo.2. mouse. [Q5SW75-2 ]

    Organism-specific databases

    CTDi 85464.
    MGIi MGI:2679255. Ssh2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117282.
    HOVERGENi HBG094002.
    KOi K05766.
    OrthoDBi EOG7B8S33.
    PhylomeDBi Q5SW75.
    TreeFami TF319444.

    Miscellaneous databases

    NextBioi 383532.
    PROi Q5SW75.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5SW75.
    CleanExi MM_SSH2.
    Genevestigatori Q5SW75.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR014876. DEK_C.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR009057. Homeodomain-like.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF08766. DEK_C. 1 hit.
    PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin."
      Ohta Y., Kousaka K., Nagata-Ohashi K., Ohashi K., Muramoto A., Shima Y., Niwa R., Uemura T., Mizuno K.
      Genes Cells 8:811-824(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ACTIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF CYS-392.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Strain: NOD.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 371-1423 (ISOFORMS 1/2).
      Tissue: Brain.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiSSH2_MOUSE
    AccessioniPrimary (citable) accession number: Q5SW75
    Secondary accession number(s): B9EJ94
    , Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Tyrosine phosphatase activity has not been demonstrated for this protein to date.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3