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Q5SW28

- PI3R5_MOUSE

UniProt

Q5SW28 - PI3R5_MOUSE

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Protein
Phosphoinositide 3-kinase regulatory subunit 5
Gene
Pik3r5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG By similarity.

Enzyme regulationi

Greatly activated by G gamma proteins By similarity.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase regulator activity Source: Ensembl
  2. G-protein beta/gamma-subunit complex binding Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. phosphatidylinositol 3-kinase signaling Source: UniProtKB
  3. positive regulation of MAP kinase activity Source: UniProtKB
  4. positive regulation of protein kinase B signaling Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.
REACT_220092. GPVI-mediated activation cascade.
REACT_223974. G beta:gamma signalling through PI3Kgamma.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-kinase regulatory subunit 5
Short name:
PI3-kinase regulatory subunit 5
Alternative name(s):
PI3-kinase p101 subunit
Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
Short name:
PtdIns-3-kinase regulatory subunit
PtdIns-3-kinase p101
p101-PI3K
Gene namesi
Name:Pik3r5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2443588. Pik3r5.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. membrane Source: UniProtKB
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Phosphoinositide 3-kinase regulatory subunit 5
PRO_0000058422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei451 – 4511Phosphoserine By similarity
Modified residuei500 – 5001Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5SW28.

PTM databases

PhosphoSiteiQ5SW28.

Expressioni

Gene expression databases

BgeeiQ5SW28.
GenevestigatoriQ5SW28.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers By similarity.

Protein-protein interaction databases

IntActiQ5SW28. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5SW28.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 10177Heterodimerization By similarity
Add
BLAST
Regioni646 – 746101Interaction with beta-gamma G protein dimers By similarity
Add
BLAST

Domaini

The heterodimerization region allows the binding to the catalytic subunit By similarity.

Phylogenomic databases

eggNOGiNOG27692.
GeneTreeiENSGT00530000063753.
HOGENOMiHOG000115865.
HOVERGENiHBG079651.
InParanoidiQ5SW28.
KOiK02649.
OMAiTRAIKAS.
OrthoDBiEOG7RV9FH.
PhylomeDBiQ5SW28.
TreeFamiTF102035.

Family and domain databases

InterProiIPR019522. PIK3R5/6.
[Graphical view]
PfamiPF10486. PI3K_1B_p101. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SW28-1 [UniParc]FASTAAdd to Basket

« Hide

MQPAATTCTE DRIQHALERC LHGLSLGRRS APWSAGLCLN CWSLQELVSR    50
DPGHFLILLE QILQKTQEVQ EKGTYDLLAP LALLFYSTVL CTPHFPPDSD 100
LLLKAASTYH CFLTWPVPYC SICREMLTFI DAELKAPGIS YQRLVRAEQG 150
LPVRSHRSST VTVLLLNPVE VQAEFLAVAD KLSTPGQSPH GTYTTLLLHA 200
FQATFGAHCD LPKLHRKLQS KTIEELEDIF TETTEAQELA SGIGDVAEAR 250
EWLRTKLQAV GEKAGFPGIL DTASPGKLHT IPIPVARCYT YSWNQDSFDI 300
LQEVLLKEQE LLQPGILGDD EEEEEEDLEM DRHCAERDSL LSTSSLVSHD 350
STLLLTSSQA SEPVLSRQML TTFVSGLSDG MDSGYVEDSE ENSEWPQKPG 400
SQKRQGHRRP GQKFNRFYKL LKSTSQLVLR RDSRSLESSV DPTLPLRRAG 450
SLCSPLDCPA QLPSRAQRSR SLPQAKLTTQ LPRWLLAPPS HHQRRRPFLS 500
GDEDPKASTL RVVVFGSDRI SGKVARAYSK LRRLETSHPI LTRFFKLQFF 550
YVPVKRSHGT SPSACPSSLS QASPLPADSL KYPSPTDLGM APWEDSTNDI 600
SHYLGMLDPW YERNVLGLMH LPPEVLCQQS LKADSRPLEG SATQLPILAD 650
MLLYYCRFAA RPVLLQVYQT ELTFVTGEKT TEIFIQSLEL GHSATTRAIK 700
ASGRGRKRLG IDDDREAVPL TLQIIYSKGA ISGRSRWSNL EKVCTSVNLS 750
KACQKPEELD SSMEALTLTL TEVVKRQNPK SKKGFNQIST SYIKVDKVQI 800
IGSSSCPFAV CLDQDERKIL QSVVRCEVSP CYKPEKSSLP PERSFSQPAE 850
TGSDLCSLLC LPIMTFSGAL P 871
Length:871
Mass (Da):96,954
Last modified:December 21, 2004 - v1
Checksum:i1D0F36A3D4042D62
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651K → E in BAE29119. 1 Publication
Sequence conflicti269 – 2691I → T in BAC40901. 1 Publication
Sequence conflicti369 – 3691M → V in AAN84787. 1 Publication
Sequence conflicti642 – 6421A → V in AAN84787. 1 Publication
Sequence conflicti647 – 6471I → T in AAN84787. 1 Publication
Sequence conflicti651 – 6511M → V in AAN84787. 1 Publication
Sequence conflicti796 – 7961D → G in BAE29119. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY156924 mRNA. Translation: AAN84787.1.
AK089483 mRNA. Translation: BAC40901.2.
AK149847 mRNA. Translation: BAE29119.1.
AK161050 mRNA. Translation: BAE36171.1.
AL606831 Genomic DNA. Translation: CAI25692.1.
CCDSiCCDS24865.1.
RefSeqiNP_796294.2. NM_177320.2.
XP_006533611.1. XM_006533548.1.
UniGeneiMm.244960.

Genome annotation databases

EnsembliENSMUST00000021283; ENSMUSP00000021283; ENSMUSG00000020901.
GeneIDi320207.
KEGGimmu:320207.
UCSCiuc007jno.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY156924 mRNA. Translation: AAN84787.1 .
AK089483 mRNA. Translation: BAC40901.2 .
AK149847 mRNA. Translation: BAE29119.1 .
AK161050 mRNA. Translation: BAE36171.1 .
AL606831 Genomic DNA. Translation: CAI25692.1 .
CCDSi CCDS24865.1.
RefSeqi NP_796294.2. NM_177320.2.
XP_006533611.1. XM_006533548.1.
UniGenei Mm.244960.

3D structure databases

ProteinModelPortali Q5SW28.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5SW28. 2 interactions.

PTM databases

PhosphoSitei Q5SW28.

Proteomic databases

PRIDEi Q5SW28.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021283 ; ENSMUSP00000021283 ; ENSMUSG00000020901 .
GeneIDi 320207.
KEGGi mmu:320207.
UCSCi uc007jno.1. mouse.

Organism-specific databases

CTDi 23533.
MGIi MGI:2443588. Pik3r5.

Phylogenomic databases

eggNOGi NOG27692.
GeneTreei ENSGT00530000063753.
HOGENOMi HOG000115865.
HOVERGENi HBG079651.
InParanoidi Q5SW28.
KOi K02649.
OMAi TRAIKAS.
OrthoDBi EOG7RV9FH.
PhylomeDBi Q5SW28.
TreeFami TF102035.

Enzyme and pathway databases

Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.
REACT_220092. GPVI-mediated activation cascade.
REACT_223974. G beta:gamma signalling through PI3Kgamma.

Miscellaneous databases

NextBioi 396255.
PROi Q5SW28.
SOURCEi Search...

Gene expression databases

Bgeei Q5SW28.
Genevestigatori Q5SW28.

Family and domain databases

InterProi IPR019522. PIK3R5/6.
[Graphical view ]
Pfami PF10486. PI3K_1B_p101. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a murine ortholog of a PI3-kinase gamma regulatory protein."
    Procko E., McColl S.R.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPI3R5_MOUSE
AccessioniPrimary (citable) accession number: Q5SW28
Secondary accession number(s): Q3TU01
, Q3UDZ2, Q8C215, Q8CGQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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