Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5SW28

- PI3R5_MOUSE

UniProt

Q5SW28 - PI3R5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoinositide 3-kinase regulatory subunit 5

Gene

Pik3r5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).By similarity

Enzyme regulationi

Greatly activated by G gamma proteins.By similarity

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase regulator activity Source: Ensembl
  2. G-protein beta/gamma-subunit complex binding Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. phosphatidylinositol 3-kinase signaling Source: UniProtKB
  3. positive regulation of MAP kinase activity Source: UniProtKB
  4. positive regulation of protein kinase B signaling Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.
REACT_220092. GPVI-mediated activation cascade.
REACT_223974. G beta:gamma signalling through PI3Kgamma.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-kinase regulatory subunit 5
Short name:
PI3-kinase regulatory subunit 5
Alternative name(s):
PI3-kinase p101 subunit
Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
Short name:
PtdIns-3-kinase regulatory subunit
PtdIns-3-kinase p101
p101-PI3K
Gene namesi
Name:Pik3r5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2443588. Pik3r5.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. membrane Source: UniProtKB
  3. nucleus Source: UniProtKB-KW
  4. phosphatidylinositol 3-kinase complex, class IB Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Phosphoinositide 3-kinase regulatory subunit 5PRO_0000058422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei451 – 4511PhosphoserineBy similarity
Modified residuei500 – 5001PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5SW28.

PTM databases

PhosphoSiteiQ5SW28.

Expressioni

Gene expression databases

BgeeiQ5SW28.
ExpressionAtlasiQ5SW28. baseline and differential.
GenevestigatoriQ5SW28.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers (By similarity).By similarity

Protein-protein interaction databases

IntActiQ5SW28. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5SW28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 10177HeterodimerizationBy similarityAdd
BLAST
Regioni646 – 746101Interaction with beta-gamma G protein dimersBy similarityAdd
BLAST

Domaini

The heterodimerization region allows the binding to the catalytic subunit.By similarity

Phylogenomic databases

eggNOGiNOG27692.
GeneTreeiENSGT00530000063753.
HOGENOMiHOG000115865.
HOVERGENiHBG079651.
InParanoidiQ5SW28.
KOiK02649.
OMAiTRAIKAS.
OrthoDBiEOG7RV9FH.
PhylomeDBiQ5SW28.
TreeFamiTF102035.

Family and domain databases

InterProiIPR019522. PIK3R5/6.
[Graphical view]
PfamiPF10486. PI3K_1B_p101. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SW28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPAATTCTE DRIQHALERC LHGLSLGRRS APWSAGLCLN CWSLQELVSR
60 70 80 90 100
DPGHFLILLE QILQKTQEVQ EKGTYDLLAP LALLFYSTVL CTPHFPPDSD
110 120 130 140 150
LLLKAASTYH CFLTWPVPYC SICREMLTFI DAELKAPGIS YQRLVRAEQG
160 170 180 190 200
LPVRSHRSST VTVLLLNPVE VQAEFLAVAD KLSTPGQSPH GTYTTLLLHA
210 220 230 240 250
FQATFGAHCD LPKLHRKLQS KTIEELEDIF TETTEAQELA SGIGDVAEAR
260 270 280 290 300
EWLRTKLQAV GEKAGFPGIL DTASPGKLHT IPIPVARCYT YSWNQDSFDI
310 320 330 340 350
LQEVLLKEQE LLQPGILGDD EEEEEEDLEM DRHCAERDSL LSTSSLVSHD
360 370 380 390 400
STLLLTSSQA SEPVLSRQML TTFVSGLSDG MDSGYVEDSE ENSEWPQKPG
410 420 430 440 450
SQKRQGHRRP GQKFNRFYKL LKSTSQLVLR RDSRSLESSV DPTLPLRRAG
460 470 480 490 500
SLCSPLDCPA QLPSRAQRSR SLPQAKLTTQ LPRWLLAPPS HHQRRRPFLS
510 520 530 540 550
GDEDPKASTL RVVVFGSDRI SGKVARAYSK LRRLETSHPI LTRFFKLQFF
560 570 580 590 600
YVPVKRSHGT SPSACPSSLS QASPLPADSL KYPSPTDLGM APWEDSTNDI
610 620 630 640 650
SHYLGMLDPW YERNVLGLMH LPPEVLCQQS LKADSRPLEG SATQLPILAD
660 670 680 690 700
MLLYYCRFAA RPVLLQVYQT ELTFVTGEKT TEIFIQSLEL GHSATTRAIK
710 720 730 740 750
ASGRGRKRLG IDDDREAVPL TLQIIYSKGA ISGRSRWSNL EKVCTSVNLS
760 770 780 790 800
KACQKPEELD SSMEALTLTL TEVVKRQNPK SKKGFNQIST SYIKVDKVQI
810 820 830 840 850
IGSSSCPFAV CLDQDERKIL QSVVRCEVSP CYKPEKSSLP PERSFSQPAE
860 870
TGSDLCSLLC LPIMTFSGAL P
Length:871
Mass (Da):96,954
Last modified:December 21, 2004 - v1
Checksum:i1D0F36A3D4042D62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651K → E in BAE29119. (PubMed:16141072)Curated
Sequence conflicti269 – 2691I → T in BAC40901. (PubMed:16141072)Curated
Sequence conflicti369 – 3691M → V in AAN84787. 1 PublicationCurated
Sequence conflicti642 – 6421A → V in AAN84787. 1 PublicationCurated
Sequence conflicti647 – 6471I → T in AAN84787. 1 PublicationCurated
Sequence conflicti651 – 6511M → V in AAN84787. 1 PublicationCurated
Sequence conflicti796 – 7961D → G in BAE29119. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY156924 mRNA. Translation: AAN84787.1.
AK089483 mRNA. Translation: BAC40901.2.
AK149847 mRNA. Translation: BAE29119.1.
AK161050 mRNA. Translation: BAE36171.1.
AL606831 Genomic DNA. Translation: CAI25692.1.
CCDSiCCDS24865.1.
RefSeqiNP_796294.2. NM_177320.2.
XP_006533611.1. XM_006533548.1.
UniGeneiMm.244960.

Genome annotation databases

EnsembliENSMUST00000021283; ENSMUSP00000021283; ENSMUSG00000020901.
GeneIDi320207.
KEGGimmu:320207.
UCSCiuc007jno.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY156924 mRNA. Translation: AAN84787.1 .
AK089483 mRNA. Translation: BAC40901.2 .
AK149847 mRNA. Translation: BAE29119.1 .
AK161050 mRNA. Translation: BAE36171.1 .
AL606831 Genomic DNA. Translation: CAI25692.1 .
CCDSi CCDS24865.1.
RefSeqi NP_796294.2. NM_177320.2.
XP_006533611.1. XM_006533548.1.
UniGenei Mm.244960.

3D structure databases

ProteinModelPortali Q5SW28.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5SW28. 2 interactions.

PTM databases

PhosphoSitei Q5SW28.

Proteomic databases

PRIDEi Q5SW28.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021283 ; ENSMUSP00000021283 ; ENSMUSG00000020901 .
GeneIDi 320207.
KEGGi mmu:320207.
UCSCi uc007jno.1. mouse.

Organism-specific databases

CTDi 23533.
MGIi MGI:2443588. Pik3r5.

Phylogenomic databases

eggNOGi NOG27692.
GeneTreei ENSGT00530000063753.
HOGENOMi HOG000115865.
HOVERGENi HBG079651.
InParanoidi Q5SW28.
KOi K02649.
OMAi TRAIKAS.
OrthoDBi EOG7RV9FH.
PhylomeDBi Q5SW28.
TreeFami TF102035.

Enzyme and pathway databases

Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.
REACT_220092. GPVI-mediated activation cascade.
REACT_223974. G beta:gamma signalling through PI3Kgamma.

Miscellaneous databases

ChiTaRSi Pik3r5. mouse.
NextBioi 396255.
PROi Q5SW28.
SOURCEi Search...

Gene expression databases

Bgeei Q5SW28.
ExpressionAtlasi Q5SW28. baseline and differential.
Genevestigatori Q5SW28.

Family and domain databases

InterProi IPR019522. PIK3R5/6.
[Graphical view ]
Pfami PF10486. PI3K_1B_p101. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a murine ortholog of a PI3-kinase gamma regulatory protein."
    Procko E., McColl S.R.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPI3R5_MOUSE
AccessioniPrimary (citable) accession number: Q5SW28
Secondary accession number(s): Q3TU01
, Q3UDZ2, Q8C215, Q8CGQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3