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Q5SW28 (PI3R5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoinositide 3-kinase regulatory subunit 5

Short name=PI3-kinase regulatory subunit 5
Alternative name(s):
PI3-kinase p101 subunit
Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
Short name=PtdIns-3-kinase regulatory subunit
PtdIns-3-kinase p101
p101-PI3K
Gene names
Name:Pik3r5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length871 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG By similarity.

Enzyme regulation

Greatly activated by G gamma proteins By similarity.

Subunit structure

Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Domain

The heterodimerization region allows the binding to the catalytic subunit By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 871871Phosphoinositide 3-kinase regulatory subunit 5
PRO_0000058422

Regions

Region25 – 10177Heterodimerization By similarity
Region646 – 746101Interaction with beta-gamma G protein dimers By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue4511Phosphoserine By similarity
Modified residue5001Phosphoserine By similarity

Experimental info

Sequence conflict651K → E in BAE29119. Ref.2
Sequence conflict2691I → T in BAC40901. Ref.2
Sequence conflict3691M → V in AAN84787. Ref.1
Sequence conflict6421A → V in AAN84787. Ref.1
Sequence conflict6471I → T in AAN84787. Ref.1
Sequence conflict6511M → V in AAN84787. Ref.1
Sequence conflict7961D → G in BAE29119. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q5SW28 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 1D0F36A3D4042D62

FASTA87196,954
        10         20         30         40         50         60 
MQPAATTCTE DRIQHALERC LHGLSLGRRS APWSAGLCLN CWSLQELVSR DPGHFLILLE 

        70         80         90        100        110        120 
QILQKTQEVQ EKGTYDLLAP LALLFYSTVL CTPHFPPDSD LLLKAASTYH CFLTWPVPYC 

       130        140        150        160        170        180 
SICREMLTFI DAELKAPGIS YQRLVRAEQG LPVRSHRSST VTVLLLNPVE VQAEFLAVAD 

       190        200        210        220        230        240 
KLSTPGQSPH GTYTTLLLHA FQATFGAHCD LPKLHRKLQS KTIEELEDIF TETTEAQELA 

       250        260        270        280        290        300 
SGIGDVAEAR EWLRTKLQAV GEKAGFPGIL DTASPGKLHT IPIPVARCYT YSWNQDSFDI 

       310        320        330        340        350        360 
LQEVLLKEQE LLQPGILGDD EEEEEEDLEM DRHCAERDSL LSTSSLVSHD STLLLTSSQA 

       370        380        390        400        410        420 
SEPVLSRQML TTFVSGLSDG MDSGYVEDSE ENSEWPQKPG SQKRQGHRRP GQKFNRFYKL 

       430        440        450        460        470        480 
LKSTSQLVLR RDSRSLESSV DPTLPLRRAG SLCSPLDCPA QLPSRAQRSR SLPQAKLTTQ 

       490        500        510        520        530        540 
LPRWLLAPPS HHQRRRPFLS GDEDPKASTL RVVVFGSDRI SGKVARAYSK LRRLETSHPI 

       550        560        570        580        590        600 
LTRFFKLQFF YVPVKRSHGT SPSACPSSLS QASPLPADSL KYPSPTDLGM APWEDSTNDI 

       610        620        630        640        650        660 
SHYLGMLDPW YERNVLGLMH LPPEVLCQQS LKADSRPLEG SATQLPILAD MLLYYCRFAA 

       670        680        690        700        710        720 
RPVLLQVYQT ELTFVTGEKT TEIFIQSLEL GHSATTRAIK ASGRGRKRLG IDDDREAVPL 

       730        740        750        760        770        780 
TLQIIYSKGA ISGRSRWSNL EKVCTSVNLS KACQKPEELD SSMEALTLTL TEVVKRQNPK 

       790        800        810        820        830        840 
SKKGFNQIST SYIKVDKVQI IGSSSCPFAV CLDQDERKIL QSVVRCEVSP CYKPEKSSLP 

       850        860        870 
PERSFSQPAE TGSDLCSLLC LPIMTFSGAL P 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a murine ortholog of a PI3-kinase gamma regulatory protein."
Procko E., McColl S.R.
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow and Skin.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY156924 mRNA. Translation: AAN84787.1.
AK089483 mRNA. Translation: BAC40901.2.
AK149847 mRNA. Translation: BAE29119.1.
AK161050 mRNA. Translation: BAE36171.1.
AL606831 Genomic DNA. Translation: CAI25692.1.
RefSeqNP_796294.2. NM_177320.2.
XP_006533611.1. XM_006533548.1.
UniGeneMm.244960.

3D structure databases

ProteinModelPortalQ5SW28.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ5SW28. 2 interactions.

PTM databases

PhosphoSiteQ5SW28.

Proteomic databases

PRIDEQ5SW28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021283; ENSMUSP00000021283; ENSMUSG00000020901.
GeneID320207.
KEGGmmu:320207.
UCSCuc007jno.1. mouse.

Organism-specific databases

CTD23533.
MGIMGI:2443588. Pik3r5.

Phylogenomic databases

eggNOGNOG27692.
GeneTreeENSGT00530000063753.
HOGENOMHOG000115865.
HOVERGENHBG079651.
InParanoidQ5SW28.
KOK02649.
OMATRAIKAS.
OrthoDBEOG7RV9FH.
PhylomeDBQ5SW28.
TreeFamTF102035.

Gene expression databases

BgeeQ5SW28.
GenevestigatorQ5SW28.

Family and domain databases

InterProIPR019522. PI3K_1B_gamma_p101_su.
[Graphical view]
PANTHERPTHR15593. PTHR15593. 1 hit.
PfamPF10486. PI3K_1B_p101. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio396255.
PROQ5SW28.
SOURCESearch...

Entry information

Entry namePI3R5_MOUSE
AccessionPrimary (citable) accession number: Q5SW28
Secondary accession number(s): Q3TU01 expand/collapse secondary AC list , Q3UDZ2, Q8C215, Q8CGQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot