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Q5SW28

- PI3R5_MOUSE

UniProt

Q5SW28 - PI3R5_MOUSE

Protein

Phosphoinositide 3-kinase regulatory subunit 5

Gene

Pik3r5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG By similarity.By similarity

    Enzyme regulationi

    Greatly activated by G gamma proteins.By similarity

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase regulator activity Source: Ensembl
    2. G-protein beta/gamma-subunit complex binding Source: UniProtKB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB
    2. phosphatidylinositol 3-kinase signaling Source: UniProtKB
    3. positive regulation of MAP kinase activity Source: UniProtKB
    4. positive regulation of protein kinase B signaling Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.
    REACT_220092. GPVI-mediated activation cascade.
    REACT_223974. G beta:gamma signalling through PI3Kgamma.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide 3-kinase regulatory subunit 5
    Short name:
    PI3-kinase regulatory subunit 5
    Alternative name(s):
    PI3-kinase p101 subunit
    Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
    Short name:
    PtdIns-3-kinase regulatory subunit
    PtdIns-3-kinase p101
    p101-PI3K
    Gene namesi
    Name:Pik3r5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2443588. Pik3r5.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. membrane Source: UniProtKB
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 871871Phosphoinositide 3-kinase regulatory subunit 5PRO_0000058422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei451 – 4511PhosphoserineBy similarity
    Modified residuei500 – 5001PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ5SW28.

    PTM databases

    PhosphoSiteiQ5SW28.

    Expressioni

    Gene expression databases

    BgeeiQ5SW28.
    GenevestigatoriQ5SW28.

    Interactioni

    Subunit structurei

    Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ5SW28. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SW28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 10177HeterodimerizationBy similarityAdd
    BLAST
    Regioni646 – 746101Interaction with beta-gamma G protein dimersBy similarityAdd
    BLAST

    Domaini

    The heterodimerization region allows the binding to the catalytic subunit.By similarity

    Phylogenomic databases

    eggNOGiNOG27692.
    GeneTreeiENSGT00530000063753.
    HOGENOMiHOG000115865.
    HOVERGENiHBG079651.
    InParanoidiQ5SW28.
    KOiK02649.
    OMAiTRAIKAS.
    OrthoDBiEOG7RV9FH.
    PhylomeDBiQ5SW28.
    TreeFamiTF102035.

    Family and domain databases

    InterProiIPR019522. PIK3R5/6.
    [Graphical view]
    PfamiPF10486. PI3K_1B_p101. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SW28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPAATTCTE DRIQHALERC LHGLSLGRRS APWSAGLCLN CWSLQELVSR    50
    DPGHFLILLE QILQKTQEVQ EKGTYDLLAP LALLFYSTVL CTPHFPPDSD 100
    LLLKAASTYH CFLTWPVPYC SICREMLTFI DAELKAPGIS YQRLVRAEQG 150
    LPVRSHRSST VTVLLLNPVE VQAEFLAVAD KLSTPGQSPH GTYTTLLLHA 200
    FQATFGAHCD LPKLHRKLQS KTIEELEDIF TETTEAQELA SGIGDVAEAR 250
    EWLRTKLQAV GEKAGFPGIL DTASPGKLHT IPIPVARCYT YSWNQDSFDI 300
    LQEVLLKEQE LLQPGILGDD EEEEEEDLEM DRHCAERDSL LSTSSLVSHD 350
    STLLLTSSQA SEPVLSRQML TTFVSGLSDG MDSGYVEDSE ENSEWPQKPG 400
    SQKRQGHRRP GQKFNRFYKL LKSTSQLVLR RDSRSLESSV DPTLPLRRAG 450
    SLCSPLDCPA QLPSRAQRSR SLPQAKLTTQ LPRWLLAPPS HHQRRRPFLS 500
    GDEDPKASTL RVVVFGSDRI SGKVARAYSK LRRLETSHPI LTRFFKLQFF 550
    YVPVKRSHGT SPSACPSSLS QASPLPADSL KYPSPTDLGM APWEDSTNDI 600
    SHYLGMLDPW YERNVLGLMH LPPEVLCQQS LKADSRPLEG SATQLPILAD 650
    MLLYYCRFAA RPVLLQVYQT ELTFVTGEKT TEIFIQSLEL GHSATTRAIK 700
    ASGRGRKRLG IDDDREAVPL TLQIIYSKGA ISGRSRWSNL EKVCTSVNLS 750
    KACQKPEELD SSMEALTLTL TEVVKRQNPK SKKGFNQIST SYIKVDKVQI 800
    IGSSSCPFAV CLDQDERKIL QSVVRCEVSP CYKPEKSSLP PERSFSQPAE 850
    TGSDLCSLLC LPIMTFSGAL P 871
    Length:871
    Mass (Da):96,954
    Last modified:December 21, 2004 - v1
    Checksum:i1D0F36A3D4042D62
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651K → E in BAE29119. (PubMed:16141072)Curated
    Sequence conflicti269 – 2691I → T in BAC40901. (PubMed:16141072)Curated
    Sequence conflicti369 – 3691M → V in AAN84787. 1 PublicationCurated
    Sequence conflicti642 – 6421A → V in AAN84787. 1 PublicationCurated
    Sequence conflicti647 – 6471I → T in AAN84787. 1 PublicationCurated
    Sequence conflicti651 – 6511M → V in AAN84787. 1 PublicationCurated
    Sequence conflicti796 – 7961D → G in BAE29119. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY156924 mRNA. Translation: AAN84787.1.
    AK089483 mRNA. Translation: BAC40901.2.
    AK149847 mRNA. Translation: BAE29119.1.
    AK161050 mRNA. Translation: BAE36171.1.
    AL606831 Genomic DNA. Translation: CAI25692.1.
    CCDSiCCDS24865.1.
    RefSeqiNP_796294.2. NM_177320.2.
    XP_006533611.1. XM_006533548.1.
    UniGeneiMm.244960.

    Genome annotation databases

    EnsembliENSMUST00000021283; ENSMUSP00000021283; ENSMUSG00000020901.
    GeneIDi320207.
    KEGGimmu:320207.
    UCSCiuc007jno.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY156924 mRNA. Translation: AAN84787.1 .
    AK089483 mRNA. Translation: BAC40901.2 .
    AK149847 mRNA. Translation: BAE29119.1 .
    AK161050 mRNA. Translation: BAE36171.1 .
    AL606831 Genomic DNA. Translation: CAI25692.1 .
    CCDSi CCDS24865.1.
    RefSeqi NP_796294.2. NM_177320.2.
    XP_006533611.1. XM_006533548.1.
    UniGenei Mm.244960.

    3D structure databases

    ProteinModelPortali Q5SW28.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5SW28. 2 interactions.

    PTM databases

    PhosphoSitei Q5SW28.

    Proteomic databases

    PRIDEi Q5SW28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021283 ; ENSMUSP00000021283 ; ENSMUSG00000020901 .
    GeneIDi 320207.
    KEGGi mmu:320207.
    UCSCi uc007jno.1. mouse.

    Organism-specific databases

    CTDi 23533.
    MGIi MGI:2443588. Pik3r5.

    Phylogenomic databases

    eggNOGi NOG27692.
    GeneTreei ENSGT00530000063753.
    HOGENOMi HOG000115865.
    HOVERGENi HBG079651.
    InParanoidi Q5SW28.
    KOi K02649.
    OMAi TRAIKAS.
    OrthoDBi EOG7RV9FH.
    PhylomeDBi Q5SW28.
    TreeFami TF102035.

    Enzyme and pathway databases

    Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.
    REACT_220092. GPVI-mediated activation cascade.
    REACT_223974. G beta:gamma signalling through PI3Kgamma.

    Miscellaneous databases

    NextBioi 396255.
    PROi Q5SW28.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5SW28.
    Genevestigatori Q5SW28.

    Family and domain databases

    InterProi IPR019522. PIK3R5/6.
    [Graphical view ]
    Pfami PF10486. PI3K_1B_p101. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a murine ortholog of a PI3-kinase gamma regulatory protein."
      Procko E., McColl S.R.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Skin.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiPI3R5_MOUSE
    AccessioniPrimary (citable) accession number: Q5SW28
    Secondary accession number(s): Q3TU01
    , Q3UDZ2, Q8C215, Q8CGQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3