Q5SW24 (DACT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dapper homolog 2

Gene names

Name:	DACT2
Synonyms:	C6orf116
ORF Names:	PP13671

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	774 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors By similarity.
Domain	The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins By similarity.
Sequence similarities	Belongs to the dapper family.
Sequence caution	The sequence AAI11791.1 differs from that shown. Reason: Erroneous initiation. The sequence AAL55843.1 differs from that shown. Reason: Frameshift at position 247.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SW24-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SW24-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5SW24-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-408: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5SW24-4)

The sequence of this isoform differs from the canonical sequence as follows:
     220-280: GDLDRALPAD...EVYPYPSPLH → ELCNAPGELD...TKSSGISRQQ
     281-774: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 774	774	Dapper homolog 2		PRO_0000326199
Regions
	Coiled coil	67 – 93	27	Potential
Natural variations
	Alternative sequence	1 – 408	408	Missing in isoform 3.		VSP_032595
	Alternative sequence	1 – 170	170	Missing in isoform 2.		VSP_032596
	Alternative sequence	220 – 280	61	GDLDR…PSPLH → ELCNAPGELDMHAPPAGCTS SSLTGVGSGLRGKCGLCGCQ LPFCSVNTSSKTKSSGISRQ Q in isoform 4.		VSP_032597
	Alternative sequence	281 – 774	494	Missing in isoform 4.		VSP_032598
	Natural variant	351	1	E → G. Corresponds to variant rs6925614 [ dbSNP | Ensembl ].		VAR_059969
	Natural variant	541	1	T → P. Corresponds to variant rs10945501 [ dbSNP | Ensembl ].		VAR_059970
Experimental info
	Sequence conflict	138	1	S → F in AAH92498. Ref.3
	Sequence conflict	725	1	A → E in AAL55843. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 0DA03DE7E12FE611	FASTA	774	82,700
	10 20 30 40 50 60 MWTPGGPPGS AGWDRRRLGA RLRAAFAGLQ ELQGLRATQQ ERVRGALALQ PPPAPAAPCG 70 80 90 100 110 120 PHGLHGPEQQ LEAALAALQE QLSRLRQQDI GLKTHLDQLD LQISKLQLDV GTASGEALDS 130 140 150 160 170 180 DSRPSSGFYE MSDGGSCSLS TSCASVCSDH ISPSLGSLLP VAQAHKARPS MGDWRPRSVD 190 200 210 220 230 240 ETTVPAWRPQ ATEEGARPPG SVEDAGQPWG TFWPRPVSTG DLDRALPADT GLQKASADAE 250 260 270 280 290 300 LLGLLCQGVD IPLHVPDPKY RQDLVSQGGR EVYPYPSPLH AVALQSPLFV LTKETPQRGG 310 320 330 340 350 360 PSFPRESPRG PAGLNTIQTG PVLEAGPARA RAYIDRLLHL WGRETPAKGS EGEQGPLRHA 370 380 390 400 410 420 ASPSPQRQGG WSTDGGGRLL VFAPGREDEG GPAQSRGAGR GGPQQQGYMP LEGPQQSGSL 430 440 450 460 470 480 PEEGSKPSNS CVLRETMVQA SPSSKAQQTP SAQDYGRGNI ISPSRMLDKS PSPASGHFAH 490 500 510 520 530 540 PSFAASLKMG PPKSKAEKIK RSPMDKVLRF ARQPLLLLDR PEGAHAAPQP SLEWDPAHWP 550 560 570 580 590 600 TGRGGLQRRP ALAWEAPGRS CSESTLYPMP VLVPLAVAPQ ESHRTSAQAL FPFEASLLTS 610 620 630 640 650 660 VARRKHRRWQ STVEISARAR LASCPESNLG PPRPVARRAG GPLARGRPSL VRQDAYTRSD 670 680 690 700 710 720 SEPSKHSAEC DPRFPSVIPE TSEGESSDHT TNRFGDRESS SSDEEGGAQS RDCDLALGYV 730 740 750 760 770 AAGHAELAWT QEAPVSSGPL LSPVPKLCRI KASKALKKKI RRFQPTALKV MTMV
	Isoform 2 [UniParc]. Checksum: 018FDB48B0545226	FASTA	604	64,898
	10 20 30 40 50 60 MGDWRPRSVD ETTVPAWRPQ ATEEGARPPG SVEDAGQPWG TFWPRPVSTG DLDRALPADT 70 80 90 100 110 120 GLQKASADAE LLGLLCQGVD IPLHVPDPKY RQDLVSQGGR EVYPYPSPLH AVALQSPLFV 130 140 150 160 170 180 LTKETPQRGG PSFPRESPRG PAGLNTIQTG PVLEAGPARA RAYIDRLLHL WGRETPAKGS 190 200 210 220 230 240 EGEQGPLRHA ASPSPQRQGG WSTDGGGRLL VFAPGREDEG GPAQSRGAGR GGPQQQGYMP 250 260 270 280 290 300 LEGPQQSGSL PEEGSKPSNS CVLRETMVQA SPSSKAQQTP SAQDYGRGNI ISPSRMLDKS 310 320 330 340 350 360 PSPASGHFAH PSFAASLKMG PPKSKAEKIK RSPMDKVLRF ARQPLLLLDR PEGAHAAPQP 370 380 390 400 410 420 SLEWDPAHWP TGRGGLQRRP ALAWEAPGRS CSESTLYPMP VLVPLAVAPQ ESHRTSAQAL 430 440 450 460 470 480 FPFEASLLTS VARRKHRRWQ STVEISARAR LASCPESNLG PPRPVARRAG GPLARGRPSL 490 500 510 520 530 540 VRQDAYTRSD SEPSKHSAEC DPRFPSVIPE TSEGESSDHT TNRFGDRESS SSDEEGGAQS 550 560 570 580 590 600 RDCDLALGYV AAGHAELAWT QEAPVSSGPL LSPVPKLCRI KASKALKKKI RRFQPTALKV MTMV
	Isoform 3 [UniParc]. Checksum: 010DEF81A7D34279	FASTA	366	39,578
	10 20 30 40 50 60 MPLEGPQQSG SLPEEGSKPS NSCVLRETMV QASPSSKAQQ TPSAQDYGRG NIISPSRMLD 70 80 90 100 110 120 KSPSPASGHF AHPSFAASLK MGPPKSKAEK IKRSPMDKVL RFARQPLLLL DRPEGAHAAP 130 140 150 160 170 180 QPSLEWDPAH WPTGRGGLQR RPALAWEAPG RSCSESTLYP MPVLVPLAVA PQESHRTSAQ 190 200 210 220 230 240 ALFPFEASLL TSVARRKHRR WQSTVEISAR ARLASCPESN LGPPRPVARR AGGPLARGRP 250 260 270 280 290 300 SLVRQDAYTR SDSEPSKHSA ECDPRFPSVI PETSEGESSD HTTNRFGDRE SSSSDEEGGA 310 320 330 340 350 360 QSRDCDLALG YVAAGHAELA WTQEAPVSSG PLLSPVPKLC RIKASKALKK KIRRFQPTAL KVMTMV
	Isoform 4 [UniParc]. Checksum: 93407A7009A408E9	FASTA	280	29,350
	10 20 30 40 50 60 MWTPGGPPGS AGWDRRRLGA RLRAAFAGLQ ELQGLRATQQ ERVRGALALQ PPPAPAAPCG 70 80 90 100 110 120 PHGLHGPEQQ LEAALAALQE QLSRLRQQDI GLKTHLDQLD LQISKLQLDV GTASGEALDS 130 140 150 160 170 180 DSRPSSGFYE MSDGGSCSLS TSCASVCSDH ISPSLGSLLP VAQAHKARPS MGDWRPRSVD 190 200 210 220 230 240 ETTVPAWRPQ ATEEGARPPG SVEDAGQPWG TFWPRPVSTE LCNAPGELDM HAPPAGCTSS 250 260 270 280 SLTGVGSGLR GKCGLCGCQL PFCSVNTSSK TKSSGISRQQ

References

[1]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF318336 mRNA. Translation: AAL55843.1. Frameshift. AL606970 Genomic DNA. Translation: CAI14850.1. BC092498 mRNA. Translation: AAH92498.1. BC111764 mRNA. Translation: AAI11765.1. BC111790 mRNA. Translation: AAI11791.1. Different initiation.
IPI	IPI00292470. IPI00844552. IPI00888696. IPI00888924.
RefSeq	NP_999627.2. NM_214462.3.
UniGene	Hs.673059.
3D structure databases
ProteinModelPortal	Q5SW24.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5SW24.
Polymorphism databases
DMDM	74743909.
Proteomic databases
PRIDE	Q5SW24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366795; ENSP00000355760; ENSG00000164488.
GeneID	168002.
KEGG	hsa:168002.
UCSC	uc003qwq.1. human.
Organism-specific databases
CTD	168002.
GeneCards	GC06M168693.
H-InvDB	HIX0032793.
HGNC	HGNC:21231. DACT2.
HPA	HPA030251. HPA030252.
MIM	608966. gene.
neXtProt	NX_Q5SW24.
PharmGKB	PA134934623.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06690.
GeneTree	ENSGT00530000063890.
HOGENOM	HBG125568.
HOVERGEN	HBG094869.
InParanoid	Q5SW24.
OMA	GREVYPY.
OrthoDB	EOG441QB1.
Enzyme and pathway databases
Pathway_Interaction_DB	tgfbrpathway. TGF-beta receptor signaling.
Gene expression databases
ArrayExpress	Q5SW24.
Bgee	Q5SW24.
CleanEx	HS_DACT2.
Genevestigator	Q5SW24.
Family and domain databases
InterPro	IPR024853. Dact2. IPR024843. Dapper. [Graphical view]
PANTHER	PTHR15919. PTHR15919. 1 hit. PTHR15919:SF8. PTHR15919:SF8. 1 hit.
ProtoNet	Search...
Other
NextBio	88697.
SOURCE	Search...

Entry information

Entry name

DACT2_HUMAN

Accession

Primary (citable) accession number: Q5SW24
Secondary accession number(s): Q2NKJ2, Q569G0, Q8WYW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.