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Protein

Dapper homolog 2

Gene

DACT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ5SW24.
SIGNORiQ5SW24.

Names & Taxonomyi

Protein namesi
Recommended name:
Dapper homolog 2
Alternative name(s):
Dapper antagonist of catenin 2
Gene namesi
Name:DACT2
Synonyms:C6orf116
ORF Names:PP13671
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21231. DACT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934623.

Polymorphism and mutation databases

BioMutaiDACT2.
DMDMi74743909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 774774Dapper homolog 2PRO_0000326199Add
BLAST

Proteomic databases

EPDiQ5SW24.
PaxDbiQ5SW24.
PRIDEiQ5SW24.

PTM databases

iPTMnetiQ5SW24.
PhosphoSiteiQ5SW24.

Expressioni

Gene expression databases

BgeeiQ5SW24.
CleanExiHS_DACT2.
GenevisibleiQ5SW24. HS.

Organism-specific databases

HPAiHPA030251.
HPA030252.

Interactioni

Subunit structurei

Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127953. 4 interactions.
STRINGi9606.ENSP00000355760.

Structurei

3D structure databases

ProteinModelPortaliQ5SW24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili67 – 9327Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi771 – 7744PDZ-bindingBy similarity

Domaini

The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.By similarity

Sequence similaritiesi

Belongs to the dapper family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK2I. Eukaryota.
ENOG410ZHU0. LUCA.
GeneTreeiENSGT00530000063890.
HOGENOMiHOG000112138.
HOVERGENiHBG094869.
InParanoidiQ5SW24.
OMAiHSEYSAE.
OrthoDBiEOG7XH6PQ.
PhylomeDBiQ5SW24.
TreeFamiTF331300.

Family and domain databases

InterProiIPR024853. Dact2.
IPR024843. Dapper.
[Graphical view]
PANTHERiPTHR15919. PTHR15919. 1 hit.
PTHR15919:SF13. PTHR15919:SF13. 1 hit.
PfamiPF15268. Dapper. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SW24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWTPGGPPGS AGWDRRRLGA RLRAAFAGLQ ELQGLRATQQ ERVRGALALQ
60 70 80 90 100
PPPAPAAPCG PHGLHGPEQQ LEAALAALQE QLSRLRQQDI GLKTHLDQLD
110 120 130 140 150
LQISKLQLDV GTASGEALDS DSRPSSGFYE MSDGGSCSLS TSCASVCSDH
160 170 180 190 200
ISPSLGSLLP VAQAHKARPS MGDWRPRSVD ETTVPAWRPQ ATEEGARPPG
210 220 230 240 250
SVEDAGQPWG TFWPRPVSTG DLDRALPADT GLQKASADAE LLGLLCQGVD
260 270 280 290 300
IPLHVPDPKY RQDLVSQGGR EVYPYPSPLH AVALQSPLFV LTKETPQRGG
310 320 330 340 350
PSFPRESPRG PAGLNTIQTG PVLEAGPARA RAYIDRLLHL WGRETPAKGS
360 370 380 390 400
EGEQGPLRHA ASPSPQRQGG WSTDGGGRLL VFAPGREDEG GPAQSRGAGR
410 420 430 440 450
GGPQQQGYMP LEGPQQSGSL PEEGSKPSNS CVLRETMVQA SPSSKAQQTP
460 470 480 490 500
SAQDYGRGNI ISPSRMLDKS PSPASGHFAH PSFAASLKMG PPKSKAEKIK
510 520 530 540 550
RSPMDKVLRF ARQPLLLLDR PEGAHAAPQP SLEWDPAHWP TGRGGLQRRP
560 570 580 590 600
ALAWEAPGRS CSESTLYPMP VLVPLAVAPQ ESHRTSAQAL FPFEASLLTS
610 620 630 640 650
VARRKHRRWQ STVEISARAR LASCPESNLG PPRPVARRAG GPLARGRPSL
660 670 680 690 700
VRQDAYTRSD SEPSKHSAEC DPRFPSVIPE TSEGESSDHT TNRFGDRESS
710 720 730 740 750
SSDEEGGAQS RDCDLALGYV AAGHAELAWT QEAPVSSGPL LSPVPKLCRI
760 770
KASKALKKKI RRFQPTALKV MTMV
Length:774
Mass (Da):82,700
Last modified:December 21, 2004 - v1
Checksum:i0DA03DE7E12FE611
GO
Isoform 2 (identifier: Q5SW24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.

Note: No experimental confirmation available.
Show »
Length:604
Mass (Da):64,898
Checksum:i018FDB48B0545226
GO
Isoform 3 (identifier: Q5SW24-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-408: Missing.

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):39,578
Checksum:i010DEF81A7D34279
GO
Isoform 4 (identifier: Q5SW24-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-280: GDLDRALPAD...EVYPYPSPLH → ELCNAPGELD...TKSSGISRQQ
     281-774: Missing.

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):29,350
Checksum:i93407A7009A408E9
GO

Sequence cautioni

The sequence AAI11791.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL55843.1 differs from that shown. Reason: Frameshift at position 247. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381S → F in AAH92498 (PubMed:15489334).Curated
Sequence conflicti725 – 7251A → E in AAL55843 (PubMed:15498874).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti351 – 3511E → G.
Corresponds to variant rs6925614 [ dbSNP | Ensembl ].
VAR_059969
Natural varianti541 – 5411T → P.
Corresponds to variant rs10945501 [ dbSNP | Ensembl ].
VAR_059970

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 408408Missing in isoform 3. 1 PublicationVSP_032595Add
BLAST
Alternative sequencei1 – 170170Missing in isoform 2. 1 PublicationVSP_032596Add
BLAST
Alternative sequencei220 – 28061GDLDR…PSPLH → ELCNAPGELDMHAPPAGCTS SSLTGVGSGLRGKCGLCGCQ LPFCSVNTSSKTKSSGISRQ Q in isoform 4. 1 PublicationVSP_032597Add
BLAST
Alternative sequencei281 – 774494Missing in isoform 4. 1 PublicationVSP_032598Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318336 mRNA. Translation: AAL55843.1. Frameshift.
AL606970 Genomic DNA. Translation: CAI14850.1.
BC092498 mRNA. Translation: AAH92498.1.
BC111764 mRNA. Translation: AAI11765.1.
BC111790 mRNA. Translation: AAI11791.1. Different initiation.
CCDSiCCDS47519.1. [Q5SW24-1]
CCDS69241.1. [Q5SW24-4]
CCDS75554.1. [Q5SW24-2]
RefSeqiNP_001273279.1. NM_001286350.1. [Q5SW24-2]
NP_001273280.1. NM_001286351.1. [Q5SW24-4]
NP_999627.2. NM_214462.4. [Q5SW24-1]
UniGeneiHs.673059.

Genome annotation databases

EnsembliENST00000366795; ENSP00000355760; ENSG00000164488. [Q5SW24-1]
ENST00000366796; ENSP00000355761; ENSG00000164488. [Q5SW24-4]
ENST00000607983; ENSP00000476434; ENSG00000164488. [Q5SW24-3]
ENST00000610183; ENSP00000476573; ENSG00000164488. [Q5SW24-2]
GeneIDi168002.
KEGGihsa:168002.
UCSCiuc003qwq.5. human. [Q5SW24-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318336 mRNA. Translation: AAL55843.1. Frameshift.
AL606970 Genomic DNA. Translation: CAI14850.1.
BC092498 mRNA. Translation: AAH92498.1.
BC111764 mRNA. Translation: AAI11765.1.
BC111790 mRNA. Translation: AAI11791.1. Different initiation.
CCDSiCCDS47519.1. [Q5SW24-1]
CCDS69241.1. [Q5SW24-4]
CCDS75554.1. [Q5SW24-2]
RefSeqiNP_001273279.1. NM_001286350.1. [Q5SW24-2]
NP_001273280.1. NM_001286351.1. [Q5SW24-4]
NP_999627.2. NM_214462.4. [Q5SW24-1]
UniGeneiHs.673059.

3D structure databases

ProteinModelPortaliQ5SW24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127953. 4 interactions.
STRINGi9606.ENSP00000355760.

PTM databases

iPTMnetiQ5SW24.
PhosphoSiteiQ5SW24.

Polymorphism and mutation databases

BioMutaiDACT2.
DMDMi74743909.

Proteomic databases

EPDiQ5SW24.
PaxDbiQ5SW24.
PRIDEiQ5SW24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366795; ENSP00000355760; ENSG00000164488. [Q5SW24-1]
ENST00000366796; ENSP00000355761; ENSG00000164488. [Q5SW24-4]
ENST00000607983; ENSP00000476434; ENSG00000164488. [Q5SW24-3]
ENST00000610183; ENSP00000476573; ENSG00000164488. [Q5SW24-2]
GeneIDi168002.
KEGGihsa:168002.
UCSCiuc003qwq.5. human. [Q5SW24-1]

Organism-specific databases

CTDi168002.
GeneCardsiDACT2.
H-InvDBHIX0032793.
HGNCiHGNC:21231. DACT2.
HPAiHPA030251.
HPA030252.
MIMi608966. gene.
neXtProtiNX_Q5SW24.
PharmGKBiPA134934623.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK2I. Eukaryota.
ENOG410ZHU0. LUCA.
GeneTreeiENSGT00530000063890.
HOGENOMiHOG000112138.
HOVERGENiHBG094869.
InParanoidiQ5SW24.
OMAiHSEYSAE.
OrthoDBiEOG7XH6PQ.
PhylomeDBiQ5SW24.
TreeFamiTF331300.

Enzyme and pathway databases

SignaLinkiQ5SW24.
SIGNORiQ5SW24.

Miscellaneous databases

GenomeRNAii168002.
PROiQ5SW24.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SW24.
CleanExiHS_DACT2.
GenevisibleiQ5SW24. HS.

Family and domain databases

InterProiIPR024853. Dact2.
IPR024843. Dapper.
[Graphical view]
PANTHERiPTHR15919. PTHR15919. 1 hit.
PTHR15919:SF13. PTHR15919:SF13. 1 hit.
PfamiPF15268. Dapper. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Placenta.

Entry informationi

Entry nameiDACT2_HUMAN
AccessioniPrimary (citable) accession number: Q5SW24
Secondary accession number(s): Q2NKJ2, Q569G0, Q8WYW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.