Q5SW18 (Q5SW18_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE27977.1

Gene names

Name:

Pafah1b1 MGI 109520

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 LisH domain. SAAS SAAS013720

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis SAAS SAAS017252 Transport SAAS SAAS017252
Cellular component	Cytoplasm Cytoskeleton SAAS SAAS017252 Microtubule SAAS SAAS017252
Domain	Coiled coil SAAS SAAS017252 Repeat SAAS SAAS013720 RuleBase RU003532 WD repeat SAAS SAAS013720 RuleBase RU000362
Gene Ontology (GO)
Biological_process	acrosome assembly Inferred from mutant phenotype PubMed 13129914. Source: MGI actin cytoskeleton organization Inferred from mutant phenotype PubMed 14507966. Source: MGI adult locomotory behavior Inferred from mutant phenotype PubMed 10541472. Source: MGI ameboidal cell migration Inferred from mutant phenotype PubMed 22073305. Source: MGI brain morphogenesis Inferred from electronic annotation. Source: Compara cerebral cortex neuron differentiation Inferred from electronic annotation. Source: Compara corpus callosum morphogenesis Inferred from electronic annotation. Source: Compara establishment of centrosome localization Inferred from electronic annotation. Source: Compara establishment of mitotic spindle orientation Inferred from electronic annotation. Source: Compara hippocampus development Inferred from mutant phenotype PubMed 10729324. Source: MGI layer formation in cerebral cortex Inferred from genetic interaction PubMed 17330141. Source: MGI learning or memory Inferred from mutant phenotype PubMed 10541472. Source: MGI microtubule cytoskeleton organization Inferred from mutant phenotype PubMed 22073305. Source: MGI microtubule organizing center organization Inferred from electronic annotation. Source: Compara mitosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of JNK cascade Inferred from genetic interaction PubMed 22073305. Source: MGI negative regulation of neuron projection development Inferred from electronic annotation. Source: Compara neuroblast proliferation Inferred from mutant phenotype PubMed 12629176. Source: MGI neuromuscular process controlling balance Inferred from mutant phenotype PubMed 10541472. Source: MGI neuron migration Inferred from mutant phenotype PubMed 14507966PubMed 15331402PubMed 9697693. Source: MGI nuclear envelope disassembly Inferred from mutant phenotype PubMed 18809722. Source: MGI nuclear migration Inferred from electronic annotation. Source: Compara osteoclast development Inferred from mutant phenotype PubMed 22073305. Source: MGI positive regulation of axon extension Inferred from electronic annotation. Source: Compara positive regulation of cytokine-mediated signaling pathway Inferred from mutant phenotype PubMed 22073305. Source: MGI positive regulation of mitotic cell cycle Inferred from electronic annotation. Source: Compara protein secretion Inferred from mutant phenotype PubMed 22073305. Source: MGI regulation of Rho GTPase activity Inferred from mutant phenotype PubMed 14507966. Source: MGI retrograde axon cargo transport Inferred from direct assay PubMed 11163259. Source: MGI stem cell division Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from mutant phenotype PubMed 10729324. Source: MGI vesicle transport along microtubule Inferred from genetic interaction PubMed 16107726. Source: MGI
Cellular_component	astral microtubule Inferred from electronic annotation. Source: Compara axon part Inferred from electronic annotation. Source: Compara cell cortex Inferred from electronic annotation. Source: Compara centrosome Inferred from direct assay PubMed 11163259PubMed 11163260. Source: MGI cytosol Inferred from electronic annotation. Source: Compara growth cone Inferred from electronic annotation. Source: Compara kinesin complex Inferred from electronic annotation. Source: Compara kinetochore Inferred from electronic annotation. Source: Compara microtubule associated complex Inferred from direct assay PubMed 11163259. Source: MGI motile primary cilium Inferred from direct assay PubMed 17314247. Source: MGI neuronal cell body Inferred from electronic annotation. Source: Compara nuclear envelope Inferred from sequence or structural similarity PubMed 18809722. Source: MGI perinuclear region of cytoplasm Inferred from direct assay PubMed 14578885. Source: MGI vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	microtubule binding Inferred from direct assay PubMed 11163259. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5SW18 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 4DBF6A24A6B131CD	FASTA	410	46,670
	10 20 30 40 50 60 MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 70 80 90 100 110 120 LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 130 140 150 160 170 180 SVMVSASEDA TIKVWDYETG DFERTLKGHT DSVQDISFDH SGKLLASCSA DMTIKLWDFQ 190 200 210 220 230 240 GFECIRTMHG HDHNVSSVAI MPNGDHIVSA SRDKTIKMWE VQTGYCVKTF TGHREWVRMV 250 260 270 280 290 300 RPNQDGTLIA SCSNDQTVRV WVVATKECKA ELREHEHVVE CISWAPESSY SSISEATGSE 310 320 330 340 350 360 TKKSGKPGPF LLSGSRDKTI KMWDVSTGMC LMTLVGHDNW VRGVLFHSGG KFILSCADDK 370 380 390 400 410 TLRVWDYKNK RCMKTLNAHE HFVTSLDFHK TAPYVVTGSV DQTVKVWECR

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAE27977.1 and C57BL/6J EMBL BAE27764.1. Tissue: Amnion EMBL BAE40742.1, Brain EMBL BAE27977.1, Mammary gland EMBL BAE26129.1, Stomach EMBL BAE40766.1 and Whole body EMBL BAE27764.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAE27977.1 and C57BL/6J EMBL BAE27764.1. Tissue: Amnion EMBL BAE40742.1, Brain EMBL BAE27977.1, Mammary gland EMBL BAE26129.1, Stomach EMBL BAE40766.1 and Whole body EMBL BAE27764.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAE27977.1 and C57BL/6J EMBL BAE27764.1. Tissue: Amnion EMBL BAE40742.1, Brain EMBL BAE27977.1, Mammary gland EMBL BAE26129.1, Stomach EMBL BAE40766.1 and Whole body EMBL BAE27764.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAE27977.1 and C57BL/6J EMBL BAE27764.1. Tissue: Amnion EMBL BAE40742.1, Brain EMBL BAE27977.1, Mammary gland EMBL BAE26129.1, Stomach EMBL BAE40766.1 and Whole body EMBL BAE27764.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAE27977.1 and C57BL/6J EMBL BAE27764.1. Tissue: Amnion EMBL BAE40742.1, Brain EMBL BAE27977.1, Mammary gland EMBL BAE26129.1, Stomach EMBL BAE40766.1 and Whole body EMBL BAE27764.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAE27977.1 and C57BL/6J EMBL BAE27764.1. Tissue: Brain EMBL BAE27977.1, Mammary gland EMBL BAE26129.1 and Whole body EMBL BAE27764.1.
[7]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE37586.1. Tissue: Amnion EMBL BAE40742.1, Stomach EMBL BAE40766.1 and Whole body EMBL BAE37586.1.
[8]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAE27977.1 and C57BL/6J EMBL BAE27764.1. Tissue: Amnion EMBL BAE40742.1, Brain EMBL BAE27977.1, Mammary gland EMBL BAE26129.1, Stomach EMBL BAE40766.1 and Whole body EMBL BAE27764.1.
[9]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAE27977.1 and C57BL/6J EMBL BAE27764.1. Tissue: Amnion EMBL BAE40742.1, Brain EMBL BAE27977.1, Mammary gland EMBL BAE26129.1, Stomach EMBL BAE40766.1 and Whole body EMBL BAE27764.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK144908 mRNA. Translation: BAE26129.1. AK147207 mRNA. Translation: BAE27764.1. AK147237 mRNA. Translation: BAE27787.1. AK147507 mRNA. Translation: BAE27961.1. AK147533 mRNA. Translation: BAE27977.1. AK164008 mRNA. Translation: BAE37586.1. AK168929 mRNA. Translation: BAE40742.1. AK168960 mRNA. Translation: BAE40766.1.
IPI	IPI00309207.
RefSeq	NP_038653.1. NM_013625.4.
UniGene	Mm.397111.
3D structure databases
SMR	Q5SW18. Positions 1-79, 92-408.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	18472.
KEGG	mmu:18472.
UCSC	uc007kce.2. mouse.
Organism-specific databases
CTD	5048.
MGI	MGI:109520. Pafah1b1.
Phylogenomic databases
GeneTree	ENSGT00700000104282.
HOVERGEN	HBG006271.
InParanoid	Q5SW18.
KO	K16794.
OMA	WVRGLAF.
Gene expression databases
Genevestigator	Q5SW18.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR017252. Dynein_regulator. IPR020472. G-protein_beta_WD-40_rep. IPR006594. LisH_dimerisation. IPR013720. LisH_dimerisation_subgr. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
PANTHER	PTHR22847:SF51. PTHR22847:SF51. 1 hit.
Pfam	PF08513. LisH. 1 hit. PF00400. WD40. 7 hits. [Graphical view]
PIRSF	PIRSF037647. Dynein_regulator_Lis1. 1 hit.
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00667. LisH. 1 hit. SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS50896. LISH. 1 hit. PS00678. WD_REPEATS_1. 4 hits. PS50082. WD_REPEATS_2. 7 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PAFAH1B1. mouse.
NextBio	294162.
SOURCE	Search...

Entry information

Entry name

Q5SW18_MOUSE

Accession

Primary (citable) accession number: Q5SW18

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)