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Protein

Zinc finger MYM-type protein 1

Gene

ZMYM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 148MYM-type 1Add BLAST39
Zinc fingeri160 – 203MYM-type 2Add BLAST44
Zinc fingeri210 – 245MYM-type 3Add BLAST36
Zinc fingeri300 – 331MYM-type 4Add BLAST32
Zinc fingeri452 – 538TTF-typeAdd BLAST87

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31621-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 1
Gene namesi
Name:ZMYM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26253. ZMYM1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197056.
PharmGKBiPA134948969.

Polymorphism and mutation databases

BioMutaiZMYM1.
DMDMi74743897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913771 – 1142Zinc finger MYM-type protein 1Add BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ5SVZ6.
MaxQBiQ5SVZ6.
PaxDbiQ5SVZ6.
PeptideAtlasiQ5SVZ6.
PRIDEiQ5SVZ6.

PTM databases

iPTMnetiQ5SVZ6.
PhosphoSitePlusiQ5SVZ6.

Expressioni

Gene expression databases

BgeeiENSG00000197056.
CleanExiHS_ZMYM1.
ExpressionAtlasiQ5SVZ6. baseline and differential.
GenevisibleiQ5SVZ6. HS.

Organism-specific databases

HPAiHPA064019.

Interactioni

Protein-protein interaction databases

BioGridi122922. 33 interactors.
IntActiQ5SVZ6. 26 interactors.
STRINGi9606.ENSP00000352920.

Structurei

3D structure databases

ProteinModelPortaliQ5SVZ6.
SMRiQ5SVZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi384 – 420Ser-richAdd BLAST37

Sequence similaritiesi

Contains 4 MYM-type zinc fingers.Curated
Contains 1 TTF-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 148MYM-type 1Add BLAST39
Zinc fingeri160 – 203MYM-type 2Add BLAST44
Zinc fingeri210 – 245MYM-type 3Add BLAST36
Zinc fingeri300 – 331MYM-type 4Add BLAST32
Zinc fingeri452 – 538TTF-typeAdd BLAST87

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IXK1. Eukaryota.
ENOG410XQ1Y. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000132949.
HOVERGENiHBG076163.
InParanoidiQ5SVZ6.
OMAiTYLQQIG.
OrthoDBiEOG091G01OH.
PhylomeDBiQ5SVZ6.
TreeFamiTF330114.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR008906. HATC_C_dom.
IPR012337. RNaseH-like_dom.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF14291. DUF4371. 1 hit.
PF06467. zf-FCS. 2 hits.
[Graphical view]
SMARTiSM00746. TRASH. 5 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5SVZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEPLLGGEC DKAVASQLGL LDEIKTEPDN AQEYCHRQQS RTQENELKIN
60 70 80 90 100
AVFSESASQL TAGIQLSLAS SGVNKMLPSV STTAIQVSCA GCKKILQKGQ
110 120 130 140 150
TAYQRKGSAQ LFCSIPCITE YISSASSPVP SKRTCSNCSK DILNPKDVIS
160 170 180 190 200
VQLEDTTSCK TFCSLSCLSS YEEKRKPFVT ICTNSILTKC SMCQKTAIIQ
210 220 230 240 250
YEVKYQNVKH NLCSNACLSK FHSANNFIMN CCENCGTYCY TSSSLSHILQ
260 270 280 290 300
MEGQSHYFNS SKSITAYKQK PAKPLISVPC KPLKPSDEMI ETTSDLGKTE
310 320 330 340 350
LFCSINCFSA YSKAKMESSS VSVVSVVHDT STELLSPKKD TTPVISNIVS
360 370 380 390 400
LADTDVALPI MNTDVLQDTV SSVTATADVI VDLSKSSPSE PSNAVASSST
410 420 430 440 450
EQPSVSPSSS VFSQHAIGSS TEVQKDNMKS MKISDELCHP KCTSKVQKVK
460 470 480 490 500
GKSRSIKKSC CADFECLENS KKDVAFCYSC QLFCQKYFSC GRESFATHGT
510 520 530 540 550
SNWKKTLEKF RKHEKSEMHL KSLEFWREYQ FCDGAVSDDL SIHSKQIEGN
560 570 580 590 600
KKYLKLIIEN ILFLGKQCLP LRGNDQSVSS VNKGNFLELL EMRAKDKGEE
610 620 630 640 650
TFRLMNSQVD FYNSTQIQSD IIEIIKTEML QDIVNEINDS SAFSIICDET
660 670 680 690 700
INSAMKEQLS ICVRYPQKSS KAILIKERFL GFVDTEEMTG THLHRTIKTY
710 720 730 740 750
LQQIGVDMDK IHGQAYDSTT NLKIKFNKIA AEFKKEEPRA LYIHCYAHFL
760 770 780 790 800
DLSIIRFCKE VKELRSALKT LSSLFNTICM SGEMLANFRN IYRLSQNKTC
810 820 830 840 850
KKHISQSCWT VHDRTLLSVI DSLPEIIETL EVIASHSSNT SFADELSHLL
860 870 880 890 900
TLVSKFEFVF CLKFLYRVLS VTGILSKELQ NKTIDIFSLS SKIEAILECL
910 920 930 940 950
SSERNDVYFK TIWDGTEEIC QKITCKGFKV EKPSLQKRRK IQKSVDLGNS
960 970 980 990 1000
DNMFFPTSTE EQYKINIYYQ GLDTILQNLK LCFSEFDYCK IKQISELLFK
1010 1020 1030 1040 1050
WNEPLNETTA KHVQEFYKLD EDIIPELRFY RHYAKLNFVI DDSCINFVSL
1060 1070 1080 1090 1100
GCLFIQHGLH SNIPCLSKLL YIALSWPITS ASTENSFSTL PRLKTYLCNT
1110 1120 1130 1140
MGQEKLTGPA LMAVEQELVN KLMEPERLNE IVEKFISQMK EI
Length:1,142
Mass (Da):128,717
Last modified:December 21, 2004 - v1
Checksum:iC8F1197AB842C3E4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03458973V → M.2 PublicationsCorresponds to variant rs2971408dbSNPEnsembl.1
Natural variantiVAR_053767454R → Q.Corresponds to variant rs7552714dbSNPEnsembl.1
Natural variantiVAR_053768493E → G.Corresponds to variant rs16837197dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537537 mRNA. Translation: CAD97777.1.
AL607089 Genomic DNA. Translation: CAI12902.1.
CH471059 Genomic DNA. Translation: EAX07428.1.
CH471059 Genomic DNA. Translation: EAX07430.1.
CCDSiCCDS41302.1.
RefSeqiNP_001276017.1. NM_001289088.1.
NP_001276018.1. NM_001289089.1.
NP_001276019.1. NM_001289090.1.
NP_001306884.1. NM_001319955.1.
NP_079048.3. NM_024772.4.
UniGeneiHs.471243.

Genome annotation databases

EnsembliENST00000359858; ENSP00000352920; ENSG00000197056.
ENST00000373330; ENSP00000362427; ENSG00000197056.
ENST00000611874; ENSP00000482579; ENSG00000197056.
GeneIDi79830.
KEGGihsa:79830.
UCSCiuc001bym.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537537 mRNA. Translation: CAD97777.1.
AL607089 Genomic DNA. Translation: CAI12902.1.
CH471059 Genomic DNA. Translation: EAX07428.1.
CH471059 Genomic DNA. Translation: EAX07430.1.
CCDSiCCDS41302.1.
RefSeqiNP_001276017.1. NM_001289088.1.
NP_001276018.1. NM_001289089.1.
NP_001276019.1. NM_001289090.1.
NP_001306884.1. NM_001319955.1.
NP_079048.3. NM_024772.4.
UniGeneiHs.471243.

3D structure databases

ProteinModelPortaliQ5SVZ6.
SMRiQ5SVZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122922. 33 interactors.
IntActiQ5SVZ6. 26 interactors.
STRINGi9606.ENSP00000352920.

PTM databases

iPTMnetiQ5SVZ6.
PhosphoSitePlusiQ5SVZ6.

Polymorphism and mutation databases

BioMutaiZMYM1.
DMDMi74743897.

Proteomic databases

EPDiQ5SVZ6.
MaxQBiQ5SVZ6.
PaxDbiQ5SVZ6.
PeptideAtlasiQ5SVZ6.
PRIDEiQ5SVZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359858; ENSP00000352920; ENSG00000197056.
ENST00000373330; ENSP00000362427; ENSG00000197056.
ENST00000611874; ENSP00000482579; ENSG00000197056.
GeneIDi79830.
KEGGihsa:79830.
UCSCiuc001bym.5. human.

Organism-specific databases

CTDi79830.
GeneCardsiZMYM1.
H-InvDBHIX0000408.
HGNCiHGNC:26253. ZMYM1.
HPAiHPA064019.
neXtProtiNX_Q5SVZ6.
OpenTargetsiENSG00000197056.
PharmGKBiPA134948969.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXK1. Eukaryota.
ENOG410XQ1Y. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000132949.
HOVERGENiHBG076163.
InParanoidiQ5SVZ6.
OMAiTYLQQIG.
OrthoDBiEOG091G01OH.
PhylomeDBiQ5SVZ6.
TreeFamiTF330114.

Enzyme and pathway databases

BioCyciZFISH:G66-31621-MONOMER.

Miscellaneous databases

GenomeRNAii79830.
PROiQ5SVZ6.

Gene expression databases

BgeeiENSG00000197056.
CleanExiHS_ZMYM1.
ExpressionAtlasiQ5SVZ6. baseline and differential.
GenevisibleiQ5SVZ6. HS.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR008906. HATC_C_dom.
IPR012337. RNaseH-like_dom.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF14291. DUF4371. 1 hit.
PF06467. zf-FCS. 2 hits.
[Graphical view]
SMARTiSM00746. TRASH. 5 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZMYM1_HUMAN
AccessioniPrimary (citable) accession number: Q5SVZ6
Secondary accession number(s): D3DPR7, Q7Z3Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.