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Protein

C-C motif chemokine

Gene

Ccl2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokineUniRule annotation
Gene namesi
Name:Ccl2Imported
ORF Names:mCG_8184Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98259. Ccl2.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_500999877824 – 148C-C motif chemokineUniRule annotationAdd BLAST125

Expressioni

Gene expression databases

BgeeiENSMUSG00000035385.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000193.

Structurei

3D structure databases

SMRiQ5SVU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 90SCYInterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
HOVERGENiHBG017871.
KOiK14624.
OMAiNAPLTCC.
OrthoDBiEOG091G14KV.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SVU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVPVMLLGL LFTVAGWSIH VLAQPDAVNA PLTCCYSFTS KMIPMSRLES
60 70 80 90 100
YKRITSSRCP KEAVVFVTKL KREVCADPKK EWVQTYIKNL DRNQMRSEPT
110 120 130 140
TLFKTASALR SSAPLNVKLT RKSEANASTT FSTTTSSTSV GVTSVTVN
Length:148
Mass (Da):16,326
Last modified:May 10, 2005 - v1
Checksum:i29A5505FC6D94837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145867 mRNA. Translation: AAI45868.1.
BC145869 mRNA. Translation: AAI45870.1.
AK132590 mRNA. Translation: BAE21250.1.
AK150937 mRNA. Translation: BAE29972.1.
AK153468 mRNA. Translation: BAE32019.1.
CT010187 mRNA. Translation: CAJ18395.1.
CH466556 Genomic DNA. Translation: EDL15657.1.
RefSeqiNP_035463.1. NM_011333.3.
UniGeneiMm.290320.

Genome annotation databases

GeneIDi20296.
KEGGimmu:20296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145867 mRNA. Translation: AAI45868.1.
BC145869 mRNA. Translation: AAI45870.1.
AK132590 mRNA. Translation: BAE21250.1.
AK150937 mRNA. Translation: BAE29972.1.
AK153468 mRNA. Translation: BAE32019.1.
CT010187 mRNA. Translation: CAJ18395.1.
CH466556 Genomic DNA. Translation: EDL15657.1.
RefSeqiNP_035463.1. NM_011333.3.
UniGeneiMm.290320.

3D structure databases

SMRiQ5SVU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20296.
KEGGimmu:20296.

Organism-specific databases

CTDi6347.
MGIiMGI:98259. Ccl2.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
HOVERGENiHBG017871.
KOiK14624.
OMAiNAPLTCC.
OrthoDBiEOG091G14KV.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035385.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SVU3_MOUSE
AccessioniPrimary (citable) accession number: Q5SVU3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 7, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.