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Protein

Kidney mitochondrial carrier protein 1

Gene

SLC25A30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.24.4 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Kidney mitochondrial carrier protein 1
Alternative name(s):
Solute carrier family 25 member 30
Gene namesi
Name:SLC25A30
Synonyms:KMCP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000174032.16
HGNCiHGNC:27371 SLC25A30
MIMi610793 gene
neXtProtiNX_Q5SVS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 26Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei71 – 89Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei105 – 124Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei264 – 283Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi253512
OpenTargetsiENSG00000174032
PharmGKBiPA134931353

Polymorphism and mutation databases

DMDMi74743890

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002889162 – 291Kidney mitochondrial carrier protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ5SVS4
PaxDbiQ5SVS4
PeptideAtlasiQ5SVS4
PRIDEiQ5SVS4

PTM databases

iPTMnetiQ5SVS4
PhosphoSitePlusiQ5SVS4

Expressioni

Gene expression databases

BgeeiENSG00000174032
CleanExiHS_SLC25A30
ExpressionAtlasiQ5SVS4 baseline and differential
GenevisibleiQ5SVS4 HS

Organism-specific databases

HPAiHPA045260

Interactioni

Subunit structurei

Interacts with VDAC1.1 Publication

Protein-protein interaction databases

BioGridi128971, 19 interactors
STRINGi9606.ENSP00000429168

Structurei

3D structure databases

ProteinModelPortaliQ5SVS4
SMRiQ5SVS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 96Solcar 1Add BLAST90
Repeati104 – 189Solcar 2Add BLAST86
Repeati198 – 289Solcar 3Add BLAST92

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOVERGENiHBG009528
InParanoidiQ5SVS4
KOiK15106
OMAiSITAECG
OrthoDBiEOG091G0BQ7
PhylomeDBiQ5SVS4
TreeFamiTF323211

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SVS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DAKFKEIRYR
60 70 80 90 100
GMLHALVRIG REEGLKALYS GIAPAMLRQA SYGTIKIGTY QSLKRLFIER
110 120 130 140 150
PEDETLPINV ICGILSGVIS STIANPTDVL KIRMQAQSNT IQGGMIGNFM
160 170 180 190 200
NIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL PVYDITKKHL ILSGLMGDTV
210 220 230 240 250
YTHFLSSFTC GLAGALASNP VDVVRTRMMN QRVLRDGRCS GYTGTLDCLL
260 270 280 290
QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF VTYEQLKKLD L
Length:291
Mass (Da):32,475
Last modified:December 21, 2004 - v1
Checksum:i76A8A6F087454B7F
GO
Isoform 2 (identifier: Q5SVS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):26,756
Checksum:i15DD66777B49F0DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204F → L in BAG64115 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0539841 – 51Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302967 mRNA Translation: BAG64115.1
AL627107 Genomic DNA No translation available.
BC132739 mRNA Translation: AAI32740.1
BC136760 mRNA Translation: AAI36761.1
CCDSiCCDS31967.1 [Q5SVS4-1]
CCDS66539.1 [Q5SVS4-2]
RefSeqiNP_001010875.1, NM_001010875.3 [Q5SVS4-1]
NP_001273735.1, NM_001286806.1 [Q5SVS4-2]
XP_016876013.1, XM_017020524.1 [Q5SVS4-1]
UniGeneiHs.591230

Genome annotation databases

EnsembliENST00000519676; ENSP00000429168; ENSG00000174032 [Q5SVS4-1]
ENST00000539591; ENSP00000443542; ENSG00000174032 [Q5SVS4-2]
GeneIDi253512
KEGGihsa:253512
UCSCiuc001vag.5 human [Q5SVS4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKMCP1_HUMAN
AccessioniPrimary (citable) accession number: Q5SVS4
Secondary accession number(s): B2RN96, B4DZK3, F5H8H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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