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Protein

Kidney mitochondrial carrier protein 1

Gene

SLC25A30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.24.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Kidney mitochondrial carrier protein 1
Alternative name(s):
Solute carrier family 25 member 30
Gene namesi
Name:SLC25A30
Synonyms:KMCP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:27371. SLC25A30.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2618Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei71 – 8919Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei105 – 12420Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei164 – 18320Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei264 – 28320Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931353.

Polymorphism and mutation databases

DMDMi74743890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 291290Kidney mitochondrial carrier protein 1PRO_0000288916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ5SVS4.
PaxDbiQ5SVS4.
PeptideAtlasiQ5SVS4.
PRIDEiQ5SVS4.

PTM databases

iPTMnetiQ5SVS4.
PhosphoSiteiQ5SVS4.

Expressioni

Gene expression databases

BgeeiENSG00000174032.
CleanExiHS_SLC25A30.
ExpressionAtlasiQ5SVS4. baseline and differential.
GenevisibleiQ5SVS4. HS.

Organism-specific databases

HPAiHPA045260.

Interactioni

Protein-protein interaction databases

BioGridi128971. 13 interactions.
STRINGi9606.ENSP00000429168.

Structurei

3D structure databases

ProteinModelPortaliQ5SVS4.
SMRiQ5SVS4. Positions 9-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 9690Solcar 1Add
BLAST
Repeati104 – 18986Solcar 2Add
BLAST
Repeati198 – 28992Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOVERGENiHBG009528.
InParanoidiQ5SVS4.
KOiK15106.
OMAiMNIYQQE.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ5SVS4.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SVS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DAKFKEIRYR
60 70 80 90 100
GMLHALVRIG REEGLKALYS GIAPAMLRQA SYGTIKIGTY QSLKRLFIER
110 120 130 140 150
PEDETLPINV ICGILSGVIS STIANPTDVL KIRMQAQSNT IQGGMIGNFM
160 170 180 190 200
NIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL PVYDITKKHL ILSGLMGDTV
210 220 230 240 250
YTHFLSSFTC GLAGALASNP VDVVRTRMMN QRVLRDGRCS GYTGTLDCLL
260 270 280 290
QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF VTYEQLKKLD L
Length:291
Mass (Da):32,475
Last modified:December 21, 2004 - v1
Checksum:i76A8A6F087454B7F
GO
Isoform 2 (identifier: Q5SVS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):26,756
Checksum:i15DD66777B49F0DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041F → L in BAG64115 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5151Missing in isoform 2. 1 PublicationVSP_053984Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302967 mRNA. Translation: BAG64115.1.
AL627107 Genomic DNA. No translation available.
BC132739 mRNA. Translation: AAI32740.1.
BC136760 mRNA. Translation: AAI36761.1.
CCDSiCCDS31967.1. [Q5SVS4-1]
CCDS66539.1. [Q5SVS4-2]
RefSeqiNP_001010875.1. NM_001010875.3. [Q5SVS4-1]
NP_001273735.1. NM_001286806.1. [Q5SVS4-2]
UniGeneiHs.591230.

Genome annotation databases

EnsembliENST00000519676; ENSP00000429168; ENSG00000174032. [Q5SVS4-1]
ENST00000539591; ENSP00000443542; ENSG00000174032. [Q5SVS4-2]
GeneIDi253512.
KEGGihsa:253512.
UCSCiuc001vag.5. human. [Q5SVS4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302967 mRNA. Translation: BAG64115.1.
AL627107 Genomic DNA. No translation available.
BC132739 mRNA. Translation: AAI32740.1.
BC136760 mRNA. Translation: AAI36761.1.
CCDSiCCDS31967.1. [Q5SVS4-1]
CCDS66539.1. [Q5SVS4-2]
RefSeqiNP_001010875.1. NM_001010875.3. [Q5SVS4-1]
NP_001273735.1. NM_001286806.1. [Q5SVS4-2]
UniGeneiHs.591230.

3D structure databases

ProteinModelPortaliQ5SVS4.
SMRiQ5SVS4. Positions 9-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128971. 13 interactions.
STRINGi9606.ENSP00000429168.

Protein family/group databases

TCDBi2.A.29.24.4. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ5SVS4.
PhosphoSiteiQ5SVS4.

Polymorphism and mutation databases

DMDMi74743890.

Proteomic databases

MaxQBiQ5SVS4.
PaxDbiQ5SVS4.
PeptideAtlasiQ5SVS4.
PRIDEiQ5SVS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000519676; ENSP00000429168; ENSG00000174032. [Q5SVS4-1]
ENST00000539591; ENSP00000443542; ENSG00000174032. [Q5SVS4-2]
GeneIDi253512.
KEGGihsa:253512.
UCSCiuc001vag.5. human. [Q5SVS4-1]

Organism-specific databases

CTDi253512.
GeneCardsiSLC25A30.
HGNCiHGNC:27371. SLC25A30.
HPAiHPA045260.
MIMi610793. gene.
neXtProtiNX_Q5SVS4.
PharmGKBiPA134931353.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOVERGENiHBG009528.
InParanoidiQ5SVS4.
KOiK15106.
OMAiMNIYQQE.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ5SVS4.
TreeFamiTF323211.

Miscellaneous databases

GenomeRNAii253512.
PROiQ5SVS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174032.
CleanExiHS_SLC25A30.
ExpressionAtlasiQ5SVS4. baseline and differential.
GenevisibleiQ5SVS4. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKMCP1_HUMAN
AccessioniPrimary (citable) accession number: Q5SVS4
Secondary accession number(s): B2RN96, B4DZK3, F5H8H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.