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Protein

TBC1 domain family member 9B

Gene

Tbc1d9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei556Arginine fingerBy similarity1
Sitei595Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 9B
Gene namesi
Name:Tbc1d9b
Synonyms:Kiaa0676
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1924045. Tbc1d9b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885021 – 1263TBC1 domain family member 9BAdd BLAST1263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei397PhosphothreonineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei433PhosphoserineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei464PhosphoserineCombined sources1
Modified residuei1254PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5SVR0.
PeptideAtlasiQ5SVR0.
PRIDEiQ5SVR0.

PTM databases

iPTMnetiQ5SVR0.
PhosphoSitePlusiQ5SVR0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036644.
CleanExiMM_TBC1D9B.
GenevisibleiQ5SVR0. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218320. 2 interactors.
IntActiQ5SVR0. 1 interactor.
STRINGi10090.ENSMUSP00000090825.

Structurei

3D structure databases

ProteinModelPortaliQ5SVR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 209GRAM 1Add BLAST68
Domaini288 – 356GRAM 2Add BLAST69
Domaini509 – 696Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST188
Domaini880 – 915EF-handPROSITE-ProRule annotationAdd BLAST36

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 2 GRAM domains.Curated
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4347. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOVERGENiHBG054142.
InParanoidiQ5SVR0.
KOiK19951.
OMAiEGEAMTI.
OrthoDBiEOG091G00RI.
PhylomeDBiQ5SVR0.
TreeFamiTF313145.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR004182. GRAM.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF02893. GRAM. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM00568. GRAM. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47923. SSF47923. 2 hits.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SVR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLGPEEVLV ANALWVTERA NPFFVLQRRR GHGKGGGLTG LLVGTLDVVL
60 70 80 90 100
DSSARVAPYR ILHQTQDSQV YWIVACGSSR KEITKHWEWL ENNLLQTLSI
110 120 130 140 150
FDNEEDITTF VKGKIHGIIA EENKNLQPQG DEDPGKFKEA ELKMRKQFGM
160 170 180 190 200
PEGEKLVNYY SCNFWKGRVP RQGWLYLTVN HLCFYSFLLG KEVSLVVQWV
210 220 230 240 250
DVTRLEKNAT LLFPESIRVD TRDQELFFSM FLNIGETFKL MEQLANLAMR
260 270 280 290 300
QLLDSEGFLE DKALPRPIRP HKNISALKRD LDARAKNECY RATFRLPKDE
310 320 330 340 350
RLDGHTGCTL WTPFNKLHIP GQMFISNNYI CFASKEEDAC RLIIPLREVT
360 370 380 390 400
IVEKADSSSV LPSPLSISTK SKMTFLFANL KDRDFLVQRI SDFLQKTPSK
410 420 430 440 450
QTGSSIGGTK ASVSDPAPES LPTPQEASEP PASPSSPLSS PPSFSTQEIP
460 470 480 490 500
TTSQGLLKVF QKNSPMEDLG AKGAKEKMKE ESWNIHFFEY GRGMCMYRTA
510 520 530 540 550
KTRELVLKGI PESLRGELWL LFSGAWNEMV THPGYYAELV EKSLGKYSLA
560 570 580 590 600
TEEIERDLHR SMPEHPAFQN ELGIAALRRV LTAYAFRNPT IGYCQAMNIV
610 620 630 640 650
TSVLLLYGSE EEAFWLLVAL CERMLPDYYN TRVVGALVDQ GIFEELTRDV
660 670 680 690 700
LPRLSEKMQE LGVISSISLS WFLTLFLSVM PFESAVVIVD CFFYEGIKVI
710 720 730 740 750
LQVALAVLDA NVEQLLDCND EGEAMTVLGR YLDNVVNKQS ISPPIPHLHA
760 770 780 790 800
LLTSGDDPPV EVDIFDLLRV SYEKFSNLRA DDIEQMRFKQ RLKVIQSLED
810 820 830 840 850
TAKRSVVRAI PGDIGFSIEE LEDLYMVFKA KHLASQYWGG NRSAAVHRDP
860 870 880 890 900
SLPYLEQYRI DASQFRELFA SLTPWACGSH TPVLAGRMFR LLDQNKDSLI
910 920 930 940 950
NFKEFVTGMS GMYHGDLTEK LKALYKLHLP PALIPEEAES ALEAAHYFTE
960 970 980 990 1000
DSSSEASPLA SDLDLFLPWE AQALLQEQQE GSGNEDTPER REEKGTSPPD
1010 1020 1030 1040 1050
YRHYLRMWAK EKEAQKETIK DLPKMNQEQF IELCKTLYNM FSEDPMEQDL
1060 1070 1080 1090 1100
YHAIATVASL LLRIGEVGKK FSALTTKKPR DGAHSGDPNS ATEEDEPPTP
1110 1120 1130 1140 1150
KLHQDPTQEC QPPAAGDRQA KASGDMHLGK ALQDSHVIVE GGSGEGQGSP
1160 1170 1180 1190 1200
SLLLSDDETK DDMSMSSYSV VSTGSLQCED LTEDTVLVGG GACSPTATSR
1210 1220 1230 1240 1250
AGGTVDTDWC ISFEQILASI LTESVLVNFF EKRVDIGLKI KDQKKVERQF
1260
STSSDHEPPG VLG
Length:1,263
Mass (Da):141,779
Last modified:December 21, 2004 - v1
Checksum:i2D12CE5E297D723E
GO
Isoform 2 (identifier: Q5SVR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     957-973: Missing.

Show »
Length:1,246
Mass (Da):139,924
Checksum:i9E7CFA8DB066EFF1
GO

Sequence cautioni

The sequence BAC27640 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32277 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73I → T in BAD32277 (PubMed:15368895).Curated1
Sequence conflicti161 – 163SCN → PCT in BAD32277 (PubMed:15368895).Curated3
Sequence conflicti415D → A in BAD32277 (PubMed:15368895).Curated1
Sequence conflicti807Missing in BAD32277 (PubMed:15368895).Curated1
Sequence conflicti1225V → M in BAE28254 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025700957 – 973Missing in isoform 2. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172999 mRNA. Translation: BAD32277.1. Different initiation.
AK012224 mRNA. Translation: BAB28107.1.
AK031992 mRNA. Translation: BAC27640.1. Different initiation.
AK035457 mRNA. Translation: BAC29068.1.
AK049999 mRNA. Translation: BAC34024.2.
AK147964 mRNA. Translation: BAE28254.1.
AL627187 Genomic DNA. Translation: CAI25112.1.
AL627187 Genomic DNA. Translation: CAI25113.1.
BC048085 mRNA. Translation: AAH48085.1.
BC058596 mRNA. Translation: AAH58596.1.
BC062928 mRNA. Translation: AAH62928.1.
BC065080 mRNA. Translation: AAH65080.1.
CCDSiCCDS36146.1. [Q5SVR0-2]
CCDS70175.1. [Q5SVR0-1]
RefSeqiNP_001277688.1. NM_001290759.1.
NP_001277689.1. NM_001290760.1. [Q5SVR0-1]
NP_084021.2. NM_029745.2. [Q5SVR0-2]
UniGeneiMm.290975.
Mm.413847.

Genome annotation databases

EnsembliENSMUST00000093138; ENSMUSP00000090825; ENSMUSG00000036644. [Q5SVR0-2]
ENSMUST00000101270; ENSMUSP00000098828; ENSMUSG00000036644. [Q5SVR0-1]
GeneIDi76795.
KEGGimmu:76795.
UCSCiuc007irp.2. mouse. [Q5SVR0-1]
uc007irq.1. mouse. [Q5SVR0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172999 mRNA. Translation: BAD32277.1. Different initiation.
AK012224 mRNA. Translation: BAB28107.1.
AK031992 mRNA. Translation: BAC27640.1. Different initiation.
AK035457 mRNA. Translation: BAC29068.1.
AK049999 mRNA. Translation: BAC34024.2.
AK147964 mRNA. Translation: BAE28254.1.
AL627187 Genomic DNA. Translation: CAI25112.1.
AL627187 Genomic DNA. Translation: CAI25113.1.
BC048085 mRNA. Translation: AAH48085.1.
BC058596 mRNA. Translation: AAH58596.1.
BC062928 mRNA. Translation: AAH62928.1.
BC065080 mRNA. Translation: AAH65080.1.
CCDSiCCDS36146.1. [Q5SVR0-2]
CCDS70175.1. [Q5SVR0-1]
RefSeqiNP_001277688.1. NM_001290759.1.
NP_001277689.1. NM_001290760.1. [Q5SVR0-1]
NP_084021.2. NM_029745.2. [Q5SVR0-2]
UniGeneiMm.290975.
Mm.413847.

3D structure databases

ProteinModelPortaliQ5SVR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218320. 2 interactors.
IntActiQ5SVR0. 1 interactor.
STRINGi10090.ENSMUSP00000090825.

PTM databases

iPTMnetiQ5SVR0.
PhosphoSitePlusiQ5SVR0.

Proteomic databases

PaxDbiQ5SVR0.
PeptideAtlasiQ5SVR0.
PRIDEiQ5SVR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093138; ENSMUSP00000090825; ENSMUSG00000036644. [Q5SVR0-2]
ENSMUST00000101270; ENSMUSP00000098828; ENSMUSG00000036644. [Q5SVR0-1]
GeneIDi76795.
KEGGimmu:76795.
UCSCiuc007irp.2. mouse. [Q5SVR0-1]
uc007irq.1. mouse. [Q5SVR0-2]

Organism-specific databases

CTDi23061.
MGIiMGI:1924045. Tbc1d9b.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4347. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOVERGENiHBG054142.
InParanoidiQ5SVR0.
KOiK19951.
OMAiEGEAMTI.
OrthoDBiEOG091G00RI.
PhylomeDBiQ5SVR0.
TreeFamiTF313145.

Miscellaneous databases

ChiTaRSiTbc1d9b. mouse.
PROiQ5SVR0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036644.
CleanExiMM_TBC1D9B.
GenevisibleiQ5SVR0. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR004182. GRAM.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF02893. GRAM. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM00568. GRAM. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47923. SSF47923. 2 hits.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBC9B_MOUSE
AccessioniPrimary (citable) accession number: Q5SVR0
Secondary accession number(s): Q3UGF5
, Q6A019, Q6P1G9, Q6PDP2, Q80ZU6, Q8C7K9, Q8CBR7, Q8CCW2, Q9CSQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.