Q5SVQ8 (ZBT41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 41

Gene names

Name:	ZBTB41
Synonyms:	FRBZ1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	909 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 14 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SVQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SVQ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     627-627: G → D
     628-909: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 909	909	Zinc finger and BTB domain-containing protein 41		PRO_0000277814
Regions
	Domain	88 – 152	65	BTB
	Zinc finger	207 – 230	24	C2H2-type 1
	Zinc finger	361 – 383	23	C2H2-type 2
	Zinc finger	389 – 411	23	C2H2-type 3
	Zinc finger	422 – 445	24	C2H2-type 4
	Zinc finger	463 – 485	23	C2H2-type 5
	Zinc finger	491 – 514	24	C2H2-type 6
	Zinc finger	518 – 541	24	C2H2-type 7
	Zinc finger	547 – 569	23	C2H2-type 8
	Zinc finger	575 – 597	23	C2H2-type 9
	Zinc finger	603 – 625	23	C2H2-type 10
	Zinc finger	631 – 654	24	C2H2-type 11
	Zinc finger	668 – 690	23	C2H2-type 12
	Zinc finger	696 – 718	23	C2H2-type 13
	Zinc finger	724 – 747	24	C2H2-type 14
Natural variations
	Alternative sequence	627	1	G → D in isoform 2.		VSP_023092
	Alternative sequence	628 – 909	282	Missing in isoform 2.		VSP_023093
	Natural variant	327	1	D → Y. Corresponds to variant rs10494751 [ dbSNP | Ensembl ].		VAR_030601
Experimental info
	Sequence conflict	182	1	F → L in BAC87496. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: BAB9F19F2F40772F	FASTA	909	105,192
	10 20 30 40 50 60 MKKRRKVTSN LEKIHLGYHK DSSEGNVAVE CDQVTYTHSA GRPTPEALHC YQELPPSPDQ 70 80 90 100 110 120 RKLLSSLQYN KNLLKYLNDD RQKQPSFCDL LIIVEGKEFS AHKVVVAVGS SYFHACLSKN 130 140 150 160 170 180 PSTDVVTLDH VTHSVFQHLL EFLYTSEFFV YKYEIPLVLE AAKFLDIIDA VKLLNNENVA 190 200 210 220 230 240 PFHSELTEKS SPEETLNELT GRLSNNHQCK FCSRHFCYKK SLENHLAKTH RSLLLGKKHG 250 260 270 280 290 300 LKMLERSFSA RRSKRNRKCP VKFDDTSDDE QESGDGSDNL NQENFDKEKS DRNDSEDPGS 310 320 330 340 350 360 EYNAEEDELE EEMSDEYSDI EEQSEKDHND AEEEPEAGDS VGNVHEGLTP VVIQNSNKKI 370 380 390 400 410 420 LQCPKCDKTF DRIGKYESHT RVHTGEKPFE CDICHQRYST KSNLTVHRKK HSNETEFHKK 430 440 450 460 470 480 EHKCPYCNKL HASKKTLAKH VKRFHPENAQ EFISIKKTKS ESWKCDICKK SFTRRPHLEE 490 500 510 520 530 540 HMILHSQDKP FKCTYCEEHF KSRFARLKHQ EKFHLGPFPC DICGRQFNDT GNLKRHIECT 550 560 570 580 590 600 HGGKRKWTCF ICGKSVRERT TLKEHLRIHS GEKPHLCSIC GQSFRHGSSY RLHLRVHHDD 610 620 630 640 650 660 KRYECDECGK TFIRHDHLTK HKKIHSGEKA HQCEECGKCF GRRDHLTVHY KSVHLGEKVW 670 680 690 700 710 720 QKYKATFHQC DVCKKIFKGK SSLEMHFRTH SGEKPYKCQI CNQSFRIKKT LTKHLVIHSD 730 740 750 760 770 780 ARPFNCQHCN ATFKRKDKLK YHIDHVHEIK SPDDPLSTSE EKLVSLPVEY SSDDKIFQTE 790 800 810 820 830 840 TKQYMDQPKV YQSEAKTMLQ NVSAEVCVPV TLVPVQMPDT PSDLVRHTTT LPPSSHEILS 850 860 870 880 890 900 PQPQSTDYPR AADLAFLEKY TLTPQPANIV HPVRPEQMLD PREQSYLGTL LGLDSTTGVQ NISTNEHHS
	Isoform 2 [UniParc]. Checksum: 350F812D7C761F03	FASTA	627	72,945
	10 20 30 40 50 60 MKKRRKVTSN LEKIHLGYHK DSSEGNVAVE CDQVTYTHSA GRPTPEALHC YQELPPSPDQ 70 80 90 100 110 120 RKLLSSLQYN KNLLKYLNDD RQKQPSFCDL LIIVEGKEFS AHKVVVAVGS SYFHACLSKN 130 140 150 160 170 180 PSTDVVTLDH VTHSVFQHLL EFLYTSEFFV YKYEIPLVLE AAKFLDIIDA VKLLNNENVA 190 200 210 220 230 240 PFHSELTEKS SPEETLNELT GRLSNNHQCK FCSRHFCYKK SLENHLAKTH RSLLLGKKHG 250 260 270 280 290 300 LKMLERSFSA RRSKRNRKCP VKFDDTSDDE QESGDGSDNL NQENFDKEKS DRNDSEDPGS 310 320 330 340 350 360 EYNAEEDELE EEMSDEYSDI EEQSEKDHND AEEEPEAGDS VGNVHEGLTP VVIQNSNKKI 370 380 390 400 410 420 LQCPKCDKTF DRIGKYESHT RVHTGEKPFE CDICHQRYST KSNLTVHRKK HSNETEFHKK 430 440 450 460 470 480 EHKCPYCNKL HASKKTLAKH VKRFHPENAQ EFISIKKTKS ESWKCDICKK SFTRRPHLEE 490 500 510 520 530 540 HMILHSQDKP FKCTYCEEHF KSRFARLKHQ EKFHLGPFPC DICGRQFNDT GNLKRHIECT 550 560 570 580 590 600 HGGKRKWTCF ICGKSVRERT TLKEHLRIHS GEKPHLCSIC GQSFRHGSSY RLHLRVHHDD 610 620 KRYECDECGK TFIRHDHLTK HKKIHSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, gene mapping, and expression of FRBZ1." Goudou D., Bitoun M., Rieger F., Perin J.-P., Alliel P.M. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain and Placenta.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Trachea.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 743-909. Tissue: Fetal kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY163816 mRNA. Translation: AAN71742.2. AY336933 mRNA. Translation: AAP97434.1. AK128549 mRNA. Translation: BAC87496.1. AL356315, AL627208 Genomic DNA. Translation: CAI13461.1. AL627208, AL356315 Genomic DNA. Translation: CAI14333.1. BC132818 mRNA. Translation: AAI32819.1. BC136600 mRNA. Translation: AAI36601.1. BX640886 mRNA. Translation: CAE45940.1.
IPI	IPI00411515. IPI00828141.
RefSeq	NP_919290.2. NM_194314.2.
UniGene	Hs.529439.
3D structure databases
HSSP	HSSP built from PDB template 1SP1 based on UniProtKB P08047.
ProteinModelPortal	Q5SVQ8.
SMR	Q5SVQ8. Positions 61-173, 334-748.
ModBase	Search...
PTM databases
PhosphoSite	Q5SVQ8.
Polymorphism databases
DMDM	74756116.
Proteomic databases
PRIDE	Q5SVQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367405; ENSP00000356375; ENSG00000177888.
GeneID	360023.
KEGG	hsa:360023.
UCSC	uc001gtx.1. human.
Organism-specific databases
CTD	360023.
GeneCards	GC01M197122.
H-InvDB	HIX0200000.
HGNC	HGNC:24819. ZBTB41.
HPA	HPA034842.
neXtProt	NX_Q5SVQ8.
PharmGKB	PA142670545.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19577.
HOGENOM	HBG713964.
HOVERGEN	HBG080093.
InParanoid	Q5SVQ8.
OMA	VGNIHEG.
OrthoDB	EOG4GTKCF.
PhylomeDB	Q5SVQ8.
Gene expression databases
ArrayExpress	Q5SVQ8.
Bgee	Q5SVQ8.
CleanEx	HS_ZBTB41.
Genevestigator	Q5SVQ8.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 12 hits.
KO	K10513.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 9 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 14 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 14 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	100007.

Entry information

Entry name

ZBT41_HUMAN

Accession

Primary (citable) accession number: Q5SVQ8
Secondary accession number(s): A2RUA8 , Q6MZT8, Q6ZR25, Q7Z4T1, Q8IZ99

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.