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Q5SVQ0

- KAT7_MOUSE

UniProt

Q5SVQ0 - KAT7_MOUSE

Protein

Histone acetyltransferase KAT7

Gene

Kat7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei434 – 4341By similarity
    Active sitei476 – 4761NucleophileBy similarity
    Binding sitei479 – 4791Acetyl-CoABy similarity
    Binding sitei514 – 5141Acetyl-CoABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri368 – 39023C2HC-typeAdd
    BLAST

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA replication Source: UniProtKB
    2. histone H3 acetylation Source: UniProtKB
    3. histone H4-K12 acetylation Source: UniProtKB
    4. histone H4-K5 acetylation Source: UniProtKB
    5. histone H4-K8 acetylation Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    DNA replication, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase KAT7 (EC:2.3.1.48)
    Alternative name(s):
    Histone acetyltransferase binding to ORC1
    Lysine acetyltransferase 7
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
    Short name:
    MYST-2
    Gene namesi
    Name:Kat7
    Synonyms:Hbo1, Myst2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2182799. Kat7.

    Subcellular locationi

    Nucleusnucleoplasm By similarity

    GO - Cellular componenti

    1. histone acetyltransferase complex Source: UniProtKB
    2. nucleoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 613613Histone acetyltransferase KAT7PRO_0000051570Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521PhosphoserineBy similarity
    Modified residuei59 – 591Phosphoserine; by PLK1By similarity
    Modified residuei87 – 871Phosphothreonine; by CDK1By similarity
    Modified residuei90 – 901Phosphothreonine; by CDK1By similarity
    Modified residuei104 – 1041PhosphoserineBy similarity
    Modified residuei126 – 1261PhosphoserineBy similarity
    Modified residuei164 – 1641PhosphoserineBy similarity
    Modified residuei166 – 1661PhosphoserineBy similarity
    Modified residuei201 – 2011N6-acetyllysine1 Publication
    Modified residuei279 – 2791N6-acetyllysine1 Publication
    Modified residuei434 – 4341N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei508 – 5081PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-59 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-87 and Thr-90 by CDK1.By similarity
    Autoacetylation at Lys-434 is required for proper function.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ5SVQ0.
    PaxDbiQ5SVQ0.
    PRIDEiQ5SVQ0.

    PTM databases

    PhosphoSiteiQ5SVQ0.

    Expressioni

    Gene expression databases

    BgeeiQ5SVQ0.
    CleanExiMM_MYST2.
    GenevestigatoriQ5SVQ0.

    Interactioni

    Subunit structurei

    Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone By similarity.By similarity

    Protein-protein interaction databases

    BioGridi229849. 2 interactions.
    IntActiQ5SVQ0. 2 interactions.
    MINTiMINT-5065215.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SVQ0.
    SMRiQ5SVQ0. Positions 185-213, 342-609.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini334 – 609276MYST-type HATAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni484 – 4907Acetyl-CoA bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi12 – 5948Ser-richAdd
    BLAST

    Domaini

    The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.By similarity
    The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.By similarity

    Sequence similaritiesi

    Belongs to the MYST (SAS/MOZ) family.Curated
    Contains 1 C2HC-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri368 – 39023C2HC-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5027.
    GeneTreeiENSGT00550000074503.
    HOVERGENiHBG053268.
    InParanoidiQ5SVQ0.
    KOiK11307.
    OMAiVYSTRRV.
    OrthoDBiEOG7WHH8N.
    PhylomeDBiQ5SVQ0.
    TreeFamiTF317619.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR002717. MOZ_SAS.
    IPR015880. Znf_C2H2-like.
    IPR002515. Znf_C2HC.
    [Graphical view]
    PfamiPF01853. MOZ_SAS. 1 hit.
    PF01530. zf-C2HC. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51726. MYST_HAT. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5SVQ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAIGVVKRNA GSSSDGTEDS DFSTDLEHTD SSESDGTSRR SARVTRSSAR    50
    LSQSSQDSSP VRNLPSFGTE EPAYSTRRVT RSQQQPTPVT PKKYPLRQTR 100
    SSGSETEQVV DFSDRETKNT ADHDESPPRT PTGNAPSSES DIDISSPNVS 150
    HDESIAKDMS LKDSGSDLSH RPKRRRFHES YNFNMKCPTP GCNSLGHLTG 200
    KHERHFSISG CPLYHNLSAD ECKVRAQSRD KQIEERMLSH RQDDNNRHAT 250
    RHQAPTERQL RYKEKVAELR KKRNSGLSKE QKEKYMEHRQ TYGNTREPLL 300
    ENLTSEYDLD LFRRAQARAS EDLEKLRLQG QITEGSNMIK TIAFGRYELD 350
    TWYHSPYPEE YARLGRLYMC EFCLKYMKSQ TILRRHMAKC VWKHPPGDEI 400
    YRKGSISVFE VDGKKNKIYC QNLCLLAKLF LDHKTLYYDV EPFLFYVMTE 450
    ADNTGCHLIG YFSKEKNSFL NYNVSCILTM PQYMRQGYGK MLIDFSYLLS 500
    KVEEKVGSPE RPLSDLGLIS YRSYWKEVLL RYLHNFQGKE ISIKEISQET 550
    AVNPVDIVST LQALQMLKYW KGKHLVLKRQ DLIDEWIAKE AKRSNSNKTM 600
    DPSCLKWTPP KGT 613
    Length:613
    Mass (Da):70,641
    Last modified:December 21, 2004 - v1
    Checksum:i7D6F05EE90A7134E
    GO
    Isoform 2 (identifier: Q5SVQ0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         224-253: Missing.

    Show »
    Length:583
    Mass (Da):66,946
    Checksum:i3F76E885AA985114
    GO
    Isoform 3 (identifier: Q5SVQ0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MAIGVV → MPRR

    Show »
    Length:611
    Mass (Da):70,611
    Checksum:i769DE7C4F03762D9
    GO
    Isoform 4 (identifier: Q5SVQ0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MAIGVV → MPRR
         224-253: Missing.

    Show »
    Length:581
    Mass (Da):66,916
    Checksum:i3F06E4C3E47EFBA3
    GO
    Isoform 5 (identifier: Q5SVQ0-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MAIGVV → MPRR
         57-115: Missing.
         224-253: Missing.

    Show »
    Length:522
    Mass (Da):60,251
    Checksum:iA3625C7287230759
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti429 – 4291L → P in AAH57102. (PubMed:15489334)Curated
    Sequence conflicti545 – 5484EISQ → GPDR in CAI24805. (PubMed:19468303)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66MAIGVV → MPRR in isoform 3, isoform 4 and isoform 5. 1 PublicationVSP_014582
    Alternative sequencei57 – 11559Missing in isoform 5. 1 PublicationVSP_014583Add
    BLAST
    Alternative sequencei224 – 25330Missing in isoform 2, isoform 4 and isoform 5. 1 PublicationVSP_014584Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL627222 Genomic DNA. Translation: CAI24800.1.
    AL627222 Genomic DNA. Translation: CAI24801.1.
    AL627222 Genomic DNA. Translation: CAI24802.1.
    AL627222 Genomic DNA. Translation: CAI24803.1.
    AL627222 Genomic DNA. Translation: CAI24804.1.
    AL627222 Genomic DNA. Translation: CAI24805.1.
    BC057102 mRNA. Translation: AAH57102.1.
    BC048904 mRNA. Translation: AAH48904.1.
    CCDSiCCDS25275.1. [Q5SVQ0-5]
    CCDS56798.1. [Q5SVQ0-4]
    CCDS56799.1. [Q5SVQ0-3]
    RefSeqiNP_001181933.1. NM_001195004.1. [Q5SVQ0-4]
    NP_808287.1. NM_177619.3. [Q5SVQ0-5]
    XP_006533076.1. XM_006533013.1. [Q5SVQ0-1]
    XP_006533077.1. XM_006533014.1. [Q5SVQ0-2]
    UniGeneiMm.472268.
    Mm.90213.

    Genome annotation databases

    EnsembliENSMUST00000072621; ENSMUSP00000072416; ENSMUSG00000038909. [Q5SVQ0-2]
    ENSMUST00000092766; ENSMUSP00000090441; ENSMUSG00000038909. [Q5SVQ0-1]
    ENSMUST00000103159; ENSMUSP00000099448; ENSMUSG00000038909. [Q5SVQ0-5]
    ENSMUST00000107733; ENSMUSP00000103361; ENSMUSG00000038909. [Q5SVQ0-4]
    ENSMUST00000107734; ENSMUSP00000103362; ENSMUSG00000038909. [Q5SVQ0-3]
    GeneIDi217127.
    KEGGimmu:217127.
    UCSCiuc007lad.2. mouse. [Q5SVQ0-5]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL627222 Genomic DNA. Translation: CAI24800.1 .
    AL627222 Genomic DNA. Translation: CAI24801.1 .
    AL627222 Genomic DNA. Translation: CAI24802.1 .
    AL627222 Genomic DNA. Translation: CAI24803.1 .
    AL627222 Genomic DNA. Translation: CAI24804.1 .
    AL627222 Genomic DNA. Translation: CAI24805.1 .
    BC057102 mRNA. Translation: AAH57102.1 .
    BC048904 mRNA. Translation: AAH48904.1 .
    CCDSi CCDS25275.1. [Q5SVQ0-5 ]
    CCDS56798.1. [Q5SVQ0-4 ]
    CCDS56799.1. [Q5SVQ0-3 ]
    RefSeqi NP_001181933.1. NM_001195004.1. [Q5SVQ0-4 ]
    NP_808287.1. NM_177619.3. [Q5SVQ0-5 ]
    XP_006533076.1. XM_006533013.1. [Q5SVQ0-1 ]
    XP_006533077.1. XM_006533014.1. [Q5SVQ0-2 ]
    UniGenei Mm.472268.
    Mm.90213.

    3D structure databases

    ProteinModelPortali Q5SVQ0.
    SMRi Q5SVQ0. Positions 185-213, 342-609.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229849. 2 interactions.
    IntActi Q5SVQ0. 2 interactions.
    MINTi MINT-5065215.

    PTM databases

    PhosphoSitei Q5SVQ0.

    Proteomic databases

    MaxQBi Q5SVQ0.
    PaxDbi Q5SVQ0.
    PRIDEi Q5SVQ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072621 ; ENSMUSP00000072416 ; ENSMUSG00000038909 . [Q5SVQ0-2 ]
    ENSMUST00000092766 ; ENSMUSP00000090441 ; ENSMUSG00000038909 . [Q5SVQ0-1 ]
    ENSMUST00000103159 ; ENSMUSP00000099448 ; ENSMUSG00000038909 . [Q5SVQ0-5 ]
    ENSMUST00000107733 ; ENSMUSP00000103361 ; ENSMUSG00000038909 . [Q5SVQ0-4 ]
    ENSMUST00000107734 ; ENSMUSP00000103362 ; ENSMUSG00000038909 . [Q5SVQ0-3 ]
    GeneIDi 217127.
    KEGGi mmu:217127.
    UCSCi uc007lad.2. mouse. [Q5SVQ0-5 ]

    Organism-specific databases

    CTDi 11143.
    MGIi MGI:2182799. Kat7.

    Phylogenomic databases

    eggNOGi COG5027.
    GeneTreei ENSGT00550000074503.
    HOVERGENi HBG053268.
    InParanoidi Q5SVQ0.
    KOi K11307.
    OMAi VYSTRRV.
    OrthoDBi EOG7WHH8N.
    PhylomeDBi Q5SVQ0.
    TreeFami TF317619.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    ChiTaRSi KAT7. mouse.
    NextBioi 375581.
    PROi Q5SVQ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5SVQ0.
    CleanExi MM_MYST2.
    Genevestigatori Q5SVQ0.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR002717. MOZ_SAS.
    IPR015880. Znf_C2H2-like.
    IPR002515. Znf_C2HC.
    [Graphical view ]
    Pfami PF01853. MOZ_SAS. 1 hit.
    PF01530. zf-C2HC. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51726. MYST_HAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 2 AND 3).
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
      Strain: C57BL/6.
      Tissue: Brain and Eye.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-201 AND LYS-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiKAT7_MOUSE
    AccessioniPrimary (citable) accession number: Q5SVQ0
    Secondary accession number(s): Q5SVQ1
    , Q5SVQ2, Q5SVQ3, Q5SVQ7, Q6PGC6, Q80Y65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3