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Protein

Histone acetyltransferase KAT7

Gene

Kat7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei510 – 5101Proton donor/acceptorBy similarity
Binding sitei514 – 5141Acetyl-CoABy similarity
Binding sitei523 – 5231Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri368 – 39023C2HC-typeAdd
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA replication Source: UniProtKB
  2. histone H3 acetylation Source: UniProtKB
  3. histone H4-K12 acetylation Source: UniProtKB
  4. histone H4-K5 acetylation Source: UniProtKB
  5. histone H4-K8 acetylation Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA replication, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_291621. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT7 (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase binding to ORC1
Lysine acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Short name:
MYST-2
Gene namesi
Name:Kat7
Synonyms:Hbo1, Myst2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2182799. Kat7.

Subcellular locationi

  1. Nucleusnucleoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. histone acetyltransferase complex Source: UniProtKB
  3. nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Histone acetyltransferase KAT7PRO_0000051570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineBy similarity
Modified residuei59 – 591Phosphoserine; by PLK1By similarity
Modified residuei87 – 871Phosphothreonine; by CDK1By similarity
Modified residuei90 – 901Phosphothreonine; by CDK1By similarity
Modified residuei104 – 1041PhosphoserineBy similarity
Modified residuei126 – 1261PhosphoserineBy similarity
Modified residuei160 – 1601PhosphoserineBy similarity
Modified residuei164 – 1641PhosphoserineBy similarity
Modified residuei166 – 1661PhosphoserineBy similarity
Modified residuei201 – 2011N6-acetyllysine1 Publication
Modified residuei279 – 2791N6-acetyllysine1 Publication
Modified residuei434 – 4341N6-acetyllysine; by autocatalysisBy similarity
Modified residuei508 – 5081PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-59 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-87 and Thr-90 by CDK1.By similarity
Autoacetylation at Lys-434 is required for proper function.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ5SVQ0.
PaxDbiQ5SVQ0.
PRIDEiQ5SVQ0.

PTM databases

PhosphoSiteiQ5SVQ0.

Expressioni

Gene expression databases

BgeeiQ5SVQ0.
CleanExiMM_MYST2.
ExpressionAtlasiQ5SVQ0. baseline and differential.
GenevestigatoriQ5SVQ0.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone.By similarity

Protein-protein interaction databases

BioGridi229849. 2 interactions.
IntActiQ5SVQ0. 2 interactions.
MINTiMINT-5065215.

Structurei

3D structure databases

ProteinModelPortaliQ5SVQ0.
SMRiQ5SVQ0. Positions 185-213, 342-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini334 – 609276MYST-type HATAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni477 – 4793Acetyl-CoA bindingBy similarity
Regioni484 – 4907Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 5948Ser-richAdd
BLAST

Domaini

The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.By similarity
The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated
Contains 1 C2HC-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri368 – 39023C2HC-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5027.
GeneTreeiENSGT00550000074503.
HOVERGENiHBG053268.
InParanoidiQ5SVQ0.
KOiK11307.
OMAiVYSTRRV.
OrthoDBiEOG7WHH8N.
PhylomeDBiQ5SVQ0.
TreeFamiTF317619.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR002717. MOZ_SAS.
IPR015880. Znf_C2H2-like.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SVQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIGVVKRNA GSSSDGTEDS DFSTDLEHTD SSESDGTSRR SARVTRSSAR
60 70 80 90 100
LSQSSQDSSP VRNLPSFGTE EPAYSTRRVT RSQQQPTPVT PKKYPLRQTR
110 120 130 140 150
SSGSETEQVV DFSDRETKNT ADHDESPPRT PTGNAPSSES DIDISSPNVS
160 170 180 190 200
HDESIAKDMS LKDSGSDLSH RPKRRRFHES YNFNMKCPTP GCNSLGHLTG
210 220 230 240 250
KHERHFSISG CPLYHNLSAD ECKVRAQSRD KQIEERMLSH RQDDNNRHAT
260 270 280 290 300
RHQAPTERQL RYKEKVAELR KKRNSGLSKE QKEKYMEHRQ TYGNTREPLL
310 320 330 340 350
ENLTSEYDLD LFRRAQARAS EDLEKLRLQG QITEGSNMIK TIAFGRYELD
360 370 380 390 400
TWYHSPYPEE YARLGRLYMC EFCLKYMKSQ TILRRHMAKC VWKHPPGDEI
410 420 430 440 450
YRKGSISVFE VDGKKNKIYC QNLCLLAKLF LDHKTLYYDV EPFLFYVMTE
460 470 480 490 500
ADNTGCHLIG YFSKEKNSFL NYNVSCILTM PQYMRQGYGK MLIDFSYLLS
510 520 530 540 550
KVEEKVGSPE RPLSDLGLIS YRSYWKEVLL RYLHNFQGKE ISIKEISQET
560 570 580 590 600
AVNPVDIVST LQALQMLKYW KGKHLVLKRQ DLIDEWIAKE AKRSNSNKTM
610
DPSCLKWTPP KGT
Length:613
Mass (Da):70,641
Last modified:December 21, 2004 - v1
Checksum:i7D6F05EE90A7134E
GO
Isoform 2 (identifier: Q5SVQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-253: Missing.

Show »
Length:583
Mass (Da):66,946
Checksum:i3F76E885AA985114
GO
Isoform 3 (identifier: Q5SVQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR

Show »
Length:611
Mass (Da):70,611
Checksum:i769DE7C4F03762D9
GO
Isoform 4 (identifier: Q5SVQ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR
     224-253: Missing.

Show »
Length:581
Mass (Da):66,916
Checksum:i3F06E4C3E47EFBA3
GO
Isoform 5 (identifier: Q5SVQ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR
     57-115: Missing.
     224-253: Missing.

Show »
Length:522
Mass (Da):60,251
Checksum:iA3625C7287230759
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti429 – 4291L → P in AAH57102 (PubMed:15489334).Curated
Sequence conflicti545 – 5484EISQ → GPDR in CAI24805 (PubMed:19468303).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66MAIGVV → MPRR in isoform 3, isoform 4 and isoform 5. 1 PublicationVSP_014582
Alternative sequencei57 – 11559Missing in isoform 5. 1 PublicationVSP_014583Add
BLAST
Alternative sequencei224 – 25330Missing in isoform 2, isoform 4 and isoform 5. 1 PublicationVSP_014584Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627222 Genomic DNA. Translation: CAI24800.1.
AL627222 Genomic DNA. Translation: CAI24801.1.
AL627222 Genomic DNA. Translation: CAI24802.1.
AL627222 Genomic DNA. Translation: CAI24803.1.
AL627222 Genomic DNA. Translation: CAI24804.1.
AL627222 Genomic DNA. Translation: CAI24805.1.
BC057102 mRNA. Translation: AAH57102.1.
BC048904 mRNA. Translation: AAH48904.1.
CCDSiCCDS25275.1. [Q5SVQ0-5]
CCDS56798.1. [Q5SVQ0-4]
CCDS56799.1. [Q5SVQ0-3]
RefSeqiNP_001181933.1. NM_001195004.1. [Q5SVQ0-4]
NP_808287.1. NM_177619.3. [Q5SVQ0-5]
XP_006533076.1. XM_006533013.2. [Q5SVQ0-1]
XP_006533077.1. XM_006533014.2. [Q5SVQ0-2]
UniGeneiMm.472268.
Mm.90213.

Genome annotation databases

EnsembliENSMUST00000072621; ENSMUSP00000072416; ENSMUSG00000038909. [Q5SVQ0-2]
ENSMUST00000092766; ENSMUSP00000090441; ENSMUSG00000038909. [Q5SVQ0-1]
ENSMUST00000103159; ENSMUSP00000099448; ENSMUSG00000038909. [Q5SVQ0-5]
ENSMUST00000107733; ENSMUSP00000103361; ENSMUSG00000038909. [Q5SVQ0-4]
ENSMUST00000107734; ENSMUSP00000103362; ENSMUSG00000038909. [Q5SVQ0-3]
GeneIDi217127.
KEGGimmu:217127.
UCSCiuc007lad.2. mouse. [Q5SVQ0-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627222 Genomic DNA. Translation: CAI24800.1.
AL627222 Genomic DNA. Translation: CAI24801.1.
AL627222 Genomic DNA. Translation: CAI24802.1.
AL627222 Genomic DNA. Translation: CAI24803.1.
AL627222 Genomic DNA. Translation: CAI24804.1.
AL627222 Genomic DNA. Translation: CAI24805.1.
BC057102 mRNA. Translation: AAH57102.1.
BC048904 mRNA. Translation: AAH48904.1.
CCDSiCCDS25275.1. [Q5SVQ0-5]
CCDS56798.1. [Q5SVQ0-4]
CCDS56799.1. [Q5SVQ0-3]
RefSeqiNP_001181933.1. NM_001195004.1. [Q5SVQ0-4]
NP_808287.1. NM_177619.3. [Q5SVQ0-5]
XP_006533076.1. XM_006533013.2. [Q5SVQ0-1]
XP_006533077.1. XM_006533014.2. [Q5SVQ0-2]
UniGeneiMm.472268.
Mm.90213.

3D structure databases

ProteinModelPortaliQ5SVQ0.
SMRiQ5SVQ0. Positions 185-213, 342-609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229849. 2 interactions.
IntActiQ5SVQ0. 2 interactions.
MINTiMINT-5065215.

PTM databases

PhosphoSiteiQ5SVQ0.

Proteomic databases

MaxQBiQ5SVQ0.
PaxDbiQ5SVQ0.
PRIDEiQ5SVQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072621; ENSMUSP00000072416; ENSMUSG00000038909. [Q5SVQ0-2]
ENSMUST00000092766; ENSMUSP00000090441; ENSMUSG00000038909. [Q5SVQ0-1]
ENSMUST00000103159; ENSMUSP00000099448; ENSMUSG00000038909. [Q5SVQ0-5]
ENSMUST00000107733; ENSMUSP00000103361; ENSMUSG00000038909. [Q5SVQ0-4]
ENSMUST00000107734; ENSMUSP00000103362; ENSMUSG00000038909. [Q5SVQ0-3]
GeneIDi217127.
KEGGimmu:217127.
UCSCiuc007lad.2. mouse. [Q5SVQ0-5]

Organism-specific databases

CTDi11143.
MGIiMGI:2182799. Kat7.

Phylogenomic databases

eggNOGiCOG5027.
GeneTreeiENSGT00550000074503.
HOVERGENiHBG053268.
InParanoidiQ5SVQ0.
KOiK11307.
OMAiVYSTRRV.
OrthoDBiEOG7WHH8N.
PhylomeDBiQ5SVQ0.
TreeFamiTF317619.

Enzyme and pathway databases

ReactomeiREACT_291621. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiKat7. mouse.
NextBioi375581.
PROiQ5SVQ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SVQ0.
CleanExiMM_MYST2.
ExpressionAtlasiQ5SVQ0. baseline and differential.
GenevestigatoriQ5SVQ0.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR002717. MOZ_SAS.
IPR015880. Znf_C2H2-like.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-201 AND LYS-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiKAT7_MOUSE
AccessioniPrimary (citable) accession number: Q5SVQ0
Secondary accession number(s): Q5SVQ1
, Q5SVQ2, Q5SVQ3, Q5SVQ7, Q6PGC6, Q80Y65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: April 1, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.