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Q5SVQ0 (KAT7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase KAT7

EC=2.3.1.48
Alternative name(s):
Histone acetyltransferase binding to ORC1
Lysine acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Short name=MYST-2
Gene names
Name:Kat7
Synonyms:Hbo1, Myst2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone By similarity.

Subcellular location

Nucleusnucleoplasm By similarity.

Domain

The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L By similarity.

The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction By similarity.

Post-translational modification

Phosphorylation at Ser-59 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-87 and Thr-90 by CDK1 By similarity.

Autoacetylation at Lys-434 is required for proper function By similarity.

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Contains 1 C2HC-type zinc finger.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5SVQ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5SVQ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     224-253: Missing.
Isoform 3 (identifier: Q5SVQ0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR
Isoform 4 (identifier: Q5SVQ0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR
     224-253: Missing.
Isoform 5 (identifier: Q5SVQ0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR
     57-115: Missing.
     224-253: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 613613Histone acetyltransferase KAT7
PRO_0000051570

Regions

Zinc finger368 – 39023C2HC-type
Region484 – 4907Acetyl-CoA binding By similarity
Compositional bias12 – 5948Ser-rich

Sites

Active site4341 By similarity
Active site4761Nucleophile By similarity
Binding site4791Acetyl-CoA By similarity
Binding site5141Acetyl-CoA By similarity

Amino acid modifications

Modified residue521Phosphoserine By similarity
Modified residue591Phosphoserine; by PLK1 By similarity
Modified residue871Phosphothreonine; by CDK1 By similarity
Modified residue901Phosphothreonine; by CDK1 By similarity
Modified residue1041Phosphoserine By similarity
Modified residue1261Phosphoserine By similarity
Modified residue1641Phosphoserine By similarity
Modified residue1661Phosphoserine By similarity
Modified residue2011N6-acetyllysine Ref.3
Modified residue2791N6-acetyllysine Ref.3
Modified residue4341N6-acetyllysine; by autocatalysis By similarity
Modified residue5081Phosphoserine By similarity

Natural variations

Alternative sequence1 – 66MAIGVV → MPRR in isoform 3, isoform 4 and isoform 5.
VSP_014582
Alternative sequence57 – 11559Missing in isoform 5.
VSP_014583
Alternative sequence224 – 25330Missing in isoform 2, isoform 4 and isoform 5.
VSP_014584

Experimental info

Sequence conflict4291L → P in AAH57102. Ref.2
Sequence conflict545 – 5484EISQ → GPDR in CAI24805. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 7D6F05EE90A7134E

FASTA61370,641
        10         20         30         40         50         60 
MAIGVVKRNA GSSSDGTEDS DFSTDLEHTD SSESDGTSRR SARVTRSSAR LSQSSQDSSP 

        70         80         90        100        110        120 
VRNLPSFGTE EPAYSTRRVT RSQQQPTPVT PKKYPLRQTR SSGSETEQVV DFSDRETKNT 

       130        140        150        160        170        180 
ADHDESPPRT PTGNAPSSES DIDISSPNVS HDESIAKDMS LKDSGSDLSH RPKRRRFHES 

       190        200        210        220        230        240 
YNFNMKCPTP GCNSLGHLTG KHERHFSISG CPLYHNLSAD ECKVRAQSRD KQIEERMLSH 

       250        260        270        280        290        300 
RQDDNNRHAT RHQAPTERQL RYKEKVAELR KKRNSGLSKE QKEKYMEHRQ TYGNTREPLL 

       310        320        330        340        350        360 
ENLTSEYDLD LFRRAQARAS EDLEKLRLQG QITEGSNMIK TIAFGRYELD TWYHSPYPEE 

       370        380        390        400        410        420 
YARLGRLYMC EFCLKYMKSQ TILRRHMAKC VWKHPPGDEI YRKGSISVFE VDGKKNKIYC 

       430        440        450        460        470        480 
QNLCLLAKLF LDHKTLYYDV EPFLFYVMTE ADNTGCHLIG YFSKEKNSFL NYNVSCILTM 

       490        500        510        520        530        540 
PQYMRQGYGK MLIDFSYLLS KVEEKVGSPE RPLSDLGLIS YRSYWKEVLL RYLHNFQGKE 

       550        560        570        580        590        600 
ISIKEISQET AVNPVDIVST LQALQMLKYW KGKHLVLKRQ DLIDEWIAKE AKRSNSNKTM 

       610 
DPSCLKWTPP KGT 

« Hide

Isoform 2 [UniParc].

Checksum: 3F76E885AA985114
Show »

FASTA58366,946
Isoform 3 [UniParc].

Checksum: 769DE7C4F03762D9
Show »

FASTA61170,611
Isoform 4 [UniParc].

Checksum: 3F06E4C3E47EFBA3
Show »

FASTA58166,916
Isoform 5 [UniParc].

Checksum: A3625C7287230759
Show »

FASTA52260,251

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 2 AND 3).
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
Strain: C57BL/6.
Tissue: Brain and Eye.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-201 AND LYS-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL627222 Genomic DNA. Translation: CAI24800.1.
AL627222 Genomic DNA. Translation: CAI24801.1.
AL627222 Genomic DNA. Translation: CAI24802.1.
AL627222 Genomic DNA. Translation: CAI24803.1.
AL627222 Genomic DNA. Translation: CAI24804.1.
AL627222 Genomic DNA. Translation: CAI24805.1.
BC057102 mRNA. Translation: AAH57102.1.
BC048904 mRNA. Translation: AAH48904.1.
RefSeqNP_001181933.1. NM_001195004.1.
NP_808287.1. NM_177619.3.
XP_006533076.1. XM_006533013.1.
XP_006533077.1. XM_006533014.1.
UniGeneMm.472268.
Mm.90213.

3D structure databases

ProteinModelPortalQ5SVQ0.
SMRQ5SVQ0. Positions 104-213, 342-609.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid229849. 2 interactions.
IntActQ5SVQ0. 2 interactions.
MINTMINT-5065215.

PTM databases

PhosphoSiteQ5SVQ0.

Proteomic databases

PaxDbQ5SVQ0.
PRIDEQ5SVQ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072621; ENSMUSP00000072416; ENSMUSG00000038909. [Q5SVQ0-2]
ENSMUST00000092766; ENSMUSP00000090441; ENSMUSG00000038909. [Q5SVQ0-1]
ENSMUST00000103159; ENSMUSP00000099448; ENSMUSG00000038909. [Q5SVQ0-5]
ENSMUST00000107733; ENSMUSP00000103361; ENSMUSG00000038909. [Q5SVQ0-4]
ENSMUST00000107734; ENSMUSP00000103362; ENSMUSG00000038909. [Q5SVQ0-3]
GeneID217127.
KEGGmmu:217127.
UCSCuc007lad.2. mouse. [Q5SVQ0-5]

Organism-specific databases

CTD11143.
MGIMGI:2182799. Kat7.

Phylogenomic databases

eggNOGCOG5027.
GeneTreeENSGT00550000074503.
HOVERGENHBG053268.
InParanoidQ5SVQ0.
KOK11307.
OMAKDMSMKD.
OrthoDBEOG7WHH8N.
PhylomeDBQ5SVQ0.
TreeFamTF317619.

Gene expression databases

BgeeQ5SVQ0.
CleanExMM_MYST2.
GenevestigatorQ5SVQ0.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR002717. MOZ_SAS.
IPR015880. Znf_C2H2-like.
IPR002515. Znf_C2HC.
[Graphical view]
PfamPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Other

ChiTaRSKAT7. mouse.
NextBio375581.
PROQ5SVQ0.
SOURCESearch...

Entry information

Entry nameKAT7_MOUSE
AccessionPrimary (citable) accession number: Q5SVQ0
Secondary accession number(s): Q5SVQ1 expand/collapse secondary AC list , Q5SVQ2, Q5SVQ3, Q5SVQ7, Q6PGC6, Q80Y65
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot