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Unreviewed, UniProtKB/TrEMBL Q5SVI6 (Q5SVI6_MOUSE)

Last modified January 19, 2010. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Glucokinase EMBL CAI25265.1
Submitted name:
    Glucokinase, isoform CRA_a EMBL EDL40567.1
Gene names
Name: Gck MGI 1270854
ORF Names: RP23-340E18.1-001 EMBL CAI25265.1, mCG_21380 EMBL EDL40567.1
OrganismMus musculus (Mouse) EMBL CAI25265.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Sequence similarities

Belongs to the hexokinase family.

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Ontologies

Keywords
   Biological processGlycolysis RuleBase RU004049V1 Spearmint SPM001312
   LigandATP-binding RuleBase RU004049V1 Spearmint SPM001312
Nucleotide-binding
   Molecular functionKinase RuleBase RU004049V1 Spearmint SPM001312 EMBL CAI25265.1
Transferase
Gene Ontology (GO)
   Biological processcarbohydrate phosphorylation

Inferred from electronic annotation. Source: Compara

cellular response to glucose starvation

Inferred from electronic annotation. Source: Compara

detection of glucose

Inferred from electronic annotation. Source: Compara

elevation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Compara

fructose 2,6-bisphosphate metabolic process

Inferred from electronic annotation. Source: Compara

glucose 6-phosphate metabolic process

Inferred from electronic annotation. Source: Compara

glycogen biosynthetic process

Inferred from electronic annotation. Source: Compara

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of epinephrine secretion

Inferred from electronic annotation. Source: Compara

positive regulation of glycolysis

Inferred from electronic annotation. Source: Compara

positive regulation of insulin secretion

Inferred from electronic annotation. Source: Compara

positive regulation of phosphorylation

Inferred from electronic annotation. Source: Compara

second-messenger-mediated signaling

Inferred from electronic annotation. Source: Compara

   Cellular componentactin filament

Inferred from electronic annotation. Source: Compara

cell cortex part

Inferred from electronic annotation. Source: Compara

cytosol

Inferred from electronic annotation. Source: Compara

mitochondrion

Inferred from electronic annotation. Source: Compara

nucleoplasm

Inferred from electronic annotation. Source: Compara

secretory granule

Inferred from electronic annotation. Source: Compara

   Molecular functionADP binding

Inferred from electronic annotation. Source: Compara

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glucokinase activity

Inferred from electronic annotation. Source: Compara

glucose binding

Inferred from electronic annotation. Source: Compara

magnesium ion binding

Inferred from electronic annotation. Source: Compara

protein phosphatase binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q5SVI6-1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: DAC911920818B811

FASTA46551,886
        10         20         30         40         50         60 
MAVDTTRRGA QSLTLVEQIL AEFQLQEEDL KKVMSRMQKE MDRGLKLETH QEASVKMLPT 

        70         80         90        100        110        120 
YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEAGQWS VKTKHQMYSI PEDAMTGTAE 

       130        140        150        160        170        180 
MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDID KGILLNWTKG FKASGAEGNN 

       190        200        210        220        230        240 
IVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDRQC EVGMIVGTGC NACYMEEMQN 

       250        260        270        280        290        300 
VELVEGDEGR MCVNTEWGAF GNSGELDEFL LEYDRMVDES SVNPGQQLYE KIIGGKYMGE 

       310        320        330        340        350        360 
LVRLVLLKLV EENLLFHGEA SEQLRTRGAF ETRFVSQVES DSGDRRQILN ILSTLGLRPS 

       370        380        390        400        410        420 
VADCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK 

       430        440        450        460 
ERFHASVRRL TPNCEITFIE SEEGSGRGAA LVSAVACKKA CMLGQ

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References

[1]Howden P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL40567.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL40567.1.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL645469 Genomic DNA. Translation: CAI25265.1.
CH466574 Genomic DNA. Translation: EDL40567.1.
IPIIPI00229807.
UniGeneMm.220358

3D structure databases

SMRQ5SVI6. Positions 14-461.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5SVI6.

Proteomic databases

PRIDEQ5SVI6.

Genome annotation databases

EnsemblENSMUST00000109822; ENSMUSP00000105447; ENSMUSG00000041798; Mus musculus. [Genome view]
ENSMUST00000109823; ENSMUSP00000105448; ENSMUSG00000041798; Mus musculus. [Genome view]
UCSCuc007hxm.1. mouse.

Organism-specific databases

MGIMGI:1270854. Gck.

Phylogenomic databases

HOGENOMHBG522186.
HOVERGENQ5SVI6.
InParanoidQ5SVI6.
OMADESSANP.
PhylomeDBQ5SVI6.

Gene expression databases

ArrayExpressQ5SVI6.
BgeeQ5SVI6.
GenevestigatorQ5SVI6.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR019807. Hexokinase_CS.
[Graphical view]
PANTHERPTHR19443. Hexokinase. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ5SVI6_MOUSE
AccessionPrimary (citable) accession number: Q5SVI6
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information