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Q5SV85

- SYNRG_MOUSE

UniProt

Q5SV85 - SYNRG_MOUSE

Protein

Synergin gamma

Gene

Synrg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Endocytosis, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synergin gamma
    Alternative name(s):
    AP1 subunit gamma-binding protein 1
    Gamma-synergin
    Gene namesi
    Name:Synrg
    Synonyms:Ap1gbp1, Syng
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1354742. Synrg.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Associated with membranes of the TGN, colocalizes with AP1G1 By similarity. Associates with membranes via the adapter protein complex AP-1.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13061306Synergin gammaPRO_0000072388Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei471 – 4711PhosphoserineBy similarity
    Modified residuei509 – 5091N6-acetyllysine1 Publication
    Modified residuei576 – 5761Phosphoserine1 Publication
    Modified residuei715 – 7151PhosphoserineBy similarity
    Modified residuei736 – 7361N6-acetyllysineBy similarity
    Modified residuei744 – 7441Phosphoserine1 Publication
    Modified residuei844 – 8441PhosphoserineBy similarity
    Modified residuei847 – 8471PhosphoserineBy similarity
    Modified residuei901 – 9011PhosphoserineBy similarity
    Modified residuei911 – 9111PhosphoserineBy similarity
    Modified residuei927 – 9271PhosphoserineBy similarity
    Modified residuei974 – 9741Phosphoserine2 Publications
    Modified residuei1067 – 10671Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ5SV85.
    PaxDbiQ5SV85.
    PRIDEiQ5SV85.

    PTM databases

    PhosphoSiteiQ5SV85.

    Expressioni

    Gene expression databases

    BgeeiQ5SV85.
    CleanExiMM_AP1GBP1.
    GenevestigatoriQ5SV85.

    Interactioni

    Subunit structurei

    Interacts with SCAMP1 via its EH-domain. Interacts with GGA1, GGA2 and GGA3. Interacts with the AP1G1 and AP1G2 subunits of the adapter protein complexes AP-1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000059000.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SV85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini293 – 404112EHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni514 – 778265Interaction with A1P1G1 and A1P1G2By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili113 – 15341Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi455 – 4595DFXDF motif 1
    Motifi685 – 6895DFXDF motif 2
    Motifi767 – 7715DFXDF motif 3

    Domaini

    The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2.By similarity

    Sequence similaritiesi

    Contains 1 EH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG136044.
    GeneTreeiENSGT00390000010789.
    HOGENOMiHOG000293152.
    HOVERGENiHBG055053.
    InParanoidiQ5SV85.
    OMAiDLDMFSS.
    OrthoDBiEOG7GXP9S.
    PhylomeDBiQ5SV85.
    TreeFamiTF316700.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR000261. EPS15_homology.
    [Graphical view]
    PROSITEiPS50031. EH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5SV85-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALRPGAGAS GAAGAGAGPG GAGSFMFPVA GGMRPPQAGL IPMQQQGFPM     50
    VSVMQPNMQG MMGMNYSSQM SQGPIAMQAG IPMGPMPAAG VPFLGQPPFL 100
    SMRPAGPQYT PDMQKQFAEE QQKRFEQQQK LLEEERKRRQ FEEQKQKLRL 150
    LSSVKPKTGE KNRDDALEAI KGNLDGFSRD AKMHPTPASH PKKQGPSLEE 200
    KLLVSCDVSA SGQEHIKLNT PDAGHKAIVP GSSKNCPGLM AHNRGAVDGC 250
    VSGPASAEAE KTSDQTLSKE ESGVGVFPSQ DPAQSRMPPW IYNESLVPDA 300
    YKKILETTMT PTGIDTAKLY PILMSSGLPR ETLGQIWALA NRTTPGRLTK 350
    EELYTVLAMV AVTQRGVPAM SPDALSQFPA APIPTLSGFP MTLPTPVSQP 400
    TAMPSGPTGS MPLTLGQPIM GINLVGPVGG AAAPTSSGFM PAYPSNQVGK 450
    TEEDDFQDFQ DASKSGSIDD SFTDFQEMPA SSKTSNSQHG NSAPSLLIPF 500
    PGTKASTDKY AVFKGISTDK PSENPASFGE SGDKYSAFRE LEQTTDSKPL 550
    GESFAEFRST GTDDGFTDFK TADSVSPLEP PTKDTFPSAF ASGAAQQTQT 600
    QVKTPLNLED LDMFSSVDCS GEKQVPFSAT FSTAKSVSTR PQPAGSAAAS 650
    AALASTKTSS LADDFGEFNL FGEYSNPASA GEQDDFADFM AFGNSSISSE 700
    PKASDKYEAL REEVSPSPLS SSTVEGAQHP PAAATKYDVF KQLSLEGAGL 750
    AMEEFKENTS STKSEDDFAD FHSSKFSSTS SDKSLGEKAV AFRHAKEDSS 800
    SVKSLDLPSI GGSSVGKEDS EDALSVQFDM KLADVGGDLK HVMSDSSLDL 850
    PTVSGQHPPA ADTEDLSCAA FGSCSSHFTV STLTSCEWSD RADALQGRKL 900
    SPFVLSAGSR SFSATSNLHT KEISFGSSEN ITMSSLSKGS ALASEDALPE 950
    TAFPAFASFK DMMPQTTEQK EFESGDFQDF TRQDMPTVDR SQETSCPSPA 1000
    SSVASHETPK EGADDFGEFQ SEKSKISKFD FLVANSQSKM KSSEEMIKSE 1050
    LATFDLSVQG SHKRSLSLGD KEISRSSPSP ALEQPFRDRS NTLSERAALP 1100
    VIRDKYKDLT GEVEENERYA YEWQRCLGSA LDVIKKANDT LNGISSSAVC 1150
    TEVIQSAQGM EYLLGVVEVY RVTKRVELGI KATAVCSEKL QQLLKDIDKV 1200
    WNNLIGFMSL ATLTPDENSL DFSSCMLRPG IKNAQELACG VCLLNVDSRS 1250
    RKEETPAEEQ PKKAFNSETD SFKLAYGGHQ YHASCANFWI NCVEPKPPGL 1300
    LLPDLL 1306
    Length:1,306
    Mass (Da):139,616
    Last modified:December 21, 2004 - v1
    Checksum:iEB149A0B7ADAE2D7
    GO
    Isoform 2 (identifier: Q5SV85-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-38: Missing.
         195-272: Missing.
         862-938: Missing.
         1252-1263: Missing.

    Show »
    Length:1,138
    Mass (Da):122,083
    Checksum:i2FDF97B632587B8E
    GO

    Sequence cautioni

    The sequence CAI25511.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei38 – 381Missing in isoform 2. 1 PublicationVSP_013251
    Alternative sequencei195 – 27278Missing in isoform 2. 1 PublicationVSP_013252Add
    BLAST
    Alternative sequencei862 – 93877Missing in isoform 2. 1 PublicationVSP_013253Add
    BLAST
    Alternative sequencei1252 – 126312Missing in isoform 2. 1 PublicationVSP_013254Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL645615 Genomic DNA. Translation: CAI25509.1.
    AL645615 Genomic DNA. Translation: CAI25510.1.
    AL645615 Genomic DNA. Translation: CAI25511.1. Sequence problems.
    BC056370 mRNA. Translation: AAH56370.1.
    CCDSiCCDS25181.1. [Q5SV85-2]
    RefSeqiNP_919322.1. NM_194341.2. [Q5SV85-2]
    UniGeneiMm.441722.
    Mm.82680.

    Genome annotation databases

    EnsembliENSMUST00000049714; ENSMUSP00000059000; ENSMUSG00000034940. [Q5SV85-1]
    ENSMUST00000092834; ENSMUSP00000090510; ENSMUSG00000034940. [Q5SV85-2]
    GeneIDi217030.
    KEGGimmu:217030.
    UCSCiuc007kqa.2. mouse. [Q5SV85-2]
    uc011ybj.1. mouse. [Q5SV85-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL645615 Genomic DNA. Translation: CAI25509.1 .
    AL645615 Genomic DNA. Translation: CAI25510.1 .
    AL645615 Genomic DNA. Translation: CAI25511.1 . Sequence problems.
    BC056370 mRNA. Translation: AAH56370.1 .
    CCDSi CCDS25181.1. [Q5SV85-2 ]
    RefSeqi NP_919322.1. NM_194341.2. [Q5SV85-2 ]
    UniGenei Mm.441722.
    Mm.82680.

    3D structure databases

    ProteinModelPortali Q5SV85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000059000.

    PTM databases

    PhosphoSitei Q5SV85.

    Proteomic databases

    MaxQBi Q5SV85.
    PaxDbi Q5SV85.
    PRIDEi Q5SV85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049714 ; ENSMUSP00000059000 ; ENSMUSG00000034940 . [Q5SV85-1 ]
    ENSMUST00000092834 ; ENSMUSP00000090510 ; ENSMUSG00000034940 . [Q5SV85-2 ]
    GeneIDi 217030.
    KEGGi mmu:217030.
    UCSCi uc007kqa.2. mouse. [Q5SV85-2 ]
    uc011ybj.1. mouse. [Q5SV85-1 ]

    Organism-specific databases

    CTDi 11276.
    MGIi MGI:1354742. Synrg.

    Phylogenomic databases

    eggNOGi NOG136044.
    GeneTreei ENSGT00390000010789.
    HOGENOMi HOG000293152.
    HOVERGENi HBG055053.
    InParanoidi Q5SV85.
    OMAi DLDMFSS.
    OrthoDBi EOG7GXP9S.
    PhylomeDBi Q5SV85.
    TreeFami TF316700.

    Miscellaneous databases

    NextBioi 375518.
    PROi Q5SV85.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5SV85.
    CleanExi MM_AP1GBP1.
    Genevestigatori Q5SV85.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR000261. EPS15_homology.
    [Graphical view ]
    PROSITEi PS50031. EH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin."
      Lui W.W.Y., Collins B.M., Hirst J., Motley A., Millar C., Schu P., Owen D.J., Robinson M.S.
      Mol. Biol. Cell 14:2385-2398(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-974, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576; SER-744; SER-974 AND SER-1067, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSYNRG_MOUSE
    AccessioniPrimary (citable) accession number: Q5SV85
    Secondary accession number(s): Q5SV84, Q6PHT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3