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Q5SV85

- SYNRG_MOUSE

UniProt

Q5SV85 - SYNRG_MOUSE

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Protein
Synergin gamma
Gene
Synrg, Ap1gbp1, Syng
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synergin gamma
Alternative name(s):
AP1 subunit gamma-binding protein 1
Gamma-synergin
Gene namesi
Name:Synrg
Synonyms:Ap1gbp1, Syng
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1354742. Synrg.

Subcellular locationi

Cytoplasmcytosol. Golgi apparatustrans-Golgi network membrane; Peripheral membrane protein
Note: Associated with membranes of the TGN, colocalizes with AP1G1 By similarity. Associates with membranes via the adapter protein complex AP-1.1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. cytosol Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13061306Synergin gamma
PRO_0000072388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei471 – 4711Phosphoserine By similarity
Modified residuei509 – 5091N6-acetyllysine1 Publication
Modified residuei576 – 5761Phosphoserine1 Publication
Modified residuei715 – 7151Phosphoserine By similarity
Modified residuei736 – 7361N6-acetyllysine By similarity
Modified residuei744 – 7441Phosphoserine1 Publication
Modified residuei844 – 8441Phosphoserine By similarity
Modified residuei847 – 8471Phosphoserine By similarity
Modified residuei901 – 9011Phosphoserine By similarity
Modified residuei911 – 9111Phosphoserine By similarity
Modified residuei927 – 9271Phosphoserine By similarity
Modified residuei974 – 9741Phosphoserine2 Publications
Modified residuei1067 – 10671Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ5SV85.
PaxDbiQ5SV85.
PRIDEiQ5SV85.

PTM databases

PhosphoSiteiQ5SV85.

Expressioni

Gene expression databases

BgeeiQ5SV85.
CleanExiMM_AP1GBP1.
GenevestigatoriQ5SV85.

Interactioni

Subunit structurei

Interacts with SCAMP1 via its EH-domain. Interacts with GGA1, GGA2 and GGA3. Interacts with the AP1G1 and AP1G2 subunits of the adapter protein complexes AP-1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059000.

Structurei

3D structure databases

ProteinModelPortaliQ5SV85.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini293 – 404112EH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni514 – 778265Interaction with A1P1G1 and A1P1G2 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili113 – 15341 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi455 – 4595DFXDF motif 1
Motifi685 – 6895DFXDF motif 2
Motifi767 – 7715DFXDF motif 3

Domaini

The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2 By similarity.

Sequence similaritiesi

Contains 1 EH domain.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG136044.
GeneTreeiENSGT00390000010789.
HOGENOMiHOG000293152.
HOVERGENiHBG055053.
InParanoidiQ5SV85.
OMAiDLDMFSS.
OrthoDBiEOG7GXP9S.
PhylomeDBiQ5SV85.
TreeFamiTF316700.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR000261. EPS15_homology.
[Graphical view]
PROSITEiPS50031. EH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5SV85-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALRPGAGAS GAAGAGAGPG GAGSFMFPVA GGMRPPQAGL IPMQQQGFPM     50
VSVMQPNMQG MMGMNYSSQM SQGPIAMQAG IPMGPMPAAG VPFLGQPPFL 100
SMRPAGPQYT PDMQKQFAEE QQKRFEQQQK LLEEERKRRQ FEEQKQKLRL 150
LSSVKPKTGE KNRDDALEAI KGNLDGFSRD AKMHPTPASH PKKQGPSLEE 200
KLLVSCDVSA SGQEHIKLNT PDAGHKAIVP GSSKNCPGLM AHNRGAVDGC 250
VSGPASAEAE KTSDQTLSKE ESGVGVFPSQ DPAQSRMPPW IYNESLVPDA 300
YKKILETTMT PTGIDTAKLY PILMSSGLPR ETLGQIWALA NRTTPGRLTK 350
EELYTVLAMV AVTQRGVPAM SPDALSQFPA APIPTLSGFP MTLPTPVSQP 400
TAMPSGPTGS MPLTLGQPIM GINLVGPVGG AAAPTSSGFM PAYPSNQVGK 450
TEEDDFQDFQ DASKSGSIDD SFTDFQEMPA SSKTSNSQHG NSAPSLLIPF 500
PGTKASTDKY AVFKGISTDK PSENPASFGE SGDKYSAFRE LEQTTDSKPL 550
GESFAEFRST GTDDGFTDFK TADSVSPLEP PTKDTFPSAF ASGAAQQTQT 600
QVKTPLNLED LDMFSSVDCS GEKQVPFSAT FSTAKSVSTR PQPAGSAAAS 650
AALASTKTSS LADDFGEFNL FGEYSNPASA GEQDDFADFM AFGNSSISSE 700
PKASDKYEAL REEVSPSPLS SSTVEGAQHP PAAATKYDVF KQLSLEGAGL 750
AMEEFKENTS STKSEDDFAD FHSSKFSSTS SDKSLGEKAV AFRHAKEDSS 800
SVKSLDLPSI GGSSVGKEDS EDALSVQFDM KLADVGGDLK HVMSDSSLDL 850
PTVSGQHPPA ADTEDLSCAA FGSCSSHFTV STLTSCEWSD RADALQGRKL 900
SPFVLSAGSR SFSATSNLHT KEISFGSSEN ITMSSLSKGS ALASEDALPE 950
TAFPAFASFK DMMPQTTEQK EFESGDFQDF TRQDMPTVDR SQETSCPSPA 1000
SSVASHETPK EGADDFGEFQ SEKSKISKFD FLVANSQSKM KSSEEMIKSE 1050
LATFDLSVQG SHKRSLSLGD KEISRSSPSP ALEQPFRDRS NTLSERAALP 1100
VIRDKYKDLT GEVEENERYA YEWQRCLGSA LDVIKKANDT LNGISSSAVC 1150
TEVIQSAQGM EYLLGVVEVY RVTKRVELGI KATAVCSEKL QQLLKDIDKV 1200
WNNLIGFMSL ATLTPDENSL DFSSCMLRPG IKNAQELACG VCLLNVDSRS 1250
RKEETPAEEQ PKKAFNSETD SFKLAYGGHQ YHASCANFWI NCVEPKPPGL 1300
LLPDLL 1306
Length:1,306
Mass (Da):139,616
Last modified:December 21, 2004 - v1
Checksum:iEB149A0B7ADAE2D7
GO
Isoform 2 (identifier: Q5SV85-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: Missing.
     195-272: Missing.
     862-938: Missing.
     1252-1263: Missing.

Show »
Length:1,138
Mass (Da):122,083
Checksum:i2FDF97B632587B8E
GO

Sequence cautioni

The sequence CAI25511.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 381Missing in isoform 2.
VSP_013251
Alternative sequencei195 – 27278Missing in isoform 2.
VSP_013252Add
BLAST
Alternative sequencei862 – 93877Missing in isoform 2.
VSP_013253Add
BLAST
Alternative sequencei1252 – 126312Missing in isoform 2.
VSP_013254Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL645615 Genomic DNA. Translation: CAI25509.1.
AL645615 Genomic DNA. Translation: CAI25510.1.
AL645615 Genomic DNA. Translation: CAI25511.1. Sequence problems.
BC056370 mRNA. Translation: AAH56370.1.
CCDSiCCDS25181.1. [Q5SV85-2]
RefSeqiNP_919322.1. NM_194341.2. [Q5SV85-2]
UniGeneiMm.441722.
Mm.82680.

Genome annotation databases

EnsembliENSMUST00000049714; ENSMUSP00000059000; ENSMUSG00000034940. [Q5SV85-1]
ENSMUST00000092834; ENSMUSP00000090510; ENSMUSG00000034940. [Q5SV85-2]
GeneIDi217030.
KEGGimmu:217030.
UCSCiuc007kqa.2. mouse. [Q5SV85-2]
uc011ybj.1. mouse. [Q5SV85-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL645615 Genomic DNA. Translation: CAI25509.1 .
AL645615 Genomic DNA. Translation: CAI25510.1 .
AL645615 Genomic DNA. Translation: CAI25511.1 . Sequence problems.
BC056370 mRNA. Translation: AAH56370.1 .
CCDSi CCDS25181.1. [Q5SV85-2 ]
RefSeqi NP_919322.1. NM_194341.2. [Q5SV85-2 ]
UniGenei Mm.441722.
Mm.82680.

3D structure databases

ProteinModelPortali Q5SV85.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000059000.

PTM databases

PhosphoSitei Q5SV85.

Proteomic databases

MaxQBi Q5SV85.
PaxDbi Q5SV85.
PRIDEi Q5SV85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049714 ; ENSMUSP00000059000 ; ENSMUSG00000034940 . [Q5SV85-1 ]
ENSMUST00000092834 ; ENSMUSP00000090510 ; ENSMUSG00000034940 . [Q5SV85-2 ]
GeneIDi 217030.
KEGGi mmu:217030.
UCSCi uc007kqa.2. mouse. [Q5SV85-2 ]
uc011ybj.1. mouse. [Q5SV85-1 ]

Organism-specific databases

CTDi 11276.
MGIi MGI:1354742. Synrg.

Phylogenomic databases

eggNOGi NOG136044.
GeneTreei ENSGT00390000010789.
HOGENOMi HOG000293152.
HOVERGENi HBG055053.
InParanoidi Q5SV85.
OMAi DLDMFSS.
OrthoDBi EOG7GXP9S.
PhylomeDBi Q5SV85.
TreeFami TF316700.

Miscellaneous databases

NextBioi 375518.
PROi Q5SV85.
SOURCEi Search...

Gene expression databases

Bgeei Q5SV85.
CleanExi MM_AP1GBP1.
Genevestigatori Q5SV85.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR000261. EPS15_homology.
[Graphical view ]
PROSITEi PS50031. EH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin."
    Lui W.W.Y., Collins B.M., Hirst J., Motley A., Millar C., Schu P., Owen D.J., Robinson M.S.
    Mol. Biol. Cell 14:2385-2398(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-974, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576; SER-744; SER-974 AND SER-1067, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSYNRG_MOUSE
AccessioniPrimary (citable) accession number: Q5SV85
Secondary accession number(s): Q5SV84, Q6PHT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi