Rad50

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	681	ZincPROSITE-ProRule annotation		1
Metal bindingⁱ	684	ZincPROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATPase activity Source: InterPro
metal ion binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA repair Source: InterPro
telomere maintenance Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Ligand

Metal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence. R-MMU-5685938. HDR through Single Strand Annealing (SSA). R-MMU-5685939. HDR through MMEJ (alt-NHEJ). R-MMU-5685942. HDR through Homologous Recombination (HRR). R-MMU-5693548. Sensing of DNA Double Strand Breaks. R-MMU-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA). R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. R-MMU-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates. R-MMU-5693571. Nonhomologous End-Joining (NHEJ). R-MMU-5693579. Homologous DNA Pairing and Strand Exchange. R-MMU-5693607. Processing of DNA double-strand break ends. R-MMU-5693616. Presynaptic phase of homologous DNA pairing and strand exchange. R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation. R-MMU-69473. G2/M DNA damage checkpoint.

Reactomeⁱ

R-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-MMU-5685938. HDR through Single Strand Annealing (SSA).
R-MMU-5685939. HDR through MMEJ (alt-NHEJ).
R-MMU-5685942. HDR through Homologous Recombination (HRR).
R-MMU-5693548. Sensing of DNA Double Strand Breaks.
R-MMU-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-MMU-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-MMU-5693571. Nonhomologous End-Joining (NHEJ).
R-MMU-5693579. Homologous DNA Pairing and Strand Exchange.
R-MMU-5693607. Processing of DNA double-strand break ends.
R-MMU-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-69473. G2/M DNA damage checkpoint.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: DNA repair protein RAD50Imported Submitted name: RAD50 homolog (S. cerevisiae)Imported
Gene namesⁱ	Name:Rad50Imported ORF Names:mCG_119249Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:109292. Rad50.

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020380.

Bgeeⁱ

ENSMUSG00000020380.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q5SV02. 1 interactor.

IntActⁱ

Q5SV02. 1 interactor.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	635 – 734	Zinc-hookInterPro annotationAdd BLAST		100

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	227 – 299	Sequence analysisAdd BLAST	73
Coiled coilⁱ	308 – 349	Sequence analysisAdd BLAST	42
Coiled coilⁱ	401 – 435	Sequence analysisAdd BLAST	35
Coiled coilⁱ	450 – 531	Sequence analysisAdd BLAST	82
Coiled coilⁱ	580 – 628	Sequence analysisAdd BLAST	49
Coiled coilⁱ	635 – 655	Sequence analysisAdd BLAST	21
Coiled coilⁱ	712 – 732	Sequence analysisAdd BLAST	21
Coiled coilⁱ	740 – 774	Sequence analysisAdd BLAST	35
Coiled coilⁱ	795 – 815	Sequence analysisAdd BLAST	21
Coiled coilⁱ	825 – 939	Sequence analysisAdd BLAST	115
Coiled coilⁱ	1024 – 1070	Sequence analysisAdd BLAST	47

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0962. Eukaryota. COG0419. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018781.
HOVERGENⁱ	HBG058033.
KEGG Orthology (KO) More...KOⁱ	K10866.
OMAⁱ	RSMVCTQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01KA.
TreeFamⁱ	TF101217.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR004584. Rad50_eukaryotes. IPR013134. Zn_hook_RAD50.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04423. Rad50_zn_hook. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 3 hits.
TIGRFAMsⁱ	TIGR00606. rad50. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51131. ZN_HOOK. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5SV02-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRIEKMSIL GVRSFGIEDK DKQIISFFSP LTILVGPNGA GKTTIIECLK 
        60         70         80         90        100
YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GEMVAVHRSM 
       110        120        130        140        150
LCSQKNKKTE FKTLEGVITR MKHGEKVSLS SKCAEIDREM ISCLGVSKSV 
       160        170        180        190        200
LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF SATRYIKALD TLRQVRQTQG 
       210        220        230        240        250
QKVKECQTEL KYLKQNKEKA CEIRDQITSK EAQLASSQEI VRSYEDELEP 
       260        270        280        290        300
LKNRLKEIEH NLSKIMKLDN EIKALESRKK QMEKDNSELE QKMEKVFQGT 
       310        320        330        340        350
DEQLNDLYHN HQRTVREKER RLVDCQRELE KLNKEARLLN QEKAELLVEQ 
       360        370        380        390        400
GRLQLQADRH QEHIRARDSL IQSLATHLEL DGFERGPFSE RQIKNFHELV 
       410        420        430        440        450
KERQEREAKT ASQLLSDLTD KEALKQRQLD ELRDRKSGLG RTIELKTEIL 
       460        470        480        490        500
TKKQSELRHV RSELQQLEGS SDRILELDQE LTKAERELSK AEKNSSIETL 
       510        520        530        540        550
KAEVMSLQNE KADLDRSLRK LDQEMEQLNH HTTTRTQMEM LTKDKTDKDE 
       560        570        580        590        600
QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE 
       610        620        630        640        650
LASAEQNKNH INNELKKKEE QLSSYEDKLF DVCGSQDLES DLGRLKEEIE 
       660        670        680        690        700
KSSKQRAMLA GATAVYSQFI TQLTDENQSC CPVCQRVFQT EAELQEVISD 
       710        720        730        740        750
LQSKLRLAPD KLKSTESELK KKERRRDEML GLVPVRQSII DLKEKEIPEL 
       760        770        780        790        800
RNRLQSVNRD IQRLKNDIEE QETLLGTIMP EEESAKVCLT DVTIMERFQM 
       810        820        830        840        850
ELKDVERKIA QQAAKLQGVD LDRTVQQVNQ EKQEKQHRLD TVTSKIELNR 
       860        870        880        890        900
KLIQDQQEQI QHLKSKTNEL KSEKLQIATN LQRRQQMEEQ SVELSTEVQS 
       910        920        930        940        950
LNREIKDAKE QISPLETALE KLQQEKEELI HRKHTSNKMA QDKINDIKEK 
       960        970        980        990       1000
VKNIHGYMKD IENYIQDGKD DYKKQKETEL NGVAVQLNEC EKHREKINKD 
      1010       1020       1030       1040       1050
MGTMRQDIDT QKIQERWLQD NLTLRKRRDE LKEVEEERKQ HLKEMGQMQV 
      1060       1070       1080       1090       1100
LQMKNEHQKL EENIDTIKRN HSLALGRQKG YEDEILHFKK ELREPQFRDA 
      1110       1120       1130       1140       1150
EEKYREMMIV MRTTELVNKD LDIYYKTLDQ AIMKFHSMKM EEINKIIRDL 
      1160       1170       1180       1190       1200
WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR 
      1210       1220       1230       1240       1250
CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDRE NIESLAHALV 
      1260       1270       1280       1290       1300
EIIKSRSQQR NFQLLVITHD EDFVELLGRS EYVEKFYRVK KNMDQCSEIV 
      1310 
KCSISSLGSY VH

Length:1,312

Mass (Da):153,547

Last modified:December 21, 2004 - v1

Checksum:ⁱFD99AF7A0C81D634

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL645741 Genomic DNA. No translation available. CH466575 Genomic DNA. Translation: EDL33574.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033038.2. NM_009012.2.
UniGeneⁱ	Mm.4888.

Genome annotation databases

Ensemblⁱ	ENSMUST00000020649; ENSMUSP00000020649; ENSMUSG00000020380.
GeneIDⁱ	19360.
KEGGⁱ	mmu:19360.
UCSC genome browser More...UCSCⁱ	uc007iwt.1. mouse.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5SV02	Q92878 A8K3I2 W5Q081 UPI00029D489E UPI0005FAE329 A0A2K6CKB5 C9JNH8 UPI0005F4A3C2 UPI000BB923AC A0A096MUK7 +170	Homo sapiens (Human) Ovis aries (Sheep) Macaca nemestrina (Pig-tailed macaque) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Delphinapterus leucas (Beluga whale) Papio anubis (Olive baboon) Myotis davidii (David's myotis) Myotis brandtii (Brandt's bat) Macaca mulatta (Rhesus macaque) Sus scrofa (Pig) And more	1,312	UniRef90_Q92878	Cluster: DNA repair protein RAD50	181

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5SV02	Q92878 A8K3I2 W5Q081 UPI00029D489E UPI0005FAE329 A0A2K6CKB5 C9JNH8 UPI0005F4A3C2 UPI000BB923AC A0A096MUK7 +172	Homo sapiens (Human) Ovis aries (Sheep) Macaca nemestrina (Pig-tailed macaque) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Delphinapterus leucas (Beluga whale) Papio anubis (Olive baboon) Myotis davidii (David's myotis) Myotis brandtii (Brandt's bat) Macaca mulatta (Rhesus macaque) Sus scrofa (Pig) And more	1,312	UniRef50_Q92878	Cluster: DNA repair protein RAD50	183

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL645741 Genomic DNA. No translation available. CH466575 Genomic DNA. Translation: EDL33574.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033038.2. NM_009012.2.
UniGeneⁱ	Mm.4888.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q5SV02. 1 interactor.

IntActⁱ

Q5SV02. 1 interactor.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	19360.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020649; ENSMUSP00000020649; ENSMUSG00000020380.
GeneIDⁱ	19360.
KEGGⁱ	mmu:19360.
UCSC genome browser More...UCSCⁱ	uc007iwt.1. mouse.

Organism-specific databases

CTDⁱ	10111.
MGIⁱ	MGI:109292. Rad50.

Phylogenomic databases

eggNOGⁱ	KOG0962. Eukaryota. COG0419. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018781.
HOVERGENⁱ	HBG058033.
KEGG Orthology (KO) More...KOⁱ	K10866.
OMAⁱ	RSMVCTQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01KA.
TreeFamⁱ	TF101217.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence. R-MMU-5685938. HDR through Single Strand Annealing (SSA). R-MMU-5685939. HDR through MMEJ (alt-NHEJ). R-MMU-5685942. HDR through Homologous Recombination (HRR). R-MMU-5693548. Sensing of DNA Double Strand Breaks. R-MMU-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA). R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. R-MMU-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates. R-MMU-5693571. Nonhomologous End-Joining (NHEJ). R-MMU-5693579. Homologous DNA Pairing and Strand Exchange. R-MMU-5693607. Processing of DNA double-strand break ends. R-MMU-5693616. Presynaptic phase of homologous DNA pairing and strand exchange. R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation. R-MMU-69473. G2/M DNA damage checkpoint.

Reactomeⁱ

R-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-MMU-5685938. HDR through Single Strand Annealing (SSA).
R-MMU-5685939. HDR through MMEJ (alt-NHEJ).
R-MMU-5685942. HDR through Homologous Recombination (HRR).
R-MMU-5693548. Sensing of DNA Double Strand Breaks.
R-MMU-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-MMU-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-MMU-5693571. Nonhomologous End-Joining (NHEJ).
R-MMU-5693579. Homologous DNA Pairing and Strand Exchange.
R-MMU-5693607. Processing of DNA double-strand break ends.
R-MMU-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-69473. G2/M DNA damage checkpoint.

Miscellaneous databases

ChiTaRSⁱ	Rad50. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020380.

Bgeeⁱ

ENSMUSG00000020380.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR004584. Rad50_eukaryotes. IPR013134. Zn_hook_RAD50.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04423. Rad50_zn_hook. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 3 hits.
TIGRFAMsⁱ	TIGR00606. rad50. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51131. ZN_HOOK. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5SV02_MOUSE
Accessionⁱ	Q5SV02Primary (citable) accession number: Q5SV02
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	February 28, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5SV02 (Q5SV02_MOUSE)

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DNA repair protein RAD50

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ