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UniProtKB - Q5SV02 (Q5SV02_MOUSE)

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Protein
Submitted name:

DNA repair protein RAD50

Gene

Rad50

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi681ZincPROSITE-ProRule annotation1
Metal bindingi684ZincPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-MMU-5685938. HDR through Single Strand Annealing (SSA).
R-MMU-5685939. HDR through MMEJ (alt-NHEJ).
R-MMU-5685942. HDR through Homologous Recombination (HRR).
R-MMU-5693548. Sensing of DNA Double Strand Breaks.
R-MMU-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-MMU-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-MMU-5693571. Nonhomologous End-Joining (NHEJ).
R-MMU-5693579. Homologous DNA Pairing and Strand Exchange.
R-MMU-5693607. Processing of DNA double-strand break ends.
R-MMU-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-69473. G2/M DNA damage checkpoint.

Names & Taxonomyi

Protein namesi
Submitted name:
DNA repair protein RAD50Imported
Submitted name:
RAD50 homolog (S. cerevisiae)Imported
Gene namesi
Name:Rad50Imported
ORF Names:mCG_119249Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109292. Rad50.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000020380.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini635 – 734Zinc-hookInterPro annotationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 299Sequence analysisAdd BLAST73
Coiled coili308 – 349Sequence analysisAdd BLAST42
Coiled coili401 – 435Sequence analysisAdd BLAST35
Coiled coili450 – 531Sequence analysisAdd BLAST82
Coiled coili580 – 628Sequence analysisAdd BLAST49
Coiled coili740 – 774Sequence analysisAdd BLAST35
Coiled coili825 – 939Sequence analysisAdd BLAST115
Coiled coili1024 – 1070Sequence analysisAdd BLAST47

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0962. Eukaryota.
COG0419. LUCA.
GeneTreeiENSGT00390000018781.
HOVERGENiHBG058033.
KOiK10866.
OMAiRSMVCTQ.
OrthoDBiEOG091G01KA.
TreeFamiTF101217.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR004584. Rad50_eukaryotes.
IPR013134. Zn_hook_RAD50.
PfamiView protein in Pfam
PF04423. Rad50_zn_hook. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00606. rad50. 1 hit.
PROSITEiView protein in PROSITE
PS51131. ZN_HOOK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SV02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIEKMSIL GVRSFGIEDK DKQIISFFSP LTILVGPNGA GKTTIIECLK 
        60         70         80         90        100
YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GEMVAVHRSM 
       110        120        130        140        150
LCSQKNKKTE FKTLEGVITR MKHGEKVSLS SKCAEIDREM ISCLGVSKSV 
       160        170        180        190        200
LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF SATRYIKALD TLRQVRQTQG 
       210        220        230        240        250
QKVKECQTEL KYLKQNKEKA CEIRDQITSK EAQLASSQEI VRSYEDELEP 
       260        270        280        290        300
LKNRLKEIEH NLSKIMKLDN EIKALESRKK QMEKDNSELE QKMEKVFQGT 
       310        320        330        340        350
DEQLNDLYHN HQRTVREKER RLVDCQRELE KLNKEARLLN QEKAELLVEQ 
       360        370        380        390        400
GRLQLQADRH QEHIRARDSL IQSLATHLEL DGFERGPFSE RQIKNFHELV 
       410        420        430        440        450
KERQEREAKT ASQLLSDLTD KEALKQRQLD ELRDRKSGLG RTIELKTEIL 
       460        470        480        490        500
TKKQSELRHV RSELQQLEGS SDRILELDQE LTKAERELSK AEKNSSIETL 
       510        520        530        540        550
KAEVMSLQNE KADLDRSLRK LDQEMEQLNH HTTTRTQMEM LTKDKTDKDE 
       560        570        580        590        600
QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE 
       610        620        630        640        650
LASAEQNKNH INNELKKKEE QLSSYEDKLF DVCGSQDLES DLGRLKEEIE 
       660        670        680        690        700
KSSKQRAMLA GATAVYSQFI TQLTDENQSC CPVCQRVFQT EAELQEVISD 
       710        720        730        740        750
LQSKLRLAPD KLKSTESELK KKERRRDEML GLVPVRQSII DLKEKEIPEL 
       760        770        780        790        800
RNRLQSVNRD IQRLKNDIEE QETLLGTIMP EEESAKVCLT DVTIMERFQM 
       810        820        830        840        850
ELKDVERKIA QQAAKLQGVD LDRTVQQVNQ EKQEKQHRLD TVTSKIELNR 
       860        870        880        890        900
KLIQDQQEQI QHLKSKTNEL KSEKLQIATN LQRRQQMEEQ SVELSTEVQS 
       910        920        930        940        950
LNREIKDAKE QISPLETALE KLQQEKEELI HRKHTSNKMA QDKINDIKEK 
       960        970        980        990       1000
VKNIHGYMKD IENYIQDGKD DYKKQKETEL NGVAVQLNEC EKHREKINKD 
      1010       1020       1030       1040       1050
MGTMRQDIDT QKIQERWLQD NLTLRKRRDE LKEVEEERKQ HLKEMGQMQV 
      1060       1070       1080       1090       1100
LQMKNEHQKL EENIDTIKRN HSLALGRQKG YEDEILHFKK ELREPQFRDA 
      1110       1120       1130       1140       1150
EEKYREMMIV MRTTELVNKD LDIYYKTLDQ AIMKFHSMKM EEINKIIRDL 
      1160       1170       1180       1190       1200
WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR 
      1210       1220       1230       1240       1250
CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDRE NIESLAHALV 
      1260       1270       1280       1290       1300
EIIKSRSQQR NFQLLVITHD EDFVELLGRS EYVEKFYRVK KNMDQCSEIV 
      1310 
KCSISSLGSY VH
Length:1,312
Mass (Da):153,547
Last modified:December 21, 2004 - v1
Checksum:iFD99AF7A0C81D634
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645741 Genomic DNA. No translation available.
CH466575 Genomic DNA. Translation: EDL33574.1.
RefSeqiNP_033038.2. NM_009012.2.
UniGeneiMm.4888.

Genome annotation databases

EnsembliENSMUST00000020649; ENSMUSP00000020649; ENSMUSG00000020380.
GeneIDi19360.
KEGGimmu:19360.
UCSCiuc007iwt.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ5SV02_MOUSE
AccessioniPrimary (citable) accession number: Q5SV02
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 5, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported