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Protein
Submitted name:

DNA repair protein RAD50

Gene

Rad50

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-MMU-5685938. HDR through Single Strand Annealing (SSA).
R-MMU-5685939. HDR through MMEJ (alt-NHEJ).
R-MMU-5685942. HDR through Homologous Recombination (HRR).
R-MMU-5693548. Sensing of DNA Double Strand Breaks.
R-MMU-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-MMU-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-MMU-5693571. Nonhomologous End-Joining (NHEJ).
R-MMU-5693579. Homologous DNA Pairing and Strand Exchange.
R-MMU-5693607. Processing of DNA double-strand break ends.
R-MMU-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-MMU-69473. G2/M DNA damage checkpoint.

Names & Taxonomyi

Protein namesi
Submitted name:
DNA repair protein RAD50Imported
Submitted name:
RAD50 homolog (S. cerevisiae)Imported
Gene namesi
Name:Rad50Imported
ORF Names:mCG_119249Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109292. Rad50.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020649.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini635 – 734100Zinc-hookInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili227 – 29973Sequence analysisAdd
BLAST
Coiled coili308 – 34942Sequence analysisAdd
BLAST
Coiled coili401 – 43535Sequence analysisAdd
BLAST
Coiled coili450 – 53182Sequence analysisAdd
BLAST
Coiled coili580 – 62849Sequence analysisAdd
BLAST
Coiled coili740 – 77435Sequence analysisAdd
BLAST
Coiled coili825 – 939115Sequence analysisAdd
BLAST
Coiled coili1024 – 107047Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0962. Eukaryota.
COG0419. LUCA.
GeneTreeiENSGT00390000018781.
HOVERGENiHBG058033.
KOiK10866.
OMAiRSMVCTQ.
OrthoDBiEOG725DGM.
TreeFamiTF101217.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR004584. Rad50_eukaryotes.
IPR013134. Zn_hook_RAD50.
[Graphical view]
PANTHERiPTHR18867. PTHR18867. 1 hit.
PfamiPF04423. Rad50_zn_hook. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00606. rad50. 1 hit.
PROSITEiPS51131. ZN_HOOK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SV02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIEKMSIL GVRSFGIEDK DKQIISFFSP LTILVGPNGA GKTTIIECLK
60 70 80 90 100
YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GEMVAVHRSM
110 120 130 140 150
LCSQKNKKTE FKTLEGVITR MKHGEKVSLS SKCAEIDREM ISCLGVSKSV
160 170 180 190 200
LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF SATRYIKALD TLRQVRQTQG
210 220 230 240 250
QKVKECQTEL KYLKQNKEKA CEIRDQITSK EAQLASSQEI VRSYEDELEP
260 270 280 290 300
LKNRLKEIEH NLSKIMKLDN EIKALESRKK QMEKDNSELE QKMEKVFQGT
310 320 330 340 350
DEQLNDLYHN HQRTVREKER RLVDCQRELE KLNKEARLLN QEKAELLVEQ
360 370 380 390 400
GRLQLQADRH QEHIRARDSL IQSLATHLEL DGFERGPFSE RQIKNFHELV
410 420 430 440 450
KERQEREAKT ASQLLSDLTD KEALKQRQLD ELRDRKSGLG RTIELKTEIL
460 470 480 490 500
TKKQSELRHV RSELQQLEGS SDRILELDQE LTKAERELSK AEKNSSIETL
510 520 530 540 550
KAEVMSLQNE KADLDRSLRK LDQEMEQLNH HTTTRTQMEM LTKDKTDKDE
560 570 580 590 600
QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE
610 620 630 640 650
LASAEQNKNH INNELKKKEE QLSSYEDKLF DVCGSQDLES DLGRLKEEIE
660 670 680 690 700
KSSKQRAMLA GATAVYSQFI TQLTDENQSC CPVCQRVFQT EAELQEVISD
710 720 730 740 750
LQSKLRLAPD KLKSTESELK KKERRRDEML GLVPVRQSII DLKEKEIPEL
760 770 780 790 800
RNRLQSVNRD IQRLKNDIEE QETLLGTIMP EEESAKVCLT DVTIMERFQM
810 820 830 840 850
ELKDVERKIA QQAAKLQGVD LDRTVQQVNQ EKQEKQHRLD TVTSKIELNR
860 870 880 890 900
KLIQDQQEQI QHLKSKTNEL KSEKLQIATN LQRRQQMEEQ SVELSTEVQS
910 920 930 940 950
LNREIKDAKE QISPLETALE KLQQEKEELI HRKHTSNKMA QDKINDIKEK
960 970 980 990 1000
VKNIHGYMKD IENYIQDGKD DYKKQKETEL NGVAVQLNEC EKHREKINKD
1010 1020 1030 1040 1050
MGTMRQDIDT QKIQERWLQD NLTLRKRRDE LKEVEEERKQ HLKEMGQMQV
1060 1070 1080 1090 1100
LQMKNEHQKL EENIDTIKRN HSLALGRQKG YEDEILHFKK ELREPQFRDA
1110 1120 1130 1140 1150
EEKYREMMIV MRTTELVNKD LDIYYKTLDQ AIMKFHSMKM EEINKIIRDL
1160 1170 1180 1190 1200
WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR
1210 1220 1230 1240 1250
CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDRE NIESLAHALV
1260 1270 1280 1290 1300
EIIKSRSQQR NFQLLVITHD EDFVELLGRS EYVEKFYRVK KNMDQCSEIV
1310
KCSISSLGSY VH
Length:1,312
Mass (Da):153,547
Last modified:December 21, 2004 - v1
Checksum:iFD99AF7A0C81D634
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645741 Genomic DNA. No translation available.
CH466575 Genomic DNA. Translation: EDL33574.1.
RefSeqiNP_033038.2. NM_009012.2.
UniGeneiMm.4888.

Genome annotation databases

EnsembliENSMUST00000020649; ENSMUSP00000020649; ENSMUSG00000020380.
GeneIDi19360.
KEGGimmu:19360.
UCSCiuc007iwt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645741 Genomic DNA. No translation available.
CH466575 Genomic DNA. Translation: EDL33574.1.
RefSeqiNP_033038.2. NM_009012.2.
UniGeneiMm.4888.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020649.

Protocols and materials databases

DNASUi19360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020649; ENSMUSP00000020649; ENSMUSG00000020380.
GeneIDi19360.
KEGGimmu:19360.
UCSCiuc007iwt.1. mouse.

Organism-specific databases

CTDi10111.
MGIiMGI:109292. Rad50.

Phylogenomic databases

eggNOGiKOG0962. Eukaryota.
COG0419. LUCA.
GeneTreeiENSGT00390000018781.
HOVERGENiHBG058033.
KOiK10866.
OMAiRSMVCTQ.
OrthoDBiEOG725DGM.
TreeFamiTF101217.

Enzyme and pathway databases

ReactomeiR-MMU-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-MMU-5685938. HDR through Single Strand Annealing (SSA).
R-MMU-5685939. HDR through MMEJ (alt-NHEJ).
R-MMU-5685942. HDR through Homologous Recombination (HRR).
R-MMU-5693548. Sensing of DNA Double Strand Breaks.
R-MMU-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-MMU-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-MMU-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-MMU-5693571. Nonhomologous End-Joining (NHEJ).
R-MMU-5693579. Homologous DNA Pairing and Strand Exchange.
R-MMU-5693607. Processing of DNA double-strand break ends.
R-MMU-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-MMU-69473. G2/M DNA damage checkpoint.

Miscellaneous databases

ChiTaRSiRad50. mouse.
NextBioi296417.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR004584. Rad50_eukaryotes.
IPR013134. Zn_hook_RAD50.
[Graphical view]
PANTHERiPTHR18867. PTHR18867. 1 hit.
PfamiPF04423. Rad50_zn_hook. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00606. rad50. 1 hit.
PROSITEiPS51131. ZN_HOOK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ5SV02_MOUSE
AccessioniPrimary (citable) accession number: Q5SV02
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.