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Q5SUV9

- Q5SUV9_MOUSE

UniProt

Q5SUV9 - Q5SUV9_MOUSE

Protein
Submitted name:

Aromatic-L-amino-acid decarboxylase

Gene

Ddc

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. amino acid binding Source: Ensembl
    2. aromatic-L-amino-acid decarboxylase activity Source: MGI
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro
    2. cellular response to alkaloid Source: Ensembl
    3. cellular response to drug Source: Ensembl
    4. cellular response to growth factor stimulus Source: Ensembl
    5. circadian rhythm Source: Ensembl
    6. isoquinoline alkaloid metabolic process Source: Ensembl
    7. multicellular organismal aging Source: Ensembl
    8. phytoalexin metabolic process Source: Ensembl
    9. response to pyrethroid Source: Ensembl
    10. response to toxic substance Source: MGI
    11. serotonin biosynthetic process Source: Ensembl
    12. synaptic vesicle amine transport Source: Ensembl

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Aromatic-L-amino-acid decarboxylaseImported
    Gene namesi
    Name:DdcImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:94876. Ddc.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: MGI
    3. neuronal cell body Source: Ensembl
    4. synaptic vesicle Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ5SUV9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000105286.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SUV9.
    SMRiQ5SUV9. Positions 1-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110825.
    HOGENOMiHOG000121941.
    HOVERGENiHBG000944.
    InParanoidiQ5SUV9.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010977. Aromatic_deC.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    PRINTSiPR00800. YHDCRBOXLASE.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q5SUV9-1 [UniParc]FASTAAdd to Basket

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    MDSREFRRRG KEMVDYIADY LDGIEGRPVY PDVEPGYLRP LIPATAPQEP    50
    ETYEDIIKDI EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC 100
    IGFSWAASPA CTELETVMMD WLGKMLELPE AFLAGRAGEG GGVIQGSASE 150
    ATLVALLAAR TKVIRQLQAA SPEFTQAAIM EKLVAYTSDQ AHSSVERAGL 200
    IGGIKLKAVP SDGNFSMRAS ALREALERDK AAGLIPFFVV ATLGTTSCCS 250
    FDN 253
    Length:253
    Mass (Da):27,401
    Last modified:December 21, 2004 - v1
    Checksum:i1509ED6DE6E8B259
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei253 – 2531Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596450 Genomic DNA. No translation available.
    AL645803 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000155690; ENSMUSP00000121096; ENSMUSG00000020182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596450 Genomic DNA. No translation available.
    AL645803 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q5SUV9.
    SMRi Q5SUV9. Positions 1-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000105286.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000155690 ; ENSMUSP00000121096 ; ENSMUSG00000020182 .

    Organism-specific databases

    MGIi MGI:94876. Ddc.

    Phylogenomic databases

    GeneTreei ENSGT00730000110825.
    HOGENOMi HOG000121941.
    HOVERGENi HBG000944.
    InParanoidi Q5SUV9.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5SUV9.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010977. Aromatic_deC.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR00800. YHDCRBOXLASE.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ5SUV9_MOUSE
    AccessioniPrimary (citable) accession number: Q5SUV9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3