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Protein

Myosin light chain kinase family member 4

Gene

Mylk4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361ATPPROSITE-ProRule annotation
Active sitei227 – 2271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi113 – 1219ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain kinase family member 4 (EC:2.7.11.1)
Alternative name(s):
Sugen kinase 85
Short name:
SgK085
Gene namesi
Name:Mylk4
Synonyms:Sgk085
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:3643758. Mylk4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Myosin light chain kinase family member 4PRO_0000261031Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5SUV5.
PRIDEiQ5SUV5.

PTM databases

iPTMnetiQ5SUV5.
PhosphoSiteiQ5SUV5.

Expressioni

Gene expression databases

BgeeiQ5SUV5.
ExpressionAtlasiQ5SUV5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060149.

Structurei

3D structure databases

ProteinModelPortaliQ5SUV5.
SMRiQ5SUV5. Positions 82-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 361255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000233016.
HOVERGENiHBG095569.
InParanoidiQ5SUV5.
OrthoDBiEOG73FQMV.
PhylomeDBiQ5SUV5.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SUV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVKRLEEI SSCHSSNPLE KVAFFQCMEE VEKVKCFLEE NSGDLDLQSG
60 70 80 90 100
DNEAEENVWS NRALDERIIV KGGRTSALTD DIPAPAAPFD HRMVMAKHAS
110 120 130 140 150
VDNLYTVSKS EILGGGRFGQ VHKCEEKATG LKLAAKIIKT RGAKDKEDVK
160 170 180 190 200
NEISVMNQLD HVNLIQLYDA FESKHDIILV MDVEGGELFD RIIDENCNLT
210 220 230 240 250
ELDTILFMKQ ICEGIRYMHQ MYILHLDLKP ENILCVNRDA KQIKIIDFGL
260 270 280 290 300
ARRYKPREKL KVNFGTPEFL APEVVNYDFV SFSTDMWSVG VITYMLLSGL
310 320 330 340 350
SPFLGDNDAE TLTNILACRW DLEDEEFQDI SEEAKEFISK LLIKEKSWRI
360 370 380
SASEALKHPW LSDHKLHSRL SAQKNCNSGV LNLTTK
Length:386
Mass (Da):43,905
Last modified:November 28, 2006 - v2
Checksum:i6BD8AAEC2A86D2C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645808 Genomic DNA. Translation: CAI25646.2.
UniGeneiMm.60041.

Genome annotation databases

EnsembliENSMUST00000134352; ENSMUSP00000116013; ENSMUSG00000044951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645808 Genomic DNA. Translation: CAI25646.2.
UniGeneiMm.60041.

3D structure databases

ProteinModelPortaliQ5SUV5.
SMRiQ5SUV5. Positions 82-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060149.

PTM databases

iPTMnetiQ5SUV5.
PhosphoSiteiQ5SUV5.

Proteomic databases

PaxDbiQ5SUV5.
PRIDEiQ5SUV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000134352; ENSMUSP00000116013; ENSMUSG00000044951.

Organism-specific databases

MGIiMGI:3643758. Mylk4.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000233016.
HOVERGENiHBG095569.
InParanoidiQ5SUV5.
OrthoDBiEOG73FQMV.
PhylomeDBiQ5SUV5.

Miscellaneous databases

ChiTaRSiMylk4. mouse.
PROiQ5SUV5.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SUV5.
ExpressionAtlasiQ5SUV5. baseline and differential.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiMYLK4_MOUSE
AccessioniPrimary (citable) accession number: Q5SUV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: June 8, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.