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Protein
Submitted name:

Protein Cacna1g

Gene

Cacna1g

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • low voltage-gated calcium channel activity Source: MGI
  • scaffold protein binding Source: MGI
  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  • action potential Source: MGI
  • calcium ion import Source: MGI
  • regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
  • regulation of heart rate Source: MGI
  • regulation of membrane potential Source: MGI
  • response to nickel cation Source: MGI
  • synaptic transmission Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Cacna1gImported
Gene namesi
Name:Cacna1gImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1201678. Cacna1g.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei123 – 14220HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23724HelicalSequence analysisAdd
BLAST
Transmembranei342 – 36322HelicalSequence analysisAdd
BLAST
Transmembranei369 – 39426HelicalSequence analysisAdd
BLAST
Transmembranei744 – 76219HelicalSequence analysisAdd
BLAST
Transmembranei774 – 79522HelicalSequence analysisAdd
BLAST
Transmembranei865 – 88420HelicalSequence analysisAdd
BLAST
Transmembranei941 – 96424HelicalSequence analysisAdd
BLAST
Transmembranei1255 – 127319HelicalSequence analysisAdd
BLAST
Transmembranei1293 – 131422HelicalSequence analysisAdd
BLAST
Transmembranei1326 – 134520HelicalSequence analysisAdd
BLAST
Transmembranei1390 – 141223HelicalSequence analysisAdd
BLAST
Transmembranei1492 – 151524HelicalSequence analysisAdd
BLAST
Transmembranei1590 – 161122HelicalSequence analysisAdd
BLAST
Transmembranei1623 – 164624HelicalSequence analysisAdd
BLAST
Transmembranei1724 – 174320HelicalSequence analysisAdd
BLAST
Transmembranei1807 – 182923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • plasma membrane Source: MGI
  • voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ5SUF9.
PRIDEiQ5SUF9.

Expressioni

Gene expression databases

BgeeiQ5SUF9.
ExpressionAtlasiQ5SUF9. baseline and differential.
GenevisibleiQ5SUF9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098127.

Structurei

3D structure databases

ProteinModelPortaliQ5SUF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 405326Ion_transInterPro annotationAdd
BLAST
Domaini743 – 970228Ion_transInterPro annotationAdd
BLAST
Domaini1253 – 1525273Ion_transInterPro annotationAdd
BLAST
Domaini1589 – 1839251Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1524 – 155128Sequence analysisAdd
BLAST
Coiled coili1828 – 185225Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.
HOVERGENiHBG050764.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
[Graphical view]
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 7 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR01629. TVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

Q5SUF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG
60 70 80 90 100
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM
110 120 130 140 150
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD
160 170 180 190 200
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL
210 220 230 240 250
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP
260 270 280 290 300
LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCGL
310 320 330 340 350
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV
360 370 380 390 400
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE
410 420 430 440 450
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR
460 470 480 490 500
LAQVSRAVGV RAGLLSSPVA RGGQEPQPSG SCSRSHRRLS VHHLVHHHHH
510 520 530 540 550
HHHHYHLGNG TLRVPRASPE IQDRDANGSR WLMLPPPSTP TPSGGPPRGA
560 570 580 590 600
ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE
610 620 630 640 650
MLKDKALVEV APSPGPPTLT SFNIPPGPFS SMHKLLETQS TGACHSSCKI
660 670 680 690 700
SSPCSKADSG ACGPDSCPYC ARTGAGEPES ADHEMPDSDS EAVYEFTQDA
710 720 730 740 750
QHSDLRDPHR RRRPSLGPDA EPSSVLAFWR LICDTFRKIV DSKYFGRGIM
760 770 780 790 800
IAILVNTLSM GIEYHEQPEE LTNALEISNI VFTSLFALEM LLKLLVYGPF
810 820 830 840 850
GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR VLKLVRFLPA
860 870 880 890 900
LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL
910 920 930 940 950
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF
960 970 980 990 1000
GNYVLFNLLV AILVEGFQAE GDATKSESEP DFFSPSVDGD GDRKKRLALV
1010 1020 1030 1040 1050
ALGEHSELRK SLLPPLIIHT AATPMSLPKS SSTGVGEALG SGSRRTSSSG
1060 1070 1080 1090 1100
SAEPGTAHHE MKSPPSARSS PHSPWSAASS WTSRRSSRNS LGRAPSLKRR
1110 1120 1130 1140 1150
SPSGERRSLL SGEGQESQDE EESSEEDRAS PAGSDHRHRG SLEREAKSSF
1160 1170 1180 1190 1200
DLPDTLQVPG LHRTASGRSS ASEHQDCNGK SASGRLARTL RADDPPLDGD
1210 1220 1230 1240 1250
DGDDEGNLSK GERLRAWVRA RLPACCRERD SWSAYIFPPQ SRFRLLCHRI
1260 1270 1280 1290 1300
ITHKMFDHVV LVIIFLNCIT IAMERPKIDP HSAERIFLTL SNYIFTAVFL
1310 1320 1330 1340 1350
AEMTVKVVAL GWCFGEQAYL RSSWNVLDGL LVLISVIDIL VSMVSDSGTK
1360 1370 1380 1390 1400
ILGMLRVLRL LRTLRPLRVI SRAQGLKLVV ETLMSSLKPI GNIVVICCAF
1410 1420 1430 1440 1450
FIIFGILGVQ LFKGKFFVCQ GEDTRNITNK SDCAEASYRW VRHKYNFDNL
1460 1470 1480 1490 1500
GQALMSLFVL ASKDGWVDIM YDGLDAVGVD QQPIMNHNPW MLLYFISFLL
1510 1520 1530 1540 1550
IVAFFVLNMF VGVVVENFHK CRQHQEEEEA RRREEKRLKR LEKKRRNLML
1560 1570 1580 1590 1600
DDVIASGSSA SAASEAQCKP YYSDYSRFRL LVHHLCTSHY LDLFITGVIG
1610 1620 1630 1640 1650
LNVVTMAMEH YQQPQILDEA LKICNYIFTV IFVLESVFKL VAFGFRRFFQ
1660 1670 1680 1690 1700
DRWNQLDLAI VLLSIMGITL EEIEVNASLP INPTIIRIMR VLRIARVLKL
1710 1720 1730 1740 1750
LKMAVGMRAL LDTVMQALPQ VGNLGLLFML LFFIFAALGV ELFGDLECDE
1760 1770 1780 1790 1800
THPCEGLGRH ATFRNFGMAF LTLFRVSTGD NWNGIMKDTL RDCDQESTCY
1810 1820 1830 1840 1850
NTVISPIYFV SFVLTAQFVL VNVVIAVLMK HLEESNKEAK EEAELEAELE
1860 1870 1880 1890 1900
LEMKTLSPQP HSPLGSPFLW PGVEGVNSPD SPKPGAPHTT AHIGAASSGF
1910 1920 1930 1940 1950
SLEHPTMVPH TEEGPVPLGP DLLTVRKSGV SRTHSLPNDS YMCRNGSTAE
1960 1970 1980 1990 2000
RSLGHRGWGL PKAQSGSILS VHSQPADTSC ILQLPKDAHY LLQPHGAPTW
2010 2020 2030 2040 2050
GAIPKLPPPG RSPLAQRPLR RQAAIRTDSL DVQGLGSRED LLSEVSGPSC
2060 2070 2080 2090 2100
PLTRSSSFWG GSSIQVQQRS GSQSKVSKHI RLPAPCPGLE PSWAKDPQET
2110 2120 2130 2140 2150
RSSLELDTEL SWISGDLLPS SQEEPLSPRD LKKCYSVEAQ SCRRRPGSWL
2160 2170 2180 2190 2200
DEQRRHSIAV SCLDSGSQPR LCPSPSSLGG QPLGGPGSRP KKKLSPPSIS
2210 2220 2230 2240 2250
IDPPESQGPR PPCSPGVCLR RRAPASDSKD PSASSPLDST AASPSPKKDA
2260
LSLSGLSSDP TDLDP
Length:2,265
Mass (Da):250,700
Last modified:December 21, 2004 - v1
Checksum:iB64F74153E91A320
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645965 Genomic DNA. No translation available.
RefSeqiNP_001171359.1. NM_001177888.1.
UniGeneiMm.29585.

Genome annotation databases

EnsembliENSMUST00000107790; ENSMUSP00000103419; ENSMUSG00000020866.
GeneIDi12291.
UCSCiuc007kyr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645965 Genomic DNA. No translation available.
RefSeqiNP_001171359.1. NM_001177888.1.
UniGeneiMm.29585.

3D structure databases

ProteinModelPortaliQ5SUF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098127.

Proteomic databases

PaxDbiQ5SUF9.
PRIDEiQ5SUF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107790; ENSMUSP00000103419; ENSMUSG00000020866.
GeneIDi12291.
UCSCiuc007kyr.2. mouse.

Organism-specific databases

CTDi8913.
MGIiMGI:1201678. Cacna1g.

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.
HOVERGENiHBG050764.

Miscellaneous databases

ChiTaRSiCacna1g. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SUF9.
ExpressionAtlasiQ5SUF9. baseline and differential.
GenevisibleiQ5SUF9. MM.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR030154. VDCC_T_a1G.
[Graphical view]
PANTHERiPTHR10037:SF137. PTHR10037:SF137. 7 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR01629. TVDCCALPHA1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ5SUF9_MOUSE
AccessioniPrimary (citable) accession number: Q5SUF9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.