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Protein

Bardet-Biedl syndrome 12 protein homolog

Gene

Bbs12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: MGI
  • eating behavior Source: MGI
  • intraciliary transport Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • photoreceptor cell maintenance Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 12 protein homolog
Gene namesi
Name:Bbs12
Synonyms:Gm1805
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2686651. Bbs12.

Subcellular locationi

  • Cell projectioncilium By similarity

  • Note: Located within the basal body of the primary cilium of differentiating preadipocytes.By similarity

GO - Cellular componenti

  • cilium Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003019821 – 708Bardet-Biedl syndrome 12 protein homologAdd BLAST708

Proteomic databases

PaxDbiQ5SUD9.
PRIDEiQ5SUD9.

PTM databases

iPTMnetiQ5SUD9.
PhosphoSitePlusiQ5SUD9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051444.
CleanExiMM_BBS12.
ExpressionAtlasiQ5SUD9. baseline and differential.
GenevisibleiQ5SUD9. MM.

Interactioni

Subunit structurei

Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052179.

Structurei

3D structure databases

ProteinModelPortaliQ5SUD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IVI6. Eukaryota.
ENOG410Z0I5. LUCA.
GeneTreeiENSGT00390000008984.
HOGENOMiHOG000294113.
HOVERGENiHBG107495.
InParanoidiQ5SUD9.
KOiK19402.
OMAiTCAYRLY.
OrthoDBiEOG091G036E.
PhylomeDBiQ5SUD9.
TreeFamiTF330844.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 2 hits.
[Graphical view]
SUPFAMiSSF52029. SSF52029. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SUD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMACRVINR RRHVGLQQLL SFAQTGRSFL GPVKATKFIT DAECHESVLI
60 70 80 90 100
SSTVRLLEGL DLTCAVGHLL NEAVQAQNNT YKIGTSTLLF LVGAWSRAVE
110 120 130 140 150
DCLHLGIPTT VIVSVMSEGL NSCIEAVVSL QVPIHNVFDH MDNTSTVYKL
160 170 180 190 200
ETVNATLCPF LQDPSGSGLL QEKRDFKDAT SPLLSTYSLS GRHAESPKFF
210 220 230 240 250
KPQNNLETEK NTLQVLKNNL YTDSFCKKSA LAHSRHFNRT DNSHWISRHD
260 270 280 290 300
GFLEQLESTP KVLRCNDFGE LAVGLSHGDH SSMALAKAAV RLQWQSLCLQ
310 320 330 340 350
QANWMAPFMF DISRLLTCCI PGLPETFSRV GLGYVTFVTM SSITLIKELQ
360 370 380 390 400
DQPFRVILIE GDLTESYRHL GFNKSVNIKT KLDSGELSED SAEELWTNHV
410 420 430 440 450
LQVLIQFNVT LILVQGSVSE HLTEKCMHSK RLVIGAVNGS VLQAFAEATR
460 470 480 490 500
AVPVAYVTQV NEDCVGSGVS VTFWMSPHDI NRSNRIAILL TAEGINLITA
510 520 530 540 550
VLTSPASAQM ETKEDRFWSC VYRLYHALKE EKVFLGGGAV EFLCLSHLQI
560 570 580 590 600
LAEQSLNRGN HACLGWLPDS SSWMASSLSV YRPTVLKSLA GGWHEFLSAI
610 620 630 640 650
MCNTATHPSA VEARTFIQQH VQNAIDSGSP SSYILSEYSK LSSGVFHSGI
660 670 680 690 700
SDNLELVPRV YDTVTPKIEA WRRALDVVLL VLQTDSEIIT GLVHTEMNSQ

ELDGVLFL
Length:708
Mass (Da):78,335
Last modified:September 11, 2007 - v2
Checksum:i31FDD3875222EEAF
GO

Sequence cautioni

The sequence CAI26237 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM14822 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136N → S in CAI26237 (PubMed:19468303).Curated1
Sequence conflicti174R → H in CAI26237 (PubMed:19468303).Curated1
Sequence conflicti262V → I in CAI26237 (PubMed:19468303).Curated1
Sequence conflicti425K → R in CAI26237 (PubMed:19468303).Curated1
Sequence conflicti588S → C in CAI26237 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645982 Genomic DNA. Translation: CAI26237.1. Different initiation.
AL691478 Genomic DNA. Translation: CAM14822.1. Different initiation.
CCDSiCCDS38417.1.
RefSeqiNP_001008502.2. NM_001008502.2.
XP_006535543.1. XM_006535480.1.
XP_011247984.1. XM_011249682.1.
XP_011247985.1. XM_011249683.1.
UniGeneiMm.32171.

Genome annotation databases

EnsembliENSMUST00000057975; ENSMUSP00000052179; ENSMUSG00000051444.
GeneIDi241950.
KEGGimmu:241950.
UCSCiuc008pan.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645982 Genomic DNA. Translation: CAI26237.1. Different initiation.
AL691478 Genomic DNA. Translation: CAM14822.1. Different initiation.
CCDSiCCDS38417.1.
RefSeqiNP_001008502.2. NM_001008502.2.
XP_006535543.1. XM_006535480.1.
XP_011247984.1. XM_011249682.1.
XP_011247985.1. XM_011249683.1.
UniGeneiMm.32171.

3D structure databases

ProteinModelPortaliQ5SUD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052179.

PTM databases

iPTMnetiQ5SUD9.
PhosphoSitePlusiQ5SUD9.

Proteomic databases

PaxDbiQ5SUD9.
PRIDEiQ5SUD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057975; ENSMUSP00000052179; ENSMUSG00000051444.
GeneIDi241950.
KEGGimmu:241950.
UCSCiuc008pan.2. mouse.

Organism-specific databases

CTDi166379.
MGIiMGI:2686651. Bbs12.

Phylogenomic databases

eggNOGiENOG410IVI6. Eukaryota.
ENOG410Z0I5. LUCA.
GeneTreeiENSGT00390000008984.
HOGENOMiHOG000294113.
HOVERGENiHBG107495.
InParanoidiQ5SUD9.
KOiK19402.
OMAiTCAYRLY.
OrthoDBiEOG091G036E.
PhylomeDBiQ5SUD9.
TreeFamiTF330844.

Miscellaneous databases

PROiQ5SUD9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051444.
CleanExiMM_BBS12.
ExpressionAtlasiQ5SUD9. baseline and differential.
GenevisibleiQ5SUD9. MM.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 2 hits.
[Graphical view]
SUPFAMiSSF52029. SSF52029. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBBS12_MOUSE
AccessioniPrimary (citable) accession number: Q5SUD9
Secondary accession number(s): A2AGT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.