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Protein

Bardet-Biedl syndrome 12 protein homolog

Gene

Bbs12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein complex assembly Source: MGI
  • chaperone-mediated protein folding Source: GO_Central
  • eating behavior Source: MGI
  • intraciliary transport Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • photoreceptor cell maintenance Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 12 protein homolog
Gene namesi
Name:Bbs12
Synonyms:Gm1805
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2686651 Bbs12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003019821 – 708Bardet-Biedl syndrome 12 protein homologAdd BLAST708

Proteomic databases

PaxDbiQ5SUD9
PRIDEiQ5SUD9

PTM databases

iPTMnetiQ5SUD9
PhosphoSitePlusiQ5SUD9

Expressioni

Gene expression databases

BgeeiENSMUSG00000051444
CleanExiMM_BBS12
ExpressionAtlasiQ5SUD9 baseline and differential
GenevisibleiQ5SUD9 MM

Interactioni

Subunit structurei

Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with MKKS.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052179

Structurei

3D structure databases

ProteinModelPortaliQ5SUD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IVI6 Eukaryota
ENOG410Z0I5 LUCA
GeneTreeiENSGT00390000008984
HOGENOMiHOG000294113
HOVERGENiHBG107495
InParanoidiQ5SUD9
KOiK19402
OMAiTCAYRLY
OrthoDBiEOG091G036E
PhylomeDBiQ5SUD9
TreeFamiTF330844

Family and domain databases

Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 2 hits
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SUD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMACRVINR RRHVGLQQLL SFAQTGRSFL GPVKATKFIT DAECHESVLI
60 70 80 90 100
SSTVRLLEGL DLTCAVGHLL NEAVQAQNNT YKIGTSTLLF LVGAWSRAVE
110 120 130 140 150
DCLHLGIPTT VIVSVMSEGL NSCIEAVVSL QVPIHNVFDH MDNTSTVYKL
160 170 180 190 200
ETVNATLCPF LQDPSGSGLL QEKRDFKDAT SPLLSTYSLS GRHAESPKFF
210 220 230 240 250
KPQNNLETEK NTLQVLKNNL YTDSFCKKSA LAHSRHFNRT DNSHWISRHD
260 270 280 290 300
GFLEQLESTP KVLRCNDFGE LAVGLSHGDH SSMALAKAAV RLQWQSLCLQ
310 320 330 340 350
QANWMAPFMF DISRLLTCCI PGLPETFSRV GLGYVTFVTM SSITLIKELQ
360 370 380 390 400
DQPFRVILIE GDLTESYRHL GFNKSVNIKT KLDSGELSED SAEELWTNHV
410 420 430 440 450
LQVLIQFNVT LILVQGSVSE HLTEKCMHSK RLVIGAVNGS VLQAFAEATR
460 470 480 490 500
AVPVAYVTQV NEDCVGSGVS VTFWMSPHDI NRSNRIAILL TAEGINLITA
510 520 530 540 550
VLTSPASAQM ETKEDRFWSC VYRLYHALKE EKVFLGGGAV EFLCLSHLQI
560 570 580 590 600
LAEQSLNRGN HACLGWLPDS SSWMASSLSV YRPTVLKSLA GGWHEFLSAI
610 620 630 640 650
MCNTATHPSA VEARTFIQQH VQNAIDSGSP SSYILSEYSK LSSGVFHSGI
660 670 680 690 700
SDNLELVPRV YDTVTPKIEA WRRALDVVLL VLQTDSEIIT GLVHTEMNSQ

ELDGVLFL
Length:708
Mass (Da):78,335
Last modified:September 11, 2007 - v2
Checksum:i31FDD3875222EEAF
GO

Sequence cautioni

The sequence CAI26237 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM14822 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136N → S in CAI26237 (PubMed:19468303).Curated1
Sequence conflicti174R → H in CAI26237 (PubMed:19468303).Curated1
Sequence conflicti262V → I in CAI26237 (PubMed:19468303).Curated1
Sequence conflicti425K → R in CAI26237 (PubMed:19468303).Curated1
Sequence conflicti588S → C in CAI26237 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645982 Genomic DNA Translation: CAI26237.1 Different initiation.
AL691478 Genomic DNA Translation: CAM14822.1 Different initiation.
CCDSiCCDS38417.1
RefSeqiNP_001008502.2, NM_001008502.2
XP_006535543.1, XM_006535480.1
XP_011247984.1, XM_011249682.1
XP_011247985.1, XM_011249683.1
UniGeneiMm.32171

Genome annotation databases

EnsembliENSMUST00000057975; ENSMUSP00000052179; ENSMUSG00000051444
GeneIDi241950
KEGGimmu:241950
UCSCiuc008pan.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBBS12_MOUSE
AccessioniPrimary (citable) accession number: Q5SUD9
Secondary accession number(s): A2AGT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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