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Q5SUC9

- SCO1_MOUSE

UniProt

Q5SUC9 - SCO1_MOUSE

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Protein

Protein SCO1 homolog, mitochondrial

Gene

Sco1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi152 – 1521CopperBy similarity
Metal bindingi156 – 1561CopperBy similarity
Metal bindingi243 – 2431CopperBy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro

GO - Biological processi

  1. cellular copper ion homeostasis Source: InterPro
  2. copper ion transport Source: InterPro
  3. respiratory chain complex IV assembly Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.
REACT_268398. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCO1 homolog, mitochondrial
Gene namesi
Name:Sco1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:106362. Sco1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: InterPro
  2. mitochondrion Source: MGI
  3. myofibril Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 284Protein SCO1 homolog, mitochondrialPRO_0000354066
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ5SUC9.
PaxDbiQ5SUC9.
PRIDEiQ5SUC9.

PTM databases

PhosphoSiteiQ5SUC9.

Expressioni

Gene expression databases

BgeeiQ5SUC9.
ExpressionAtlasiQ5SUC9. baseline and differential.
GenevestigatoriQ5SUC9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104330.

Structurei

3D structure databases

ProteinModelPortaliQ5SUC9.
SMRiQ5SUC9. Positions 118-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 11414Important for dimerizationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SCO1/2 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1999.
GeneTreeiENSGT00390000004323.
HOGENOMiHOG000258140.
HOVERGENiHBG000428.
InParanoidiQ5SUC9.
KOiK07152.
PhylomeDBiQ5SUC9.
TreeFamiTF313752.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR003782. SCO1/SenC.
IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12151. PTHR12151. 1 hit.
PfamiPF02630. SCO1-SenC. 1 hit.
[Graphical view]
PIRSFiPIRSF037736. SCO1. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5SUC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALVRAAVV RSQCRQLWRL FPRGHGLRDV AERPRPEEAC SCLRSRAFSA
60 70 80 90 100
GPPPPGAGPE PKGGQAGSHR PKPGPVSWKS LALTFAIGGS LLAGMKYFKK
110 120 130 140 150
EKIEKLEKQR HRSIGKPLLG GPFSLTTHNG EPKTDKDYLG QWVLIYFGFT
160 170 180 190 200
HCPDICPEEL EKMIEVVEEI DSIPSLPNLT PLFITIDPER DTKEAIATYV
210 220 230 240 250
KEFSPKLVGL TGTKEEIDGV ARAYRVYYSP GPKDEDEDYI VDHTIIMYLI
260 270 280
GPDGEFLDYF GQNKKKAEIA GSIAAHMRSH MKKR
Length:284
Mass (Da):31,617
Last modified:December 21, 2004 - v1
Checksum:i9CEC7E19F9977FF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645988 Genomic DNA. Translation: CAI25980.1.
BC139008 mRNA. Translation: AAI39009.1.
BC139009 mRNA. Translation: AAI39010.1.
AK139512 mRNA. Translation: BAE24044.1.
CCDSiCCDS36183.1.
RefSeqiNP_001035115.1. NM_001040026.1.
UniGeneiMm.129731.
Mm.473182.

Genome annotation databases

EnsembliENSMUST00000092996; ENSMUSP00000090673; ENSMUSG00000069844.
GeneIDi52892.
KEGGimmu:52892.
UCSCiuc007jlu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645988 Genomic DNA. Translation: CAI25980.1 .
BC139008 mRNA. Translation: AAI39009.1 .
BC139009 mRNA. Translation: AAI39010.1 .
AK139512 mRNA. Translation: BAE24044.1 .
CCDSi CCDS36183.1.
RefSeqi NP_001035115.1. NM_001040026.1.
UniGenei Mm.129731.
Mm.473182.

3D structure databases

ProteinModelPortali Q5SUC9.
SMRi Q5SUC9. Positions 118-280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000104330.

PTM databases

PhosphoSitei Q5SUC9.

Proteomic databases

MaxQBi Q5SUC9.
PaxDbi Q5SUC9.
PRIDEi Q5SUC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092996 ; ENSMUSP00000090673 ; ENSMUSG00000069844 .
GeneIDi 52892.
KEGGi mmu:52892.
UCSCi uc007jlu.1. mouse.

Organism-specific databases

CTDi 6341.
MGIi MGI:106362. Sco1.

Phylogenomic databases

eggNOGi COG1999.
GeneTreei ENSGT00390000004323.
HOGENOMi HOG000258140.
HOVERGENi HBG000428.
InParanoidi Q5SUC9.
KOi K07152.
PhylomeDBi Q5SUC9.
TreeFami TF313752.

Enzyme and pathway databases

Reactomei REACT_262523. Respiratory electron transport.
REACT_268398. Orphan transporters.

Miscellaneous databases

NextBioi 309683.
PROi Q5SUC9.
SOURCEi Search...

Gene expression databases

Bgeei Q5SUC9.
ExpressionAtlasi Q5SUC9. baseline and differential.
Genevestigatori Q5SUC9.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR003782. SCO1/SenC.
IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR12151. PTHR12151. 1 hit.
Pfami PF02630. SCO1-SenC. 1 hit.
[Graphical view ]
PIRSFi PIRSF037736. SCO1. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-284.
    Strain: C57BL/6J.
    Tissue: Egg.

Entry informationi

Entry nameiSCO1_MOUSE
AccessioniPrimary (citable) accession number: Q5SUC9
Secondary accession number(s): Q3UTD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3