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Q5SUC9

- SCO1_MOUSE

UniProt

Q5SUC9 - SCO1_MOUSE

Protein

Protein SCO1 homolog, mitochondrial

Gene

Sco1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi152 – 1521CopperBy similarity
    Metal bindingi156 – 1561CopperBy similarity
    Metal bindingi243 – 2431CopperBy similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro

    GO - Biological processi

    1. cellular copper ion homeostasis Source: InterPro
    2. copper ion transport Source: InterPro
    3. respiratory chain complex IV assembly Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SCO1 homolog, mitochondrial
    Gene namesi
    Name:Sco1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:106362. Sco1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: InterPro
    2. mitochondrion Source: MGI
    3. myofibril Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 284Protein SCO1 homolog, mitochondrialPRO_0000354066
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ5SUC9.
    PaxDbiQ5SUC9.
    PRIDEiQ5SUC9.

    PTM databases

    PhosphoSiteiQ5SUC9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5SUC9.
    BgeeiQ5SUC9.
    GenevestigatoriQ5SUC9.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000104330.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SUC9.
    SMRiQ5SUC9. Positions 118-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni101 – 11414Important for dimerizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SCO1/2 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1999.
    GeneTreeiENSGT00390000004323.
    HOGENOMiHOG000258140.
    HOVERGENiHBG000428.
    KOiK07152.
    PhylomeDBiQ5SUC9.
    TreeFamiTF313752.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR003782. SCO1/SenC.
    IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR12151. PTHR12151. 1 hit.
    PfamiPF02630. SCO1-SenC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037736. SCO1. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5SUC9-1 [UniParc]FASTAAdd to Basket

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    MAALVRAAVV RSQCRQLWRL FPRGHGLRDV AERPRPEEAC SCLRSRAFSA    50
    GPPPPGAGPE PKGGQAGSHR PKPGPVSWKS LALTFAIGGS LLAGMKYFKK 100
    EKIEKLEKQR HRSIGKPLLG GPFSLTTHNG EPKTDKDYLG QWVLIYFGFT 150
    HCPDICPEEL EKMIEVVEEI DSIPSLPNLT PLFITIDPER DTKEAIATYV 200
    KEFSPKLVGL TGTKEEIDGV ARAYRVYYSP GPKDEDEDYI VDHTIIMYLI 250
    GPDGEFLDYF GQNKKKAEIA GSIAAHMRSH MKKR 284
    Length:284
    Mass (Da):31,617
    Last modified:December 21, 2004 - v1
    Checksum:i9CEC7E19F9977FF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL645988 Genomic DNA. Translation: CAI25980.1.
    BC139008 mRNA. Translation: AAI39009.1.
    BC139009 mRNA. Translation: AAI39010.1.
    AK139512 mRNA. Translation: BAE24044.1.
    CCDSiCCDS36183.1.
    RefSeqiNP_001035115.1. NM_001040026.1.
    UniGeneiMm.129731.
    Mm.473182.

    Genome annotation databases

    EnsembliENSMUST00000092996; ENSMUSP00000090673; ENSMUSG00000069844.
    GeneIDi52892.
    KEGGimmu:52892.
    UCSCiuc007jlu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL645988 Genomic DNA. Translation: CAI25980.1 .
    BC139008 mRNA. Translation: AAI39009.1 .
    BC139009 mRNA. Translation: AAI39010.1 .
    AK139512 mRNA. Translation: BAE24044.1 .
    CCDSi CCDS36183.1.
    RefSeqi NP_001035115.1. NM_001040026.1.
    UniGenei Mm.129731.
    Mm.473182.

    3D structure databases

    ProteinModelPortali Q5SUC9.
    SMRi Q5SUC9. Positions 118-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000104330.

    PTM databases

    PhosphoSitei Q5SUC9.

    Proteomic databases

    MaxQBi Q5SUC9.
    PaxDbi Q5SUC9.
    PRIDEi Q5SUC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092996 ; ENSMUSP00000090673 ; ENSMUSG00000069844 .
    GeneIDi 52892.
    KEGGi mmu:52892.
    UCSCi uc007jlu.1. mouse.

    Organism-specific databases

    CTDi 6341.
    MGIi MGI:106362. Sco1.

    Phylogenomic databases

    eggNOGi COG1999.
    GeneTreei ENSGT00390000004323.
    HOGENOMi HOG000258140.
    HOVERGENi HBG000428.
    KOi K07152.
    PhylomeDBi Q5SUC9.
    TreeFami TF313752.

    Miscellaneous databases

    NextBioi 309683.
    PROi Q5SUC9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5SUC9.
    Bgeei Q5SUC9.
    Genevestigatori Q5SUC9.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR003782. SCO1/SenC.
    IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR12151. PTHR12151. 1 hit.
    Pfami PF02630. SCO1-SenC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037736. SCO1. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-284.
      Strain: C57BL/6J.
      Tissue: Egg.

    Entry informationi

    Entry nameiSCO1_MOUSE
    AccessioniPrimary (citable) accession number: Q5SUC9
    Secondary accession number(s): Q3UTD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3