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Protein
Submitted name:

Calnexin, isoform CRA_a

Gene

Canx

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calnexin, isoform CRA_aImported
Gene namesi
Name:CanxImported
ORF Names:mCG_125213Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88261 Canx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei483 – 504HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_501420590021 – 591UniRule annotationAdd BLAST571

Proteomic databases

MaxQBiQ5SUC3
PRIDEiQ5SUC3

Expressioni

Gene expression databases

BgeeiENSMUSG00000020368
ExpressionAtlasiQ5SUC3 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili525 – 558Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the calreticulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0675 Eukaryota
ENOG410XP7T LUCA
HOVERGENiHBG005407
KOiK08054
OMAiNHKNPKT
OrthoDBiEOG091G04SS

Family and domain databases

Gene3Di2.10.250.10, 1 hit
InterProiView protein in InterPro
IPR001580 Calret/calnex
IPR018124 Calret/calnex_CS
IPR009033 Calreticulin/calnexin_P_dom_sf
IPR013320 ConA-like_dom_sf
PANTHERiPTHR11073 PTHR11073, 1 hit
PfamiView protein in Pfam
PF00262 Calreticulin, 1 hit
PRINTSiPR00626 CALRETICULIN
SUPFAMiSSF49899 SSF49899, 2 hits
SSF63887 SSF63887, 1 hit
PROSITEiView protein in PROSITE
PS00803 CALRETICULIN_1, 1 hit
PS00804 CALRETICULIN_2, 1 hit
PS00805 CALRETICULIN_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SUC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKWLLCLL LVLGTAAVEA HDGHDDDAID IEDDLDDVIE EVEDSKSKSD
60 70 80 90 100
ASTPPSPKVT YKAPVPTGEV YFADSFDRGS LSGWILSKAK KDDTDDEIAK
110 120 130 140 150
YDGKWEVDEM KETKLPGDKG LVLMSRAKHH AISAKLNKPF LFDTKPLIVQ
160 170 180 190 200
YEVNFQNGIE CGGAYVKLLS KTAELSLDQF HDKTPYTIMF GPDKCGEDYK
210 220 230 240 250
LHFIFRHKNP KTGVYEEKHA KRPDADLKTY FTDKKTHLYT LILNPDNSFE
260 270 280 290 300
ILVDQSVVNS GNLLNDMTPP VNPSREIEDP EDRKPEDWDE RPKIADPDAV
310 320 330 340 350
KPDDWDEDAP SKIPDEEATK PEGWLDDEPE YIPDPDAEKP EDWDEDMDGE
360 370 380 390 400
WEAPQIANPK CESAPGCGVW QRPMIDNPNY KGKWKPPMID NPNYQGIWKP
410 420 430 440 450
RKIPNPDFFE DLEPFKMTPF SAIGLELWSM TSDIFFDNFI ISGDRRVVDD
460 470 480 490 500
WANDGWGLKK AADGAAEPGV VLQMLEAAEE RPWLWVVYIL TVALPVFLVI
510 520 530 540 550
LFCCSGKKQS NAMEYKKTDA PQPDVKDEEG KEEEKNKRDE EEEEEKLEEK
560 570 580 590
QKSDAEEDGV TGSQDEEDSK PKAEEDEILN RSPRNRKPRR E
Length:591
Mass (Da):67,278
Last modified:May 10, 2005 - v1
Checksum:i0D9F8FE03434BADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165508 mRNA Translation: BAE38226.1
AK166649 mRNA Translation: BAE38916.1
CH466575 Genomic DNA Translation: EDL33703.1
CH466575 Genomic DNA Translation: EDL33704.1
CH466575 Genomic DNA Translation: EDL33705.1
RefSeqiNP_001103969.1, NM_001110499.1
NP_001103970.1, NM_001110500.1
NP_031623.1, NM_007597.3
UniGeneiMm.248827

Genome annotation databases

GeneIDi12330
KEGGimmu:12330

Similar proteinsi

Entry informationi

Entry nameiQ5SUC3_MOUSE
AccessioniPrimary (citable) accession number: Q5SUC3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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