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Q5STT8

- Q5STT8_MOUSE

UniProt

Q5STT8 - Q5STT8_MOUSE

Protein
Submitted name:

IL2-inducible T-cell kinase

Gene

Itk

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: Ensembl

    GO - Biological processi

    1. interferon-gamma production Source: MGI
    2. interleukin-4 production Source: MGI
    3. intracellular signal transduction Source: InterPro
    4. NK T cell differentiation Source: MGI

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    IL2-inducible T-cell kinaseImported
    Submitted name:
    Tyrosine-protein kinase ITK/TSKImported
    Gene namesi
    Name:ItkImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96621. Itk.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: MGI

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ5STT8.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PH domain.UniRule annotation
    Contains 1 SH3 domain.UniRule annotation
    Contains PH domain.SAAS annotation
    Contains SH2 domain.SAAS annotation
    Contains SH3 domain.SAAS annotation
    Contains SHdomain.SAAS annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00640000091251.
    HOVERGENiHBG008761.
    KOiK07363.
    OrthoDBiEOG7KM5SC.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view]
    PfamiPF00779. BTK. 1 hit.
    PF00169. PH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00402. TECBTKDOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5STT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT    50
    LKGSIELSRI KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ 100
    RWVLTLKEET RNNNSLVSKY HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK 150
    NASKKPLPPT PEDNRRSFQE PEETLVIALY DYQTNDPQEL ALRCDEEYYL 200
    LDSSEIHWWR VQDKNGHEGY APSSYLVEKS PNNLETYEWY NKSISRDKAE 250
    KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIISENPCIK HYHIKETNDS 300
    PKRYYVAEKY VFDSIPLLIQ YHQYNGGGLV TRLRYPVCSW RQKAPVTAGL 350
    RYGKWVIQPS ELTFVQEIGS GQFGLVHLGY WLNKDKVAIK TIQEGAMSEE 400
    DFIEEAEVMM KLSHPKLVQL YGVCLEQAPI CLVFEFMEHG CLSDYLRSQR 450
    GLFAAETLLG MCLDVCEGMA YLEKACVIHR DLAARNCLVG ENQVIKVSDF 500
    GMTRFVLDDQ YTSSTGTKFP VKWASPEVFS FSRYSSKSDV WSFGVLMWEV 550
    FSEGKIPYEN RSNSEVVEDI STGFRLYKPR LASCHVYQIM NHCWKEKPED 600
    RPPFSQLLSQ LAEIAEAGL 619
    Length:619
    Mass (Da):71,574
    Last modified:May 10, 2005 - v1
    Checksum:iFF97AA30F8545B6B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL662806 Genomic DNA. No translation available.
    BC128374 mRNA. Translation: AAI28375.1.
    RefSeqiNP_034713.2. NM_010583.3.
    UniGeneiMm.339927.

    Genome annotation databases

    EnsembliENSMUST00000020664; ENSMUSP00000020664; ENSMUSG00000020395.
    GeneIDi16428.
    KEGGimmu:16428.
    UCSCiuc007iog.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL662806 Genomic DNA. No translation available.
    BC128374 mRNA. Translation: AAI28375.1 .
    RefSeqi NP_034713.2. NM_010583.3.
    UniGenei Mm.339927.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020664 ; ENSMUSP00000020664 ; ENSMUSG00000020395 .
    GeneIDi 16428.
    KEGGi mmu:16428.
    UCSCi uc007iog.1. mouse.

    Organism-specific databases

    CTDi 3702.
    MGIi MGI:96621. Itk.

    Phylogenomic databases

    GeneTreei ENSGT00640000091251.
    HOVERGENi HBG008761.
    KOi K07363.
    OrthoDBi EOG7KM5SC.

    Miscellaneous databases

    NextBioi 289653.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q5STT8.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view ]
    Pfami PF00779. BTK. 1 hit.
    PF00169. PH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00402. TECBTKDOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ5STT8_MOUSE
    AccessioniPrimary (citable) accession number: Q5STT8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3