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Protein

Tyrosine-protein kinase

Gene

Itk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:ItkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96621 Itk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000020395

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 111PHInterPro annotationAdd BLAST108
Domaini171 – 231SH3InterPro annotationAdd BLAST61
Domaini239 – 337SH2InterPro annotationAdd BLAST99
Domaini362 – 614Protein kinaseInterPro annotationAdd BLAST253

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000119011
HOVERGENiHBG008761

Family and domain databases

CDDicd11908 SH3_ITK, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035583 ITK_SH3
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001562 Znf_Btk_motif
PfamiView protein in Pfam
PF00779 BTK, 1 hit
PF00169 PH, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00402 TECBTKDOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00107 BTK, 1 hit
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit
PS51113 ZF_BTK, 1 hit

Sequencei

Sequence statusi: Complete.

Q5STT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT
60 70 80 90 100
LKGSIELSRI KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ
110 120 130 140 150
RWVLTLKEET RNNNSLVSKY HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK
160 170 180 190 200
NASKKPLPPT PEDNRRSFQE PEETLVIALY DYQTNDPQEL ALRCDEEYYL
210 220 230 240 250
LDSSEIHWWR VQDKNGHEGY APSSYLVEKS PNNLETYEWY NKSISRDKAE
260 270 280 290 300
KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIISENPCIK HYHIKETNDS
310 320 330 340 350
PKRYYVAEKY VFDSIPLLIQ YHQYNGGGLV TRLRYPVCSW RQKAPVTAGL
360 370 380 390 400
RYGKWVIQPS ELTFVQEIGS GQFGLVHLGY WLNKDKVAIK TIQEGAMSEE
410 420 430 440 450
DFIEEAEVMM KLSHPKLVQL YGVCLEQAPI CLVFEFMEHG CLSDYLRSQR
460 470 480 490 500
GLFAAETLLG MCLDVCEGMA YLEKACVIHR DLAARNCLVG ENQVIKVSDF
510 520 530 540 550
GMTRFVLDDQ YTSSTGTKFP VKWASPEVFS FSRYSSKSDV WSFGVLMWEV
560 570 580 590 600
FSEGKIPYEN RSNSEVVEDI STGFRLYKPR LASCHVYQIM NHCWKEKPED
610
RPPFSQLLSQ LAEIAEAGL
Length:619
Mass (Da):71,574
Last modified:May 10, 2005 - v1
Checksum:iFF97AA30F8545B6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662806 Genomic DNA No translation available.
BC128374 mRNA Translation: AAI28375.1
RefSeqiNP_034713.2, NM_010583.3
UniGeneiMm.339927

Genome annotation databases

EnsembliENSMUST00000020664; ENSMUSP00000020664; ENSMUSG00000020395
GeneIDi16428
UCSCiuc007iog.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ5STT8_MOUSE
AccessioniPrimary (citable) accession number: Q5STT8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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