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Q5STT8

- Q5STT8_MOUSE

UniProt

Q5STT8 - Q5STT8_MOUSE

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Protein
Submitted name:

IL2-inducible T-cell kinase

Gene
Itk
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: Ensembl

GO - Biological processi

  1. interferon-gamma production Source: MGI
  2. interleukin-4 production Source: MGI
  3. intracellular signal transduction Source: InterPro
  4. NK T cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
IL2-inducible T-cell kinaseImported
Submitted name:
Tyrosine-protein kinase ITK/TSKImported
Gene namesi
Name:ItkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96621. Itk.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ5STT8.

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains PH domain.SAAS annotations
Contains SH2 domain.SAAS annotations
Contains SH3 domain.SAAS annotations
Contains SHdomain.SAAS annotations
Contains protein kinase domain.SAAS annotations

Keywords - Domaini

SH2 domainSAAS annotations, SH3 domainUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00640000091251.
HOVERGENiHBG008761.
KOiK07363.
OrthoDBiEOG7KM5SC.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5STT8-1 [UniParc]FASTAAdd to Basket

« Hide

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT    50
LKGSIELSRI KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ 100
RWVLTLKEET RNNNSLVSKY HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK 150
NASKKPLPPT PEDNRRSFQE PEETLVIALY DYQTNDPQEL ALRCDEEYYL 200
LDSSEIHWWR VQDKNGHEGY APSSYLVEKS PNNLETYEWY NKSISRDKAE 250
KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIISENPCIK HYHIKETNDS 300
PKRYYVAEKY VFDSIPLLIQ YHQYNGGGLV TRLRYPVCSW RQKAPVTAGL 350
RYGKWVIQPS ELTFVQEIGS GQFGLVHLGY WLNKDKVAIK TIQEGAMSEE 400
DFIEEAEVMM KLSHPKLVQL YGVCLEQAPI CLVFEFMEHG CLSDYLRSQR 450
GLFAAETLLG MCLDVCEGMA YLEKACVIHR DLAARNCLVG ENQVIKVSDF 500
GMTRFVLDDQ YTSSTGTKFP VKWASPEVFS FSRYSSKSDV WSFGVLMWEV 550
FSEGKIPYEN RSNSEVVEDI STGFRLYKPR LASCHVYQIM NHCWKEKPED 600
RPPFSQLLSQ LAEIAEAGL 619
Length:619
Mass (Da):71,574
Last modified:May 10, 2005 - v1
Checksum:iFF97AA30F8545B6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL662806 Genomic DNA. No translation available.
BC128374 mRNA. Translation: AAI28375.1.
RefSeqiNP_034713.2. NM_010583.3.
UniGeneiMm.339927.

Genome annotation databases

EnsembliENSMUST00000020664; ENSMUSP00000020664; ENSMUSG00000020395.
GeneIDi16428.
KEGGimmu:16428.
UCSCiuc007iog.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL662806 Genomic DNA. No translation available.
BC128374 mRNA. Translation: AAI28375.1 .
RefSeqi NP_034713.2. NM_010583.3.
UniGenei Mm.339927.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020664 ; ENSMUSP00000020664 ; ENSMUSG00000020395 .
GeneIDi 16428.
KEGGi mmu:16428.
UCSCi uc007iog.1. mouse.

Organism-specific databases

CTDi 3702.
MGIi MGI:96621. Itk.

Phylogenomic databases

GeneTreei ENSGT00640000091251.
HOVERGENi HBG008761.
KOi K07363.
OrthoDBi EOG7KM5SC.

Miscellaneous databases

NextBioi 289653.
SOURCEi Search...

Gene expression databases

Genevestigatori Q5STT8.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view ]
Pfami PF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTi SM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ5STT8_MOUSE
AccessioniPrimary (citable) accession number: Q5STT8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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