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Protein
Submitted name:

Tyrosine-protein kinase ITK/TSK

Gene

Itk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. non-membrane spanning protein tyrosine kinase activity Source: MGI

GO - Biological processi

  1. innate immune response Source: GO_Central
  2. interferon-gamma production Source: MGI
  3. interleukin-4 production Source: MGI
  4. intracellular signal transduction Source: InterPro
  5. NK T cell differentiation Source: MGI
  6. peptidyl-tyrosine autophosphorylation Source: GO_Central
  7. regulation of cell proliferation Source: GO_Central
  8. transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein kinase ITK/TSKImported
Gene namesi
Name:ItkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96621. Itk.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ5STT7.

Expressioni

Gene expression databases

ExpressionAtlasiQ5STT7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104860.

Structurei

3D structure databases

ProteinModelPortaliQ5STT7.
SMRiQ5STT7. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119011.
HOGENOMiHOG000214181.
KOiK07363.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00402. TECBTKDOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5STT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT
60 70 80 90 100
LKGSIELSRI KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ
110 120 130 140 150
RWVLTLKEET RNNNSLVSKY HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK
160 170 180 190 200
NASKKPLPPT PEDNRRSFQE PEETLVIALY DYQTNDPQEL ALRCDEEYYL
210 220 230 240 250
LDSSEIHWWR VQDKNGHEGY APSSYLVEKS PNNLETYEWY NKSISRDKAE
260
KLLLDTVKKW TRIL
Length:264
Mass (Da):31,287
Last modified:December 21, 2004 - v1
Checksum:iA8C30A72892DC755
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662806 Genomic DNA. No translation available.
RefSeqiNP_001268896.1. NM_001281967.1.
UniGeneiMm.339927.

Genome annotation databases

EnsembliENSMUST00000101306; ENSMUSP00000098864; ENSMUSG00000020395.
GeneIDi16428.
KEGGimmu:16428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662806 Genomic DNA. No translation available.
RefSeqiNP_001268896.1. NM_001281967.1.
UniGeneiMm.339927.

3D structure databases

ProteinModelPortaliQ5STT7.
SMRiQ5STT7. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104860.

Proteomic databases

PRIDEiQ5STT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101306; ENSMUSP00000098864; ENSMUSG00000020395.
GeneIDi16428.
KEGGimmu:16428.

Organism-specific databases

CTDi3702.
MGIiMGI:96621. Itk.

Phylogenomic databases

GeneTreeiENSGT00760000119011.
HOGENOMiHOG000214181.
KOiK07363.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ5STT7. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00402. TECBTKDOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ5STT7_MOUSE
AccessioniPrimary (citable) accession number: Q5STT7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.