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Protein
Submitted name:

TNF

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TNFImported
Submitted name:
TNFA proteinImported
Submitted name:
Tumor necrosis factorImported
Submitted name:
Tumor necrosis factor (TNF superfamily, member 2)Imported
Submitted name:
Tumor necrosis factor ligand 1FImported
Submitted name:
Tumor necrosis factor-alphaImported
Submitted name:
cDNA, FLJ95875, Homo sapiens tumor necrosis factor (TNF superfamily, member 2)(TNF), mRNAImported
Gene namesi
Name:TNFImported
Synonyms:TNFAImported, TNLG1FImported
ORF Names:hCG_43716Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 55HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA435.

Expressioni

Gene expression databases

BgeeiENSG00000232810.

Interactioni

Subunit structurei

Homotrimer.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ5STB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 233TNF_2InterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410ISAN. Eukaryota.
ENOG410YQC4. LUCA.
HOVERGENiHBG012516.
KOiK03156.
OMAiPWYEPIY.
OrthoDBiEOG091G0HIG.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
PANTHERiPTHR11471:SF46. PTHR11471:SF46. 1 hit.
PfamiView protein in Pfam
PF00229. TNF. 1 hit.
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5STB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL
60 70 80 90 100
LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG
110 120 130 140 150
QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV
160 170 180 190 200
LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF
210 220 230
QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
Length:233
Mass (Da):25,644
Last modified:May 10, 2005 - v1
Checksum:i3DF90F96C9031FFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ201306 mRNA. Translation: ADV31546.2.
KF887965 Genomic DNA. Translation: AHJ25918.1.
KF887966 Genomic DNA. Translation: AHJ25919.1.
KF887967 Genomic DNA. Translation: AHJ25920.1.
KF887968 Genomic DNA. Translation: AHJ25921.1.
KF887969 Genomic DNA. Translation: AHJ25922.1.
KF887970 Genomic DNA. Translation: AHJ25923.1.
KF887971 Genomic DNA. Translation: AHJ25924.1.
KF887972 Genomic DNA. Translation: AHJ25925.1.
KY500676 Genomic DNA. Translation: AQY77148.1.
KY500678 Genomic DNA. Translation: AQY77150.1.
AB202113 Genomic DNA. Translation: BAE78639.1.
AB103618 Genomic DNA. Translation: BAF31279.1.
AK314960 mRNA. Translation: BAG37464.1.
LN874317 mRNA. Translation: CTQ86082.1.
CH471081 Genomic DNA. Translation: EAX03424.1.
RefSeqiNP_000585.2. NM_000594.3.
UniGeneiHs.241570.

Genome annotation databases

GeneIDi7124.
KEGGihsa:7124.
UCSCiuc003nui.5. human.

Similar proteinsi

Entry informationi

Entry nameiQ5STB3_HUMAN
AccessioniPrimary (citable) accession number: Q5STB3
Secondary accession number(s): E7DB75
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: August 30, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.