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Protein
Submitted name:

TNFA protein

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cell activation Source: Ensembl
  4. cellular extravasation Source: Ensembl
  5. cellular response to amino acid stimulus Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to Gram-positive bacterium Source: Ensembl
  8. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  9. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  10. extracellular matrix organization Source: Ensembl
  11. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  12. glucose metabolic process Source: Ensembl
  13. humoral immune response Source: Ensembl
  14. inflammatory response Source: Ensembl
  15. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  16. JNK cascade Source: Ensembl
  17. negative regulation of alkaline phosphatase activity Source: Ensembl
  18. negative regulation of cell proliferation Source: Ensembl
  19. negative regulation of glucose import Source: Ensembl
  20. negative regulation of growth of symbiont in host Source: Ensembl
  21. negative regulation of L-glutamate transport Source: Ensembl
  22. negative regulation of myoblast differentiation Source: Ensembl
  23. negative regulation of osteoblast differentiation Source: Ensembl
  24. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  25. osteoclast differentiation Source: Ensembl
  26. positive regulation of action potential Source: Ensembl
  27. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
  28. positive regulation of fever generation Source: Ensembl
  29. positive regulation of hair follicle development Source: Ensembl
  30. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  31. positive regulation of interferon-gamma production Source: Ensembl
  32. positive regulation of interleukin-18 production Source: Ensembl
  33. positive regulation of interleukin-6 production Source: Ensembl
  34. positive regulation of JNK cascade Source: Ensembl
  35. positive regulation of mitotic nuclear division Source: Ensembl
  36. positive regulation of neuron apoptotic process Source: Ensembl
  37. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  38. positive regulation of protein kinase B signaling Source: Ensembl
  39. positive regulation of synaptic transmission Source: Ensembl
  40. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  41. positive regulation of translational initiation by iron Source: Ensembl
  42. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
  43. regulation of immunoglobulin secretion Source: Ensembl
  44. regulation of osteoclast differentiation Source: Ensembl
  45. regulation of protein phosphorylation Source: Ensembl
  46. regulation of reactive oxygen species metabolic process Source: Ensembl
  47. response to activity Source: Ensembl
  48. response to drug Source: Ensembl
  49. response to gold nanoparticle Source: Ensembl
  50. response to hypoxia Source: Ensembl
  51. response to radiation Source: Ensembl
  52. skeletal muscle contraction Source: Ensembl
  53. tumor necrosis factor-mediated signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TNFA proteinImported
Submitted name:
Tumor necrosis factorImported
Submitted name:
Tumor necrosis factor (TNF superfamily, member 2)Imported
Submitted name:
Tumor necrosis factor-alphaImported
Submitted name:
cDNA, FLJ95875, Homo sapiens tumor necrosis factor (TNF superfamily, member 2)(TNF), mRNAImported
Gene namesi
Name:TNFImported
Synonyms:TNFAImported
ORF Names:hCG_43716Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane raft Source: Ensembl
  5. phagocytic cup Source: Ensembl
  6. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA435.

PTM / Processingi

Proteomic databases

PRIDEiQ5STB3.

Expressioni

Gene expression databases

BgeeiQ5STB3.
ExpressionAtlasiQ5STB3. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ5STB3.
SMRiQ5STB3. Positions 85-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000062992.
HOVERGENiHBG012516.
KOiK03156.
OMAiPWYEPIY.
PhylomeDBiQ5STB3.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5STB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL
60 70 80 90 100
LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG
110 120 130 140 150
QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV
160 170 180 190 200
LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF
210 220 230
QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
Length:233
Mass (Da):25,644
Last modified:May 10, 2005 - v1
Checksum:i3DF90F96C9031FFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ201306 mRNA. Translation: ADV31546.2.
KF887965 Genomic DNA. Translation: AHJ25918.1.
KF887966 Genomic DNA. Translation: AHJ25919.1.
KF887967 Genomic DNA. Translation: AHJ25920.1.
KF887968 Genomic DNA. Translation: AHJ25921.1.
KF887969 Genomic DNA. Translation: AHJ25922.1.
KF887970 Genomic DNA. Translation: AHJ25923.1.
KF887971 Genomic DNA. Translation: AHJ25924.1.
KF887972 Genomic DNA. Translation: AHJ25925.1.
AB202113 Genomic DNA. Translation: BAE78639.1.
AB103618 Genomic DNA. Translation: BAF31279.1.
AK314960 mRNA. Translation: BAG37464.1.
CH471081 Genomic DNA. Translation: EAX03424.1.
RefSeqiNP_000585.2. NM_000594.3.
UniGeneiHs.241570.

Genome annotation databases

GeneIDi7124.
KEGGihsa:7124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ201306 mRNA. Translation: ADV31546.2.
KF887965 Genomic DNA. Translation: AHJ25918.1.
KF887966 Genomic DNA. Translation: AHJ25919.1.
KF887967 Genomic DNA. Translation: AHJ25920.1.
KF887968 Genomic DNA. Translation: AHJ25921.1.
KF887969 Genomic DNA. Translation: AHJ25922.1.
KF887970 Genomic DNA. Translation: AHJ25923.1.
KF887971 Genomic DNA. Translation: AHJ25924.1.
KF887972 Genomic DNA. Translation: AHJ25925.1.
AB202113 Genomic DNA. Translation: BAE78639.1.
AB103618 Genomic DNA. Translation: BAF31279.1.
AK314960 mRNA. Translation: BAG37464.1.
CH471081 Genomic DNA. Translation: EAX03424.1.
RefSeqiNP_000585.2. NM_000594.3.
UniGeneiHs.241570.

3D structure databases

ProteinModelPortaliQ5STB3.
SMRiQ5STB3. Positions 85-233.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ5STB3.

Proteomic databases

PRIDEiQ5STB3.

Protocols and materials databases

DNASUi7124.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7124.
KEGGihsa:7124.

Organism-specific databases

CTDi7124.
PharmGKBiPA435.

Phylogenomic databases

GeneTreeiENSGT00530000062992.
HOVERGENiHBG012516.
KOiK03156.
OMAiPWYEPIY.
PhylomeDBiQ5STB3.

Miscellaneous databases

ChiTaRSiTNF. human.
GenomeRNAii7124.
NextBioi27879.

Gene expression databases

BgeeiQ5STB3.
ExpressionAtlasiQ5STB3. baseline and differential.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Peripheral blood leukocyteImported.
  4. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Cited for: NUCLEOTIDE SEQUENCE.
  6. Rajmani R., Tiwari A., Ravi Kumar G., Sahoo A., Doley J., Singh P., Rajiv K., Lovleen S., Shikha S., Chaturvedi U., Palia S., Tiwari S.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "TNF and LTA diversity in Caucasians."
    Selby S.T., Hou L., Steiner N., Hurley C.K., Posch P.E.
    Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ5STB3_HUMAN
AccessioniPrimary (citable) accession number: Q5STB3
Secondary accession number(s): E7DB75
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 1, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.