Q5STB3 (Q5STB3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
TNFA protein EMBL BAF31279.1

Submitted name:
Tumor necrosis factor (TNF superfamily, member 2) EMBL BAE78639.1
Submitted name:
Tumor necrosis factor-alpha EMBL ADV31546.2
Submitted name:
cDNA, FLJ95875, Homo sapiens tumor necrosis factor (TNF superfamily, member 2)(TNF), mRNA EMBL BAG37464.1

Gene names

Name:	TNF EMBL BAE78639.1
Synonyms:	TNFA EMBL BAF31279.1
ORF Names:	hCG_43716 EMBL EAX03424.1

Organism

Homo sapiens (Human) EMBL ADV31546.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Cellular component	Membrane SAAS SAAS006052 Secreted SAAS SAAS006053
Molecular function	Cytokine SAAS SAAS006052
Gene Ontology (GO)
Biological_process	JNK cascade Inferred from electronic annotation. Source: Compara calcium-mediated signaling Inferred from electronic annotation. Source: Compara cell activation Inferred from electronic annotation. Source: Compara cellular extravasation Inferred from electronic annotation. Source: Compara cellular response to amino acid stimulus Inferred from electronic annotation. Source: Compara defense response to Gram-positive bacterium Inferred from electronic annotation. Source: Compara epithelial cell proliferation involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara extracellular matrix organization Inferred from electronic annotation. Source: Compara extrinsic apoptotic signaling pathway via death domain receptors Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara humoral immune response Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara negative regulation of L-glutamate transport Inferred from electronic annotation. Source: Compara negative regulation of alkaline phosphatase activity Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of glucose import Inferred from electronic annotation. Source: Compara negative regulation of growth of symbiont in host Inferred from electronic annotation. Source: Compara negative regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara organ morphogenesis Inferred from electronic annotation. Source: Compara osteoclast differentiation Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of JNK cascade Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of chronic inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara positive regulation of fever generation Inferred from electronic annotation. Source: Compara positive regulation of hair follicle development Inferred from electronic annotation. Source: Compara positive regulation of humoral immune response mediated by circulating immunoglobulin Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara positive regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of translational initiation by iron Inferred from electronic annotation. Source: Compara regulation of branching involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara regulation of immunoglobulin secretion Inferred from electronic annotation. Source: Compara regulation of osteoclast differentiation Inferred from electronic annotation. Source: Compara regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara response to activity Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to mechanical stimulus Inferred from electronic annotation. Source: Compara skeletal muscle contraction Inferred from electronic annotation. Source: Compara tumor necrosis factor-mediated signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara phagocytic cup Inferred from electronic annotation. Source: Compara recycling endosome Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5STB3 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 3DF90F96C9031FFE	FASTA	233	25,644
	10 20 30 40 50 60 MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR 70 80 90 100 110 120 EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR 130 140 150 160 170 180 DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE 190 200 210 220 230 TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL

References

[1]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S. Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Peripheral blood leukocyte EMBL BAE78639.1.
[3]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Rajmani R.S., Tiwari A.K., Subudhi P., Ravi Kumar G., Sahoo A., Palia S.K., Uttara C., Lovleen S., Shika S., Sangeeta T., Doley J., Singh P.K. Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	Rajmani R., Tiwari A., Ravi Kumar G., Sahoo A., Doley J., Singh P., Rajiv K., Lovleen S., Shikha S., Chaturvedi U., Palia S., Tiwari S. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HQ201306 mRNA. Translation: ADV31546.2. AB202113 Genomic DNA. Translation: BAE78639.1. AB103618 Genomic DNA. Translation: BAF31279.1. AK314960 mRNA. Translation: BAG37464.1. CH471081 Genomic DNA. Translation: EAX03424.1.
IPI	IPI00001671.
RefSeq	NP_000585.2. NM_000594.3.
UniGene	Hs.241570.
3D structure databases
ProteinModelPortal	Q5STB3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5STB3.
Proteomic databases
PRIDE	Q5STB3.
Protocols and materials databases
DNASU	7124.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7124.
KEGG	hsa:7124.
Organism-specific databases
CTD	7124.
PharmGKB	PA435.
Phylogenomic databases
HOVERGEN	HBG012516.
KO	K03156.
OMA	WYEPIYL.
PhylomeDB	Q5STB3.
Gene expression databases
ArrayExpress	Q5STB3.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR006052. TNF. IPR006053. TNF_a/b/c. IPR002959. TNF_alpha. IPR021184. TNF_CS. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00229. TNF. 1 hit. [Graphical view]
PRINTS	PR01234. TNECROSISFCT. PR01235. TNFALPHA.
SMART	SM00207. TNF. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TNF. human.
GenomeRNAi	7124.
NextBio	27879.

Entry information

Entry name

Q5STB3_HUMAN

Accession

Primary (citable) accession number: Q5STB3
Secondary accession number(s): E7DB75

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.