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Q5STB3

- Q5STB3_HUMAN

UniProt

Q5STB3 - Q5STB3_HUMAN

Protein
Submitted name:

TNFA protein

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cell activation Source: Ensembl
    4. cellular amino acid biosynthetic process Source: Ensembl
    5. cellular extravasation Source: Ensembl
    6. cellular response to amino acid stimulus Source: Ensembl
    7. defense response to Gram-positive bacterium Source: Ensembl
    8. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    9. extracellular matrix organization Source: Ensembl
    10. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    11. glucose metabolic process Source: Ensembl
    12. humoral immune response Source: Ensembl
    13. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    14. JNK cascade Source: Ensembl
    15. negative regulation of alkaline phosphatase activity Source: Ensembl
    16. negative regulation of cell proliferation Source: Ensembl
    17. negative regulation of glucose import Source: Ensembl
    18. negative regulation of growth of symbiont in host Source: Ensembl
    19. negative regulation of L-glutamate transport Source: Ensembl
    20. negative regulation of osteoblast differentiation Source: Ensembl
    21. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    22. organ morphogenesis Source: Ensembl
    23. osteoclast differentiation Source: Ensembl
    24. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
    25. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    26. positive regulation of fever generation Source: Ensembl
    27. positive regulation of hair follicle development Source: Ensembl
    28. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
    29. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    30. positive regulation of interferon-gamma production Source: Ensembl
    31. positive regulation of interleukin-18 production Source: Ensembl
    32. positive regulation of interleukin-6 production Source: Ensembl
    33. positive regulation of JNK cascade Source: Ensembl
    34. positive regulation of mitosis Source: Ensembl
    35. positive regulation of neuron apoptotic process Source: Ensembl
    36. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    37. positive regulation of protein kinase B signaling Source: Ensembl
    38. positive regulation of synaptic transmission Source: Ensembl
    39. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    40. positive regulation of translational initiation by iron Source: Ensembl
    41. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
    42. regulation of immunoglobulin secretion Source: Ensembl
    43. regulation of osteoclast differentiation Source: Ensembl
    44. regulation of protein phosphorylation Source: Ensembl
    45. response to activity Source: Ensembl
    46. response to drug Source: Ensembl
    47. response to hypoxia Source: Ensembl
    48. response to mechanical stimulus Source: Ensembl
    49. skeletal muscle contraction Source: Ensembl
    50. tumor necrosis factor-mediated signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    CytokineSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TNFA proteinImported
    Submitted name:
    Tumor necrosis factorImported
    Submitted name:
    Tumor necrosis factor (TNF superfamily, member 2)Imported
    Submitted name:
    Tumor necrosis factor-alphaImported
    Submitted name:
    cDNA, FLJ95875, Homo sapiens tumor necrosis factor (TNF superfamily, member 2)(TNF), mRNAImported
    Gene namesi
    Name:TNFImported
    Synonyms:TNFAImported
    ORF Names:hCG_43716Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane raft Source: Ensembl
    5. phagocytic cup Source: Ensembl
    6. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    Membrane, SecretedSAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA435.

    Structurei

    3D structure databases

    SMRiQ5STB3. Positions 85-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG012516.
    KOiK03156.
    OMAiPWYEPIY.
    PhylomeDBiQ5STB3.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5STB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL    50
    LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG 100
    QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV 150
    LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF 200
    QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL 233
    Length:233
    Mass (Da):25,644
    Last modified:May 10, 2005 - v1
    Checksum:i3DF90F96C9031FFE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ201306 mRNA. Translation: ADV31546.2.
    KF887965 Genomic DNA. Translation: AHJ25918.1.
    KF887966 Genomic DNA. Translation: AHJ25919.1.
    KF887967 Genomic DNA. Translation: AHJ25920.1.
    KF887968 Genomic DNA. Translation: AHJ25921.1.
    KF887969 Genomic DNA. Translation: AHJ25922.1.
    KF887970 Genomic DNA. Translation: AHJ25923.1.
    KF887971 Genomic DNA. Translation: AHJ25924.1.
    KF887972 Genomic DNA. Translation: AHJ25925.1.
    AB202113 Genomic DNA. Translation: BAE78639.1.
    AB103618 Genomic DNA. Translation: BAF31279.1.
    AK314960 mRNA. Translation: BAG37464.1.
    CH471081 Genomic DNA. Translation: EAX03424.1.
    RefSeqiNP_000585.2. NM_000594.3.
    UniGeneiHs.241570.

    Genome annotation databases

    GeneIDi7124.
    KEGGihsa:7124.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ201306 mRNA. Translation: ADV31546.2 .
    KF887965 Genomic DNA. Translation: AHJ25918.1 .
    KF887966 Genomic DNA. Translation: AHJ25919.1 .
    KF887967 Genomic DNA. Translation: AHJ25920.1 .
    KF887968 Genomic DNA. Translation: AHJ25921.1 .
    KF887969 Genomic DNA. Translation: AHJ25922.1 .
    KF887970 Genomic DNA. Translation: AHJ25923.1 .
    KF887971 Genomic DNA. Translation: AHJ25924.1 .
    KF887972 Genomic DNA. Translation: AHJ25925.1 .
    AB202113 Genomic DNA. Translation: BAE78639.1 .
    AB103618 Genomic DNA. Translation: BAF31279.1 .
    AK314960 mRNA. Translation: BAG37464.1 .
    CH471081 Genomic DNA. Translation: EAX03424.1 .
    RefSeqi NP_000585.2. NM_000594.3.
    UniGenei Hs.241570.

    3D structure databases

    SMRi Q5STB3. Positions 85-233.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 7124.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7124.
    KEGGi hsa:7124.

    Organism-specific databases

    CTDi 7124.
    PharmGKBi PA435.

    Phylogenomic databases

    HOVERGENi HBG012516.
    KOi K03156.
    OMAi PWYEPIY.
    PhylomeDBi Q5STB3.

    Miscellaneous databases

    ChiTaRSi TNF. human.
    GenomeRNAii 7124.
    NextBioi 27879.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
      Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
      , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
      Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Peripheral blood leukocyteImported.
    4. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    5. Cited for: NUCLEOTIDE SEQUENCE.
    6. Rajmani R., Tiwari A., Ravi Kumar G., Sahoo A., Doley J., Singh P., Rajiv K., Lovleen S., Shikha S., Chaturvedi U., Palia S., Tiwari S.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    7. "TNF and LTA diversity in Caucasians."
      Selby S.T., Hou L., Steiner N., Hurley C.K., Posch P.E.
      Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ5STB3_HUMAN
    AccessioniPrimary (citable) accession number: Q5STB3
    Secondary accession number(s): E7DB75
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.