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Protein
Submitted name:

LTB

Gene

LTB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
LTBImported
Submitted name:
LTB proteinImported
Submitted name:
Lymphotoxin betaImported
Submitted name:
Lymphotoxin beta (TNF superfamily, member 3)Imported
Submitted name:
Lymphotoxin beta (TNF superfamily, member 3), isoform CRA_bImported
Gene namesi
Name:LTBImported
ORF Names:hCG_43683Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000227507.2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 47HelicalSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30475.

Expressioni

Gene expression databases

BgeeiENSG00000227507.
ExpressionAtlasiQ5STB2. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ5STB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 243TNF_2InterPro annotationAdd BLAST155

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IJP9. Eukaryota.
ENOG410ZHBF. LUCA.
HOVERGENiHBG000209.
KOiK03157.
OMAiYCHVGYR.
OrthoDBiEOG091G0J9M.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR006053. TNF.
IPR002961. TNF_C.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00229. TNF. 1 hit.
PRINTSiPR01234. TNECROSISFCT.
PR01237. TNFC.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5STB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD
60 70 80 90 100
QGGLVTETAD PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ
110 120 130 140 150
GLGWETTKEQ AFLTSGTQFS DAEGLALPQD GLYYLYCLVG YRGRAPPGGG
160 170 180 190 200
DPQGRSVTLR SSLYRAGGAY GPGTPELLLE GAETVTPVLD PARRQGYGPL
210 220 230 240
WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA VMVG
Length:244
Mass (Da):25,390
Last modified:May 10, 2005 - v1
Checksum:iF41569459830ED4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY500414 Genomic DNA. Translation: AQY76901.1.
AB088106 Genomic DNA. Translation: BAC54938.1.
AB202114 Genomic DNA. Translation: BAE78640.1.
AB103612 Genomic DNA. Translation: BAF31273.1.
CH471081 Genomic DNA. Translation: EAX03426.1.
RefSeqiNP_002332.1. NM_002341.1.
UniGeneiHs.376208.

Genome annotation databases

GeneIDi4050.
KEGGihsa:4050.
UCSCiuc003nuk.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ5STB2_HUMAN
AccessioniPrimary (citable) accession number: Q5STB2
Secondary accession number(s): A8MQV6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.